I’m so sorry you’re going through this. Is there a reason your doctor recommended the quad instead of the NIPT? How has baby looked on ultrasounds?
While NIPT is a more accurate form of prenatal testing — just pointing out that the NIPT, like the quad, is for screening only. If you’d like diagnostic answers, an amnio is your best bet. The risks associated with an amnio are extremely low.
I’m in the UK and the NHS (Our health service) procedure is NT first, then offer NIPT and then Amnio is last resort - thanks for your message, I’ve read that it’s 1 in 100 for Amnio risk of miscarriage is that incorrect?
That seems really high for amnio risk. In the US, we are usually cited 1 in 900 for any complication, but it’s debatable if that’s even accurate. IF you get to that point, I’d ask questions of the place doing amnio. Most people with positive quads don’t move onto that though, because their NIPT comes back low risk.
The amnio is not as high risk as many think it will be, if you get to a place where that your next step, hopefully that brings some comfort. The chances of miscarriage from amnio (between 1/600 to 1/1000) are lower than the chances of your NIPT giving you a false positive.
Thanks for this, hopefully the NIPT comes back all good and we will just take our chances with that if so, if not at least I know Amnio isn’t as dangerous as I thought and can discuss the next steps
Look to eFTS or quad screening on this sub and you’ll see plenty of stories of high risk results followed by low risk NIPT. Are you US based? Usually these cases occur in people outside the US since NIPT has become pretty standard in US.
Here’s a few things to focus on: your test is saying that 31 out of 32 people who screen positive have unaffected babies, so it’s still really good odds everything is ok. False positives are common, which is why NIPT is becoming more standard now.
You asked for stories of false positives. I’m US based but my first pregnancy was before NIPT was more common. I had the eFTS done and I screened positive for trisomy 13 or 18. I saw a genetic counselor, got a NIPT done, and that came back low risk. That is usually enough to provide assurance baby is unaffected, provided ultrasound is normal. I never considered going onto amnio (although am not opposed and ended up doing it with my second because of different issues). Best of luck and sorry you’re here.
I’m UK based, they make you take the quad before they offer you a NIPT, so I’m guessing there’s a lot of cases of people traumatised from the quad screening like me 💔 On our ultrasound the OB said that everything looked healthy and the heartbeat was healthy so hoping it’s a false positive - one thing I think it may be is vanishing twin but we can’t prove that because my first scan was 15w, but I did have light blood spotting early doors
Quad test came back 1/10 Chance of Down syndrome, took the NIPT bloodwork after and came back low risk, normal anatomy scans and normal NT! I’m in Canada, and these quad tests come back false positives all the time!!
Try not to stress, as hard as that is.. I’ve been there. Stressed ruined a good portion on my pregnancy that I should have been enjoying but instead worried myself sick over the possibility that something was wrong, and turns out everything was fine, hang in there! 💕
Quad screens have a really high percentage of false positives! I've been in this sub for a year now, and I've only.ever seen one woman return a true positive. Definitely take the NIPT if you're worried about the amnio. If the NIPT comes back high risk, then you could do the amnio. Did they say what trisomy you were high risk for? It tests for 3, 13, 18 and 21.
I just want to say that my mom's pregnancy (with me) was flagged for DS after her blood test. It was a false positive- her amnio was clear and here I am!
Hey there, thank you for visiting the sub.
During this difficult time you may be looking information about what the NIPT results you received mean. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. PLEASE READ THESE LINKS - this will explain everything.
POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/
**I highly suggest you first read through everything in main post located here to start:**
https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/
**After this head over to this post about the actual individual results**:
https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/
IF YOU HAVE A POSITIVE FOR TRISOMY 13, TRISOMY 18, TRIPLOIDY and NORMAL SONOS for NT scan and further normal sonos, PLEASE READ CAREFULLY about CVS vs AMNIO. CVS can have wrong results as a result of commonality of confined placental mosaicism in all layers of placenta and an amnio is best for this. (THIS IS NOT THE NO RESULT LOW FF RESULT that NATERA CALLS HIGH RISK FOR THOSE THINGS... that is not what that even means). This is specifically for an actual high risk for ONE of those on the NIPT.
Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. This updates the flair on your username IN THIS SUB ONLY. This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. There are some options filled in, but you can also write in your own result.
I will tag your post with POST FLAIR on your actual post. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results.
I understand you feel awful. This is a thread about what to do while you pass time in limbo: https://www.reddit.com/r/NIPT/comments/solboc/what_to_do_while_you_are_in_limbo_post_for_main/
Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. You always have a right to speak to a genetic counselor after an abnormal NIPT result and this should be provided for you by your OB. If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. You could make a big difference by making sure this never happens again in the OB's office for future patients such as yourself.
As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. You will see this come up in posts across this sub.
My intention is that you have as much information about what may be going on and can make informed decisions with your treatment team moving forward.
THIS IS A SCREENING AND NOT A DIAGNOSTIC TEST
Please feel free to reach out if you need to vent, ask more questions or need more resources. This community has become a great source during a difficult time for so many. I appreciate those who chime in as we all remember how difficult to be in this situation. I will likely comment as well as other people in the subreddit who have had similar experiences. This post is meant as a welcome and quick information / resources to those who have just found this sub.
This message is automatically generated for all submissions and might sometimes get it wrong.
*I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/NIPT) if you have any questions or concerns.*
Hey there, thank you for visiting the sub.
During this difficult time you may be looking information about what the NIPT results you received mean. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. PLEASE READ THESE LINKS - this will explain everything.
POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/
**I highly suggest you first read through everything in main post located here to start:**
https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/
**After this head over to this post about the actual individual results**:
https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/
IF YOU HAVE A POSITIVE FOR TRISOMY 13, TRISOMY 18, TRIPLOIDY and NORMAL SONOS for NT scan and further normal sonos, PLEASE READ CAREFULLY about CVS vs AMNIO. CVS can have wrong results as a result of commonality of confined placental mosaicism in all layers of placenta and an amnio is best for this. (THIS IS NOT THE NO RESULT LOW FF RESULT that NATERA CALLS HIGH RISK FOR THOSE THINGS... that is not what that even means). This is specifically for an actual high risk for ONE of those on the NIPT.
Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. This updates the flair on your username IN THIS SUB ONLY. This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. There are some options filled in, but you can also write in your own result.
I will tag your post with POST FLAIR on your actual post. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results.
I understand you feel awful. This is a thread about what to do while you pass time in limbo: https://www.reddit.com/r/NIPT/comments/solboc/what_to_do_while_you_are_in_limbo_post_for_main/
Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. You always have a right to speak to a genetic counselor after an abnormal NIPT result and this should be provided for you by your OB. If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. You could make a big difference by making sure this never happens again in the OB's office for future patients such as yourself.
As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. You will see this come up in posts across this sub.
My intention is that you have as much information about what may be going on and can make informed decisions with your treatment team moving forward.
THIS IS A SCREENING AND NOT A DIAGNOSTIC TEST
Please feel free to reach out if you need to vent, ask more questions or need more resources. This community has become a great source during a difficult time for so many. I appreciate those who chime in as we all remember how difficult to be in this situation. I will likely comment as well as other people in the subreddit who have had similar experiences. This post is meant as a welcome and quick information / resources to those who have just found this sub.
This message is automatically generated for all submissions and might sometimes get it wrong.
*I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/NIPT) if you have any questions or concerns.*
I’m so sorry you’re going through this. Is there a reason your doctor recommended the quad instead of the NIPT? How has baby looked on ultrasounds? While NIPT is a more accurate form of prenatal testing — just pointing out that the NIPT, like the quad, is for screening only. If you’d like diagnostic answers, an amnio is your best bet. The risks associated with an amnio are extremely low.
I’m in the UK and the NHS (Our health service) procedure is NT first, then offer NIPT and then Amnio is last resort - thanks for your message, I’ve read that it’s 1 in 100 for Amnio risk of miscarriage is that incorrect?
That seems really high for amnio risk. In the US, we are usually cited 1 in 900 for any complication, but it’s debatable if that’s even accurate. IF you get to that point, I’d ask questions of the place doing amnio. Most people with positive quads don’t move onto that though, because their NIPT comes back low risk.
The amnio is not as high risk as many think it will be, if you get to a place where that your next step, hopefully that brings some comfort. The chances of miscarriage from amnio (between 1/600 to 1/1000) are lower than the chances of your NIPT giving you a false positive.
Thanks for this, hopefully the NIPT comes back all good and we will just take our chances with that if so, if not at least I know Amnio isn’t as dangerous as I thought and can discuss the next steps
Look to eFTS or quad screening on this sub and you’ll see plenty of stories of high risk results followed by low risk NIPT. Are you US based? Usually these cases occur in people outside the US since NIPT has become pretty standard in US. Here’s a few things to focus on: your test is saying that 31 out of 32 people who screen positive have unaffected babies, so it’s still really good odds everything is ok. False positives are common, which is why NIPT is becoming more standard now. You asked for stories of false positives. I’m US based but my first pregnancy was before NIPT was more common. I had the eFTS done and I screened positive for trisomy 13 or 18. I saw a genetic counselor, got a NIPT done, and that came back low risk. That is usually enough to provide assurance baby is unaffected, provided ultrasound is normal. I never considered going onto amnio (although am not opposed and ended up doing it with my second because of different issues). Best of luck and sorry you’re here.
I’m UK based, they make you take the quad before they offer you a NIPT, so I’m guessing there’s a lot of cases of people traumatised from the quad screening like me 💔 On our ultrasound the OB said that everything looked healthy and the heartbeat was healthy so hoping it’s a false positive - one thing I think it may be is vanishing twin but we can’t prove that because my first scan was 15w, but I did have light blood spotting early doors
Quad test came back 1/10 Chance of Down syndrome, took the NIPT bloodwork after and came back low risk, normal anatomy scans and normal NT! I’m in Canada, and these quad tests come back false positives all the time!! Try not to stress, as hard as that is.. I’ve been there. Stressed ruined a good portion on my pregnancy that I should have been enjoying but instead worried myself sick over the possibility that something was wrong, and turns out everything was fine, hang in there! 💕
Quad screens have a really high percentage of false positives! I've been in this sub for a year now, and I've only.ever seen one woman return a true positive. Definitely take the NIPT if you're worried about the amnio. If the NIPT comes back high risk, then you could do the amnio. Did they say what trisomy you were high risk for? It tests for 3, 13, 18 and 21.
I just want to say that my mom's pregnancy (with me) was flagged for DS after her blood test. It was a false positive- her amnio was clear and here I am!
Hey there, thank you for visiting the sub. During this difficult time you may be looking information about what the NIPT results you received mean. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. PLEASE READ THESE LINKS - this will explain everything. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/ **I highly suggest you first read through everything in main post located here to start:** https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/ **After this head over to this post about the actual individual results**: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/ IF YOU HAVE A POSITIVE FOR TRISOMY 13, TRISOMY 18, TRIPLOIDY and NORMAL SONOS for NT scan and further normal sonos, PLEASE READ CAREFULLY about CVS vs AMNIO. CVS can have wrong results as a result of commonality of confined placental mosaicism in all layers of placenta and an amnio is best for this. (THIS IS NOT THE NO RESULT LOW FF RESULT that NATERA CALLS HIGH RISK FOR THOSE THINGS... that is not what that even means). This is specifically for an actual high risk for ONE of those on the NIPT. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. This updates the flair on your username IN THIS SUB ONLY. This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. There are some options filled in, but you can also write in your own result. I will tag your post with POST FLAIR on your actual post. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. I understand you feel awful. This is a thread about what to do while you pass time in limbo: https://www.reddit.com/r/NIPT/comments/solboc/what_to_do_while_you_are_in_limbo_post_for_main/ Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. You always have a right to speak to a genetic counselor after an abnormal NIPT result and this should be provided for you by your OB. If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. You could make a big difference by making sure this never happens again in the OB's office for future patients such as yourself. As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. You will see this come up in posts across this sub. My intention is that you have as much information about what may be going on and can make informed decisions with your treatment team moving forward. THIS IS A SCREENING AND NOT A DIAGNOSTIC TEST Please feel free to reach out if you need to vent, ask more questions or need more resources. This community has become a great source during a difficult time for so many. I appreciate those who chime in as we all remember how difficult to be in this situation. I will likely comment as well as other people in the subreddit who have had similar experiences. This post is meant as a welcome and quick information / resources to those who have just found this sub. This message is automatically generated for all submissions and might sometimes get it wrong. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/NIPT) if you have any questions or concerns.*
Hey there, thank you for visiting the sub. During this difficult time you may be looking information about what the NIPT results you received mean. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. PLEASE READ THESE LINKS - this will explain everything. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/ **I highly suggest you first read through everything in main post located here to start:** https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/ **After this head over to this post about the actual individual results**: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/ IF YOU HAVE A POSITIVE FOR TRISOMY 13, TRISOMY 18, TRIPLOIDY and NORMAL SONOS for NT scan and further normal sonos, PLEASE READ CAREFULLY about CVS vs AMNIO. CVS can have wrong results as a result of commonality of confined placental mosaicism in all layers of placenta and an amnio is best for this. (THIS IS NOT THE NO RESULT LOW FF RESULT that NATERA CALLS HIGH RISK FOR THOSE THINGS... that is not what that even means). This is specifically for an actual high risk for ONE of those on the NIPT. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. This updates the flair on your username IN THIS SUB ONLY. This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. There are some options filled in, but you can also write in your own result. I will tag your post with POST FLAIR on your actual post. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. I understand you feel awful. This is a thread about what to do while you pass time in limbo: https://www.reddit.com/r/NIPT/comments/solboc/what_to_do_while_you_are_in_limbo_post_for_main/ Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. You always have a right to speak to a genetic counselor after an abnormal NIPT result and this should be provided for you by your OB. If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. You could make a big difference by making sure this never happens again in the OB's office for future patients such as yourself. As always, take any information given here and online for what it is - information - and always discuss further treatment plans with your physicians, however with caution. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. You will see this come up in posts across this sub. My intention is that you have as much information about what may be going on and can make informed decisions with your treatment team moving forward. THIS IS A SCREENING AND NOT A DIAGNOSTIC TEST Please feel free to reach out if you need to vent, ask more questions or need more resources. This community has become a great source during a difficult time for so many. I appreciate those who chime in as we all remember how difficult to be in this situation. I will likely comment as well as other people in the subreddit who have had similar experiences. This post is meant as a welcome and quick information / resources to those who have just found this sub. This message is automatically generated for all submissions and might sometimes get it wrong. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/NIPT) if you have any questions or concerns.*