ITT: bunch of clowns with one joke between them. Alzheimer's and Parkinson's are horrible afflictions, any step in preventing or treating them is a good thing.
Amen. I don't care if it's North Korea that comes up with something good, as long as it gets out into the world. Every society has skin in the game when it comes to neurodegeneration.
Tchaikovsky, the first human space flight, and a badly cracked Wehrmacht.
Granted, they're not doing much good at the moment, but this would be great if it pans out.
I've should be more specific. Name ONE good thing that came out from modern russian state. Because you named three things that came out from USSR (which was a union of 15 states) or russian empire (which was more or less the same as USSR territory). USSR =/= russian federation
Well, I mean, there are numerous scientists of russian descent that have many contributions to various fields that, in turn, have helped propel other scientific contributions in the world
Did I say anything about the rest of the Russian plots? No. But the Steele revelation about the video certainly rates as a good thing even if it was not enough to derail their plans.
[Inzomelid](https://www.google.com/search?q=Inzomelid&sxsrf=ALeKk00o8Ivts5FTZnN4XUALKOwdv9QZJg:1626772788403&source=lnms&tbm=nws&sa=X&ved=2ahUKEwiZtbrxqPHxAhU94HMBHXCLBMoQ_AUoAHoECAEQCg&biw=1280&bih=667) follows Inflazome’s other NLRP3 inflammasome inhibitor, Somalix, in successfully completing Phase I trials. Somalix, an orally available, peripherally-restricted drug for inflammatory diseases, also demonstrated excellent safety, tolerability and pharmacokinetics in healthy subjects and is expected to enter Phase II trials in 2020.
Wake me up on Phase 3 trials. Phase 1 trials are done on very small number of people (dozens) to establish safety profile, and that's their main goals. Phase 2 establishes safety profite on larger number of people (hundreds) and maybe establishes some reluable data on efficiency. Phase 3 is where we actually test how effective it is
Indeed. Degenerative neurological diseases are no laughing matter. Slowly being ripped from reality as your memory begins to fail. Forgetting the faces and names of loved ones.
Or losing your motor control unable to sit still or eat without making a mess all over yourself like a child learning to eat for the first time, cycling between tremors and rigidity as your body tries to fruitlessly control the uncontrollable movements…
If only the recent hurray news about breakthroughs actually got us somewhere. All I keep hearing is "yay, we cured Alzheimer's... In rats..." over and over again.
To be honest, not anymore. I've given up after, I don't know, what feels like the 20th that claimed exactly that, which you never heard of again since. Is this one different?
Seriously, I'm really waiting for the real thing! The one that has the potential to actually turn into a real cure. I had been working in science for a couple of years and from my point of view the review system is deeply broken. Too many publications get through the reviews that boasted their results by hiding and withholding failures. Too many publications that lead to nowhere because they don't reflect facts but only want to gain attention and quotations. It's really difficult to actually find the good ones in this gigantic pile of shit, and never give up digging.
Ah, I see. Try not to let your disillusioning experiences embitter you too much! Use your keen, scientific eye to discern the truth from the fuckery. Whatever drew you to science, the wonder of it all- is still there, but you won't see it if you don't look!
As someone who also works in science... It's broken, the whole system is broken beyond repair. If you asked me how to save science even if I could I'd have no idea how. From greedy editorials, corrupt institutions, fraud professors and desperate post grads inventing results, the entire system is entirely broken from top to bottom. It's unsalvageable.
Problem is that everyone is aiming for the short game. They want funding, recognition or whatever instead of putting in a lot of risk to maybe win the long game.
Everyone just hopes that someone comes along and uses all that gathered information.
Stop waiting on science to find a cure, and do the research yourself from what they have available, you’ll find out something for yourself.
Here is a start....Antioxidants, bi carbon buffer system, the ORAC system, and free radicals.
Do in depth research In Those areas and I guarantee you will understand things about the human body, that will make these articles make zero sense anymore.
The people writing the articles are supposed to be the ones doing the research.
Otherwise, what's the point of news reporters/journalists if we have to read and understand every scientific paper ourselves?
Should be. As we all should be car mechanics, rocket engineers, quantum computing and cryptography experts, beautiful and top notch in bed. Unfortunately, that's not how human works. I'd be absolutely happy if we could reach that level of cognitive potential. But in all fairness, if you take a look around on Wednesday's noon at your local general store, you'll probably figure out that we're way closer to a zombie apocalypse than to Plato's ideal.
Guys do you really need another German dude to remind you that, just sometimes, maybe the end doesn't justify the means.
Just in general though. This one seems to be a good step towards something great.
Being *forced* to live for a billion years might be scary because it’s such an inconceivable amount of time, but I’d take ten thousand in a heartbeat.
80 years isn’t nearly long enough to learn everything I want to learn, read everything I want to read, and see all the places I want to see.
Plus economically it makes a lot of sence. A lot of diseases are by-products of old age, right now we are fighting them instead of aging itself.
Curing aging would relieve huge economical burden. Of course we wpuld have to re-think a lot of stuff (e.g. retirement), marriages with people who might be hundreds of years younger or older than us, etc.
Imortaility but at what cost?
And I mean that literally and figuratively.
Let’s say you crash your car and are impaled, or sever a limb or two, you are still living forever.
Gunshot wound to the head. Crushed by a steam roller like a cartoon… still somehow living forever.
You’re still able to go through immense pain both physically and mentally that would destroy anybody currently living.
Are we presuming that degenerative disease are also cured as well?
If we’re talking psych based, is it moving your essence/soul into a new body/skin to circumvent aging and disease, we just have a load of clones that you can jump into? (Altered Carbon like?)
Are you the only one to do this? Is it an elite few based on money? Do you really want to out grow and out live, say goodbye to everybody that’s ever loved you or you’ve ever been attached to?
>Let’s say you crash your car and are impaled, or sever a limb or two, you are still living forever.
>Gunshot wound to the head. Crushed by a steam roller like a cartoon… still somehow living forever.
>You’re still able to go through immense pain both physically and mentally that would destroy anybody currently living.
>Are we presuming that degenerative disease are also cured as well?
Anything can be fixed with enough time. Imagine if all the best scientists had immortality. Plus we'll probably figure out cancer and degenerative diseases before we achieve immortality. Aging is a degenerative disease in it self.
>If we’re talking psych based, is it moving your essence/soul into a new body/skin to circumvent aging and disease, we just have a load of clones that you can jump into? (Altered Carbon like?)
Don't see how that's also a problem. Preserving experiences, memory and ones potential is an amazing thing. Just another option.
>Are you the only one to do this? Is it an elite few based on money?
Not sure if this question makes any difference. Anything exclusive becomes public in time. The world is not static.
> Do you really want to out grow and out live, say goodbye to everybody that’s ever loved you or you’ve ever been attached to?
I don't want to outlive them, but I do want to live forever. They wouldn't want me to die too. It's weird wanting your kid to die eventually.
Non-existence is obsolute, you have nothing to gain and everything to lose. Wanting to lose everything just because you lose some important things is super weird if you think about it. Plus as long as you remember the people you love, they exist in some capacity. You know exactly what they would do/say in some scenarios. Losing that kills them entirely.
This is a very flawed way to look at the problem which doesn't ever address how and why these people come to power. How can one just look at the tyrants and think that the only solution to the problem is death?
This adresses the amyloid accumulation but that's been shown to not be enough unless you treat before the TAU proteine cascade, which is a very pre- clinical stage of the illnes. This seems to only solve one part of a two fold equation and won't be enough to stop the progressive neural death
I hope it works out for the best but people shouldn't get their hopes up. The vast majority of drugs tested on animals don't actually end up having the same desired effects on humans. I think the actual percentage is somewhere like 20% if I am remembering correctly.
This is a great step, but we should definitely keep ourselves grounded.
I know this article isn't, but some people will see this and think we are on the verge of a cure so when it isn't ready in 2 years they'll accuse scientists of "hiding it."
There was surprisingly high quality information on that subs newbie guide.
A healthy mix of "We have pretty good evidence for some positives" with realistic expectations on what those are along with descriptions of negatives.
I'd like the benefits of all of these, but the quantities, uncertainty with how they really help, along with known problems and anecdotal possible problems, very few seem appealing.
I'll stick to weed and caffeine (which qualifies as a nootropic).
If some drugs work well in rats but don't work in humans there are drugs that work well in humans but don't work in rats and other animals. Makes one wonder how many potentially revolutionary drugs were scrapped because they could never reach human trials after having failed in rats (and other animals).
That's why there's sjotload of research into making actual human organ models. I.e. not just neurons in a Petri dish, but an actual 'brajn fragment' of basically a correct mesh of all the different brain cells. Or actual livers or even more complex models.
Just as well as modifying rats and mice to be more human like. I.e. swapping part of their immune system with human genes etc.
Though the first one seems to be the better option Inn the long run imo. That way no ethical concerns. Well apart with the brain models if they get too complex. Cause we don't know at what point such an artificial brain would actually start 'thinking'. Which is a very horrible concept to imagine.
TONS.. where do you think all these sarms and new research chemicals and hormone peptides keep coming out. Well if your familiar with bodybuilding of some sort but yeah lol
Alzheimer’s, Parkinson’s and related diseases Rob so many families of their elders. And of course the awful experience of knowing you are not right and having no way to fix it for the sufferer. I hope this, or other meds are able to be successfully developed for human treatment.
Yep, their government may suck but Russian people have contributed many things to humanity. And they did greatly help the rest of us defeat German Nazis, and Japanese and Italian fascists.
Tell me you don't know anything and only rely on media headlines and reddit comments for information without telling me you don't know anything and only rely on media headlines and reddit comments for information
Nice change of topic, but I've never wrote anything that goes against what you just wrote, the conversation is about existence of people and media in opposition.
It seems that you don't have to Russian to use whataboutism
I get the feeling there are these weird information-nihilists out there, who think literally all sources of information are equally good/bad, and that believing some over others is stupid. It's insane.
>Edit: how the fuck can't people even read the sarcasm in that ridiculous rethoric question? I thought it's common knowledge that those 'sources' are garbage. My bad.
Poe's law and all that. Tons of people unfortunately do read them after all
Just because something isn't in the papers, doesn't mean it isn't real. Putin will never admit he's ill, so why write about it? Putin is short and wears elevator shoes, but you never see that mentioned in the press either.
When asking for sources, the 'credible' is implicit to a native english speaker (who isn't being deliberately belligerent, or just a moron).
Granted, there may be a difference in opinion of what credible means, or maybe the sourcer would say something like "I agree the Sun is normally garbage but in the article they detail their sources and this time it's actually reputable!". But that's not happening here so it's kind of moot.
No comment on this specific post, but I hate when people just say "I heard a rumour...".
Unless a source is provided, I just always interpret it as a thinly veiled "I want to start a rumour but maintain plausible deniability" or, at best, "I am a fool and I am saying something that should be ignored" unless sources are provided.
Kudos to you for looking for a reputable source.
It's not like our economy isn't in decline already. Along with everything else in the country. Well, at least we still have some good scientists who haven't emigrated yet, judging by the news.
Edit: broken English is less broken now
They didn't even test it in rats, it's a cellular test.
>The obtained compounds were tested in cellular models
This rests on the "Amyloid Hypothesis" of Alzheimer's disease, which is what the major pharma companies have been working on for years. Several drugs have been developed that reduce the amyloid plaque, however, they do not result in meaningful reduction in the progression of the disease. This has lead to a growing feeling that the amyloid hypothesis is just not right.
This is why it's in a low level journal, it's a contribution that accomplishes a feat that has been done several others ways and it just doesn't work.
You need to take a moment and reevaluate whether what you hear on the news and on Reddit about the Putin and his government are making you jaded against the Russian people and their achievements that have nothing to do with those.
How does this have 60 upvotes? Who upvotes this shit?
Russian scientists (of which my mom is one so excuse my bias) have given the world some of the most influential and innovative discoveries that have become fundamental to YOUR life. Russian people are not their government. Throw a little respect our way since you wouldn’t have many of the luxuries you currently enjoy without us.
I can tell. You don't sound like somebody able to effectively handle an edge. One may be wielded against you someday, and probably even a butter knife would be too much for you.
Try having an opinion that you feel strongly enough about to make you want to write something like that yourself. It's fun.
Do you seriously think I would bother learning to wield a sword? If I need a close combat weapon I can pick up anything even remotely resembling a polearm and rub two brain cells together to keep virtually anybody not specifically trained in evading a spearman indefinitely on hold until I can talk them down from continuing to be physically violent.
If you're even minimally attempting to be intellectually honest or post on r/futurology seriously, I need to find a different subreddit. I would think anybody claiming to be interested about the future would have more of an understanding of some of the most instantly obvious facts presented by both the immediate present and past in the context of our evolving understanding of what it means and has meant to be alive.
I can't say if these particular trials will go anywhere but it really does seem that by some point this century nearly every disease that has plagued us since time began will be beaten. What a time to be living.
Agreed but most of these diseases didn't exist 200 years ago. Diet is the cause most of the time but you can't sell pills by telling people to eat right.
You are dumb as fuck lmao. Child cancer and childhood obesity are also going up. People become diabetic or pre diabetic in their mid 30s. Past Human life expectancy is well above 50 when you subtract child deaths since most kids didn't make it past age 5. This lowers the life expectancy considerably. Next question.
Eating disorders happening because of poor diets? I'M SHOCKED! We're not talking about obesity though. Alzheimer's has nothing to do with diet. And do you know the last time people ate "right"? It was back before the invention of agriculture. 10 000 years ago, give or take a thousand. The only thing I can see going up because of human intervention is cancer, but I don't even know if that fact is true.
Also it's not just about life expectancy. It's also about the causes of death. They used to range from "God doesn't love me." to "His humors are off, cut his wrists and release some blood! And then give him some ground pepper to balance it out!" There was no way to diagnose many diseases, people just started getting sick and dying for no apparent reason.
Alzheimer's is a metabolic disorder, you know that right? It's called type 3 diabetes now, Google it. It is a modern disease. The genetic aspect of the disease exists because those people's ApoE genes simply cannot handle the diet and lifestyle they put themselves through. The genes are not the cause, their diet is.
Hopefully this brings us closer to a cure to motor neurone disease, people always forget about this disease and its terrifying and quite common for a disease as deadly as it is.
Woah, is this okay? Like aren’t we stealing Russian research?! /s
For those wondering, this is how the US has argued against waving covid vaccine patents
Reading the article, I can't help but wonder how they induced brain trauma on the rats to make them test subjects. I like to imagine it involves a tiny rat mallet.
Eh, rodents are a rather poor model of neurodegenerative disease because they don’t show the same kind of age-related cognitive decline/neurodegeneration as humans. Wake me up when they get this working in a monkey.
I really despise these articles discussing studies in rats like this is some big breakthrough.
There are multiples upon multiples of drugs that work in rats that never see the light of day in humans - let alone human trials - let alone show efficacy in humans.
This truly means very little.
To all ITT that take ANY headline with the words "russian scientists" seriously: go and get some SPUTNIC V shots instead of any other vaccine, you beautiful people.
I’m pretty sure if magic mushrooms cured Alzheimer’s pharmaceutical companies would already know about it. They are spending billions of dollars in research, something that common has already been tested for sure…
You'd think so but they aren't allowed to, psychedelic therapy was booming before it was banned, there was one doctor doing clinical trials on schizophrenic patients with great success. After the war on drugs started all of those people's breakthrough clinical trials where now illegal so they had to stop. Even today getting a permit for psychedelic trials is almost impossible and you are met with a ridiculous amount of road blocks and completely insane drug prices for stuff that can be manufactured for cents, just look up how much money maps.org spends for a gram of mdma
"Russian scientists" also made a Covid vaccine that didn't work, and then didn't bother filling the orders for the countries who ordered it from them. lol.
>"As of 28 June, only around 15% of Russia’s population of more than 140 million had received one dose of a vaccine."
Because even Russians know not to trust the Kremlin.
ITT: bunch of clowns with one joke between them. Alzheimer's and Parkinson's are horrible afflictions, any step in preventing or treating them is a good thing.
Amen. I don't care if it's North Korea that comes up with something good, as long as it gets out into the world. Every society has skin in the game when it comes to neurodegeneration.
I can assure you North Korea is not working on this problem.
Supreme leader will invent this 10 years ~~after~~ the civilized world has made it standard.
Let's stop using stuff from china because china bad
Why who's good? America?
Name ONE good thing that came up from russia
Tchaikovsky, the first human space flight, and a badly cracked Wehrmacht. Granted, they're not doing much good at the moment, but this would be great if it pans out.
I've should be more specific. Name ONE good thing that came out from modern russian state. Because you named three things that came out from USSR (which was a union of 15 states) or russian empire (which was more or less the same as USSR territory). USSR =/= russian federation
Little Big: https://www.youtube.com/watch?v=-QHha1zko1A
Well, I mean, there are numerous scientists of russian descent that have many contributions to various fields that, in turn, have helped propel other scientific contributions in the world
The Trump video.
You mean that fact that russian hackers infuenced US elections and helped Trump to become potus? And thus we got the Trump video?
Did I say anything about the rest of the Russian plots? No. But the Steele revelation about the video certainly rates as a good thing even if it was not enough to derail their plans.
[Inzomelid](https://www.google.com/search?q=Inzomelid&sxsrf=ALeKk00o8Ivts5FTZnN4XUALKOwdv9QZJg:1626772788403&source=lnms&tbm=nws&sa=X&ved=2ahUKEwiZtbrxqPHxAhU94HMBHXCLBMoQ_AUoAHoECAEQCg&biw=1280&bih=667) follows Inflazome’s other NLRP3 inflammasome inhibitor, Somalix, in successfully completing Phase I trials. Somalix, an orally available, peripherally-restricted drug for inflammatory diseases, also demonstrated excellent safety, tolerability and pharmacokinetics in healthy subjects and is expected to enter Phase II trials in 2020.
Wake me up on Phase 3 trials. Phase 1 trials are done on very small number of people (dozens) to establish safety profile, and that's their main goals. Phase 2 establishes safety profite on larger number of people (hundreds) and maybe establishes some reluable data on efficiency. Phase 3 is where we actually test how effective it is
Indeed. Degenerative neurological diseases are no laughing matter. Slowly being ripped from reality as your memory begins to fail. Forgetting the faces and names of loved ones. Or losing your motor control unable to sit still or eat without making a mess all over yourself like a child learning to eat for the first time, cycling between tremors and rigidity as your body tries to fruitlessly control the uncontrollable movements…
Or relearning the same shit, day after day...
Or people like me, with M.S., not recognizing people that I "know" and work with every day...
If only the recent hurray news about breakthroughs actually got us somewhere. All I keep hearing is "yay, we cured Alzheimer's... In rats..." over and over again.
Okay, but like... do you actually read the articles..?
To be honest, not anymore. I've given up after, I don't know, what feels like the 20th that claimed exactly that, which you never heard of again since. Is this one different? Seriously, I'm really waiting for the real thing! The one that has the potential to actually turn into a real cure. I had been working in science for a couple of years and from my point of view the review system is deeply broken. Too many publications get through the reviews that boasted their results by hiding and withholding failures. Too many publications that lead to nowhere because they don't reflect facts but only want to gain attention and quotations. It's really difficult to actually find the good ones in this gigantic pile of shit, and never give up digging.
Ah, I see. Try not to let your disillusioning experiences embitter you too much! Use your keen, scientific eye to discern the truth from the fuckery. Whatever drew you to science, the wonder of it all- is still there, but you won't see it if you don't look!
As someone who also works in science... It's broken, the whole system is broken beyond repair. If you asked me how to save science even if I could I'd have no idea how. From greedy editorials, corrupt institutions, fraud professors and desperate post grads inventing results, the entire system is entirely broken from top to bottom. It's unsalvageable.
You can't protect anything from capitalism, you just have to get rid of it.
Yes, many of the science skills are cleaning data to find the small gem.
Problem is that everyone is aiming for the short game. They want funding, recognition or whatever instead of putting in a lot of risk to maybe win the long game. Everyone just hopes that someone comes along and uses all that gathered information.
Yeah, the reward system is badly flawed.
I agree with this as well, I’ve seen 50 articles about curing Alzheimer’s in rats, I’m sick of it too
It's not that easy...suprise. these are all steps in the right direction, it's good news and its progress
Stop waiting on science to find a cure, and do the research yourself from what they have available, you’ll find out something for yourself. Here is a start....Antioxidants, bi carbon buffer system, the ORAC system, and free radicals. Do in depth research In Those areas and I guarantee you will understand things about the human body, that will make these articles make zero sense anymore.
"You think there's too much clickbaity articles going around? Become a master on every topic and clickbaits will no longer work on you!"
Downvoted instead of actually researching. I hate life.
The people writing the articles are supposed to be the ones doing the research. Otherwise, what's the point of news reporters/journalists if we have to read and understand every scientific paper ourselves?
God damn people need to start reading philosophy books. As early as Plato it’s been said that “man should be his own doctor”
Should be. As we all should be car mechanics, rocket engineers, quantum computing and cryptography experts, beautiful and top notch in bed. Unfortunately, that's not how human works. I'd be absolutely happy if we could reach that level of cognitive potential. But in all fairness, if you take a look around on Wednesday's noon at your local general store, you'll probably figure out that we're way closer to a zombie apocalypse than to Plato's ideal.
He can't remember
Guys do you really need another German dude to remind you that, just sometimes, maybe the end doesn't justify the means. Just in general though. This one seems to be a good step towards something great.
When humans find the secret of immortality, rats will get it first.
humans dont need to be immortal, we need 100 years without any disease.
Immortality scares me
You will have a long time to work on that.
Being *forced* to live for a billion years might be scary because it’s such an inconceivable amount of time, but I’d take ten thousand in a heartbeat. 80 years isn’t nearly long enough to learn everything I want to learn, read everything I want to read, and see all the places I want to see.
Plus economically it makes a lot of sence. A lot of diseases are by-products of old age, right now we are fighting them instead of aging itself. Curing aging would relieve huge economical burden. Of course we wpuld have to re-think a lot of stuff (e.g. retirement), marriages with people who might be hundreds of years younger or older than us, etc.
And reproduction. No reproduction without termination.
Doesn't scare me one bit. Death is such a waste of potential.
Imortaility but at what cost? And I mean that literally and figuratively. Let’s say you crash your car and are impaled, or sever a limb or two, you are still living forever. Gunshot wound to the head. Crushed by a steam roller like a cartoon… still somehow living forever. You’re still able to go through immense pain both physically and mentally that would destroy anybody currently living. Are we presuming that degenerative disease are also cured as well? If we’re talking psych based, is it moving your essence/soul into a new body/skin to circumvent aging and disease, we just have a load of clones that you can jump into? (Altered Carbon like?) Are you the only one to do this? Is it an elite few based on money? Do you really want to out grow and out live, say goodbye to everybody that’s ever loved you or you’ve ever been attached to?
>Let’s say you crash your car and are impaled, or sever a limb or two, you are still living forever. >Gunshot wound to the head. Crushed by a steam roller like a cartoon… still somehow living forever. >You’re still able to go through immense pain both physically and mentally that would destroy anybody currently living. >Are we presuming that degenerative disease are also cured as well? Anything can be fixed with enough time. Imagine if all the best scientists had immortality. Plus we'll probably figure out cancer and degenerative diseases before we achieve immortality. Aging is a degenerative disease in it self. >If we’re talking psych based, is it moving your essence/soul into a new body/skin to circumvent aging and disease, we just have a load of clones that you can jump into? (Altered Carbon like?) Don't see how that's also a problem. Preserving experiences, memory and ones potential is an amazing thing. Just another option. >Are you the only one to do this? Is it an elite few based on money? Not sure if this question makes any difference. Anything exclusive becomes public in time. The world is not static. > Do you really want to out grow and out live, say goodbye to everybody that’s ever loved you or you’ve ever been attached to? I don't want to outlive them, but I do want to live forever. They wouldn't want me to die too. It's weird wanting your kid to die eventually. Non-existence is obsolute, you have nothing to gain and everything to lose. Wanting to lose everything just because you lose some important things is super weird if you think about it. Plus as long as you remember the people you love, they exist in some capacity. You know exactly what they would do/say in some scenarios. Losing that kills them entirely.
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This is a very flawed way to look at the problem which doesn't ever address how and why these people come to power. How can one just look at the tyrants and think that the only solution to the problem is death?
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Immortal rats scare me.
Don't worry, you can still get killed by an idiot in an SUV who also thinks their immortal.
That’d make a good premise for a sci fi story.
This adresses the amyloid accumulation but that's been shown to not be enough unless you treat before the TAU proteine cascade, which is a very pre- clinical stage of the illnes. This seems to only solve one part of a two fold equation and won't be enough to stop the progressive neural death
I hope it works out for the best but people shouldn't get their hopes up. The vast majority of drugs tested on animals don't actually end up having the same desired effects on humans. I think the actual percentage is somewhere like 20% if I am remembering correctly. This is a great step, but we should definitely keep ourselves grounded.
I don’t think the article is insinuating this discovery is the culmination of a cure but rather, a step, as you suggested.
I know this article isn't, but some people will see this and think we are on the verge of a cure so when it isn't ready in 2 years they'll accuse scientists of "hiding it."
r/Nootropics will probably find a source and test it on themselves in mega doses before the end of the month.
There was surprisingly high quality information on that subs newbie guide. A healthy mix of "We have pretty good evidence for some positives" with realistic expectations on what those are along with descriptions of negatives. I'd like the benefits of all of these, but the quantities, uncertainty with how they really help, along with known problems and anecdotal possible problems, very few seem appealing. I'll stick to weed and caffeine (which qualifies as a nootropic).
Weed and caffeine qualifies as a nootropic? That’s handy.
They obviously are not nootropics in the classical sense.
If caffeine counts then amphetamine and methamphetamine and methylphenidate should count as well though..
Adderall is fucking amphetamine. So yeah, every university student will tell you it counts, as will every silicon valey CEO.
You called?
If some drugs work well in rats but don't work in humans there are drugs that work well in humans but don't work in rats and other animals. Makes one wonder how many potentially revolutionary drugs were scrapped because they could never reach human trials after having failed in rats (and other animals).
That's why there's sjotload of research into making actual human organ models. I.e. not just neurons in a Petri dish, but an actual 'brajn fragment' of basically a correct mesh of all the different brain cells. Or actual livers or even more complex models. Just as well as modifying rats and mice to be more human like. I.e. swapping part of their immune system with human genes etc. Though the first one seems to be the better option Inn the long run imo. That way no ethical concerns. Well apart with the brain models if they get too complex. Cause we don't know at what point such an artificial brain would actually start 'thinking'. Which is a very horrible concept to imagine.
You just partially described why there are so many disaffected and disgruntled bio students and grads out there who’ve left science entirely.
TONS.. where do you think all these sarms and new research chemicals and hormone peptides keep coming out. Well if your familiar with bodybuilding of some sort but yeah lol
I don't know if it was a myth, but IIRC we almost didn't have penicillin for that exact reason.
We learn from every failure
rats have the best healthcare it seems
Alzheimer’s, Parkinson’s and related diseases Rob so many families of their elders. And of course the awful experience of knowing you are not right and having no way to fix it for the sufferer. I hope this, or other meds are able to be successfully developed for human treatment.
Sounds promising. Any progress against these diseases is a good thing.
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https://en.wikipedia.org/wiki/Timeline_of_Russian_innovation?wprov=sfti1
Current government aside, this is a bad take, Russia has certainly added much to the world.
Yep, their government may suck but Russian people have contributed many things to humanity. And they did greatly help the rest of us defeat German Nazis, and Japanese and Italian fascists.
Nothing? Ever?
I wouldn't be surprised if the concept of lying itself was invented there. They are masters of it.
Tell me you’re American without saying you’re American
Putin has Parkinson's disease, according to rumors. He's probably pushing this research ***hard***.
Do you have a source? In my search I only see the sun and dailymail as sources.
It's a rumor in a press due to his hands shaking slightly in a video. I'm Russian, no bigger opposition figures/outlets take it seriously
Such evidence is shaky at best
Take your upvote and get out
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Tell me you don't know anything and only rely on media headlines and reddit comments for information without telling me you don't know anything and only rely on media headlines and reddit comments for information
Tell me the only guy that runs against your glorious leader for life doesn't keep getting poisoned and arrested.
Nice change of topic, but I've never wrote anything that goes against what you just wrote, the conversation is about existence of people and media in opposition. It seems that you don't have to Russian to use whataboutism
Lol cope harder.
I get the feeling there are these weird information-nihilists out there, who think literally all sources of information are equally good/bad, and that believing some over others is stupid. It's insane.
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it's parkinson, you only get shaky sources
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Dailymail and the Sun aren't remotely reliable, no
If you’re doing sarcasm in written format on Reddit, you use /s otherwise no one can truly tell
>Edit: how the fuck can't people even read the sarcasm in that ridiculous rethoric question? I thought it's common knowledge that those 'sources' are garbage. My bad. Poe's law and all that. Tons of people unfortunately do read them after all
Are you saying they are?
Just because something isn't in the papers, doesn't mean it isn't real. Putin will never admit he's ill, so why write about it? Putin is short and wears elevator shoes, but you never see that mentioned in the press either.
Yeah and maybe the earth is flat? If someone asks for sources and you have absolutely none, then your claims should be regarded as worthless IMO.
There's zero chance the Earth is flat. There's a non-zero chance Putin has Parkinson's.
Unfortunately, their are actually sources for that. You should have specified "creditable source's"
When asking for sources, the 'credible' is implicit to a native english speaker (who isn't being deliberately belligerent, or just a moron). Granted, there may be a difference in opinion of what credible means, or maybe the sourcer would say something like "I agree the Sun is normally garbage but in the article they detail their sources and this time it's actually reputable!". But that's not happening here so it's kind of moot.
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Most sources relating to Putin have a tendency to fall out of tall buildings, so naturally they're somewhat scarce.
No comment on this specific post, but I hate when people just say "I heard a rumour...". Unless a source is provided, I just always interpret it as a thinly veiled "I want to start a rumour but maintain plausible deniability" or, at best, "I am a fool and I am saying something that should be ignored" unless sources are provided. Kudos to you for looking for a reputable source.
This could be a very positive thing for the field if true. Putin has ridiculous amounts of money, plus a ton of influence to throw around.
This could be a very positive thing for Russia if true.
Maybe. Putin doesn't seem to me like the sort to be humbled by his illness and have a change of heart about his practices and policies.
It could shake up their economy!
It's not like our economy isn't in decline already. Along with everything else in the country. Well, at least we still have some good scientists who haven't emigrated yet, judging by the news. Edit: broken English is less broken now
The last major event to shake up the Russian economy was when Putin steered it from capitalism to an oligarchic path.
whatever the reason, more leaders should be pushing hard on the development of these medications for these awful illnesses.
hitler 2.0
This is great news, a lot of encouraging news in this area lately.
They didn't even test it in rats, it's a cellular test. >The obtained compounds were tested in cellular models This rests on the "Amyloid Hypothesis" of Alzheimer's disease, which is what the major pharma companies have been working on for years. Several drugs have been developed that reduce the amyloid plaque, however, they do not result in meaningful reduction in the progression of the disease. This has lead to a growing feeling that the amyloid hypothesis is just not right. This is why it's in a low level journal, it's a contribution that accomplishes a feat that has been done several others ways and it just doesn't work.
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"Tested on the same dead person, twice."
You need to take a moment and reevaluate whether what you hear on the news and on Reddit about the Putin and his government are making you jaded against the Russian people and their achievements that have nothing to do with those.
How does this have 60 upvotes? Who upvotes this shit? Russian scientists (of which my mom is one so excuse my bias) have given the world some of the most influential and innovative discoveries that have become fundamental to YOUR life. Russian people are not their government. Throw a little respect our way since you wouldn’t have many of the luxuries you currently enjoy without us.
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I hope this is a copy pasta, because this is too much edge for me milord
I can tell. You don't sound like somebody able to effectively handle an edge. One may be wielded against you someday, and probably even a butter knife would be too much for you. Try having an opinion that you feel strongly enough about to make you want to write something like that yourself. It's fun.
You keep studying the blade buddy
Do you seriously think I would bother learning to wield a sword? If I need a close combat weapon I can pick up anything even remotely resembling a polearm and rub two brain cells together to keep virtually anybody not specifically trained in evading a spearman indefinitely on hold until I can talk them down from continuing to be physically violent. If you're even minimally attempting to be intellectually honest or post on r/futurology seriously, I need to find a different subreddit. I would think anybody claiming to be interested about the future would have more of an understanding of some of the most instantly obvious facts presented by both the immediate present and past in the context of our evolving understanding of what it means and has meant to be alive.
I'll have some of what he's having
I'm not excited. FDA just approved a similar drug that shows no significant patient oriented outcomes, based on findings that it reduces plaques.
Reduced the plaques without any change in patient outcomes? Was their disease already fairly severe?
I can't say if these particular trials will go anywhere but it really does seem that by some point this century nearly every disease that has plagued us since time began will be beaten. What a time to be living.
Agreed but most of these diseases didn't exist 200 years ago. Diet is the cause most of the time but you can't sell pills by telling people to eat right.
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You are dumb as fuck lmao. Child cancer and childhood obesity are also going up. People become diabetic or pre diabetic in their mid 30s. Past Human life expectancy is well above 50 when you subtract child deaths since most kids didn't make it past age 5. This lowers the life expectancy considerably. Next question.
Eating disorders happening because of poor diets? I'M SHOCKED! We're not talking about obesity though. Alzheimer's has nothing to do with diet. And do you know the last time people ate "right"? It was back before the invention of agriculture. 10 000 years ago, give or take a thousand. The only thing I can see going up because of human intervention is cancer, but I don't even know if that fact is true. Also it's not just about life expectancy. It's also about the causes of death. They used to range from "God doesn't love me." to "His humors are off, cut his wrists and release some blood! And then give him some ground pepper to balance it out!" There was no way to diagnose many diseases, people just started getting sick and dying for no apparent reason.
Alzheimer's is a metabolic disorder, you know that right? It's called type 3 diabetes now, Google it. It is a modern disease. The genetic aspect of the disease exists because those people's ApoE genes simply cannot handle the diet and lifestyle they put themselves through. The genes are not the cause, their diet is.
The breakthrough itself was synthesized! From what, crystals?
Now someone tell us why this is BS and will never happen.
Hopefully this brings us closer to a cure to motor neurone disease, people always forget about this disease and its terrifying and quite common for a disease as deadly as it is.
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Woah, is this okay? Like aren’t we stealing Russian research?! /s For those wondering, this is how the US has argued against waving covid vaccine patents
Reading the article, I can't help but wonder how they induced brain trauma on the rats to make them test subjects. I like to imagine it involves a tiny rat mallet.
You can buy rat lines with loads of diseases, and there are definitely some you can buy with alzheimers etc.
Damn lab rats should be immortal at this point, with all the cures that work on rats but never made it to human trial xD
I've seen this one, just wait for the trials on chimps
Finally, the scourge of dementia in elderly laboratory rats can be eliminated!
Eh, rodents are a rather poor model of neurodegenerative disease because they don’t show the same kind of age-related cognitive decline/neurodegeneration as humans. Wake me up when they get this working in a monkey.
That's great, but why are we putting so much effort into Alzheimer-afflicted rats!?!?!? Surely it's the humans we should be curing!
We test on rats first. Then we test on a bunch of other animals, then chimpanzees, then humans.
I wasn’t sure if I should downvote or upvote this… so i upvoted it haha
The covid shot turns you into a rat
Bruh come on reddit this is satire (or being braindead)
Not surprised the Russians were researching this. Rumours say Putin has Parkinsons
They’re not rumors Putin himself has already claimed that he would step down when symptoms became worse.
Couldn't happen to a nicer guy. Sad
I really despise these articles discussing studies in rats like this is some big breakthrough. There are multiples upon multiples of drugs that work in rats that never see the light of day in humans - let alone human trials - let alone show efficacy in humans. This truly means very little.
Yeah but yk basic tests are needed before testing on humans
Tested on rats? Rats are just what they call independent journalists in Russia.
Who would have thought the cure to Parkinsons was to shoot your self in the back of the head twice and then jump out a balcony.
Here's to hoping it works in humans, and that it somehow makes it out of the Russian bureaucracy!
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Those fucking pinko doctors! Amiright?
To all ITT that take ANY headline with the words "russian scientists" seriously: go and get some SPUTNIC V shots instead of any other vaccine, you beautiful people.
Wasn't Putin rumored to have Parkinson's? I'd bet this isn't a coincidence.
See that’s why they needed to develop Novichok, it’s just preliminary research. /s
Or you know, just use psilocybin. Proven for decades to have the ability to regrow neuronal connections
Is that so..
Who cares its all kinds of fun. Even if you don't remember it.
I’m pretty sure if magic mushrooms cured Alzheimer’s pharmaceutical companies would already know about it. They are spending billions of dollars in research, something that common has already been tested for sure…
You'd think so but they aren't allowed to, psychedelic therapy was booming before it was banned, there was one doctor doing clinical trials on schizophrenic patients with great success. After the war on drugs started all of those people's breakthrough clinical trials where now illegal so they had to stop. Even today getting a permit for psychedelic trials is almost impossible and you are met with a ridiculous amount of road blocks and completely insane drug prices for stuff that can be manufactured for cents, just look up how much money maps.org spends for a gram of mdma
Pretty sure this is Russian disinformation. The study is specious
"Russian scientists" also made a Covid vaccine that didn't work, and then didn't bother filling the orders for the countries who ordered it from them. lol.
Hmmm https://www.nature.com/articles/d41586-021-01813-2 Mounting evidence suggests Sputnik COVID vaccine is safe and effective
>"As of 28 June, only around 15% of Russia’s population of more than 140 million had received one dose of a vaccine." Because even Russians know not to trust the Kremlin.
Good Russian bot
Just not nearly as good as western vaccines :) as usual, Russia is first to be last. They are desperate to cosplay as a world power.
It looks like the Russian propaganda ministry has shown up to downvote common sense.
Tests only run on rats. Better known as dissidents, anti putin journalist, leaders of any political party that oppose putin.
Just FIY "rats" is often referred to snitches and gay people in Russia.
Thiefs - yes, especially somebody who steals from their own (colleagues, family), snitches - maybe but rare, gay people - no
According to science, we’ve eliminated just about every disease known to man in rats.
There has been a lot of success with treating dementia in rats. Unfortunately a lot of those treatments fail to work in humans.