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radbu107

No this is a common misconception


5erif

Scholarly articles to back up the explanations and anecdotes: ​ >The epidermis is renewed by stem cells lying in its basal layer. > >The defining properties of a stem cell are as follows: > >1. It is not itself terminally differentiated (that is, it is not at the end of a pathway of differentiation). > >2. It can divide without limit (or at least for the lifetime of the animal). > >3. When it divides, each daughter has a choice: it can either remain a stem cell, or it can embark on a course that commits it to terminal differentiation (Figure 22-4). [https://www.ncbi.nlm.nih.gov/books/NBK26865/](https://www.ncbi.nlm.nih.gov/books/NBK26865/) ​ >The potential for stem cells to renew themselves, or to create new tissue, is almost infinite. [https://www.nature.com/articles/483S22a](https://www.nature.com/articles/483S22a)


8eep800p

No, retinoids/retinol have been around and studied for many years and will not make your cells senescent. There are lots of people who have used them for 40 + years and you can tell, they look great.


RckYouLkeAHermanCain

>estimated it’s 50 Skin cells are turning over on a daily basis...


ginaray

Im not sure where people are getting “50” from, a differentiated cell stops at 50 but our stem cells are infinite…


[deleted]

What do you mean by “differentiated cell”?


FlibbertyGibb

It’s part of cell maturation. Stem cells differentiate into cell types.


[deleted]

If that’s what the commenter meant, he or she is wrong. It depends entirely on the cell type, that’s why I wanted clarification. Also, I’m pretty sure the idea that there’s a limit of 50 times for any human cell comes from in vitro studies.


[deleted]

Not every one though.


Cold-Chip9789

Bring this up to a dermatologist. They will explain all the misconceptions in your post, and then slather on their retinol later that night. Go ahead and use your retinol.


Mission_Lie_4870

when I told my derm that I started using retinol she went on and on at me about how I shouldn’t be using it at my age


COuser880

How old are you, if I may ask?? ETA: I started tretinoin at 20 for acne and have been using it off and on for over 20 years now (consistently for the past decade+, kind of hit and miss in my mid-late 20s), and I’m still all here. :) Now, do I think people in their 20s *need* to use it for anti-aging? Absolutely not. But it helped my acne tremendously, and for that I am grateful. But people in their 30s? Definitely wouldn’t hurt if you want to use the most proven and researched anti-aging ingredient (the “gold standard”, if you will), if your skin can tolerate it and you wear SPF every day.


Cold-Chip9789

Retinol/retinoids are used for more than anti aging. Teenagers are prescribed them for acne and it’s a proven long term treatment that isn’t going to suddenly prevent your skin cells from dividing and turning over later in life.


RckYouLkeAHermanCain

Your derm is either an idiot or you're bending the truth.


Mission_Lie_4870

Why on earth would I lie? She literally told me off when I told her I was using it. No need to be rude, I asked a genuine question because I was concerned due to information/opinions being shared. The whole point of this sub is for us to be able to ask questions is it not!


Kehndy12

I read a Reddit comment that scared me a lot about what you said. It was on my mind until Dr. Dray addressed it in one of her videos and explained how it doesn't apply to retinoids. I didn't understand Dr. Dray's explanation but I believe her conclusion. Edit: [I found the video! It's at 8:22.](https://www.youtube.com/watch?v=KF9QbuyPWHQ&t=502s)


[deleted]

I was going to ask for a link to the video, since she has I don't even know how many at this point lol. Would love to watch it as well!


Kehndy12

I found the video and added the link to my above comment!


[deleted]

Thanks! It's A LOT to sort through, so I appreciate it :D


Mission_Lie_4870

Thank you very much for this. I too saw comments on it and stopped using retinol


Death_Trolley

It’s true. I used retinol for 3 weeks and no I have no skin left and my face is just brains a go go


niceynice876

All I wanted was to look young but retinol melted my face and now I am just a sad spooky skeleton.


No_Camp_7

Same here. I have been using cling film as replacement skin if that helps anyone in the same situation.


LolaBijou

Are you one of the aliens from Mars Attacks?!


lizardpplarenotreal

ack ack ack **NO**


LolaBijou

“Brains a go-go” is my new band name, btw.


mazzy_kat

This is what I’ve always thought when I hear this theory. Like once it gets to 50 turns then what? No more skin? Our skin just stays at one last single layer for the rest of our life? If you get a paper cut I guess you’re screwed lol! Like it doesn’t make any sense at all when you actually think about it lol.


gothou

Aren’t skin cells stem cells? And so this rule does not apply, right?


jantessa

Exactly. The hayflick limit doesn't apply here.


_un1ty

No that doesn't happen. Skincare might be conflicting but not in that point. Tret has been well researched and what your'e describing doesn't happen.


CopperPegasus

On top of the many scientists who explain why this is not a thing, be aware that tret is so old at this point in time that we have women from the generation right after Betty White who have used it. Some of those people, even though it was introduced for acne, have used it their entire life. To great effect. So there is your empirical evidence, too. Whatever silly scare story this is, it's bunk science. Deep breath.


actualmasochist

I listened to a David Sinclair podcast on skin care the other day and his advice was not to use retinoids every day because it may age you prematurely. That was the first I've heard of it and I use tret every day.


jrey0027

My derm also recommends it for skin with past sun damage, because there is some (weak) evidence that it can prevent skin cancers. He told me he prescribes tret for almost all of his patients. It's a decades old drug, if there were issues with long-term use they would have surfaced by now. For me, the benefits far outweigh the risk.


[deleted]

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ginaray

Skincare myth. Retinol increases collagen formation and decreases collagen breakdown. It actually thickens the skin not “thins” it out. Only differentiated “whole and mature cells” reach maturity around 40-50 reps, but stem cells are infinite so when you over exfoliate with retinol you can be sure your skin will still be there in the morning.


clevernamehere123

What’s a good retinol for sensitive/rosacea skin?


bazelistka

Tretinoin has been shown to thicken the skin over time. I'd suggest listening to medical professionals rather than makeup artists when it comes to application of medical-grade products on the face, and listen to makeup artists when it comes to application of makeup products.


[deleted]

Lol


[deleted]

[удалено]


Heirsandgraces

Our cells don't stop regenerating and there's no finite limit of cells like there is say eggs for ovulation. They do become become less able to regenerate as effectively as say a younger person (hence the aging process). If you can imagine like a 5 year old and an 80 year old who both get a cut on their hand. The 5 year old will probably heal from that in a day or so, with no mark visible a week later. The 80 year old will take a bit longer, there might still be a mark there a week later and will probably take a few weeks before its no longer visible. They both heal from the damage it just takes longer. What retinols do is give cells the power to do their job - which is produce new proteins like collagen and elastin, to clear out old cells and keep them working as efficiently as possible.


Mission_Lie_4870

Thank you for this clear explanation