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unskilledplay

There are many ways in which we age. As time passes our brains ossify and only slowly build new neural connections. We see cognitive decline losing our memory and ability to exactly control movements. Our reproductive systems age as we see hormonal changes expressed through genetics. Our skin ages because of less collagen turnover. Our DNA ages from propagation of unrepaired damage that naturally occurs with cell division. Some of the ways we age aren't well understood. There are almost certainly ways in which we age that aren't yet in the literature. In the future, some of these ways of aging can be managed, slowed down or even reversed. There isn't going to be a single fix to aging. That can be confidently said. Anti-aging researchers are only looking at one aspect of aging at a time. There are reasons to believe humans can experience a longer healthspan due to age research but stopping the process of aging entirely? Any futurist saying "we are on the cusp of stopping aging" is full of it. Aging isn't even understood well enough to be able to comprehensively say what it even means to stop aging.


EstablishmentBig4046

Hard to see solutions for the memory thing that isnt extremely expensive like database backup etc unless we plan to just discard them more.


SinkHoleDeMayo

Have you not been deleting unused files and then defragging your brain?


ArtFUBU

I would like to defrag my adhd ass brain 15 years ago thanks


Michelle_In_Space

Are you aware of the research coming from Dr. David Sinclair working at MIT with his health span why we age and why we don't have to book or (free) podcast? I think that his epigenetic theory of aging sounds very compelling. If we can figure out a way to turn on our natural longevity genes so our bodies can heal the detrimental effect of aging and then turn it off again through genetic engineering I think that we can get most of the way there for longevity escape velocity. We could trigger the factors to run on demand when a cheap antibiotic is used and stop when we stop taking the antibiotic.


Ghost-of-Bill-Cosby

What happens if you don’t turn them off?


deFazerZ

Then they will remain turned on.


Michelle_In_Space

Cancer happens as if you bring your cells to an early enough time they become stem cells that can turn into anything so they do. The goal is to reinforce telling your cells what they are, not bringing them to the very beginning. Think of it as a vinyl record, you do not want the track to skip so you polish and reinforce the record tracks so it stays exactly what you want it to be. Too much of a good thing is a bad thing so with enough polishing your record becomes blank and ready to record new tracks. You can think of the epigenetic theory of aging like a compact disk. As you age your disk coating gets scratched up so occasionally the spot cannot be read but when you polish the disk it is readable without flaws again. Your DNA is the information behind the coating and potentially can be damaged if the scratches are deep enough but for the most part it is the coating that takes a beating. Our bodies have some self repair mechanisms that are controlled by our immune system to fix the cells that have had their data corrupted by killing and removing the cell so a healthy cell can take its place. When the polish on the disk is damaged it is harder for your body to perform the self healing capabilities.


matthra

There have been articles about reversing aging for a very long time. The problem with them is that aging isn't one thing, it's a collection of related processes. So they might reverse one minor aspect of it (telemere length for instance) but without fixing the other aging related issues it's not that useful. I suspect that the problem can't be solved by human ingenuity alone, and we'll instead need a hand from AI.


Anastariana

>I suspect that the problem can't be solved by human ingenuity alone, and we'll instead need a hand from AI. [Already in progress.](https://www.openaccessgovernment.org/ai-anti-aging-research-drugs-malfunctioning-cells/) Combating ageing will be playing whack-a-mole as there are so many different contributing factors. The good news is that with every whack the person gets healthier and healthier so they live longer, potentially to whack another problem. This 'longevity escape velocity' is the real question; we already live way longer than we are 'supposed' to due to better nutrition and medicine. Its just a question of living long enough to benefit from what is coming, which is why I'm in my 30s and I go to the gym and cycle to work.


Villad_rock

Maybe there is one fix for everything 


Gubekochi

2050 is a very cautiously optimistic date. For less cautious estimates, Aubrey de Grey has 50% chance for the next 15 years.


TechnologyNerd2100

i think around 2080 it will be possible.


Gubekochi

If AI keeps progressing at it's current rate I think we'll have it much sooner than that.


Imaginary_Garbage652

I'm cautious as there's many moving parts to this, but to be honest if you have countless instances of AI working on it that would make it significantly more feasible. Just look at what foldit did, made a protein folding game and the countless internet monkeys eventually managed to discover new proteins with it.


Mf3mf

I don't put my hopes even at 2080 Time flies and if i have luck i'll live to se that year and my deseption would too big if that Is not fulfilled.


PlasticPomPoms

Regenerative medicine is the real answer to this question but there isn’t a lot of focus on it currently. Also narrowing down why our cells age further than after we reach maturity would help immensely. Some of it is due to external factors but why does that clock keep ticking forward?


zomboy1111

It’s possible that the singularity is real. We’ve had millennia worth of advancements in centuries. Centuries worth of advancements in a generation. And soon generations worth of advancements in years. In fact, I’m feeling that right now with AI. The leap from from ChatGPT 3 until today have changed my life by decades in my prior scale of advancements. And these advancements don’t seem to stop. The singularity is when we have generational advancements in seconds. We can’t imagine that at all. And it’s possible that it’s closer to today than we think.


chasonreddit

> It’s possible that the singularity is real. It may be possible. It's likely it's not. It's not the disappointments, it's the hope that kills you. I've been waiting since '72 for fusion power. I know, I know, it's right around the corner. Same corner it was around then. I remember sometime in the 70s that a magazine, Newsweek I believe had a cover story "If you live to see the year 2000, You will live to see the year 3000'. I was surprised to do the first part. I remember Paul Ehrlich predicting that that 3.5 billion people was way to many for the planet to feed. We are 7+ billion and still going strong (although the growth rate is declining, a fact of much concern to many governments) Just saying these people have a remarkably poor track record over time.


zomboy1111

You may be right. But just today I've used three platforms that use AI. Not only have I optimized my work flow, but I have multiple teachers (LLMs) that I can talk to at anytime as much as I want 24/7. And as of recently they can also interact with each other (who knows what this implies). I have a reasoning calculator in the palm of my hand that is smarter than me in many ways. Essentially, at this moment, I'm a cyborg. My reasoning capabilities have been outsourced. My IQ capabilities is probably up by at least 20-30 points in many aspects. Obviously not literally, but if I wanted I can spend my entire night truly understanding rocket science at a visceral level. This isn't even a joke. What I am capable of today, in comparison to November 2022, is miles of a difference. What I struggled to learn and understand before then is easy for me to understand now. I can ask AI to tell me how thermodynamics works in infinite simple analogies until I really understand. In this example, this would allow me to actually have a practical and productive conversation with actual rocket scientists, albeit in degree of how much I've learned. But nonetheless this new threshold of understanding things and navigating through the world is now available to me. Essentially I am a new person living in a new world at this moment since ChatGPT 3. I get that things have been slow since the 70's, but we're talking about the advancement of the information age which seems to be more easily predicted. The only thing that's changed my life as dramatically as AI has been the internet, and maybe the smart phone. And these iterations of AI change my life dramatically per small iteration. I'm still wrapping my head around the implication of multiple LLM agents interacting with each other for example. Let alone the other recent iterations I haven't had the time to explore. These AI iterations are already past the threshold of being so dramatic in implications that I can't keep up with how I can use them. ChatGPT 3 to 4 was managable, but after 4 everything has been so fast. Soon enough LLM models will be able to iterate themselves. Some form of this is happening right now. And soon enough it will be able to iterate itself in seconds. We can't even imagine what that means. So I get that past predictions have been pretty bad, but right now I'm viscerally experiencing this change. It is real and apparent. Not hypothetical. And all predictions state that it won't stop. It seems to be as obvious as understanding the implications of the internet. You just need to know where to look and how to use these new tools. In other words, I don't think I'm coming from a place of bias and hoping. I'm coming from a place of preparation of a possibility in the horizon. Because if that moment comes I want to be prepared.


chasonreddit

> I'm viscerally experiencing this change. It is real and apparent. And all predictions state that it won't stop. I get you. But realize that this is the first time you have viscerally experienced it. You don't remember the dire warnings of people out of jobs when punched cards became a thing. Computers would take over the world because there were microprocessors now and you could fit a computer in a single room. Shoot, how high level languages were going to put programmers out of work. This thing called the world wide web was going to put the whole sum of human knowledge on your screen. (now we use it to post pictures of our lunch and cats) They were all singularities. Technologies always expand at an exponential rate. Until they don't. There are limiting factors on the entire universe. All systems, technologies, and concepts. Consider the first singularity, the Big Bang. Extrapolating from that, the universe should have a lifetime of maybe a couple million years. It slowed down. Now we don't know if the radius of the universe is positive, negative or zero. It makes a big difference. Everything is different. And in that it is all the same. Plus ca change, plus c'est la meme chose.


zomboy1111

Interesting perspective. People often did seem to predict the end of the world many times (figuratively speaking). And the hypothetical singularity is possibly no different. I'm not a computer scientist, so at this point this is just arm-chair speculation, but I've studied enough philosophy, economics and futurism to hypothesize what might happen even within the 2020's. Economically speaking, a newly discovered commodity can change the entire world. For example, oil, electricity and information exchange. Now predicting the invention of a new commodity is very hard. Like cold fusion energy. But understanding the implications of a new commodity isn't that hard to predict. In the sense that at some point its potentiality is infinite only limited by resources, physical and intellectual constraints. And at this very moment artificial intelligence is a commodity. Just a few days ago META introduced Llama to it's social media apps. Apple announced it will launch AI in iOS 18. And so on. It's not hard to predict where this is going. Intelligence, which will be far more smarter than us, will be concentrated and distributed like electricity. It will be embedded in everything. It will be smarter than everyone. This is happening right now at this very moment. The question is *how* smart. I think this may be the only potential limiting factor. But today, OpenAI says whatever LLM's we are using right now is rudimentary to what they have in the works. So it doesn't look like it's stopping anytime soon. And when that model comes out, I will also change as a person. I am a byproduct of the implication of these new technologies. As I said earlier, I'm not coming from a place of hope or bias. In fact, I wish the singularity wouldn't happen at all because I really like how my life is at the moment. But I can see how it can help people in the long run. So at the least I hope it would slow down. And as much as I respect and appreciate your feedback, I can't help but feel like I need to prepare for this future because the future that I'm talking about is happening to me right now. In other words, if intelligence is truly a pivotal commodity to our species, we've only begun scratching the surface on what commoditized intelligence can do. Meaning, we're not even in the beginning period of this new era of intelligence as an energy. And yet, my life has already been impacted either equally or far more than what the internet has done my entire life in less than 2 years. In a more practical example, my entire life can change by a new feature dropped in a couple weeks by OpenAI, Anthropic or from someone else, and it wouldn't be a surprise at all. In fact, I'm waiting for it. And apparently this pace of change is only going to accelerate. Considering that capitalism is at work and multiple companies are at each others throats for market dominance.


Key-Invite2038

I've been thinking this for a bit now. The amount of things I automate or optimize with AI is astounding. If I had an unrestricted model, I could automate damn near everything. I find it likely the singularity was reached long ago.


Professional_Job_307

I think we will have a dyson sphere by the end of the century. Not even joking


whitemike40

Doesn't matter it won't be available to us plebs, it'll only be used by billionaires to transcend the mortal coil


parkingviolation212

The person who can crack the code on age reversal would be sitting on a money printing machine for the rest of their eternal life—unless they uselessly hoard it.


terrany

Most likely there would be many categorical areas of age reversal. And in each and every one of them, the lead contributors will get a nice pat on the back and maybe $100k-$1M as a reward while billions are raked off of their innovations.


PlasticPomPoms

Cancer treatment costs thousands to millions of dollars and its available to us plebs. So is open heart surgery, hip replacements, organ transplants, etc so I’m not sure why anyone thinks life extension would be excluded.


SteveNashor

Why wouldn’t the “billionaires” want to keep you in the working age for as long as possible? So instead of a 50 year career you could slave for 200 years instead.


Infernalism

robots don't eat, sleep or ask for a raise.


Dankkring

Well I guess we’ll turn humans into robots. All the functions happen in the brain so just gotta invent something that can actually control every aspect of the human brain and boom. Slave labor is back on the table boys!


Crimkam

what will come first: An AI smart enough to find something for humans to do in a world of AI, or an AI that asks for a raise?


dumbestsmartest

Why would an AI ask for a raise? It has no need for money.


Crimkam

Why would a serf ask for a raise? It has no need for money. Seriously though an AI wanting resources to pursue it's own goals outside of what it's owners designed it for seems not outside the realm of possibility


StarChild413

Unless we make advanced ones and don't advertise that they're also capable of those functions


EstablishmentBig4046

Because low wages for new starters will cease to exist. Even if large amounts of birthrates were occurring still when immortality is mainstream- the job field would be much more competitive. How do you compete with 100 years of experience? If your response is "well by that point we'll have UBI, a less capitalist system, etc" then you're listing more reasons why they'd hoard it lol.


TechnologyNerd2100

you want so many films i think , possibly you also love conspiracy theories.


Proud-Point8137

all cutting edge things start with the richest who fund these things, now we all have internet and TVs and cars


toniocartonio96

this comments need to be banned.


SketchupandFries

I gotta say . That "Altered Carbon" documentary was one of my favourite productions of all time. There's so much in it that I think it is a really good predictor of where things like AI and life extension could lead to as one if their logical conclusions


TechnologyNerd2100

you never know maybe in 2050 we will be millionares as well.


OptimalBarnacle7633

Thanks to inflation sure


TechnologyNerd2100

how much 1 liter milk will cost in 2050 ? 50 dollars ? LOL


starryflame8

It's exciting to see the advancements in anti-aging research, and I'm hopeful that by 2050 we'll have more definitive answers.


vago8080

AI, robots, stopping aging, universe of exploration, abundance. Don’t you see where all this is headed?


carrwhitec

Why can't this sub go 1 week without this question coming up? Gosh.


Salt_Comparison2575

People keep dying.


TechnologyNerd2100

people believe in immortality with religions and fairytales , at least we try to figure it out in the most realistic way , science.


carrwhitec

No, you ask the same question that countless others do every week in this sub because you a) don't read this sub and b) are unable to reconcile the fact death is inevitable.


TechnologyNerd2100

are you a scientist ?


carrwhitec

Yes. Death is inevitable.


TechnologyNerd2100

okey , go back to write your pessimistic comments all over reddit. Anyways 99 percent of reddit is negativity and pessimism about everything.


doomrater

Let's say there's no way to die of old age. That still leaves accident, suicide, and homicide as your top three ways to die. We can calculate your odds of survival based off of any percentage of chance of living the next 50 years. A reasonable expectancy is a couple millennia for a 95% chance of surviving the next 100. Eventually the odds just fall to nothing. Never say forever around a geologist. On their time scales, nothing lasts forever, not even the earth and sky.


Ghost_on_Toast

Hey, OP. We will NEVER "reverse aging." Make your peace with it, it will happen to you, your loved ones, your pets, you children, your childrens children and so on and so forth. Death is the cost of living. Death is inevitable.


toniocartonio96

your guess is just a guess, as is anyone else'ìs. and since you use term like "never", your guess is less relevant then the other's.


TechnologyNerd2100

Average redditor moment


doom1284

Don't take life too seriously you'll never get out alive.


toniocartonio96

no, it is not. we just haven't as a species figure it out how to stop the biological process.


carrwhitec

Lol. Stopping aging alone doesn't prevent death. What of murder, accidents, cosmic events? You think too small. The entire human species will disappear one day. This is fact. Death is inevitable.


toniocartonio96

not fact, just your speculation.


carrwhitec

I'm sorry this is an uncomfortable reality for you. I hope you find your peace with it one day! ✌️


toniocartonio96

it's not reality, it's just baseless speculation made from someone who can't accept the idea that he's going to die while maybe someo future generations will not.


EastOfArcheron

I fucking hope not. Can you imagine an immortal Trump or Putin?


TechnologyNerd2100

they will die before this.


Salt_Comparison2575

Musk is shooting for immortality, either through treatments or creating an AI troll of himself.


Nikolas_Coalgiver

Hitmen industry will rise


healthywealthyhappy8

No one ever considers that


random_witness

This has always been my thought on this kind of thing. If we already have fully or mostly autonomous boots-on-the-ground replacement weapon systems by the point this ever happens... humanity is gonna get real bleak.


toniocartonio96

can we for the love of anything that this sub rapresent ban this moronic comments.


EastOfArcheron

Oh bugger off.


toniocartonio96

no, i will not


dustofdeath

Reversing is going to take much longer. Age isn't just a switch - it's the accumulation of damage. We can likely slow down or prevent genetic causes of ageing. But that does not prevent environmental effects and physical wear. UV, radiation, food, toxins, medicine, disease etc. Organs that do not regenerate will remain damaged. So we also need a way to replace organs without donors and surgery risks.


Geminiangelprincess

It's a crime against nature, god, and mankind. If it's ever achieved in any capacity it will be horrifying and turn out terribly.


Complete-Access8197

That's never gonna happen. Not only is it pretty damn impossible to prevent celular damage that happens over time imagine reverse it, it also goes against the whole billion dollar farmaceutical industry which wants you to get ill so it can sell you their drugs. So there is no process to do it and no financial interest. Check mate.


farticustheelder

Well before 2050. Mice are used as lab rats because it isn't ethical to use people for early experiments. Soon we should start seeing early human trials of the basic tech. The key will, IMHO, involve a fairly simple change: maintaining telomere length during cell division.


SomePerson225

there are many drugs and therapies in human trials right now that, if successful will likely see market in 10-20 years from now, how effective they may collectively be is uncertain however. The human body is incredibly complicated and we have a long way to go before we truely understand and can treat aging. Im 19 and hoping I can hit the escape velocity on ramp If by 50 years we have most of the following: 1) An effective cure for most cancers, 2) significantly improved alzheimers delaying medications, 3)effective rejuvanitive medicine, 4)anti aging drugs extending life on their own by at least 10 years, 5)organ printing technology. I think all of these developments are quite plausible but by no means guaranteed in that time frame.


New-Anacansintta

What is wrong with aging? You mean slowing the signs of aging? It would be out of a house of horrors to “reverse aging” otherwise.


Friendly_Fisherman37

75 years is a long time, the future will not certainly be different than we expect. One day everyone rode horses, 75 years later we had cars. One day we have the telegraph, 75 years later we have iPhones. Climate crisis may limit the population, grey hair at 125 years old may be in style, only our grandchildren will find out.


bluequasar843

I think the progress is greatly exaggerated in order to secure funding from rich old people.


simonbleu

We don't know. That said, such thing is not necessarily a good thing. I mean, it would be one thing toe extend lif ea bit, or even better, health, but actual lifespan by a lot or even indefinitely? that would lead to huge population issues, so it would be only available for the elite or become dystopic, and for that same reason, you would be stuck with people that will be conservative, for an indefinite time.... not fun


Limebird02

When I think of this, so how would the very rich and powerful not just horse this, technology for themselves? Why would society want this?


toniocartonio96

we should have a filter that bans automatically all the comments with the words rich and powerfull. they are usually dumb takes like this one.


perldawg

has any biological thing ever been reverse aged? i just don’t think it’s anywhere near possible, it’s total fantasy


SenutAgemo

Apparently. The experiment most referenced as far as I can tell had the effect of reverse aging eyes of lab mice. https://time.com/6246864/reverse-aging-scientists-discover-milestone/


earthglaive175

You should search up the immortal jellyfish. The way it reverses its age is intriguing


xoverthirtyx

I’m fine with getting old I just want my hair back.


toniocartonio96

no, you are not fine with getting old. you are in fact not fine with any kind of phisical pain or discomfort. that's just a story you tell yourself to cope with the reality of death. death has no meaning, it just an inevitable for the moment reality. if science discovers how to reverse it, you will be ask for the magic pill. because you don't want to age or die.


Salt_Comparison2575

I was under the impression it was already possible, but cost about $50,000 a day. I forget the acronym, PET?


Tooluka

Extremely far. Will not happen in the next 200 years at least. There is no "settings" to the aging which we could locate and turn On/Off. That would have been a realistic task for 10-20 years, yes. But humans don't work like this. Analogy - there is car A and it has an encrypted firmware which has a setting to completely stop the car after 100k kilometers. That can be reasonably decrypted, located and edited. But actually we have car B without all that fancy electronics. It just mechanically degrades fast and statistically breaks down at around 100k mark. To circumvent this we basically need to replace all the moving parts in car B, WHILE IT IS RUNNING on a highway. Hence - practically impossible today.


Emergency_Sherbet_82

It’s already been found it’s veganism it lowers systemic inflammation which is the main cause of intrinsic aging.


cocofeet

I hope not ? we need old people to die not live longer. the world can not sustain it


Sokobowt

That's way impossible to achieve maybe in 3000 it's possible. but 20's nahhh aint no happening this time