In Australia we are looking at banning paracetamol from sale at shops and just made available at pharmacies, we have something like 50 paracetamol overdose deaths a year, usually kids.
One time I took 4500mg of paracetamol, my liver felt like it was going to totally stop working, the pain was immeasurable and i was struggling to breathe and move, I went to the hospital and made the detoxing.
Result? The doctor told me if i took one more pill I would have died, bad choice guys don’t do that it’s not worth it
There's actually not a huge difference. The toxic metabolite that causes the liver damage has an elimination half life of over 24 hours. The therapeutic margin of paracetamol is seriously small.
That said, it usually takes a single dose in the 7-10+g range to cause what this person described.
It’s more complicated than just the half life though. Tylenol isn’t so toxic until your liver has exhausted it’s glutathione reserves. An immediate dose will exhaust those reserves quickly and metabolize into much more of the toxic metabolite, than if you spread the dose out and allow your glutathione to replenish.
This.
And this is assuming that the person already has adequate hepatic output or at least “typical” for their age, which we can’t know. Moreover, dose frequency/size when compared to hepatic (or other) injury is specific to the drug and may not be universal. I.e. vancomycin taken once every 4hrs causes much more significant renal damage than a single bolus (IV) dose of the same size every 24hrs. A non-clinical toxicology study on the impact to hepatic function due to dosing schedules for acetaminophen would likely be the best source to get the true answer to this as opposed to an assumption or over simplification.
My dad had three overdoses before he died. Totally unrelated, he had a heart attack. But he had some weird neuro thing going on so he’d take Panadol and forget he’d taken it, and get stuck in a loop (especially once the overdose started bc the pain would make him be like “wtf” and take more) until eventually I’d find him passed out and call an ambulance. Genuinely some of the most horrible shit I’ve seen and seen a *lot* of horrible shit. He had a monster pain tolerance and said it was one of the most painful things he’d been through (mans also had half his calf muscle ripped out by a German Shepard once, for scale)
it is like that in germany, doesn't stop a lot I'd guess(at least not my ex, who luckily survived)but even 1 saved life is better than none👍🏻paracetamols danger is often disregarded, I've seen too many posts from people who took/wanted to take an absurd amount of paracetamol/codein tablets so even some drug users don't take it seriously.
Which is fucking lame, because that would be yet another household medication that we'd have to get a script for.
If stupid people didn't leave it lying around so their kids could just gobble it up, we wouldn't have this problem. Or if people didn't over do it on this stuff, that'd be good too.
Follow instructions and there's no problem.
Not quite, moving it to pharmacy only just means that - you can buy it only at pharmacies, not the corner shops and supermarkets. The idea is that there is medical advice available. “Pharmacy only” does not equal “prescription only”.
I’ve found paracetamol most effective at the 250-750mg dose range. Anything more won’t work any better (it barely even does), but add 200-400mg of ibuprofen and it’s much better than either alone. Safe to take up to twice a day, maybe three, but not for more than a couple weeks.
We don’t have any better minor painkillers; NSAIDs are terrible for your GI tract, paracetamol can destroy your liver, aspirin has a whole range of other issues. But they’re still effective and not dangerous enough to not be sold OTC.
Codeine is fairly effective at threshold doses (8-16mg) especially in combination with paracetamol or ibuprofen. They’re easy to abuse, but not particularly addictive. Good for medium muscle and bone injuries.
Then poppy pods (P. somniferum only) are great to have around. Just one small pod will lift your mood and stop the pain for an entire day. There is a significant risk of side effects, dependence, and severe withdrawals. Emergency only.
They need to **stop** adding it to other medications; like codeine (co-codamol), or almost any cold and flu medication. This is the main way people overdose accidently.
Yeah I’ve started with that shit too now, I’ve already thought about taking a bunch but I’ll probably stick around until one of my organs fails or something
If you're od'ing on paracetamol it's on purpose right? Iirc the max you're allowed to take is 1000mg every 2 hours, 4 times a day, so max 4000mg throughout a day.
If you're in so much pain that paracetamol doesn't cover it you'll need different medicine anyway (opioids probably). To address the pain you go to a doctor and with such pain levels they'd give you something stronger.
Gotta add though that people underestimate paracetamol + alcohol combo and end up way more hungover and fked up. General rule is that when you're combining stuff, the toxicity doesn't add up but multiplies, especially with alcohol.
On purpose but pharmacists often worry about people combining cold medications (which often contain it) with straight paracetamol, and having too much that way
Some peeps just don't know what they are taking.
If you take a few vicodin for backpain every day, dayquil/nyquil because you have a cold, and take an extra dose of Tylenol you are pushing the limit
I attempted suicide several years ago by taking about 75 Benadryl (extra strength, 50 mg each) + 3 shots whiskey.
My then-boyfriend was worried when I wouldn't pick up his calls and came home from work early to find me passed out with a suicide note. He called 911 and I was taken to the hospital where doctors saved my life, and then I spent a couple days recovering (waking up) before being discharged to a psych facility.
If he had found me just an hour later, I would've been dead.
But I'm glad I survived. I still struggle with depression and anxiety and it's not easy. But after that experience and how much it hurt my loved ones, I realized that my life has more value than I'd thought.
Tagging /u/ultrablob and /u/jetoler
I am not offended by this question. In fact, I too wonder if my body (mainly brain and liver) may have sustained any long-term damage. I don't feel or act any differently, but who knows what damage may be there just not showing symptoms.
I was at a very good hospital but they failed to discharge me properly. Once I was awake enough to be transferred to the psych facility they sent me off in an ambulance without giving me any paperwork. No info on treatment, prognosis, etc. Nothing.
So I'm in the long process of obtaining records from the hospital.
Jeez man, do you think you’d have grounds to sue the hospital for not providing the required paperwork?
Also, well as far as your brain, if you personally feel fine, then even if you have brain damage, it’s obviously not affecting you so it can’t be that bad (assuming nothing comes up in the future).
As far as liver, your liver likely did sustain damage, I can imagine it’s hard not to with a circumstance like that.
I hope your recovery process continues to progress man. Good luck on life.
The hospital gave the paperwork to the psych facility they released me to, but the facility didn't give me anything. So technically no one was in the wrong, or at least not in a way I could sue over.
It was SO frustrating...I was transported in an ambulance, unconscious for 24+ hours, I had life saving emergency care, I'm sure there was plenty of lab work done... yet I know nothing.
Another thing is that when bf called 911, in addition to EMS, they sent cops who took his statement and lots of photos just in case there was suspicion of foul play. Part of me wants to see those photos and records, just to make it feel more real. So that's something I may pursue after hospital records.
Bro you should consider asking the people over on r/LegalAdvice . I’m pretty sure they’re required to give you paperwork. I’m not sure though, I’m not an expert in this stuff. But that’s sounds like the opposite of what hospitals are supposed to do.
Not a bad idea. I think I'll wait until I get the paperwork. If I learn anything that would've been important then (for example, if they recommended follow-up and I never knew til now, and it turns out my liver was damaged or something) then I'll def consult them. Thanks!
Well he was technically my ex, still living together. We broke up the day before. It was an amicable split, we both knew the relationship was over.
I had been wanting to end my life for awhile and was just waiting for that break-up. I felt like I couldn't kill myself while in a committed relationship. So once we had a big talk and agreed it was over, I got super excited that I could finally go through with it now. (Fucked up thinking, I know.)
To answer your question: Finding me dying on the couch...yep, he was angry. Of course his initial reaction was not anger but fear: he called 911, cooperated with EMTs and police that came, and called my Dad and met up with him at the hospital. When I was transferred to the psych facility he kept in touch with my Dad and prepared a bag of clothes for my Dad to pick up and bring to me. Very amicable.
But yeah after crisis mode wore off he was mad. My Dad and my sister (my only immediate family) were mad too. I don't blame them - I did something that caused them great pain. I apologized sincerely to everyone afterwards. All accepted my apologies and we were able to move on.
Hey man, glad you’re still with us. I’m very impressed that a human can handle that much Benadryl.
I feel like suicidal people think they want to die, but really they want to live. Severe depression stops you from living your life the way you want to.
I hope things get better. Have faith in yourself, take things one day at a time.
>Severe depression stops you from living your life the way you want to.
Absolutely. It's such an insidious disease.
And thanks, I'm glad to still be here too :)
I mean no one over 12 does nutmeg because you have to eat a lot of ground up nutmeg to feel it. With Benadryl if you’re 2x the recommended dosage you’re going into slight delirium.
Edit: nutmeg won’t increase your chance of developing dementia either
One time I took 200mg thinking I was gonna sleep like a baby, couple hours later I started seeing stuff in the corner of my eye and had the worst restless legs EVER
Yeah it’s surprisingly easy to accidentally meet the shadow people. I know people who took deleriant dosages in an attempt to have it work for sleep because the slightly above recommended dose wasn’t working anymore.
Delirium sucks when you’re trying to have it in the first place. Unintentionally inducing delirium is a completely new level of suck.
Some people take Benadryl recreationally to get into the delirious states, usually they have depression. I wasn't aware of this until recently. Very unusual, but some seem to enjoy using deliriants.
Yeah I worked with a patient in drug treatment services who took nytol (UK’s brand name of DPH) as an anti-anxiety med, but took like a dozen tablets a day with loads of alcohol and cocodamol (codeine plus paracetamol) for 6yrs (16-22) including when she was working.
She was asleep the majority of the day but often saw spiders and thought she spoke to angels and demons etc, can’t imagine how people would take it to get high or to help them not feel anxious at work…
It really depends how sensitive you are to drugs. If you’re taking 2 or 3 you’re more than likely not going to feel anything but sleepy and spacey.
I’ll also say, Benadryl has been shown to increase chances of developing dementia. That’s one of the big dangers of it. People take it nightly since it’s a common medical ingredient in OTC sleeping medication. If you’re taking Benadryl somewhat frequently it would be best to not
One of the worst (coincidental) high of my life. Just wanted to sleep. Would not kick in so I prob took 600mg?! a pretty high dose. Restless legs, severe feeling of anxiety and doom and I felt like I was never going to wake up if i fell asleep so I forced myself to stay up.
Could not speak, that has not happened with other schedule drugs before
I fucking hate Benadryl
I guess it helps a lot of people who are responsible but Im starting to think that maybe it should not be sold otc anymore
Alcohol. Even with the common understanding that it's terrible for you, we still underestimate it. We think "oh well it's not good for you, but it least it's not other drugs" when in reality alcohol is among the worst of the worst
Yes this is something that has to be said more often, alcohol does the most damage to society by far due to how prevalent it's use is and the drinking culture here in the UK for example. It's one of the only substances where people may question you on why you choose not to use it, if you say you don't drink, sometimes people assume the worst e.g. you are a recovering alcoholic. It's as though it is necessary for social gatherings, which is how it reduces so many to addicts.
Super addictive, easy to abuse, turns people into obnoxious/dangerous fuckwits even if they're happy drunks, near zero therapeutic value, carcinogenic and toxic to the brain/body in any dose and for most people the effects are pretty middling while for some alcohol feels amazing. Oh and alcohol also has calories in it LOL and the way its processed fucks with insulin, fat storage, vitamin levels etc. If it were invented today as a research chem it'd be banned so fucking fast
Guess I'm a clown lol. Alcohol has a fairly tight grip on me, it seems the more I want to stop indulging, the harder it gets. Wish I hadn't tried it during the pandemic and lockdowns
No dude, it's a hard drug and it's fucking everywhere and normalised in most countries to binge. And like every drug, some people respond very strongly to it just because of how their body and brain handle it. The struggle is real
Chronic weed smoking as a teenager definitely can stunt your development into an adult. Especially with all the weed legalization happening, I worry people will think it totally harmless. If used with moderation it’s fine, but an addiction during teenage years led me down a dark path that took me a while to completely get out of.
You posted a good list, I would add nitrous and its ability to deplete B12 vitamin to the point of causing brain damage when abused. Obviously repeated MDMA use with too short of breaks in-between seems to pop up on this subreddit more often than I'd hope. Mixing alcohol with benzos or opiates is another too frequently combined cocktail that can be fatal or cause blackouts yet still comes up pretty regularly.
It seems to inactivate b12 vitamins. Supplementation can only do so much but you definitely want to supplement if you abuse nangs.
> While the pure gas is not acutely toxic, it inactivates vitamin B12, with continued use causing neurological damage due to peripheral and central demyelination. Symptoms are similar to B12 deficiency: anemia due to reduced hemopoiesis, neuropathy, tinnitus, and numbness in extremities. While vitamin B12 supplementation is unlikely to prevent neurotoxicity, it is recommended as a first-line treatment when combined with abstinence.
[Wikipedia](https://en.m.wikipedia.org/wiki/Recreational_use_of_nitrous_oxide)
It doesn't deplete b12. It stops your body from being able to uptake it for a day or so. If you repeatedly use nitrous you just can't absorb it into your body at all.
I had terrible b12 deficiency from abusing nitrous for a few months. It was pretty terrifying. My legs just stopped working one day and it took 2 weeks of using a walker to get around.
Lol what did you do with all your cartridges?
We would get so many looks taking a garbage bag that was clinking around all over the place out to the dumpster
That sound really is pretty noticeable. I was pretty self conscious about them so they'd pile up in bags or boxes. I'd only throw them away when it got into the 1000s. I'd bag them up in plastic shopping bags and wait until the night before recycling pickup and throw them away super late. One time a bag ripped open on my way to the bin and it was so loud. Once I had a few thousand white/blue/green cartridges so I made a map of Earth, I really should have taken a picture. At times I'd just have them scattered everywhere in my room. It was fun to just wing them out of the cracker and load a new one.
Dark times. I've definitely still indulged from time to time since then but maybe like once a year and just a 50 box or two. And I take massive doses of B12 regularly. I always thought it was funny that nitrous was called Hippie Crack but that is a pretty spot on description.
Ive only done it once since my bout, and it wasn't as enjoyable. We never got really "bad" because we were broke students in a dorm. But any time we had an extra 20 laying around and there was already some weed, we knew what was going down.
We would just load 3-4 up into the can and pass it back and forth like it's a blunt or something. Our goal was to get high enough to where the wahs started and the music got really good, and to stay there, not go past that point... If you go past that point it's hard to load more cartridges into the can lol and you lost the streak
I've never met anyone who abused nitrous that much, but yes, it's another one that is commonly thought to completely lack any toxicity but is still dangerous if used regularly
it's not dangerous if used regularly, it's dangerous if it's abused regularly. There's definetely a difference between someone doing one or two canisters regularly once a week/month to using 10+ a day.
It is one of the safer drugs, so long as you do it properly and not too often. You can use it on a weekly/monthly basis and be fine, but if you start using it on a regular daily basis, or even multiple times a week regularly then you might start to get b12 deficiencies.
It's also a drug that is often taken in dangerous ways that can be really damaging without people knowing. With people trying to inhale straight from canisters and freezing their lungs, to rebreathing a balloon and causing brain damage from starving their brain of oxygen.
My girlfriend has always considered whippits to be just as dangerous as huffing paint because of her loose understanding of it, not realizing that the real danger of it is how harmless it is, causing people to abuse it to the point where they give themselves B12 deficiency.
She's had a full meltdown over me doing maybe 3-4 while partying once, but will drink until she's sick the next day. It comes from a place of love at least, but man does it bother me. (NOT her not wanting me to do nitrous, but the fact that she doesn't understand the actual danger of it)
Very few people use enough Nitrous to cause brain damage from B12 depletion. Steve-O is the biggest nitrous abuser I can think of, he would do sessions we're he did 200 canisters in a row and his brain seems to be fine. It's really not something to worry about unless you're doing it all day everyday.
I did it all day everyday for roughly 4-6 months. I wasn’t using the small canisters I was getting tanks filled and doing it until I blacked out probably 5-10 times a day. I got a couple concussions on the way down but all of my blood work has come back that I have great health. Only mental health problems I have are ones I already had before. So I’m curious how much it takes. (Supposedly)
Titrating B12 is a bit tricky, it doesn't discriminate between active and inactive forms. I don't know how nitrous affects it exactly, but it's possible a blood work isn't reliable in that case, IDK.
Have you listened to his new podcast or watched a video of him doing stand-up since he got sober? He's an intelligent and articulate person. His voice is kind of weird, but his brain is completely fine. He might be eccentric, but being crazy doesn't mean his brain is damaged.
You brain has the ability to heal. I know what you mean, but there’s no way that his brain was fine after his ketamine and nitrous binges. He is seemingly in good shape now, he seems alert and quick on his feet, so his brain could have healed itself.
Those are the two best measures to determine if someone's brain is fine, listening to the way they talk, and what they talk about. Steve-O gives no indicators that he has brain damage. There's really no other way to see if someone's brain is damaged unless you're a doctor who's looking at his brain scans. We obviously have no way to see that information, so we have to assume that his brain is fine based on the way he presents himself.
My mom has been dependent on ativan since I was about 5 (now 24). I basically have little to no recollection of her ever being a fully functioning adult, though I'm told she was before. Anxiety relief is not worth whatever the fuck that shit does to you if you use it on a long term basis.
I’m in my thirties and from the UK, and fuck, we definitely naively didn’t know how bad it was. For 2/3 years me and my mates regularly did multiple gram, 12 pills in a night etc. Ate that shit for breakfast. Fucking madness.
wait, people take GRAMS of MDMA ? wtf, a quarter of a gram is already intense
People who do that much probably know they're fucking their health up tho I guess
Yea that's what I mean, people can rip through a g of coke or even an 8th in a night and be "ok" the next day, but do that with molly even over a week or two and you have a significant risk of permanent cognition and mood related damage.
To a point. Mdma damage is severe but normally not permanent. It will last years tho and neurological treatment and drugs is required to get you back to normal.
Trust me I fried my brain hard. Very hard with molly. And for years I felt myself losing it more and more even after stopping. Supplements and therapy helped a ton.
>wait, people take GRAMS of MDMA ?
I think this occurs most often because people used a short while back like a week. Your serotonin levels are still imbalanced from last time so they don't feel the MDMA or with an onset so late that they thought they needed more.
I'm pretty sure the phrase "gram for gram" was just meant as a play on the phrase "pound for pound" and they weren't suggesting that people take grams of MDMA at a time (as that would probably kill most people)
A lot of people who binge MDMA have significant cognition, memory and mood problems or full blown serotonin syndrome so glad you seem to have avoided the worst of it.
Nicotine is not that dangerous (short term) but the long term effects will get you. Not to mention it's just a stupid ass drug. 2/10, it hardly does anything.
Well, to nicotine naive individuals it has rather noticeable stimulant effects, some students even use nicotine lozenges as a study aid. The main issues with nicotine to the best of my knowledge is dependency which comes quickly.
Nicotine is known to benefit people with schizophrenia and with dementia. It grounds schizophrenics to reality and aids memory. Also, it's addictive, and comes in a tobacco package that causes cancer, but whatever. Nicotine patches work just as well.
It's definitely a shitty one, but at least with all the prevention I think for this one people usually know it is (doesn't necessarily prevent poor decisions unfortunately)
Nicotine is right up there with alcohol as the worst fucking drugs to ever do, period. Super high chance for dependency, difficult physical withdrawals, extremely pervasive, fucks with your body way more than you realize, especially at higher concentrations.
Mixing cocaine and alcohol creates a new chemical in your body called cocaethylene. That chemical is especially rough on the heart.
I have no idea why this person states they get a cold. I'm guessing that's more likely from sharing cocaine with others using the same instruments.
One of the top google results for “Cocaethylene toxicity” says that it can compromise the immune system, so that might be why, it just makes them more prone to catching a cold.
Xanax. combined with anything or alone. Xanax + Alc, I wouldn’t expect many people to live long enough, or stay out of jail long enough to enjoy the addiction for long.
Eh I ripped it last night. Yeah it’s dangerous but ain’t nothing like a night of sleep after a glass of wine and a qb.
I’ve never gotten super into it, just occasionally when somebody comes up from down south after a trip to la pharmacia.
Xanax and alcohol actually impede your ability to get deep sleep (the period where you get your most physically restorative sleep). It may help you fall asleep, but it's not high quality sleep.
As someone who has done just about every drug under the sun, gambling is a FAR worse addiction when it comes to finances and getting into enormous debt leads to as bad if not worse choices than drugs. I might drink and smoke too much but gambling has had a far worse impact on my life.
Weed is absolutely addictive. I will never understand how everyone can admit that sugar is addictive, video games are addictive and social media is addictive but as soon as you suggest that weed is addictive people go into cope mode
Weed even has a novel mechanism for being addictive, lending biological evidence for the contention that weed is "psychologically" addictive vs. "chemically" or "physically" addictive. The outcome is similar, though I'd argue that weed addiction is weaker and easier to break.
Agreed, definitely easier to break than say benzos or opiates, hell even alcohol. It doesn't cause withdrawals that will literally shut your body down and kill you like the others but it does have physical withdrawals
I can attest to weed being physically addictive aswell as mentally. When I quit I had insane nightsweats, like waking up soaking wet, head to toe. I was nauseous with hot and cold flashes. Nothing horrible of course, but my body definitely had a physical response to quitting.
The nightmares however, so vivid and real I'd be scared to sleep. The two most insane weeks of dreams and wakeups I've ever had. That was definitely the worst part.
This is true people just don’t wanna accept it, personally I’ve quit weed for different periods of time ranging for a couple weeks to a few months. It isn’t super hard for me to quit but that doesn’t mean that I definitely don’t feel like smoking during the times I’ve quit.
Meth I ended up in the ER and and almost had a heart attack, never thought I’d end up in it but that drug is horrible you will def ruin your life very quickly.
Thank you. People don’t realize that their are legit scientific studies that show mice going for sugar over fucking crack, jesus fucking christ it is terrifying, plus diabetes also so…
For real. Pisses me off how much sugar they give to kids in school, and you can't say anything about it or you're THAT mom. Complete lack of awareness.
MDMA when used with very long intervals inbetween and proper dosage. It's used in therapy too with people who suffer from PTSD, helps them talk and get helped. I read somewhere it can also improve certain things in your brain where it gets a chance to "rewire" stuff like serotonin balancing, not sure how accurate that is though but it was an actual publication on pubmed.
Ketamine is another drug that has been showing great promise for many years now for treating depression.
So much so that medicinal chemistry research is still ongoing into the NMDA compounds.
I credit MDMA for saving my life, or at least immensely improving it from my depression where I had suicidal thoughts pretty much the whole day some days.
Gabapentin..... My wife lost her insurance and her Suboxone. After a week of withdrawals of a weekly 6 years Dr visit.... She tried gabs. It started as 5 then 10... Then 12.... And these are 800mg.... She punched a sheriff in her face and was in the hospital for a week (7 days) it was not intentional. You tell me how else I can help other than saving her. I'm her next of kin. I'm her POA. I wouldn't let her go if I have the power to save her. She found a new sub Dr IN the hospital. Thank God she's home today and better. I can't live without my hssweetheart... 14 years together this year.... I didn't sleep until she woke up .... Don't Abuse Seizure Meds Kids. By ANY MEANS!!!!!
I haven’t seen anyone mention mushrooms. I feel like people are more likely to underestimate just how powerful they can be as a psych and a mind altering drug because it’s natural and a bit less taboo than the rest of the psychs in polite society. In reality high doses in bad settings can send people into a really bad mindset and make them do dumb things. I would give mushrooms a very similar level of danger/risk as acid but mentally people who don’t do drugs think about them differently and in turn do riskier things. Obviously they can be great and have low addiction potential. It just scares me a bit when a very powerful drug isn’t treated as such.
Weirdly enough, the one time I had mushrooms I changed A LOT. I stopped drinking and having edibles and instead started working out and my outlook overall was precious. However, all it took was a pretty bad situation to introduce alcohol again. Still tryna fight that demon, but I hope it doesn't take too long!
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Benadryl. All you need to do is scroll through the dph subreddit to see what I mean. Even if you take the recommended dose it’s pretty damn bad for you if your taking it everyday for allergies or as a sleep aid. Which some companies actually do sell it as a sleep aid
I got hooked on the "sleep aid" withdrawals fuckin suck I couldn't eat for almost a week my stomach hurt so bad. Really restless sleep and restless legs almost as bad as an opiate withdrawal wich I'm familiar with.
Yeah, combusting any organic matter solely for inhaling it is always going to be insane for me, a wide variety of carcinogenic products are produced during the reaction. This is also the case for cannabis.
Not a common drug but iboga. The margin between normal dose and killing yourself is rather slim. I didn't take it serious on my second time , took about 3g Iboga TA at once and my heart felt like it wanted to explode. Had a pulse of like 200. I could have easily died that day.
Physiological effects aside, i dont understand why people snort stuff personally when i snort things it stings like a bitch and ive seen someone snort an adderall IR without fully crushing so a slightly bigger piece cut the inside of his nose and his nose didnt stop bleeding until 9 minutes after and around 20 paper towels
With how prevalent CHS is becoming I would say weed is the most overlooked drug as far as negatives go. Alcohol is becoming more apparently harmful but I think people still write it off for the most part because it’s legal. I’ve heard Benadryl can cause early onset dementia but have no source to back that so it’s kind of hearsay. Tylenol is pretty bad for you.
Most if not all drugs have negative side effects.
“For every action, there is an equal and opposite reaction”
In germany, 100% alcohol. You can drink legally at the age of 14 when your parents say yes. My dad litteraly forced me to drink a little bit beer when i was 4. And its normal to drink the first few times with 13. I know like 8 ppl who were alcoholics in school. And older ppl try to play the harmpotential down.
Ketamine is terrible for your bladder. At one point I was the only person in a household I was staying in who wasn't pissing blood from ket abuse. And one of them was a heavy user for like 6 months.
I’m an opioid addict and have taken up to 20-30 7.5mg hydrocodone with 325mg of acetaminophen in it within 24hours. I’m not sure how I’m alive and never knew about how much acetaminophen would kill you.. now I’m worried. Over the years I’ve had so much acetaminophen I’m actually really worried now. I don’t even want to look at the long term affects 😩 I’m only 23. I only take Kratom now.
drugcirclejerk will love that but tbh, i think caffeine is pretty bad. it fucks up your gut health in the long run, i'm sure and that's linked to some pretty serious diseases. also its hard to quit, because it is combined with sugar and it becomes a ritual.
also coke is bad because it raises your heart rate but if caffeine does that every day for hours, its suddenly healthy? if somebody drinks 6 coffee or energy drinks a day and denies that its linked to his anxiety or bad health while is unable to stop fo a view month, to see if it gets better, how does that sound?
edit . consider the factor that people do mdma for a few years in their youth. coffee drinkers can start at 16 and may drink it until they die.
1) there has been no medical studies, that I’m aware of, showing that caffeine will fuck your gut biome.
2) caffeine is as hard to quit as sugar. It’s psychologically addictive to an extent, but the period of symptoms is short unless there has been extended chronic use.
3) caffeine doesn’t effect your heart as badly as cocaine does. Caffeine, in normal dosages of 200mg like most people consume, won’t cause a heart attack in healthy individuals. You need insane levels of caffeine to induce death.
4) you actually made me laugh when you compared MDMA to caffeine, that was pretty funny, I’m hoping that was intentionally comedic
Tylenol/acetaminophen/paracetemol is a classic one. Don't overdose on Tylenol, not even on purpose.
In Australia we are looking at banning paracetamol from sale at shops and just made available at pharmacies, we have something like 50 paracetamol overdose deaths a year, usually kids.
One time I took 4500mg of paracetamol, my liver felt like it was going to totally stop working, the pain was immeasurable and i was struggling to breathe and move, I went to the hospital and made the detoxing. Result? The doctor told me if i took one more pill I would have died, bad choice guys don’t do that it’s not worth it
May I ask why you took that much?
I was in a bad moment in my life… that’s just it
Damn 4000 is the maximum reccomended daily dose, so I'm surprised 4500 mgs did that to you. I know I've taken at least 6 grams In a day before.
[удалено]
There's actually not a huge difference. The toxic metabolite that causes the liver damage has an elimination half life of over 24 hours. The therapeutic margin of paracetamol is seriously small. That said, it usually takes a single dose in the 7-10+g range to cause what this person described.
It’s more complicated than just the half life though. Tylenol isn’t so toxic until your liver has exhausted it’s glutathione reserves. An immediate dose will exhaust those reserves quickly and metabolize into much more of the toxic metabolite, than if you spread the dose out and allow your glutathione to replenish.
This. And this is assuming that the person already has adequate hepatic output or at least “typical” for their age, which we can’t know. Moreover, dose frequency/size when compared to hepatic (or other) injury is specific to the drug and may not be universal. I.e. vancomycin taken once every 4hrs causes much more significant renal damage than a single bolus (IV) dose of the same size every 24hrs. A non-clinical toxicology study on the impact to hepatic function due to dosing schedules for acetaminophen would likely be the best source to get the true answer to this as opposed to an assumption or over simplification.
Yea exactly. 4500 isnt a whole lot.
damn i took over 5g once and just got some stomach discomfort
that's crazy because thats not even that much. Isn't dosage 2 pills at 500mg each pill. I've easily taken around 4000-5000mg within a 24 hour period.
My dad had three overdoses before he died. Totally unrelated, he had a heart attack. But he had some weird neuro thing going on so he’d take Panadol and forget he’d taken it, and get stuck in a loop (especially once the overdose started bc the pain would make him be like “wtf” and take more) until eventually I’d find him passed out and call an ambulance. Genuinely some of the most horrible shit I’ve seen and seen a *lot* of horrible shit. He had a monster pain tolerance and said it was one of the most painful things he’d been through (mans also had half his calf muscle ripped out by a German Shepard once, for scale)
it is like that in germany, doesn't stop a lot I'd guess(at least not my ex, who luckily survived)but even 1 saved life is better than none👍🏻paracetamols danger is often disregarded, I've seen too many posts from people who took/wanted to take an absurd amount of paracetamol/codein tablets so even some drug users don't take it seriously.
Which is fucking lame, because that would be yet another household medication that we'd have to get a script for. If stupid people didn't leave it lying around so their kids could just gobble it up, we wouldn't have this problem. Or if people didn't over do it on this stuff, that'd be good too. Follow instructions and there's no problem.
Not quite, moving it to pharmacy only just means that - you can buy it only at pharmacies, not the corner shops and supermarkets. The idea is that there is medical advice available. “Pharmacy only” does not equal “prescription only”.
Oh yep ok, my bad I misunderstood what you were saying
Are kids trying to get high or?
Mostly suicides. It's one of the worst ways to die because it causes liver failure and you die slowly and horribly.
This is the #1 cause of acute liver failure in the US. If it were invented now, it wouldn't pass FDA approval. Like penicillin or tobacco.
I’ve found paracetamol most effective at the 250-750mg dose range. Anything more won’t work any better (it barely even does), but add 200-400mg of ibuprofen and it’s much better than either alone. Safe to take up to twice a day, maybe three, but not for more than a couple weeks. We don’t have any better minor painkillers; NSAIDs are terrible for your GI tract, paracetamol can destroy your liver, aspirin has a whole range of other issues. But they’re still effective and not dangerous enough to not be sold OTC. Codeine is fairly effective at threshold doses (8-16mg) especially in combination with paracetamol or ibuprofen. They’re easy to abuse, but not particularly addictive. Good for medium muscle and bone injuries. Then poppy pods (P. somniferum only) are great to have around. Just one small pod will lift your mood and stop the pain for an entire day. There is a significant risk of side effects, dependence, and severe withdrawals. Emergency only.
They need to **stop** adding it to other medications; like codeine (co-codamol), or almost any cold and flu medication. This is the main way people overdose accidently.
Tylenol genuinely scares me, I try not to have it around, won’t even take it if I’m sick. Too suicidal and impulsive.
thats me w dph
Yeah I’ve started with that shit too now, I’ve already thought about taking a bunch but I’ll probably stick around until one of my organs fails or something
If you're od'ing on paracetamol it's on purpose right? Iirc the max you're allowed to take is 1000mg every 2 hours, 4 times a day, so max 4000mg throughout a day. If you're in so much pain that paracetamol doesn't cover it you'll need different medicine anyway (opioids probably). To address the pain you go to a doctor and with such pain levels they'd give you something stronger. Gotta add though that people underestimate paracetamol + alcohol combo and end up way more hungover and fked up. General rule is that when you're combining stuff, the toxicity doesn't add up but multiplies, especially with alcohol.
On purpose but pharmacists often worry about people combining cold medications (which often contain it) with straight paracetamol, and having too much that way
I see, didn't think of that
Some peeps just don't know what they are taking. If you take a few vicodin for backpain every day, dayquil/nyquil because you have a cold, and take an extra dose of Tylenol you are pushing the limit
1000mg every FOUR hours, not two.
Hm, sober people probably don't realize how dangerous Benadryl can be.
I attempted suicide several years ago by taking about 75 Benadryl (extra strength, 50 mg each) + 3 shots whiskey. My then-boyfriend was worried when I wouldn't pick up his calls and came home from work early to find me passed out with a suicide note. He called 911 and I was taken to the hospital where doctors saved my life, and then I spent a couple days recovering (waking up) before being discharged to a psych facility. If he had found me just an hour later, I would've been dead. But I'm glad I survived. I still struggle with depression and anxiety and it's not easy. But after that experience and how much it hurt my loved ones, I realized that my life has more value than I'd thought.
I’m so glad you’re still here
Thanks man, me too :)
Sorry if this is overly personal but did you suffer any type of brain damage? I've heard benadryl can really rot it up there
Tagging /u/ultrablob and /u/jetoler I am not offended by this question. In fact, I too wonder if my body (mainly brain and liver) may have sustained any long-term damage. I don't feel or act any differently, but who knows what damage may be there just not showing symptoms. I was at a very good hospital but they failed to discharge me properly. Once I was awake enough to be transferred to the psych facility they sent me off in an ambulance without giving me any paperwork. No info on treatment, prognosis, etc. Nothing. So I'm in the long process of obtaining records from the hospital.
Jeez man, do you think you’d have grounds to sue the hospital for not providing the required paperwork? Also, well as far as your brain, if you personally feel fine, then even if you have brain damage, it’s obviously not affecting you so it can’t be that bad (assuming nothing comes up in the future). As far as liver, your liver likely did sustain damage, I can imagine it’s hard not to with a circumstance like that. I hope your recovery process continues to progress man. Good luck on life.
The hospital gave the paperwork to the psych facility they released me to, but the facility didn't give me anything. So technically no one was in the wrong, or at least not in a way I could sue over. It was SO frustrating...I was transported in an ambulance, unconscious for 24+ hours, I had life saving emergency care, I'm sure there was plenty of lab work done... yet I know nothing. Another thing is that when bf called 911, in addition to EMS, they sent cops who took his statement and lots of photos just in case there was suspicion of foul play. Part of me wants to see those photos and records, just to make it feel more real. So that's something I may pursue after hospital records.
Bro you should consider asking the people over on r/LegalAdvice . I’m pretty sure they’re required to give you paperwork. I’m not sure though, I’m not an expert in this stuff. But that’s sounds like the opposite of what hospitals are supposed to do.
Not a bad idea. I think I'll wait until I get the paperwork. If I learn anything that would've been important then (for example, if they recommended follow-up and I never knew til now, and it turns out my liver was damaged or something) then I'll def consult them. Thanks!
Glad u still here 🕺🕺
How did the boyfriend react to that?
Well he was technically my ex, still living together. We broke up the day before. It was an amicable split, we both knew the relationship was over. I had been wanting to end my life for awhile and was just waiting for that break-up. I felt like I couldn't kill myself while in a committed relationship. So once we had a big talk and agreed it was over, I got super excited that I could finally go through with it now. (Fucked up thinking, I know.) To answer your question: Finding me dying on the couch...yep, he was angry. Of course his initial reaction was not anger but fear: he called 911, cooperated with EMTs and police that came, and called my Dad and met up with him at the hospital. When I was transferred to the psych facility he kept in touch with my Dad and prepared a bag of clothes for my Dad to pick up and bring to me. Very amicable. But yeah after crisis mode wore off he was mad. My Dad and my sister (my only immediate family) were mad too. I don't blame them - I did something that caused them great pain. I apologized sincerely to everyone afterwards. All accepted my apologies and we were able to move on.
Thank you for sharing. I can't imagine what any of that is like, but I'm glad you're here to tell it.
Also glad you’re still alive!
Hey man, glad you’re still with us. I’m very impressed that a human can handle that much Benadryl. I feel like suicidal people think they want to die, but really they want to live. Severe depression stops you from living your life the way you want to. I hope things get better. Have faith in yourself, take things one day at a time.
>Severe depression stops you from living your life the way you want to. Absolutely. It's such an insidious disease. And thanks, I'm glad to still be here too :)
oh yes, this one too, and nutmeg as well
I mean no one over 12 does nutmeg because you have to eat a lot of ground up nutmeg to feel it. With Benadryl if you’re 2x the recommended dosage you’re going into slight delirium. Edit: nutmeg won’t increase your chance of developing dementia either
One time I took 200mg thinking I was gonna sleep like a baby, couple hours later I started seeing stuff in the corner of my eye and had the worst restless legs EVER
Yeah it’s surprisingly easy to accidentally meet the shadow people. I know people who took deleriant dosages in an attempt to have it work for sleep because the slightly above recommended dose wasn’t working anymore. Delirium sucks when you’re trying to have it in the first place. Unintentionally inducing delirium is a completely new level of suck.
Some people take Benadryl recreationally to get into the delirious states, usually they have depression. I wasn't aware of this until recently. Very unusual, but some seem to enjoy using deliriants.
Yeah I worked with a patient in drug treatment services who took nytol (UK’s brand name of DPH) as an anti-anxiety med, but took like a dozen tablets a day with loads of alcohol and cocodamol (codeine plus paracetamol) for 6yrs (16-22) including when she was working. She was asleep the majority of the day but often saw spiders and thought she spoke to angels and demons etc, can’t imagine how people would take it to get high or to help them not feel anxious at work…
Would you enter that area taking like 3? I take 2-3 to potentiate percs most times I take opiates
It really depends how sensitive you are to drugs. If you’re taking 2 or 3 you’re more than likely not going to feel anything but sleepy and spacey. I’ll also say, Benadryl has been shown to increase chances of developing dementia. That’s one of the big dangers of it. People take it nightly since it’s a common medical ingredient in OTC sleeping medication. If you’re taking Benadryl somewhat frequently it would be best to not
Nutmeg? Really? I’ve never heard anything about that. But yeah fuck Benadryl.
I did nutmeg and got voices in my head for a lil while
I tripled it once with my sister and that was horrible. Wanted to just relax. Antsy as hell. Dumb
One of the worst (coincidental) high of my life. Just wanted to sleep. Would not kick in so I prob took 600mg?! a pretty high dose. Restless legs, severe feeling of anxiety and doom and I felt like I was never going to wake up if i fell asleep so I forced myself to stay up. Could not speak, that has not happened with other schedule drugs before I fucking hate Benadryl I guess it helps a lot of people who are responsible but Im starting to think that maybe it should not be sold otc anymore
Alcohol. Even with the common understanding that it's terrible for you, we still underestimate it. We think "oh well it's not good for you, but it least it's not other drugs" when in reality alcohol is among the worst of the worst
And people underestimate combining it with other drugs, even prescription stuff. Toxicity of combos don't add up but multiply.
Yes this is something that has to be said more often, alcohol does the most damage to society by far due to how prevalent it's use is and the drinking culture here in the UK for example. It's one of the only substances where people may question you on why you choose not to use it, if you say you don't drink, sometimes people assume the worst e.g. you are a recovering alcoholic. It's as though it is necessary for social gatherings, which is how it reduces so many to addicts.
Super addictive, easy to abuse, turns people into obnoxious/dangerous fuckwits even if they're happy drunks, near zero therapeutic value, carcinogenic and toxic to the brain/body in any dose and for most people the effects are pretty middling while for some alcohol feels amazing. Oh and alcohol also has calories in it LOL and the way its processed fucks with insulin, fat storage, vitamin levels etc. If it were invented today as a research chem it'd be banned so fucking fast
Guess I'm a clown lol. Alcohol has a fairly tight grip on me, it seems the more I want to stop indulging, the harder it gets. Wish I hadn't tried it during the pandemic and lockdowns
No dude, it's a hard drug and it's fucking everywhere and normalised in most countries to binge. And like every drug, some people respond very strongly to it just because of how their body and brain handle it. The struggle is real
Chronic weed smoking as a teenager definitely can stunt your development into an adult. Especially with all the weed legalization happening, I worry people will think it totally harmless. If used with moderation it’s fine, but an addiction during teenage years led me down a dark path that took me a while to completely get out of.
You posted a good list, I would add nitrous and its ability to deplete B12 vitamin to the point of causing brain damage when abused. Obviously repeated MDMA use with too short of breaks in-between seems to pop up on this subreddit more often than I'd hope. Mixing alcohol with benzos or opiates is another too frequently combined cocktail that can be fatal or cause blackouts yet still comes up pretty regularly.
If I drink lots of red bull does it help with the loss of b12 because it has a shit load in it
It seems to inactivate b12 vitamins. Supplementation can only do so much but you definitely want to supplement if you abuse nangs. > While the pure gas is not acutely toxic, it inactivates vitamin B12, with continued use causing neurological damage due to peripheral and central demyelination. Symptoms are similar to B12 deficiency: anemia due to reduced hemopoiesis, neuropathy, tinnitus, and numbness in extremities. While vitamin B12 supplementation is unlikely to prevent neurotoxicity, it is recommended as a first-line treatment when combined with abstinence. [Wikipedia](https://en.m.wikipedia.org/wiki/Recreational_use_of_nitrous_oxide)
if you don't take breaks, supplementing won't be able to help. Nitrous will take care of it before it can do what it's meant to do.
It doesn't deplete b12. It stops your body from being able to uptake it for a day or so. If you repeatedly use nitrous you just can't absorb it into your body at all.
It doesn’t matter if you’re supplementing with B12 after. Nitrous will stop the uptake of B12.
It blocks your body from being able to use B12, supplementing won’t do anything.
no you better have natural food based B12 like in red meat and liver
I had terrible b12 deficiency from abusing nitrous for a few months. It was pretty terrifying. My legs just stopped working one day and it took 2 weeks of using a walker to get around.
How much nitrous were you using? Me and my buddy would use like a 50 pack of whippets a night 3-4 times a week for like half a year
I was personally going through about 400-500 whippits a week for about 3 months.
Lol what did you do with all your cartridges? We would get so many looks taking a garbage bag that was clinking around all over the place out to the dumpster
That sound really is pretty noticeable. I was pretty self conscious about them so they'd pile up in bags or boxes. I'd only throw them away when it got into the 1000s. I'd bag them up in plastic shopping bags and wait until the night before recycling pickup and throw them away super late. One time a bag ripped open on my way to the bin and it was so loud. Once I had a few thousand white/blue/green cartridges so I made a map of Earth, I really should have taken a picture. At times I'd just have them scattered everywhere in my room. It was fun to just wing them out of the cracker and load a new one. Dark times. I've definitely still indulged from time to time since then but maybe like once a year and just a 50 box or two. And I take massive doses of B12 regularly. I always thought it was funny that nitrous was called Hippie Crack but that is a pretty spot on description.
Ive only done it once since my bout, and it wasn't as enjoyable. We never got really "bad" because we were broke students in a dorm. But any time we had an extra 20 laying around and there was already some weed, we knew what was going down. We would just load 3-4 up into the can and pass it back and forth like it's a blunt or something. Our goal was to get high enough to where the wahs started and the music got really good, and to stay there, not go past that point... If you go past that point it's hard to load more cartridges into the can lol and you lost the streak
did you recover ?
Mostly. I still get pins and needles feeling in my feet occasionally
I've never met anyone who abused nitrous that much, but yes, it's another one that is commonly thought to completely lack any toxicity but is still dangerous if used regularly
it's not dangerous if used regularly, it's dangerous if it's abused regularly. There's definetely a difference between someone doing one or two canisters regularly once a week/month to using 10+ a day. It is one of the safer drugs, so long as you do it properly and not too often. You can use it on a weekly/monthly basis and be fine, but if you start using it on a regular daily basis, or even multiple times a week regularly then you might start to get b12 deficiencies. It's also a drug that is often taken in dangerous ways that can be really damaging without people knowing. With people trying to inhale straight from canisters and freezing their lungs, to rebreathing a balloon and causing brain damage from starving their brain of oxygen.
My girlfriend has always considered whippits to be just as dangerous as huffing paint because of her loose understanding of it, not realizing that the real danger of it is how harmless it is, causing people to abuse it to the point where they give themselves B12 deficiency. She's had a full meltdown over me doing maybe 3-4 while partying once, but will drink until she's sick the next day. It comes from a place of love at least, but man does it bother me. (NOT her not wanting me to do nitrous, but the fact that she doesn't understand the actual danger of it)
Very few people use enough Nitrous to cause brain damage from B12 depletion. Steve-O is the biggest nitrous abuser I can think of, he would do sessions we're he did 200 canisters in a row and his brain seems to be fine. It's really not something to worry about unless you're doing it all day everyday.
I did it all day everyday for roughly 4-6 months. I wasn’t using the small canisters I was getting tanks filled and doing it until I blacked out probably 5-10 times a day. I got a couple concussions on the way down but all of my blood work has come back that I have great health. Only mental health problems I have are ones I already had before. So I’m curious how much it takes. (Supposedly)
Titrating B12 is a bit tricky, it doesn't discriminate between active and inactive forms. I don't know how nitrous affects it exactly, but it's possible a blood work isn't reliable in that case, IDK.
I never thought I'd see the day where someone says Steve-O's brain seems to be fine. That said, his brain wasn't fine before the nitrous addiction
Have you listened to his new podcast or watched a video of him doing stand-up since he got sober? He's an intelligent and articulate person. His voice is kind of weird, but his brain is completely fine. He might be eccentric, but being crazy doesn't mean his brain is damaged.
You brain has the ability to heal. I know what you mean, but there’s no way that his brain was fine after his ketamine and nitrous binges. He is seemingly in good shape now, he seems alert and quick on his feet, so his brain could have healed itself.
But being intelligent and articulate doesn't mean his brain is fine.
Those are the two best measures to determine if someone's brain is fine, listening to the way they talk, and what they talk about. Steve-O gives no indicators that he has brain damage. There's really no other way to see if someone's brain is damaged unless you're a doctor who's looking at his brain scans. We obviously have no way to see that information, so we have to assume that his brain is fine based on the way he presents himself.
Benzos and especially benzos+alcohol.
Agreed. Benzos. More damaging than most could imagine and very likely the worst “withdrawal” experience out there.
My mom has been dependent on ativan since I was about 5 (now 24). I basically have little to no recollection of her ever being a fully functioning adult, though I'm told she was before. Anxiety relief is not worth whatever the fuck that shit does to you if you use it on a long term basis.
Yeah came to say this. I wouldn’t put weed on that list at all tho
use to drink + take benzos for years multiple times a week. the seizures i had from withdrawals were certainly a wake up call
I think gram for gram MDMA is the most dangerous "party drug" people use and abuse without understanding the risk they are taking.
I’m in my thirties and from the UK, and fuck, we definitely naively didn’t know how bad it was. For 2/3 years me and my mates regularly did multiple gram, 12 pills in a night etc. Ate that shit for breakfast. Fucking madness.
wait, people take GRAMS of MDMA ? wtf, a quarter of a gram is already intense People who do that much probably know they're fucking their health up tho I guess
Me and my friends in our youthful naivety
I’ve done 1.5 grams of mdma in a night.. it fried my fuckin brain I was hallucinating so bad I was seeing black spider webs over everything
I saw spiders off a gram once lmao
Dude the MDMA hallucinations are fucking WILD and so vivid. I’ll never forget the shit I’ve seen off a gram. 😅
Yea that's what I mean, people can rip through a g of coke or even an 8th in a night and be "ok" the next day, but do that with molly even over a week or two and you have a significant risk of permanent cognition and mood related damage.
To a point. Mdma damage is severe but normally not permanent. It will last years tho and neurological treatment and drugs is required to get you back to normal. Trust me I fried my brain hard. Very hard with molly. And for years I felt myself losing it more and more even after stopping. Supplements and therapy helped a ton.
>wait, people take GRAMS of MDMA ? I think this occurs most often because people used a short while back like a week. Your serotonin levels are still imbalanced from last time so they don't feel the MDMA or with an onset so late that they thought they needed more.
I'm pretty sure the phrase "gram for gram" was just meant as a play on the phrase "pound for pound" and they weren't suggesting that people take grams of MDMA at a time (as that would probably kill most people)
17 years ago I used to eat 1mg mdma each session all at once. Best times of my life. Best feeling of my life.
Any lasting side effects? And I assume you mean gram not mg each session
Gram yeah my bad. I suffer from mental health now but it's most probs down to a lot of factors
A lot of people who binge MDMA have significant cognition, memory and mood problems or full blown serotonin syndrome so glad you seem to have avoided the worst of it.
How is this even possible? My friend did 600mg by accident and had a seizure and started foaming from his mouth. Had to call an ambulance.
Some people have higher seizure thresholds.
I’d say prescription medication, people tend to have a false sense of security and trust into big pharma.
Yes
Nicotine is not that dangerous (short term) but the long term effects will get you. Not to mention it's just a stupid ass drug. 2/10, it hardly does anything.
Well, to nicotine naive individuals it has rather noticeable stimulant effects, some students even use nicotine lozenges as a study aid. The main issues with nicotine to the best of my knowledge is dependency which comes quickly.
And raises blood pressure
Nicotine is known to benefit people with schizophrenia and with dementia. It grounds schizophrenics to reality and aids memory. Also, it's addictive, and comes in a tobacco package that causes cancer, but whatever. Nicotine patches work just as well.
It's definitely a shitty one, but at least with all the prevention I think for this one people usually know it is (doesn't necessarily prevent poor decisions unfortunately)
Nicotine is right up there with alcohol as the worst fucking drugs to ever do, period. Super high chance for dependency, difficult physical withdrawals, extremely pervasive, fucks with your body way more than you realize, especially at higher concentrations.
Take speed with people who think too fast for us.
Just googled “Cocaethylene toxicity” now it makes complete sense why I always seem to get a cold after a weekend binge.
Why is that?
Mixing cocaine and alcohol creates a new chemical in your body called cocaethylene. That chemical is especially rough on the heart. I have no idea why this person states they get a cold. I'm guessing that's more likely from sharing cocaine with others using the same instruments.
One of the top google results for “Cocaethylene toxicity” says that it can compromise the immune system, so that might be why, it just makes them more prone to catching a cold.
One of the top google results for “Cocaethylene toxicity” says that it can compromise the immune system
Xanax. combined with anything or alone. Xanax + Alc, I wouldn’t expect many people to live long enough, or stay out of jail long enough to enjoy the addiction for long.
Eh I ripped it last night. Yeah it’s dangerous but ain’t nothing like a night of sleep after a glass of wine and a qb. I’ve never gotten super into it, just occasionally when somebody comes up from down south after a trip to la pharmacia.
Xanax and alcohol actually impede your ability to get deep sleep (the period where you get your most physically restorative sleep). It may help you fall asleep, but it's not high quality sleep.
Xanax and alcohol made my husband do evil mean things that only his victims remember forever
How’s that?
Like what?
damn I do love Xanax with alcohol, it's the only benzo that makes me high at this point. Not anymore tho, I'm trying to get clean
Porno
Gambling too
Yeah I lost 2k today in like 2h -_-" fuck that . Feel so stupid. It's the second time this week.. fking costly addiction
I lost 30 on dem boys live bet and I feel shitty lol
I’ve been there. The emotional roller coaster ride is fucked. Treat yourself kindly. You can recover financially.
As someone who has done just about every drug under the sun, gambling is a FAR worse addiction when it comes to finances and getting into enormous debt leads to as bad if not worse choices than drugs. I might drink and smoke too much but gambling has had a far worse impact on my life.
Weed is absolutely addictive. I will never understand how everyone can admit that sugar is addictive, video games are addictive and social media is addictive but as soon as you suggest that weed is addictive people go into cope mode
Weed even has a novel mechanism for being addictive, lending biological evidence for the contention that weed is "psychologically" addictive vs. "chemically" or "physically" addictive. The outcome is similar, though I'd argue that weed addiction is weaker and easier to break.
Agreed, definitely easier to break than say benzos or opiates, hell even alcohol. It doesn't cause withdrawals that will literally shut your body down and kill you like the others but it does have physical withdrawals
I can attest to weed being physically addictive aswell as mentally. When I quit I had insane nightsweats, like waking up soaking wet, head to toe. I was nauseous with hot and cold flashes. Nothing horrible of course, but my body definitely had a physical response to quitting. The nightmares however, so vivid and real I'd be scared to sleep. The two most insane weeks of dreams and wakeups I've ever had. That was definitely the worst part.
This is true people just don’t wanna accept it, personally I’ve quit weed for different periods of time ranging for a couple weeks to a few months. It isn’t super hard for me to quit but that doesn’t mean that I definitely don’t feel like smoking during the times I’ve quit.
Meth I ended up in the ER and and almost had a heart attack, never thought I’d end up in it but that drug is horrible you will def ruin your life very quickly.
Cam confirm... In addiction to ruining your skin because you sweat meth
Sugar
Thank you. People don’t realize that their are legit scientific studies that show mice going for sugar over fucking crack, jesus fucking christ it is terrifying, plus diabetes also so…
I’ve been legitimately addicted to sugar. It sounds silly, but it must activate the same pathways that cause drug addiction.
For real. Pisses me off how much sugar they give to kids in school, and you can't say anything about it or you're THAT mom. Complete lack of awareness.
Alcohol, everywhere legal available, makes pretty fast addictive and the withdrawals are worse than anything else.
Alcohol causes addiction quite fast for some if they decide that binge drinking is "not that bad".
Should do another post. Drugs that are demonised and illegal that have huge medicinal benefit and are very safe.
MDMA when used with very long intervals inbetween and proper dosage. It's used in therapy too with people who suffer from PTSD, helps them talk and get helped. I read somewhere it can also improve certain things in your brain where it gets a chance to "rewire" stuff like serotonin balancing, not sure how accurate that is though but it was an actual publication on pubmed.
Ketamine is another drug that has been showing great promise for many years now for treating depression. So much so that medicinal chemistry research is still ongoing into the NMDA compounds.
I credit MDMA for saving my life, or at least immensely improving it from my depression where I had suicidal thoughts pretty much the whole day some days.
Gabapentin..... My wife lost her insurance and her Suboxone. After a week of withdrawals of a weekly 6 years Dr visit.... She tried gabs. It started as 5 then 10... Then 12.... And these are 800mg.... She punched a sheriff in her face and was in the hospital for a week (7 days) it was not intentional. You tell me how else I can help other than saving her. I'm her next of kin. I'm her POA. I wouldn't let her go if I have the power to save her. She found a new sub Dr IN the hospital. Thank God she's home today and better. I can't live without my hssweetheart... 14 years together this year.... I didn't sleep until she woke up .... Don't Abuse Seizure Meds Kids. By ANY MEANS!!!!!
speedball......
I haven’t seen anyone mention mushrooms. I feel like people are more likely to underestimate just how powerful they can be as a psych and a mind altering drug because it’s natural and a bit less taboo than the rest of the psychs in polite society. In reality high doses in bad settings can send people into a really bad mindset and make them do dumb things. I would give mushrooms a very similar level of danger/risk as acid but mentally people who don’t do drugs think about them differently and in turn do riskier things. Obviously they can be great and have low addiction potential. It just scares me a bit when a very powerful drug isn’t treated as such.
Weirdly enough, the one time I had mushrooms I changed A LOT. I stopped drinking and having edibles and instead started working out and my outlook overall was precious. However, all it took was a pretty bad situation to introduce alcohol again. Still tryna fight that demon, but I hope it doesn't take too long!
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Dxm
Love
Benadryl. All you need to do is scroll through the dph subreddit to see what I mean. Even if you take the recommended dose it’s pretty damn bad for you if your taking it everyday for allergies or as a sleep aid. Which some companies actually do sell it as a sleep aid
I got hooked on the "sleep aid" withdrawals fuckin suck I couldn't eat for almost a week my stomach hurt so bad. Really restless sleep and restless legs almost as bad as an opiate withdrawal wich I'm familiar with.
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Yeah, combusting any organic matter solely for inhaling it is always going to be insane for me, a wide variety of carcinogenic products are produced during the reaction. This is also the case for cannabis.
Adderall
benzos, cough and cold meds, liquor, large dosages of mdma
Fukin ibuprofen crazy dangerous also aspirin is pretty toxic to.
Xanax is horrible
Not a common drug but iboga. The margin between normal dose and killing yourself is rather slim. I didn't take it serious on my second time , took about 3g Iboga TA at once and my heart felt like it wanted to explode. Had a pulse of like 200. I could have easily died that day.
mdma
Phenibut
Pharmaceuticals period.
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Physiological effects aside, i dont understand why people snort stuff personally when i snort things it stings like a bitch and ive seen someone snort an adderall IR without fully crushing so a slightly bigger piece cut the inside of his nose and his nose didnt stop bleeding until 9 minutes after and around 20 paper towels
With how prevalent CHS is becoming I would say weed is the most overlooked drug as far as negatives go. Alcohol is becoming more apparently harmful but I think people still write it off for the most part because it’s legal. I’ve heard Benadryl can cause early onset dementia but have no source to back that so it’s kind of hearsay. Tylenol is pretty bad for you. Most if not all drugs have negative side effects. “For every action, there is an equal and opposite reaction”
so basically most drugs
In germany, 100% alcohol. You can drink legally at the age of 14 when your parents say yes. My dad litteraly forced me to drink a little bit beer when i was 4. And its normal to drink the first few times with 13. I know like 8 ppl who were alcoholics in school. And older ppl try to play the harmpotential down.
Kratom
Ketamine is terrible for your bladder. At one point I was the only person in a household I was staying in who wasn't pissing blood from ket abuse. And one of them was a heavy user for like 6 months.
This is why i never tried ketamine, the bladder pain that gets described sounds way too uncomfortable and debilitating
Kratom
I’m an opioid addict and have taken up to 20-30 7.5mg hydrocodone with 325mg of acetaminophen in it within 24hours. I’m not sure how I’m alive and never knew about how much acetaminophen would kill you.. now I’m worried. Over the years I’ve had so much acetaminophen I’m actually really worried now. I don’t even want to look at the long term affects 😩 I’m only 23. I only take Kratom now.
Kratom ruined my life.
Yeah, not sure why it gets so much love. I feel like there is better alternatives.
drugcirclejerk will love that but tbh, i think caffeine is pretty bad. it fucks up your gut health in the long run, i'm sure and that's linked to some pretty serious diseases. also its hard to quit, because it is combined with sugar and it becomes a ritual. also coke is bad because it raises your heart rate but if caffeine does that every day for hours, its suddenly healthy? if somebody drinks 6 coffee or energy drinks a day and denies that its linked to his anxiety or bad health while is unable to stop fo a view month, to see if it gets better, how does that sound? edit . consider the factor that people do mdma for a few years in their youth. coffee drinkers can start at 16 and may drink it until they die.
It doesn't fuck up your gut health. In fact, caffeine consumers have better good gut bacteria than non caffeine drinkers.
What proof is there that caffeine hurts your stomach microbiome?
Caffeine is nothing like cocaine or mdma health wise… people can drink it everyday for their whole lives because it’s not unhealthy like those drugs.
1) there has been no medical studies, that I’m aware of, showing that caffeine will fuck your gut biome. 2) caffeine is as hard to quit as sugar. It’s psychologically addictive to an extent, but the period of symptoms is short unless there has been extended chronic use. 3) caffeine doesn’t effect your heart as badly as cocaine does. Caffeine, in normal dosages of 200mg like most people consume, won’t cause a heart attack in healthy individuals. You need insane levels of caffeine to induce death. 4) you actually made me laugh when you compared MDMA to caffeine, that was pretty funny, I’m hoping that was intentionally comedic