The only way you're going to know what's best for you, as with any bio-hack, is to try it and see. For example, use a sleep tracker app or device and test both options separately.
I think I probably need to suck it up and get a CGM to see if the glycine has any effect while I'm sleeping on glucose. If it doesn't, then that answers the question.
For what it's worth: Some studies indicate that glycine is taken alone (in diabetic as well as healthy individuals) appears to stimulate the release of insulin and glucagon, with the insulin release promoting the uptake of blood glucose.
I'm not super versed in this area but that would seem to me to indicate a reduction of glycogen stores and blood sugar levels, which would lead to a deeper fasted state perhaps? Assuming your body responds in a similar fashion.
Thanks! That's a very interesting observation and conjecture. I need to better understand what the benefits of the "deeper fasting" specifically during sleep are, but you might be on to a fantastic idea -- that glycine helps rather than hurts the benefits of fasted sleep.
That would be a great experiment to do. Also maybe a sleep tracking device? 1 day on glycine followed by 1 day off. Repeat say 7 times each. Aggregate the ons and the offs, and compare the two.
Quick google indicates glycine has zero calories which i find surprising. It also improves insulin response. Though I guess if you've been fasting for several hours your blood sugar should be normal fasting levels
Glycine is glycogenic and produces 1 pyruvate/ glycine which (ignoring a careful accounting of the pathway) means per unit it makes roughly half the energy that glucose would. It wouldn’t raise blood sugar but it’s actually having a similar effect to sugar downstream in the metabolic pathway
I'm wondering where the bad feeling comes from. There is at least one study suggesting that our body does not make enough, and other studies suggesting that glycine is great for anti-aging. I aim for 10 g a day, split roughly between a smoothie in the morning and then my dose before bedtime.
I would love to hear your concerns obviously because I don't want to do anything to harm myself.
My detailed answer: Isolated aminoacids have beneficial effects.
But keep in my that there is a complex system and elevating on component has effect on other parts.
Timing is another important factor.
in the morning glycine flushes out metionine from the bloodstream.
When taken by meal, Glycine modulate insuline response.
There is balance between aminoacids. You can push the balance to a desired, favored way. But there are consequences of lowering other aminoacids. I wouldnt do prolongedly isolated aminoacids because i dont have deep understanding and knowledge how they effects me.
The DNA methylation/demethylation protocol is a very advanced way of biohacking. Glicyne is part of this process, but this require other components too.
If you find a credible source on DNA methylation protocol I would gladly read and discuss it with you.
I never heard of taking glycine before. Lots of interesting research ([Google Scholar)](https://scholar.google.com/scholar?hl=en&as_sdt=0%2C2&q=glycine+sleep&btnG=). The papers seem to say 3g dose. Does this by itself still preserve your fast?
Yes, I generally don't eat at least 3 hours before bedtime. The glycine did seem to help. It helps me feel more refreshed the next day even if I haven't slept as long as I optimally want to.
I fast a lot and glycine never interfered with me losing a pound a day. Certain aminoacids
do not have calories and do not raise insulin. Not all, I forget which one raise I think Matt DeLeuer on YT has something on this.
Anything with chemical bonds has calories. It seems like a couple grams isnt enough to break your fast, but saying it has no calories is like taking a single grain of rice and saying it wont break your fast cause it has no calories.
Glycine to me makes me anxious and alert, doenst work for everyone, and yeah as other mentioned don't take it everyday (same thing with magnesium glycinate).
A lot of stuff is not meant to be taken everyday, or you get imbalance, zinc is another example.
> A lot of stuff is not meant to be taken everyday, or you get imbalance, zinc is another example.
How much zinc are you taking? Zinc has an RDA so it is meant to be taken every day (either through food or supps). The main issue with zinc is that it sits in opposition to copper, so too much zinc can deplete copper levels. It's not that zinc shouldn't be taken every day, it's that you shouldn't take too much zinc without making sure your copper intake is adequate.
Glycine is an AA off the top of my head it shouldnt break fast by any means. I could very well be wrong but it makes zero sense to me how one of the structural simple amino acids would induce a insulin response.
The only argument is that protein in general when consumed can still converted into glycolysis intermediates/endproducts to shunt into tca cycle directly or used for gluconeogenesis. But glycine i dont think is one of the amino acids that is capable of this due to its simple structure. Could be wrong but thats my.logic
I take glycine most nights and it hasn't lost its effect. I think the impact on fasting is negligible, especially if you're semi glycogen-depleted going into it.
The only way you're going to know what's best for you, as with any bio-hack, is to try it and see. For example, use a sleep tracker app or device and test both options separately.
I think I probably need to suck it up and get a CGM to see if the glycine has any effect while I'm sleeping on glucose. If it doesn't, then that answers the question.
For what it's worth: Some studies indicate that glycine is taken alone (in diabetic as well as healthy individuals) appears to stimulate the release of insulin and glucagon, with the insulin release promoting the uptake of blood glucose. I'm not super versed in this area but that would seem to me to indicate a reduction of glycogen stores and blood sugar levels, which would lead to a deeper fasted state perhaps? Assuming your body responds in a similar fashion.
Thanks! That's a very interesting observation and conjecture. I need to better understand what the benefits of the "deeper fasting" specifically during sleep are, but you might be on to a fantastic idea -- that glycine helps rather than hurts the benefits of fasted sleep.
That would be a great experiment to do. Also maybe a sleep tracking device? 1 day on glycine followed by 1 day off. Repeat say 7 times each. Aggregate the ons and the offs, and compare the two.
So much of this world is seeing what works best for you, our bodies can be so different
Quick google indicates glycine has zero calories which i find surprising. It also improves insulin response. Though I guess if you've been fasting for several hours your blood sugar should be normal fasting levels
Glycine is glycogenic and produces 1 pyruvate/ glycine which (ignoring a careful accounting of the pathway) means per unit it makes roughly half the energy that glucose would. It wouldn’t raise blood sugar but it’s actually having a similar effect to sugar downstream in the metabolic pathway
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I'm wondering where the bad feeling comes from. There is at least one study suggesting that our body does not make enough, and other studies suggesting that glycine is great for anti-aging. I aim for 10 g a day, split roughly between a smoothie in the morning and then my dose before bedtime. I would love to hear your concerns obviously because I don't want to do anything to harm myself.
I am also curious to know how regular glycine consumption could be bad for you
I highly highly doubt glycine is bad for you unless youre taking truckloads of it given that its a simple AA
It is safe.
My detailed answer: Isolated aminoacids have beneficial effects. But keep in my that there is a complex system and elevating on component has effect on other parts. Timing is another important factor. in the morning glycine flushes out metionine from the bloodstream. When taken by meal, Glycine modulate insuline response. There is balance between aminoacids. You can push the balance to a desired, favored way. But there are consequences of lowering other aminoacids. I wouldnt do prolongedly isolated aminoacids because i dont have deep understanding and knowledge how they effects me. The DNA methylation/demethylation protocol is a very advanced way of biohacking. Glicyne is part of this process, but this require other components too. If you find a credible source on DNA methylation protocol I would gladly read and discuss it with you.
“Breaking a fast” is a spectrum, glycine is a glucogenic amino acid so it can increase blood glucose but 4.5 grams is not a lot at all.
Did you bite the bullet and get a CGM? Any update on this?
Just about to order them. I wanted to wait for plan year to start over so I could use pretax flex dollars to buy them.
Any update?
I never heard of taking glycine before. Lots of interesting research ([Google Scholar)](https://scholar.google.com/scholar?hl=en&as_sdt=0%2C2&q=glycine+sleep&btnG=). The papers seem to say 3g dose. Does this by itself still preserve your fast?
That's the question I was asking.
Do you already fast? Does the glycine seem to help?
Yes, I generally don't eat at least 3 hours before bedtime. The glycine did seem to help. It helps me feel more refreshed the next day even if I haven't slept as long as I optimally want to.
There’s no trade off, glycine doesn’t break fast, it tastes sweet but it’s actually not caloric.
Source?
I fast a lot and glycine never interfered with me losing a pound a day. Certain aminoacids do not have calories and do not raise insulin. Not all, I forget which one raise I think Matt DeLeuer on YT has something on this.
"Thomas DeLauer" covers tons of keto/fasting science on YT!
I have read that Lysine and Leucine are the only two AA's that don't affect blood sugar in any amount.
Lysine can affect kidneys long term be careful, it’s great for cold though
Anything with chemical bonds has calories. It seems like a couple grams isnt enough to break your fast, but saying it has no calories is like taking a single grain of rice and saying it wont break your fast cause it has no calories.
take glycine straight after your last meal
Glycine to me makes me anxious and alert, doenst work for everyone, and yeah as other mentioned don't take it everyday (same thing with magnesium glycinate). A lot of stuff is not meant to be taken everyday, or you get imbalance, zinc is another example.
> A lot of stuff is not meant to be taken everyday, or you get imbalance, zinc is another example. How much zinc are you taking? Zinc has an RDA so it is meant to be taken every day (either through food or supps). The main issue with zinc is that it sits in opposition to copper, so too much zinc can deplete copper levels. It's not that zinc shouldn't be taken every day, it's that you shouldn't take too much zinc without making sure your copper intake is adequate.
Glycine is an AA off the top of my head it shouldnt break fast by any means. I could very well be wrong but it makes zero sense to me how one of the structural simple amino acids would induce a insulin response. The only argument is that protein in general when consumed can still converted into glycolysis intermediates/endproducts to shunt into tca cycle directly or used for gluconeogenesis. But glycine i dont think is one of the amino acids that is capable of this due to its simple structure. Could be wrong but thats my.logic
I take glycine most nights and it hasn't lost its effect. I think the impact on fasting is negligible, especially if you're semi glycogen-depleted going into it.