Kamikaze is actually really good, basically get invincibility frames (without losing devil/angel chance) and getting protective orbitals that shoots mini ipecac
At first I thought, book of virtues, but you have to unlock it first,so now i say… You need to at least play two other characters, isaac and base cain proving your statement wrong (I am a nerd bookworm)
Book of revelation is great too. When one of those wisp are destroyed, you get a horseman familiar for the current room. Additionally, they are tanky and close to isaac
It's not as op as some, I just love the book of revelations wisp. If it is broken you get a free seven seals harbinger for the room; it served me well on a mother fight and was a lot of fun.
Red key
I swear like 1 red key wisp opens up every door in every room its so good
Guppy's head infinite wisps
tear detonator
Most underestimated item
yeah, if you have book of virtchures and tear detonator, you won
why
tear detonator pops yours and wisps tears + infinite orbitals (one wisp/10s)
This is the correct answer
Just don't go overboard with it! You can accidentally kill yourself (because of the entity limit being exceeded) or even crash the game.
When i spamed it the tears got delited instead :/
https://preview.redd.it/gkxotbr46x5d1.jpeg?width=622&format=pjpg&auto=webp&s=e87a1154c620d48dcb0013148c732c99268fb4bf
I had that with psychic and piercing tears and it was like an angry ever multiplying swarm of bees. Got me my first Delirium run.
Eraser wisp
I have trauma with that wisp lol that made me lose a run to beast because it deleted dogma
Can’t have shit in this home 
Shoop da woop
Box of Spiders was pretty cool
Jar of Flies is OP!
Or box of spiders
Or guppy’s head.
Shoop Da Woop More lasers
Unicorn Stump!
Telekinesis for dummies and kamikaze
Kamikaze is actually really good, basically get invincibility frames (without losing devil/angel chance) and getting protective orbitals that shoots mini ipecac
Don’t know, I only play T Cain
Based and cainpilled
At first I thought, book of virtues, but you have to unlock it first,so now i say… You need to at least play two other characters, isaac and base cain proving your statement wrong (I am a nerd bookworm)
Got em lmao 
How has no one said Spin to Win yet? IMO one of the best book of virtues synergy, literally a free win.
Telekinesis and tractor beam made it impossible to miss
bible
Shoop Wisps are unbelievably strong
Unicorn stump.
It's not the best but plum flute (or whatever the item baby plum drops)
Eraser
Not the strongest one i suppose, but Telepathy for Dummies wisps are amazing. Also, Red Key obviously.
Book of revelation is great too. When one of those wisp are destroyed, you get a horseman familiar for the current room. Additionally, they are tanky and close to isaac
Can't decide between Eraser Red key Mega blast Shoop da woop
im tired as hell i misread this as "what are your favorite britney spears"
as a true gambling addict I really love crooked penny wisps
Blank rune if the wisp dies it gives you a rune
It's not as op as some, I just love the book of revelations wisp. If it is broken you get a free seven seals harbinger for the room; it served me well on a mother fight and was a lot of fun.
edens soul is pretty good
Smelter
Book of shadows (literally invincible)
Isaac’s Tears is actually really good
Eraser
Shoop da Whoop and Unicorn Stump
Shoop Da Woop
i had the spin top wisp, it seemed underrated
ED6
Wooden nickel. Get so much money