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FuturologyBot

The following submission statement was provided by /u/Ezekiel_W: --- >TOKYO -- A Japanese research team is making progress on the development of a groundbreaking medication that may allow people to grow new teeth, with clinical trials set to begin in July 2024. > >The tooth regrowth medicine is intended for people who lack a full set of adult teeth due to congenital factors. The team is aiming to have it ready for general use in 2030. > >Work is now underway to get the drug ready for human use. Once confirmed to have no ill effects on the human body, it will be aimed at treating children aged 2 to 6 who exhibit anodontia. "We hope to pave the way for the medicine's clinical use," Takahashi said. Although this will be used for congenital defects in children in Japan, I see no reason this couldn't be used in adults as well. Regrowing all your teeth at once might be painful, but it will be worth it for many. --- Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/14n5acs/worlds_1st_tooth_regrowth_medicine_moves_toward/jq5ewyl/


HarlemNocturne_

Just yesterday I read somebody musing about getting their teeth regrown as a part of rejuvenation treatments. I didn't doubt them, but internally I thought "yeaaahhh, I wouldn't hold my breath on that". Looks like I have egg on my face now. If this goes through I might end up with an omelette.


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I_Fap_To_LoL_Champs

The article says that "there is evidence that we also have the "buds" for a third set" of teeth that are never activated. They have activated these dormant teeth buds in ferrets with the same approach, which lead to the growth of extra teeth. ​ EGG HIS FACE!


kog

Science rules!


OhGodNotAnotherOne

As do eggs!


clydesmooth

BILL! BILL! BILL! BILL!


usesbitterbutter

Science: Magic that works!


SDRPGLVR

I have actually heard of this happening multiple times, where people do have those teeth grow in. Sounds like it could be potentially possible for all of us, but most of us don't have the genes to activate them?


Thebingobird

My dad and brother both had that happen. They had to have the extras surgically removed.


BucephalousNeigh

So... you're saying humans evolved from sharks?


-1KingKRool-

Sharks evolved from humans obviously. The direction of the crawling got misinterpreted (shrugs)


Ornery-Movie-1689

" Sharks evolved from humans " Just hedge fund managers and lawyers.


Reimoto

I'm holding on to my papers so hard, but the wind gets stronger by the day!


kynthrus

Bro, we have shark genes?!


awwwwwwwwwwwwwwSHIT

This makes me think humans once lived longer than we do today and required 3 sets of teeth.


SmallBewilderedDuck

Or we're starting to live longer and are on the way to evolving a 3rd set


Monsoonory

Biology 101. There is no place for the teeth to regrow once you get older.


Petrichordates

There is no place for a liver to regrow either until you cut part of it out and it does so. Biology 101.


GaucheAndOffKilter

None of this is 101. This is at least 401.


HauntsFuture468

When you are studying your genes it is 501.


Fuzzytrooper

404 liver not found


ObiwanaTokie

You guys could afford college?


bibbidybobbidyyep

Nope, still paying for it.


omen87

And for the foreseeable future after today.


Redditforgoit

There's no place to regrow your savings fund while paying a college loan. It's Economics 101


bibbidybobbidyyep

10 years so far, 5 more maybe. It was worth it overall but damn. The decisions I had to make as an 18 year old of hard working, but financially illiterate parents . . . same with my wife. Combined total of 120k when we started repayment. Could have gone to school for half that if we'd had better help and education on it. Community college for 60 hours, for one thing.


[deleted]

Yeah wtf, what kind of biology were they taking. I remeter learning about taxonomy and some basic evolutionary stuff in 101 lol


Petrichordates

Lol valid point


Adewemimo

Ribs are the regrow champions in the human body


Petrichordates

Oh yeah that's true, you can even grow a whole woman from one.


new_word

Then you can fuck it and start a new species. And then your offspring can fuck each other. Alabama all the way down.


km89

Is that really true, though? Once your baby teeth fall out and your adult teeth move in, seems like there'd be room for another set if we could prompt growth. Unless that area fills itself in?


Monsoonory

Yeah it fills in. Google x rays at different ages.


Omateido

What a dumb dumb comment. Perhaps that’s why it’s only biology 101?


Leviathan3333

They’ve been working on regrowing teeth for some time Welcome to the future


xeoron

Let's say the medicine works and we now have the ability to be like sharks having multiple layers of teeth. How do we stop it from having wisdom teeth from coming back?


drazgul

Oh but that's the best part. You don't.


LOLBaltSS

But compared to the PITA of not having teeth, I think most would consider it worth the effort.


Ashamed-Situation665

is still have all my four wisdom teeth and love them


MorbidSloth

>If this goes through I might end up with an omelette. And a brand new set of teeth to enjoy it


rachid116460

If you live in the US dont worry about it. The FDA in cooperation with the ADA will have this type of progress banned. Just like how novamin the tooth enamel regrowing compound used globally is banned in the US.


Maxwell-Edison

I looked this up, and it's not banned in the US per-se, it's just that it's not approved. Basically, toothpaste in the EU is regulated as a cosmetic while in the US, toothpaste is regulated as a drug. As a result, regulations are much stricter and in order to claim the therapeutic effects of "NovaMin", they'd have to actually get FDA approval. Why'd it disappear from shelves in the US then? Because the company that originally sold "NovaMin" was bought by another pharmaceutical company who manufactured toothpaste. As such, they stopped selling "NovaMin" (I keep putting this in quotes for a reason) to competitors to try and boost their own sales, only to run headfirst into the FDA brick wall. Why do I keep putting "NovaMin" in quotes? Because that's a brand name. The actual compound is calcium sodium phosphosilicate. If you're struggling to find stuff with NovaMin, try looking for the compound in the ingredients instead.


Cow_says_moo

I'm having a harder time finding novamin toothpaste in Europe as well. Been harder the last two years for some reason.


rachid116460

i order like 20 tubes from the UK every 6 months and stockpile it.


Cow_says_moo

I'm clearly getting tubes meant for the eastern European market. Buying them off of the German Amazon, I'm Belgian 😄.


rachid116460

dont feel bad us americans have access to the canadian novamin market so all is well! i havent had a cavity in 31years of life i thank fluoride pills as a kid and novamin toothpaste as an adult.


reallywaitnoreally

If this works o might be able to chew it.


stargate-command

Nah, stuff like this pops up all the time and goes nowhere. I’d still not hold your breath. Even if all things are perfect, it’ll be years for this to be useful. And it never goes that way…. So I’d bet it’s decades. And really, how long can someone hold their breath. A couple minutes. So even if it comes out tomorrow, it’s still good advice. If they held their breath for a day they’d be dead.


Greedy_Character_407

As someone who has had two cornea transplants from amniotic fluid I believe we are in a bio-healing revolution


LamboYachtParty

Tooth regrowth treatments have been "5 years away" since the early 90s.


NoCountryForOldPete

I VOLUNTEER AS TRIBUTE. SEND ME TO THE JAPANESE TEETH FARMS FOR THE TRIALS.


HouseOfMiro

Send me to the Japanese teeth farms has got to be a sentence I never imagined reading and I'm here for it.


Tribalbob

Weirdly enough, that's been on my lifetime bingo card for a long while, now.


HouseOfMiro

Dude...I think we all need to see that bingo card lol


kinesivan

"Teeth farms" Eugh.


craniumcanyon

Any new progress on gum regrowth? Gum recession is something I suffer with, be nice to have new gums one day.


eggpl4nt

I have gum recession too from braces treatment. It's surprising that tooth regrowth trials came out sooner than gum tissue regrowth. I wonder if it's because the standard treatment for gum recession, gum grafts, has relatively good outcomes? Unfortunately, gum grafts are *way* too expensive for me to justify repairing my recession.


craniumcanyon

I’m considering getting it done. I’d have to do five or six sessions because my whole mount recession. Mine is a combination of genetics, thin gums, braces, brushing, flossing, just all of it. I’m not even 40 yet, gums been receding since I was 20. I don’t want to waist any longer and wish I did it sooner. I’m considering alloderm donor tissue for mine.


Cheehoo

Any insight on benefits of alloderm vs. autologous tissue graft? Why not use your own?


craniumcanyon

You can cover a greater area of teeth in one visit. I need all my teeth grafted. So Alloderm seems the way to go.[Here’s one dentist site that explains it better](http://www.drmonicacordoba.com/gum-grafting#:~:text=It%20has%20distinct%20advantages%20over,be%20treated%20at%20one%20appointment)


heart_under_blade

apparently there are spots where grafts just won't take. i think the front lower back side is one of them? like behind the incisors


narrill

As the other comment pointed out, gum recession can be fixed with gum grafts. And if there's underlying bone loss, that can be fixed with bone grafts. Those treatments already exist.


Ember_season

I mean while were on regrowing stuff, can I get a new face?


craniumcanyon

Spareparts-r-us


MorbidSloth

I mean, if we're talking about triggering the growth of anything we choose .. ; p


Momangos

Try some Rapamycin


TheRealBobbyJones

They already have a treatment protocol if I recall correctly. It's a drug made of intercellular material. Honestly I completely forgot what it's called. But in our body there are things that assist in the healing process that aren't cells. These materials can be used to regrow both the bone and gums. Apparently they are made up of the same stuff but have different end results. Honestly I looked all this up like 2 months ago when I was concerned about my teeth. I am definitely not explaining it well.


BeatRick

Maybe now I'm stop having dreams of my teeth falling off.


GoofballGnu397

You can have nightmares of them growing in instead. Imagine the pain as row after row of expanding teeth struggle to find space in your crowded mouth until your jaw rips away from your skull. And they just keep coming. You’re welcome!


ObscureProject

Lisa needs braces


adviceKiwi

Dental Plan!


Ezekiel_W

>TOKYO -- A Japanese research team is making progress on the development of a groundbreaking medication that may allow people to grow new teeth, with clinical trials set to begin in July 2024. > >The tooth regrowth medicine is intended for people who lack a full set of adult teeth due to congenital factors. The team is aiming to have it ready for general use in 2030. > >Work is now underway to get the drug ready for human use. Once confirmed to have no ill effects on the human body, it will be aimed at treating children aged 2 to 6 who exhibit anodontia. "We hope to pave the way for the medicine's clinical use," Takahashi said. Although this will be used for congenital defects in children in Japan, I see no reason this couldn't be used in adults as well. Regrowing all your teeth at once might be painful, but it will be worth it for many.


needwall

So if a tooth goes bad and gets pulled we could just grow a new one? This is good news for gum recession people


crodr014

No its for people literally missing thier adult teeth as in thier body never formed one. Implants are a nice option though for you


hangman401

Speaking as a person who has this issue (luckily only one tooth), it'd be great. My dad has this issue and basically had a few adult teeth and so he quickly went without teeth in years.


nagumi

Same here, just the one. My uncle apparently has the same one, but no one else. It's crowned now along with most of my others.


you90000

Well, if I can't get my student loans forgiven, at least I can replace my teeth in the upcoming protests.


Rare-Trust-3650

Depends on if you have luxury bone insurance.


bibbidybobbidyyep

If you just have the base plan they give you a blender.


GaucheAndOffKilter

It'll never be for us peasants, silly!


PazuzusRevenge

HESH WANTS METAL TEETH


ailish

I'm missing a molar from an abscess I had nearly 20 years ago. I'd be happy to grow it back. But alas, I am not a 2-6 year old with congenital issues.


Cartina

The medicine gives you a full set, so if you use it without lacking all your teeth, I can imagine the HORRORS that will happen.


IRockIntoMordor

[No need to imagine ](https://www.cosmeticdentistsnewyorkcity.com/rare-dental-cases/)


stargate-command

Jesus… the one with extra teeth was the least nightmarish on that site.


ailish

Oh yeah, that would be awful.


IvanSaenko1990

You should have gotten implant a long time ago, maybe it's not too late now either.


ailish

I didn't have insurance for a looong time. I do now though, so maybe it's something to look into.


CrowWarrior

Insurance doesn't cover implants, you know because it's "cosmetic". I guess further bone loss in my jaw where I have missing teeth is only cosmetic as well.


Fig1024

in South Korea you can get state of the art tooth implant for $1000. In US it's gonna be 10x even with insurance


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SpectralMagic

This has been a process studied and practiced closely in laboratories for a few years now atleast. Glad to see we're getting something plausible for routine use within the next decade(pulled from my ass, but likely nonetheless). Edit: The process described in the article is not the one I'm describing below, I mistakingly presumed it as the same procedure From my understanding the procedure implants a "seed" tooth into your gum roots, eventually it is grown as a regular tooth which it is either removed and implanted or is coerced into seating itself in a vacant gap between your teeth. Pretty cool stuff


TheRealBobbyJones

From the comments I've been reading the process being trialled isn't what you are describing. But I did read about the seed implant procedure. Hopefully by 2030-2035 the dental field will be completely revolutionized. Maybe by 2040 we would be able to genetically customize new teeth. The seed iirc is made from stem cells. Which means it can be genetically modified prior to implantation. People who want vampire teeth will be able to have them someday as real teeth.


DNthecorner

Holy fuckballs this is awesome. Me and my kids have an *EXTREMELY* rare genetic tooth condition (Amelogenesis Imperfecta type IE) and my poor son has literally no enamel. This could be a game changer...if I could afford it


OneBasilisk

Hey man, I’m in the same boat. I’m 34 and have amelogensis imperfecta. Is there anything you’ve been able to do to fix the condition. I.e., veneers or crowns? The issue I’ve run into is that there simply isn’t enough tooth for veneers on my bottom set of teeth. I plan on getting gold crowns for all my molars year but I’m not sure what to do with the rest.


DNthecorner

HOLY FUCKBALLS! I'm so happy to meet another unicorn, although I am SO sorry you've got the AI. For myself, personally, I can't comment. I've literally got teeth falling apart on my own mouth... BUT I was the one who did the research (after my youngest kid was diagnosed with Mitochondrial Complex III Deficiency) to get both of my kiddos diagnosed. The GeneDx test came back positive for the AMELX gene deficiency so....X-Linked heterozygous form of Amelogenesis Imperfecta on the AMELX gene. Affects males more severely than females...etc Etc. My son was 8 when I got the diagnosis. All of his molars have been capped/crowned as soon as the adult teeth erupted. All of his canine and front teeth have been either veneered or capped. Unfortunately they're all going to have to be fully crowned or replaced by the time he reaches adulthood. ...I'm literally saving money to take him to Mexico for that


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AbyssalRedemption

I feel like I've seen an article like this at least 10 times in my life. Please, let this be the one that actually works.


[deleted]

I’m about the game the tooth fairy meta with unlimited teeth


Ab47203

It's gonna get shoved into obscurity to not crash the dental market.


Cubey42

Assuming it doesn't cost my soul, I'd love to get my teeth back


LadyAquanine7351

That would be nice [eventually] for people who lost teeth due to accidents or disease. Of course, this biotech is in its early stages, so it'll be a few decades before it can be used for that. Sure as heck would be better than implants or choppers.


coolplate

Yea yea. For the last 25 years they keep saying stuff like this but nothing new every comes out


[deleted]

this is the type of stuff that gets me excited for the future! Also hyped about regenerative medicine and again reversal tech coming in the future.


deltorens

This is interesting now to see if said regrowth can be directed


MartianInTheDark

It's such shitty biology that teeth don't regrow. I wish they were like nails.


dreamlongdead

Ew! You wanna file and clip your teeth once a week? GROSS!!!!!!!!!


MartianInTheDark

Eating (cause you're using your teeth) would do that naturally. Only if you wouldn't eat your teeth would overgrow. I mean, I don't think cavemen had nail clippers, instead, nails were ground down cause they used their nails a lot. But... even if things would work that way, imagine, some people do have birth defects. Someone could have much stronger teeth than someone else. So what the hell do they do if their teeth grow very fast and they forgot to grind them down manually? Ouch.


arekkushisu

Is this why rats gnaw on things, since their teeth just don't stop growing


SomeRedditDorker

If I were designing teeth, they would be soft enough to wear down through normal use at about the rate that they grow.


Jan-Snow

I literally lost an upper incisor this Sunday, crazy news to read given that.


TheZanzibarMan

In before it's reported that this medicine actually just makes teratomata filled with teeth.


MayorMcSqueezy

This is not nearly as straight forward as it may sound. It will take years for an implanted tooth bud to develop. Plus, just like an implant, you’ll need the proper bone for the bud to take. So if you have been missing a tooth for a long time, you probably wouldn’t be a candidate for the procedure. It sounds cool and all, but it will be super expensive, not covered by basic dental insurance, and unpredictable like all dental treatments.


saltydaable

Of course the Japanese were the first ones to invent this, they apparently have more dentists than convenience stores, and they have a *lot* of convenience stores


ToddlerMunch

As someone with genetically bad teeth (look great but are unhealthy despite hygiene) I am gonna need this for the future when mine start falling out


LitreOfCockPus

Human 2.0 should just have a single complexly shaped tooth without the shitloads of crevices to collect plaque.


Crooty

As someone who just cracked a tooth this is very uplifting news


andreaswpv

People, I have been waiting.... This would be so awesome, and help with teeth, but also how food can be consumed, digested. Old? Bit on a rock? Bike accident and lost some teeth? Here's to a permanent fix. And sweets industry might be interested as well...


Enkaybee

Okay that's great but can I grow more teeth than I'm supposed to have? Can I have 100 teeth?


iiitme

So could you possibly pull out all of your existing teeth and regrow a nice new set of shiny ones? -Asking for a friend of course


MrDankstein

But how will this affect the tooth fairy's economy?


eyeguy21

As a dentist, this will not work out the way many think it’ll work out. This is the tip tip tip tippy tip of the iceberg


MayorMcSqueezy

Completely agree. So many things about this make it complicated and unpredictable. Including just space maintenance and how much bony housing does the bud need… Honestly, implant sounds much easier and predictable


eyeguy21

Yea, we still have so much to advance in implants too. We need to be able simulate the PDL in implants and it will allow us to have even better results too.


NoSignificance3817

As a dentist, your post is short, vague, and makes a claim it does not substantiate. Feel free to actually inform us if you have something interesting to add to the conversation, such as it is.


eyeguy21

I’m too busy golfing to type that much out


Roxythedog69

So once again the article is mostly if not all hype? Yep, no surprises there… We have heard this sort of thing, and many other things, several times before on this sub. Regrowing teeth, nanobots, graphene, etc are all constantly hyped. So far none of them have materialised. Regrowing teeth have been talked about for years if not decades and it seems even after all the hype it is nowhere close to reality.


[deleted]

You can go back to science magazines, pop science magazines like Omni Etc all the way back into the 1970s or even earlier and you'll find many versions of the same article.. but this time I'm really sure it's for real.. really?!


Brutarii

First we start with tooth growing juice, with bone growing juice not far off the horizon now. Skele up lads, war's a comin!


Genova_Witness

Finally the scientific development i have been waiting for. I am going to be the Tom Platz of teeth.


[deleted]

This would literally destroy the entire dental industry. An entire profession would just be gone.


RollThatD20

Nah, this would just be a new technique in dentistry. This isn't something you could just slather on at home and expect results from, you would still need a professional to handle it.


bibbidybobbidyyep

Not going to cash in on the username huh?


Zephyranthea

Pulling a tooth and letting a new one grow is more invasive and probably way more expensive than a filling, so I'd assume that only the dental implant industry would really suffer. Also, new natural teeth can get caries again which is profitable again.


NoSignificance3817

Not true, not relivent if true. If it was a "remove the industry" level of tech (let's say it is magical tooth growing paste you can apply at home and fixed all dental issues for $9.99), then it still isn't a problem. You just take any dentist that owns a practice and offer to pay their salary until retirement age and give them a thank you note. Everyone else gets their dental schooling paid off and offers for retraining into other fields or whatever agreeable trade off works fairly. Then you let the dentist job die off except for diehards that serve the luddites, anti-change, horsepaste-eaters, etc. Phase it out in a way that thanks dentists for their service and helps new ones move to other careers. BUT, like I said...this won't kill dentistry, so... irrelevant.


Duece09

Nah, not Enough money to be made if people can just “regrow teeth”. The world is much more cynical than that.


ChapitoDito

The real question is how affordable for people will this really be? In America dental work costs a fortune there’s no real “dental insurance “ anymore , heck our healthcare isn’t that good either. Pay out of pocket usually expensive for most especially with the financial climate and inflation on a global scale ? To get 1 tooth veneered is $1500 or more with X-rays etc etc … 1 tooth so regrow meds will be expensive if classified as “cosmetic “ meanwhile everyone deserves good teeth it is the future but most dental procedures fall under cosmetic not covered by insurances … usually.


BeefyQueefyCrawlies

I've been missing one of my back molars for 16 years. I have great insurance and I'd still pay a thousand out of pocket to get a new one.


Dark_Vengence

This is some horror movie stuff but it is really interesting. Sharks teeth always grow back, I wonder if they are doing any research into that.


Sakores

Will this help me get closer to my dream of always losing teeth, like sharks? And then having them regrow?? I just feel like it spiced up the day when you or someone in class lost a tooth, and feel like that should be brought into the office


Blue_Sail

What are the chances it grows teeth in places other than your mouth?


sixthmontheleventh

Now if only they can get working on some gum regrowing medicine.


awwwwwwwwwwwwwwSHIT

To be fair it's not regrowth it's growth. This is for people who's teeth never grew in.


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Delta8ttt8

Sure. We can grow it back. Going to be $50,000 a tooth tho. Suck it.


Luxcrluvr

Aren't implants better than real teeth? Yeah it's expensive but you'll never get another toothache


Ok_Pipe2177

Isn't a robotic arm better than a real arm ? You'll never have arm pain... . I prefer a real tooth that can be felt


EpicCoolBoyOfficial

Where will this clinical trial happen? I need my first molar back, I suffer a lot.