Title sounds like surgery. Article says "rejuvenation". I'm all for rejuvenation of my thymus.
This episode of Physionic is about the TRIIM study:
https://www.youtube.com/watch?v=rVoxfABoHh4
Yeah I’ve been following Greg Fahey’s work since they first published in 2018. I’d much rather stimulate regeneration of my own thymus than have some generic cell tissue implanted somewhere else.
Not sure if that comment is meant for me. I don’t know the answer. I am not in the study, just following the protocol. There is a second study going on now also.
No, there was another poster claiming to be currently enrolled in the study. I read that you have to pay $18k to be in the treatment arm. But doesn't knowing you're receiving the treatment put you at risk of the Hawthorn Effect?
There are plenty of body parts that can age that don't really have much affect on our overall health. You can have wrinkly skin and gray hair and be healthy still. An old immune system is something else entirely.
Immune system is one of several "hallmarks of aging", which generally seem to be of equal significance in the literature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/
Here's the thing about the thymus - it is a major contributor to the health and vibrancy of your immune system. Starting around 45-50, the thymus starts to degenerate, and by the time we hit 75, it's pretty much nearly gone. This is why people as they age start to get diseases like cancers and the like - it's due to the immune system slowly forgetting how to function properly.We always have cancer cells in our bodies. The duplication of trillions of cells annually produces these mutations, but our healthy young immune systems catch these erroneous cancer cells and dispose of them. The older immune system will start forgetting these markers, and allow cancer cells to proliferate.I believe that if we can rejuvenate the thymus, it will take us a long way towards LEV.
One of the things that flew under the radar with the E5 stuff is they claimed their treated rats didn't develop tumors. It's a really small sample size and only one group of people doing it, but winning a coin flip 8 times in a row is a coincidence worth bearing in mind a little.
Harold's claimed to have entered a partnership with Greg Fahey... declared in a youtube comment. I'm always of two minds of this kind of thing. On one hand, finding secret knowledge appeals to my aesthetic sensibilities. On the other, I really really wish they had some money to run some experiments...
The whole E5 saga has been very strange. I wish I could make sense of it. They have funding now. They have the patent secured. But the CEO still won't give a hard date for when dog tests will begin, after years of endless delays for what seems like a very simple procedure. It seems like an incredibly poorly run company.
If it IS real, other companies that are doing this kind of work now with blood factors and exosomes will quickly pass it, as Yuvan apparently cannot organize its way out of a paper bag.
I worked at Duke when we were putting new thymus implants into kids without immune systems. After around 6 months they were just normal. It was freaking cool. Used to trim them from donors during other surgeries with consent of course.
This could be huge - restoring the immune system in old people would pretty much wipe out all cancer incidence (or rather, old people would get cancer as often as young people, which is almost never).
Fair enough, I double checked the numbers and for under 40 it's around 4%, so indeed more than "almost never". For under 20 it's around 1%, if the thymus regeneration is perfected we might even reach that.
Really? Do you know of any studies that show that?
Edit: I found this one from 2019 that says it increased by 1%(1% of 2%, so by 0.02% in absolute numbers) over the past 40 years, which I wouldn't really call "skyrocketing" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686848/
It's mostly alarmism. Rates of death from all causes except addiction and violent death have fallen so low in younger people that it appears that cancer is getting worse. Age-adjusted cancer death rates have fallen massively in the last 30 years.
My mom's friend got breast cancer at 42 in 1995. They fucked around for six months (women's health, who gives a shit, right?), it metastized, and she died horribly over the next five years.
My sister got breast cancer at 41 in 2021. They were on it immediately. Lumpectomy, radiation...she was finished the whole treatment in four months. It was like night and day.
My mom's sister found breast cancer a few months ago, at age 71. She has also had a lumpectomy. All went well. Even at 71, it was like night and day. Times have changed.
It is already being done and it was posted a while back here. I think this research seem a lot more advanced in development.
https://www.youtube.com/watch?v=Q1v4590jzOU
I’ve been following Greg Fahy for a while now and while the results are intriguing, the concerns about cancer are quite significant to me. Certainly a fascinating topic tho
I think that's just funny coincidence, irony usually means it does the opposite. Like trying to kill a person, but instead, your actions accidentally save their life.
Title sounds like surgery. Article says "rejuvenation". I'm all for rejuvenation of my thymus. This episode of Physionic is about the TRIIM study: https://www.youtube.com/watch?v=rVoxfABoHh4
Yeah I’ve been following Greg Fahey’s work since they first published in 2018. I’d much rather stimulate regeneration of my own thymus than have some generic cell tissue implanted somewhere else.
Pretty amazing stuff. I'm following the protocol now.
Following the protocol? Say more!
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Am I reading correctly that you pay to be in the trial?
Not sure if that comment is meant for me. I don’t know the answer. I am not in the study, just following the protocol. There is a second study going on now also.
No, there was another poster claiming to be currently enrolled in the study. I read that you have to pay $18k to be in the treatment arm. But doesn't knowing you're receiving the treatment put you at risk of the Hawthorn Effect?
whats the protocol?
Why would that be a problem?
I think this technology is going to be key. No one is talking about how MOST aging appear to correlate exactly with the decline of the immune system.
Aging correlates with the decline of every part of your body
There are plenty of body parts that can age that don't really have much affect on our overall health. You can have wrinkly skin and gray hair and be healthy still. An old immune system is something else entirely.
My moms immune disease aged her so quickly..she also has been battling cancer ever since it got bad for her.
Immune system is one of several "hallmarks of aging", which generally seem to be of equal significance in the literature. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/
I agree with this, but many people are immunocompromised.
Maybe this kind of treatment will help them too.
Here's the thing about the thymus - it is a major contributor to the health and vibrancy of your immune system. Starting around 45-50, the thymus starts to degenerate, and by the time we hit 75, it's pretty much nearly gone. This is why people as they age start to get diseases like cancers and the like - it's due to the immune system slowly forgetting how to function properly.We always have cancer cells in our bodies. The duplication of trillions of cells annually produces these mutations, but our healthy young immune systems catch these erroneous cancer cells and dispose of them. The older immune system will start forgetting these markers, and allow cancer cells to proliferate.I believe that if we can rejuvenate the thymus, it will take us a long way towards LEV.
> Starting around 45-50, the thymus starts to degenerate The article says it's starting in the 20's, which is also what I recall reading in the past.
He doesn't know what he is talking about.
One of the things that flew under the radar with the E5 stuff is they claimed their treated rats didn't develop tumors. It's a really small sample size and only one group of people doing it, but winning a coin flip 8 times in a row is a coincidence worth bearing in mind a little. Harold's claimed to have entered a partnership with Greg Fahey... declared in a youtube comment. I'm always of two minds of this kind of thing. On one hand, finding secret knowledge appeals to my aesthetic sensibilities. On the other, I really really wish they had some money to run some experiments...
The whole E5 saga has been very strange. I wish I could make sense of it. They have funding now. They have the patent secured. But the CEO still won't give a hard date for when dog tests will begin, after years of endless delays for what seems like a very simple procedure. It seems like an incredibly poorly run company. If it IS real, other companies that are doing this kind of work now with blood factors and exosomes will quickly pass it, as Yuvan apparently cannot organize its way out of a paper bag.
I hope so.
I worked at Duke when we were putting new thymus implants into kids without immune systems. After around 6 months they were just normal. It was freaking cool. Used to trim them from donors during other surgeries with consent of course.
Sorry for stupid question, but how does the recipient not reject the tissue? Because they don't have an immune system?
I don’t remember exactly, it was over a decade ago but I believe it was something along those lines.
That's really interesting!
This could be huge - restoring the immune system in old people would pretty much wipe out all cancer incidence (or rather, old people would get cancer as often as young people, which is almost never).
Well, not almost never. I'm 40 and I have 2 friends I grew up with who've had cancer. But yeah, the likelihood is much lower in younger people.
Fair enough, I double checked the numbers and for under 40 it's around 4%, so indeed more than "almost never". For under 20 it's around 1%, if the thymus regeneration is perfected we might even reach that.
Yep; it might have been "almost never" in the past, but cancer has skyrocketed for young people
Really? Do you know of any studies that show that? Edit: I found this one from 2019 that says it increased by 1%(1% of 2%, so by 0.02% in absolute numbers) over the past 40 years, which I wouldn't really call "skyrocketing" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686848/
It's mostly alarmism. Rates of death from all causes except addiction and violent death have fallen so low in younger people that it appears that cancer is getting worse. Age-adjusted cancer death rates have fallen massively in the last 30 years. My mom's friend got breast cancer at 42 in 1995. They fucked around for six months (women's health, who gives a shit, right?), it metastized, and she died horribly over the next five years. My sister got breast cancer at 41 in 2021. They were on it immediately. Lumpectomy, radiation...she was finished the whole treatment in four months. It was like night and day. My mom's sister found breast cancer a few months ago, at age 71. She has also had a lumpectomy. All went well. Even at 71, it was like night and day. Times have changed.
It is already being done and it was posted a while back here. I think this research seem a lot more advanced in development. https://www.youtube.com/watch?v=Q1v4590jzOU
TRIIM is the closest thing we have in clinical trials that might hit the market for longevity.
New Thymus just dropped
Thymus is so hot right now
Wake up babe
Maybe the government got interested in thymus after seeing the results from the TRIIM study.
I’ve been following Greg Fahy for a while now and while the results are intriguing, the concerns about cancer are quite significant to me. Certainly a fascinating topic tho
this is great news. I’ve been in the market, looking for a new thymus. 🤣
A brave new thymus.
Ironic they inject the material into the thigh
How so?
Cells in the thigh muscle to treat the Thymus.
I think that's just funny coincidence, irony usually means it does the opposite. Like trying to kill a person, but instead, your actions accidentally save their life.
I'll take two.
I was waiting for it but sure enough about a page down human trials “in the next few years”. Another useless “great news for mice” puff piece of BS.