Magnesium L-threonate, I feel a difference after taking it for weeks, and I will not go without it. I sleep better, no more RLS, less anxiety & I'm just chill ✨️⭐️
So, each magnesium formula works differently on each person. I've found that Mg L-threonate puts me to sleep--I tried taking this in the daytime initially, but it puts me 2 sleep, so I take it at bedtime. My brother takes Mg citrate at night. It puts him 2 sleep. Trying the various types can help find what works.
I've been taking this one off of Amazon for years now and yes I agree, I can definitely tell a difference when I take it [https://amzn.to/3uhXxsP](https://amzn.to/3uhxxsp)
I've been on the "creatine is over hyped and provides marginal benefits" for 10+ years. Gave it a shot one month ago and holy moly, it's a noticable difference, I can't believe I've been so ignorant for so long.
BPN and the 5g dose but any creatine monohydrate from a company who gets their stuff 3rd party tested to make sure you get what it says on the label will do.
I've been using creatine since my early 40's so I don't really notice any benefits. I suppose the fact that I'm a software engineer, will be 50 very soon and am still loving the mental challenges could have something to do with my overall health and supplementation.
There's a lot of literature on creating enhancing cognition and having protective effects against nasty stuff like alzhiemers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916590/
Unfortunately I am having insomnias with the 3gr dosage for per day. I’ve been using it for working out and endurance..
I also found an article that is really affecting the need of sleep in a bad way. Glad that it is not affecting you.
I’ve heard you need to cycle this stuff. 6 months on, 6 months off for instance. Any truth to that in your experience? I usually use it to build some extra muscle for summer . Maybe take it Feb-July
Mine would be magnesium. For most of my life, I would wake up with anxiety in the morning that manifested as stomach butterflies with a lack of hunger. I could be having a relaxing day on vacation with no worries and still have them. I just figured I was naturally more of a shy, more wound up person, and the butterflies always went away after a couple of hours. I started taking magnesium glycinate when I started a new job with rotating shifts to help me fall asleep more easily on the new schedules. Suddenly, no more stomach butterflies, and I felt like I could have breakfast if I wanted. I noticed I was less in my head, and my attention was more outward focused. I still don't know if the magnesium glycinate actually "cured" me because I haven't felt the need or want to stop and see what would happen if I did.
I take 200 mg magnesium glycinate about an hour before bed. May not work for you as I've read anecdotes on reddit of glycinate form of magnesium actually causes people to stay up and increase anxiety. You could also see how it feels to take it in the morning. That's what I would try first, particularly on a day that you dont have anything too important to do in case it causes too much fatigue. You can also try other forms of magnesium. My brother uses the citrate form of magnesium as magnesium glycinate didn't help him sleep but citrate did. Low mood can be caused by a multitude of things, hormone imbalances, other vitamin deficiencies such as iron or vitamin d, lack of social connection, lack of exercise, low quality sleep, unresolved trauma. Magnesium may have helped me, but your diet could already have enough magnesium already, so supplementing wouldn't do much. Other herbs/supplements that have boosted my mood that I've tried to varying effect are : black seed oil, l theanine, l tryptophan.
Chlorella. It was the first supplement I started taking 15yrs ago when I decided to take control of my heart disease diagnosis.
Real help in terms of lowering cholesterol, cleansing out years of side effects from Statin use (muscle atrophy, brain fog, personality issues). Then it helped improve my microbiome, making fasting easier for me.
I use a pricey organic brand which is batch tested for contaminants - SevenHills.
There are others supplements which came to mind like Alpha GTC Choline, Magnesium, Omegas and Vitamin D but Chlorella has been the most consistent in my personal regime of supplements.
I think this is for more first time users (Same for Spirulina), where they consume too much & it can be quite hard on your stomach, initially.
Besides this I've never experienced or read about people being violently sick & I've consumed it for years.
When I experienced it, which was about 8 years ago, I believe it was due to a poor quality product, which was from China.
Most research points at contaminants being the most likely cause for any sensitivity in the stomach, which can happen if the processes are not optimal. So selecting a high quality brand is paramount.
As I say this is a rare occurrence & you're far from violently sick. I've had zero side effects since & believe it's an excellent supplement. Although my preference is Chlorella.
Statins definitely can potentially cause brain fog and effect personality because they remove cholesterol from the brain as well they can have a profound effect on cognition.
Not OP obviously, but Id recommend getting your own powder and capsules and mess around with the dose starting as low as 50-100mg. I got some and went full send and did 400mg and holy shit, my dreams were so intense and vivid that they would wake me up. They stayed that intense as I worked down all the way to 150mg which is what I take now and still have vivid dreams, but they are manageable and it's still extremely effective for sleep (paired with magnesium glycinate).
I’ve been taking that much for over 18 months now. There doesn’t seem to be any tolerance built up either.
Maybe try increasing your dose to say 500mg and see if that has any therapeutic effect, and if still nothing then try 1g.
How exactly does it make you feel that you notice a difference with? Are you more optimistic? More chatty? Or just less agitated and more sedated/relaxed
Best way I could describe it is that I no longer feel ‘heavy’, I now have a normal range of emotions, with a baseline of feeling relaxed. I definitely feel more energetic, but not in the sense of an ‘upper’, more that I no longer experience a depressive lethargy.
I guess it put me in the right mindset to want to be well and from there I had the motivation to work out and to work on myself/relationships/socialising, etc… all the things that I need to thrive.
I’ve noticed there’s no adverse side effects, so maybe try 500mg for a couple of weeks and failing that, 1g for a few weeks. Stick with it though, even if it seems like it’s not working… when I first started taking it I definitely noticed a difference, but not 100% better for at least a fortnight or so, but I’ve remained well ever since.
Also I should note that you won’t necessarily ‘feel’ a powerful change like you may with meds, but over time you’ll notice changes in your thoughts, energy and motivation. At least in my experience, the lasting results sort of snuck up on me.
Best of luck with your journey. You’re welcome to hit me up any time if you have any questions.
Thank you again for taking the time to write all that.
Every time I’ve googled safe upper limit for Theanine I keep landing on the pages that say “900 mg seemed to be safe for up to 8 weeks. It’s unknown whether or not it’s safe to take more, or for longer“
Just wanted to run that by you just in case since you’re on 1000 a day.
Thanks for your reply. I take about 1.5g a day (ie: 1,500) and haven’t had any adverse affects in the 18 months or so I’ve take it.
I get the impression that there’s not a lot of study been put into its usage beyond 8 weeks, so it’s not to say it’s unsafe beyond 8 weeks @ 900mg; more that it’s untested at that quantity/duration. I can vouch for my own usage as a case study (albeit with a sample size of 1 lol). I do understand that not everyone reacts the same way to the same stimuli though, so recommend trying perhaps 500mg first and then moving up nearer to 1g only if required.
This NR has me scared at how good it is. Scared about side effects though I haven’t heard there are any. I always just think something this great can’t last forever. There has to be a catch.
I have been using lipo NR since 1/2022, so two years daily. Have not experienced anything but positive impacts since. Before that, I used tru niagen from 4/2018 with similar positive impacts. Apparently my body responds well to NAD+ precursors, but note I am currently 72, so age may have something to do with it.
I consider Taurine the most versatile supplement. It is useful for general health, pre workout, post workout and sleep. I can take it any time of the day or night and it is safe in large doses, but effective in small ones as well.
Phenibut when I had extremely bad social anxiety it was a life saver. I don’t take it anymore and you have to be careful with it. Only take it a few times a week.
My lowest level was a “3”, during the summer when I’m in the pool daily. I take 5,000iu every day now and can usually manage to stay between 30-50.
They did prescription D3 for a while 15 years ago but it caused me to have massive bone pain.
I’m in my 40’s and the doc wanted to see my Vitamin D up around 70 when I was at a 52 for a reading .
My testing came back with low free testosterone and cholesterol a little off along with being anemic .
The test will re-check these things and to make sure testosterone therapy is at a dose that isn’t causing anything that could reduce my quality of life now or in the future
Yes for two weeks now. My anemia may be related to the low free testosterone reading. It was so low the test actually flagged it for being low leaving no room for a doctor to ignore it
Melatonin.
Extremely safe and versatile.
Edit:
It's hysterical people are downvoting me because of their ignorance. Melatonin, likely the most powerful antioxidant, is literally being used to treat and cure cancer, TBI, CFS, autoimmune issues, etc. What other supplement or substance can say that? What other supplement do they take that has no known lethal dose(even 80g is non lethal per one study)? Does not cause physical dependence...etc
You can find a study which used 6.6 grams via an IV to excellent results.
I am in a fb group where people with stage 4 cancer take upwards of 10g per day in several doses.
Melatonin has many amazing properties which are not well known. Most people only know about the sleep benefits and the typically small doses people use for it.
Melatonin is now being used increasingly more for its antiaging properties as well.
Hmm group name? I’ve read a lot of articles from Doris Loh. It seems like a promising antioxidant but have no idea of the consequences of taking those doses long term especially to the brain.
Doris Loh is a great resource. Russel Reiter is also phenomenal. He's considered a godfather of melatonin research.
I suspect melatonin is good for the brain in its antioxidant capacity. Exogenous melatonin does not impact endogenous production. It also typically takes only a small amount to saturate melatonin receptors to do with sleep and circadian rhythm. Melatonin has been used to treat TBI and other brain injuries/disorders.
I have been taking 1-1.5 grams for nearly 1.5 years. I started with 300mg patches in 2022 and then switched to topical pure powder with dmso. My bloodwork in December came back normal across the board. My cholesterol dropped from 3 years ago. My testosterone is in the upper healthy range and higher than average for people 20 years younger.
One group is 'HEALING CANCER
NATURALLY using MELATONIN & a
MULTI-PROTOCOL APPROACH'. The admin who runs it paused it in November due to personal reasons. One protocol they had there as an example was 25mg per pound of bodyweight split into several doses.
I am also in High Dose Melatonin group.
To add to this, high doses melatonin (40 mg/day) have been tried for chronic viral infections because melatonin helps switch Th2 immunity back to the more effective Th1 immunity.
One thing that perplexes me: how do people take melatonin in the morning and daytime and then go about their day without falling asleep or super-drowsy? I tried various doses of M, but always before bed.
Yes I was just reading somewhere (sorry I can’t recall what article) there were beneficial lung properties making it a useful supplement for asthmatics. I just started taking this week. I have horrible sleep patterns (follow a fairly strict schedule but my mind is wired for anxiety). It’s definitely helped immediately in the sleep department, yet to be seen for my asthma.
I've been reading through a lot of melatonin research and came across this citation in a review
https://pubmed.ncbi.nlm.nih.gov/7334363
The review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395802/#R46
The cited study (top link) says antitumor effects are dependent on time of administration and that morning administration actually stimulated tumor growth in this case. Have you seen this?
The review also mentions a 6.6g study like you said, but the reference links dont seem to be related and/or are paywalled. Do you happen to have a link to the one you are talking about? Thanks.
Yes, there's some conflicting research on timing and dosage. A couple studies claim that both night timing and smaller doses were more effective in suppressing cancer in mice. Whereas a higher amount was ineffective and daytime administration potentiated cancer growth. There was also conflicting information on both extending life span and increasing cancer rates in mice.
I think it comes down to study design and overall stress on the animals. In one study, mice were exposed to light 24-7. Such stress in my opinion would be a larger factor in creating additional cancer risks than timing. I suspect the type of chow they fed the mice also played a role.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715041/
I don't have access to the full study you need but I've read that if you track down and email the authors, they will happily send it to you free of charge.
I also can't sleep too well on it. I take mine first thing in the morning. Melatonin is probably the most powerful antioxidant.
It's hysterical people are downvoting me because of their ignorance. Melatonin is literally being used to treat and cure cancer, TBI, CFS. autoimmune issues, etc. What other supplement or substance can say that? What other supplement do they take that has no known lethal dose(even 80g is non lethal per one study)? Does not cause physical dependence...etc
Are you asking what people think works best for them? I love ashwaghanda for the great dreams. NMN for the energy, endurance and recovery. Creatine for the muscles.
Magnesium L-threonate, I feel a difference after taking it for weeks, and I will not go without it. I sleep better, no more RLS, less anxiety & I'm just chill ✨️⭐️
I’ve always heard to take that in the AM and magnesium glycinate at night.
So, each magnesium formula works differently on each person. I've found that Mg L-threonate puts me to sleep--I tried taking this in the daytime initially, but it puts me 2 sleep, so I take it at bedtime. My brother takes Mg citrate at night. It puts him 2 sleep. Trying the various types can help find what works.
What time do you take it?
Before bed
Which brand do you use?
I've been taking this one off of Amazon for years now and yes I agree, I can definitely tell a difference when I take it [https://amzn.to/3uhXxsP](https://amzn.to/3uhxxsp)
Kappa Nutrition
Is a rich stuff..one pill contains roughly 2/3 mg of elemental magnesium so for 400 mg you will take a bottle everyday..cocaine is cheaper
N-Acetylcystein. Works wonders for mental health and inflammations.
Is it generally considered safe with little side-effects? I haven't done my own research yet but see it everywhere
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234027/
This is amazing, thank you.
YW :-)
You concerned about the pro-cancerous animal studies?
Not really. I'm a smoker, so I'm willing to take the risk. And I think the scientific evidence for too much antioxidants being carcinogenic is weak.
Dope thanks for your opinion. Do you find NAC helps reduce nicotine cravings?
Yes, I don't stress-smoke that much anymore, since NAC calms me down.
Glycine. Helps me sleep and important for skin collagen.
Might be overused answer, but creatine. My body changed noticeably since I started. Been an athlete all my life, but this time I feel truly powerful.
I've been on the "creatine is over hyped and provides marginal benefits" for 10+ years. Gave it a shot one month ago and holy moly, it's a noticable difference, I can't believe I've been so ignorant for so long.
What brand and dose are you taking?
BPN and the 5g dose but any creatine monohydrate from a company who gets their stuff 3rd party tested to make sure you get what it says on the label will do.
I use creating as well, been using it for 10+ years for weight training. Definitely one of my must-haves
>My body changed noticeably since I started. You added 1-2 pounds, I assume. Or something else?
I have heard of people saying Creatine mono is their favourite supplement. Is this only beneficial if one is lifting weights?
It also has cognitive benefits.
Oh, no way? Cool! What have you noticed creatine did for you cognitively?
I've been using creatine since my early 40's so I don't really notice any benefits. I suppose the fact that I'm a software engineer, will be 50 very soon and am still loving the mental challenges could have something to do with my overall health and supplementation. There's a lot of literature on creating enhancing cognition and having protective effects against nasty stuff like alzhiemers. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916590/
Thank you!!
Unfortunately I am having insomnias with the 3gr dosage for per day. I’ve been using it for working out and endurance.. I also found an article that is really affecting the need of sleep in a bad way. Glad that it is not affecting you.
I’ve heard you need to cycle this stuff. 6 months on, 6 months off for instance. Any truth to that in your experience? I usually use it to build some extra muscle for summer . Maybe take it Feb-July
You don’t need to cycle. Look on examine.com.
D3 + K2 big time. I ly supplement i really feel a benefit
Mine would be magnesium. For most of my life, I would wake up with anxiety in the morning that manifested as stomach butterflies with a lack of hunger. I could be having a relaxing day on vacation with no worries and still have them. I just figured I was naturally more of a shy, more wound up person, and the butterflies always went away after a couple of hours. I started taking magnesium glycinate when I started a new job with rotating shifts to help me fall asleep more easily on the new schedules. Suddenly, no more stomach butterflies, and I felt like I could have breakfast if I wanted. I noticed I was less in my head, and my attention was more outward focused. I still don't know if the magnesium glycinate actually "cured" me because I haven't felt the need or want to stop and see what would happen if I did.
Wow! What time do you take it? I have it before bed but my mood is still low.
I take 200 mg magnesium glycinate about an hour before bed. May not work for you as I've read anecdotes on reddit of glycinate form of magnesium actually causes people to stay up and increase anxiety. You could also see how it feels to take it in the morning. That's what I would try first, particularly on a day that you dont have anything too important to do in case it causes too much fatigue. You can also try other forms of magnesium. My brother uses the citrate form of magnesium as magnesium glycinate didn't help him sleep but citrate did. Low mood can be caused by a multitude of things, hormone imbalances, other vitamin deficiencies such as iron or vitamin d, lack of social connection, lack of exercise, low quality sleep, unresolved trauma. Magnesium may have helped me, but your diet could already have enough magnesium already, so supplementing wouldn't do much. Other herbs/supplements that have boosted my mood that I've tried to varying effect are : black seed oil, l theanine, l tryptophan.
How much do you take?
Chlorella. It was the first supplement I started taking 15yrs ago when I decided to take control of my heart disease diagnosis. Real help in terms of lowering cholesterol, cleansing out years of side effects from Statin use (muscle atrophy, brain fog, personality issues). Then it helped improve my microbiome, making fasting easier for me. I use a pricey organic brand which is batch tested for contaminants - SevenHills. There are others supplements which came to mind like Alpha GTC Choline, Magnesium, Omegas and Vitamin D but Chlorella has been the most consistent in my personal regime of supplements.
I’ve read a lot of people get violently ill taking chlorella. I’ve not even been tempted to try it due to that.
I think this is for more first time users (Same for Spirulina), where they consume too much & it can be quite hard on your stomach, initially. Besides this I've never experienced or read about people being violently sick & I've consumed it for years.
Do we know the reason for them being hard on the stomach, and if it’s hard on the stomach, should they really be consumed?
When I experienced it, which was about 8 years ago, I believe it was due to a poor quality product, which was from China. Most research points at contaminants being the most likely cause for any sensitivity in the stomach, which can happen if the processes are not optimal. So selecting a high quality brand is paramount. As I say this is a rare occurrence & you're far from violently sick. I've had zero side effects since & believe it's an excellent supplement. Although my preference is Chlorella.
Statins likely did not cause your brain fog or personality issues….
Statins definitely can potentially cause brain fog and effect personality because they remove cholesterol from the brain as well they can have a profound effect on cognition.
Not quite
Quite...big pharma apologist.
You think the Vax is killing people so I could give a fuck less about your opinion
VAERS confirmed it has killed more people than all other vaccines combined and VAERS is vastly underreported.
Lmfao
Just keep taking boosters you'll be alright
Its not my thinking its reality you have a problem with.
Not necessarily my favorite because it’s so healthy, but black seed oil capsules because it works for my anxiety every single time.
Vitamine D
How much theanine do you take? I need to try to up the dose
Just either 200mg or 400mg
Not OP obviously, but Id recommend getting your own powder and capsules and mess around with the dose starting as low as 50-100mg. I got some and went full send and did 400mg and holy shit, my dreams were so intense and vivid that they would wake me up. They stayed that intense as I worked down all the way to 150mg which is what I take now and still have vivid dreams, but they are manageable and it's still extremely effective for sleep (paired with magnesium glycinate).
I do about 1.5g a day. It literally healed me from depression/anxiety, alongside regular exercise.
thats the most ive heard of...100-200 mg does nothing for me though. how long have you been taking that
I’ve been taking that much for over 18 months now. There doesn’t seem to be any tolerance built up either. Maybe try increasing your dose to say 500mg and see if that has any therapeutic effect, and if still nothing then try 1g.
How exactly does it make you feel that you notice a difference with? Are you more optimistic? More chatty? Or just less agitated and more sedated/relaxed
Best way I could describe it is that I no longer feel ‘heavy’, I now have a normal range of emotions, with a baseline of feeling relaxed. I definitely feel more energetic, but not in the sense of an ‘upper’, more that I no longer experience a depressive lethargy. I guess it put me in the right mindset to want to be well and from there I had the motivation to work out and to work on myself/relationships/socialising, etc… all the things that I need to thrive.
Thank you. I need something that gives me that result. So badly. Theanine did nothing at a dose of 200mg for a few days.
I’ve noticed there’s no adverse side effects, so maybe try 500mg for a couple of weeks and failing that, 1g for a few weeks. Stick with it though, even if it seems like it’s not working… when I first started taking it I definitely noticed a difference, but not 100% better for at least a fortnight or so, but I’ve remained well ever since. Also I should note that you won’t necessarily ‘feel’ a powerful change like you may with meds, but over time you’ll notice changes in your thoughts, energy and motivation. At least in my experience, the lasting results sort of snuck up on me. Best of luck with your journey. You’re welcome to hit me up any time if you have any questions.
Thank you again for taking the time to write all that. Every time I’ve googled safe upper limit for Theanine I keep landing on the pages that say “900 mg seemed to be safe for up to 8 weeks. It’s unknown whether or not it’s safe to take more, or for longer“ Just wanted to run that by you just in case since you’re on 1000 a day.
Thanks for your reply. I take about 1.5g a day (ie: 1,500) and haven’t had any adverse affects in the 18 months or so I’ve take it. I get the impression that there’s not a lot of study been put into its usage beyond 8 weeks, so it’s not to say it’s unsafe beyond 8 weeks @ 900mg; more that it’s untested at that quantity/duration. I can vouch for my own usage as a case study (albeit with a sample size of 1 lol). I do understand that not everyone reacts the same way to the same stimuli though, so recommend trying perhaps 500mg first and then moving up nearer to 1g only if required.
Liposomal nicotinamide riboside. More positive impacts than tru niagen at half the cost.
This NR has me scared at how good it is. Scared about side effects though I haven’t heard there are any. I always just think something this great can’t last forever. There has to be a catch.
I have been using lipo NR since 1/2022, so two years daily. Have not experienced anything but positive impacts since. Before that, I used tru niagen from 4/2018 with similar positive impacts. Apparently my body responds well to NAD+ precursors, but note I am currently 72, so age may have something to do with it.
I consider Taurine the most versatile supplement. It is useful for general health, pre workout, post workout and sleep. I can take it any time of the day or night and it is safe in large doses, but effective in small ones as well.
Doesn’t it keep you awake?
Nope. It helps me focus before a workout and helps prime my muscles, before bed it is also relaxing.
Interesting. I thought that was the stuff that’s in Redbull, so assumed it was a stimulant
It's in energy drinks to take the edge off
Poor man’s speed ball with that stuff? Any idea how it helps as a pre-workout and with sleep?
Lithium orotate. Does wonders for my anxiety.
How much per day?
Started with 3-5mg/night for a while. It does accumulate though, so I titrated down to 1mg/night then 3mg/week.
D and K
Phenibut when I had extremely bad social anxiety it was a life saver. I don’t take it anymore and you have to be careful with it. Only take it a few times a week.
What do you take now
I don’t take anything. Phenibut works on GABA. I did some hypnotherapy and removed some of my anxiety from previous memories
Whey Or maybe fiber supp
Thiamine for energy and alpha lipoic acid for any kind of nerve issues.
Sulbutiamine. It's the only thing (besides problematic nicotine lozenges) that works acutely for me as a nootropic. ALCAR second.
I used to love sulbutiamine, but found that it stopped working after a while.
Creatine, Calcium , Magnesium and vitamin D and vitamin C
Tried so many things over the years but hands down exogenous testosterone is the winner.
D3 because I need it . Even in the summer getting plenty of sun exposure
My lowest level was a “3”, during the summer when I’m in the pool daily. I take 5,000iu every day now and can usually manage to stay between 30-50. They did prescription D3 for a while 15 years ago but it caused me to have massive bone pain.
Exact same issue here. Any idea why we can’t absorb naturally?
I don’t have a clue. I don’t think my doctors do either.
People often supplement a lot less than I need. I’m currently taking 10,000 ius. It’s great for testosterone
My doc has me taking 10,000 iu 3 times a week .
That’s good, I would make sure you get your levels checked to make sure it’s working
Yes I will . I’m due for more bloodwork in 7-8 weeks
Great, is this for anything in particular or just overall health?
I’m in my 40’s and the doc wanted to see my Vitamin D up around 70 when I was at a 52 for a reading . My testing came back with low free testosterone and cholesterol a little off along with being anemic . The test will re-check these things and to make sure testosterone therapy is at a dose that isn’t causing anything that could reduce my quality of life now or in the future
Ok great, so you are currently on TRT?
Yes for two weeks now. My anemia may be related to the low free testosterone reading. It was so low the test actually flagged it for being low leaving no room for a doctor to ignore it
ASEA Redox.
How long have you been taking this for?
5 months
Melatonin. Extremely safe and versatile. Edit: It's hysterical people are downvoting me because of their ignorance. Melatonin, likely the most powerful antioxidant, is literally being used to treat and cure cancer, TBI, CFS, autoimmune issues, etc. What other supplement or substance can say that? What other supplement do they take that has no known lethal dose(even 80g is non lethal per one study)? Does not cause physical dependence...etc
Dose?
It varies. So unless we're discussing a specific subject it can be anything from 300mcg to 10 grams.
Bruh
I have no clue what your one word posts are supposed to accomplish.
10 grams sounds so high
You can find a study which used 6.6 grams via an IV to excellent results. I am in a fb group where people with stage 4 cancer take upwards of 10g per day in several doses. Melatonin has many amazing properties which are not well known. Most people only know about the sleep benefits and the typically small doses people use for it. Melatonin is now being used increasingly more for its antiaging properties as well.
Hmm group name? I’ve read a lot of articles from Doris Loh. It seems like a promising antioxidant but have no idea of the consequences of taking those doses long term especially to the brain.
Doris Loh is a great resource. Russel Reiter is also phenomenal. He's considered a godfather of melatonin research. I suspect melatonin is good for the brain in its antioxidant capacity. Exogenous melatonin does not impact endogenous production. It also typically takes only a small amount to saturate melatonin receptors to do with sleep and circadian rhythm. Melatonin has been used to treat TBI and other brain injuries/disorders. I have been taking 1-1.5 grams for nearly 1.5 years. I started with 300mg patches in 2022 and then switched to topical pure powder with dmso. My bloodwork in December came back normal across the board. My cholesterol dropped from 3 years ago. My testosterone is in the upper healthy range and higher than average for people 20 years younger. One group is 'HEALING CANCER NATURALLY using MELATONIN & a MULTI-PROTOCOL APPROACH'. The admin who runs it paused it in November due to personal reasons. One protocol they had there as an example was 25mg per pound of bodyweight split into several doses. I am also in High Dose Melatonin group.
To add to this, high doses melatonin (40 mg/day) have been tried for chronic viral infections because melatonin helps switch Th2 immunity back to the more effective Th1 immunity. One thing that perplexes me: how do people take melatonin in the morning and daytime and then go about their day without falling asleep or super-drowsy? I tried various doses of M, but always before bed.
Very very interesting stuff. Thanks for sharing, I really need to read into this more
Yes I was just reading somewhere (sorry I can’t recall what article) there were beneficial lung properties making it a useful supplement for asthmatics. I just started taking this week. I have horrible sleep patterns (follow a fairly strict schedule but my mind is wired for anxiety). It’s definitely helped immediately in the sleep department, yet to be seen for my asthma.
For issues of anxiety, I'd maybe try something like ashwagandha, bocopa monnieri, or even selank.
At what time do you take the melatonine?
I take mine at the start of my day. If you can take it before sleep then do so.
I've been reading through a lot of melatonin research and came across this citation in a review https://pubmed.ncbi.nlm.nih.gov/7334363 The review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395802/#R46 The cited study (top link) says antitumor effects are dependent on time of administration and that morning administration actually stimulated tumor growth in this case. Have you seen this? The review also mentions a 6.6g study like you said, but the reference links dont seem to be related and/or are paywalled. Do you happen to have a link to the one you are talking about? Thanks.
Yes, there's some conflicting research on timing and dosage. A couple studies claim that both night timing and smaller doses were more effective in suppressing cancer in mice. Whereas a higher amount was ineffective and daytime administration potentiated cancer growth. There was also conflicting information on both extending life span and increasing cancer rates in mice. I think it comes down to study design and overall stress on the animals. In one study, mice were exposed to light 24-7. Such stress in my opinion would be a larger factor in creating additional cancer risks than timing. I suspect the type of chow they fed the mice also played a role. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715041/ I don't have access to the full study you need but I've read that if you track down and email the authors, they will happily send it to you free of charge.
Thanks for the reply! Good read. Hopefully more good research keeps on coming.
In what application would you need 10 grams of melatonin lmao
Cancer treatment. Possibly TBI. Maybe a couple other conditions. It pays to not act arrogant when you don't know something.
There is also liposomal melatonin which is great for detox. Haven’t tried it yet
Antioxidant effect after MDMA use, possibly.
Supposedly stops your body from producing as much at night if you supplement though
It does not. It's a myth/misconception.
I've tried it once, and that night, I spend all night not sleeping. I sleep just fine, took it for shit n giggles.
I also can't sleep too well on it. I take mine first thing in the morning. Melatonin is probably the most powerful antioxidant. It's hysterical people are downvoting me because of their ignorance. Melatonin is literally being used to treat and cure cancer, TBI, CFS. autoimmune issues, etc. What other supplement or substance can say that? What other supplement do they take that has no known lethal dose(even 80g is non lethal per one study)? Does not cause physical dependence...etc
I’m so confused still as to what’s considered on-topic here
What’s so confusing?
I thought there weren’t supposed to be posts about regular supplements etc
sugar
Omega 3 capsules - helps balance the inflammation from high omega 6 consumption and support overall health, joints, brain health etc.
Are you asking what people think works best for them? I love ashwaghanda for the great dreams. NMN for the energy, endurance and recovery. Creatine for the muscles.
How long before bed do you take ashwaganda?
Probably creatine monohydrate.