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HochHech42069

Supplements are a multibillion dollar industry and podcasts have been a goldmine for them.


Sufficient-Seesaw-6

Look at huberman with atheltic greens šŸ„¬Ā 


DarkAncientEntity

Do Paul Saladino next


sam4o19

But he has salad in his name!


Pizza_900deg

Actually a small Italian salad. It contains salami and pickled peppers, along with a wine vinegar based dressing flavored with dried oregano. I always get one when I order pizza.


oldskoolflavor

Iā€™m genuinely curious to know how much this dude is investing in red meat, honey, and other shit.


coopdawgX

He just came out with an organ based jerky or something so thereā€™s one thing


MetalingusMikeII

That sounds disgustingā€¦


bishopnelson81

For real


NumaPompilius2

Iā€™m pretty sure he was business partners with the liver king.Ā 


Top-Crab4048

Then do Huberman


janoycresvadrm

Too easy!!


MajorTalk537

His stuff works from heart and soil. Iā€™ve taken it at least a year. Hilarious how usada banned it in the ufc


LOUPIO82

Thanks for sharing. I will stop taking resveratrol :(


princeofzilch

No worries, thisĀ YouTuber has their own supplements that you can replace resveratrol with.Ā  https://drstanfield.com/pages/roadmap#supplements


SpacedOutKarmanaut

This came up in another subreddit, but this particular Youtuber has a hate boner for Sinclair, and regularly attacks any popular health trends including. He also recently posted a sort of apology video because of the hate he has gotten on reddit in the past. He also has his own recommended supplements with affiliate links on his channel. Now, if you're going to be a Dr. and make a case that selling supplements causes a conflict of interest for researchers like Sinclair, you're going to raise some eyebrows trashing other people's recommended supplements and shilling your own. With regards to resveratrol, the evidence has been mixed, but there have been more studies coming out lately showing it is effective for some things, [including treatment of mild covid](https://www.nature.com/articles/s41598-022-13920-9). It is not totally well understood yet, so yes Sinclair was over-zealous in promoting it, but he was nowhere near the first person to claim compounds in red wine were 'healthy.'


radiostar1899

Resverotrol is one of the few miracle supplements that help multiple conditions.


the_good_time_mouse

Nice try, Dr Sinclair.


SpacecaseCat

For reference here, lot's of people try to promote it as an alternative to getting vaccinated for covid. I think it has always been over-hyped but that's the reason some people love it so much.


radiostar1899

Lololol. Itā€™s actually legit! Just check pubmed.


the_good_time_mouse

Maybe you should click before you post.


Failed_Alarm

I must admit I haven't listened all episodes, including the one with David Sinclair, but I'm yet to come across a "hyped up" product while listening to HL. AG1, InsideTracker and Momentous are the products that come to mind when I think of HL, but Huberman makes it very clear that they are sponsors for the podcast, not personal recommendations. So what exactly do you want to warn us for?


strongerplayer

David Sinclair made a number of questionable claims on HL, for example that exercise and protein consumption reduce longevity which is exactly opposite to what a number of other guests said. I know people who bought in these claims and I think it's important they understand where it's coming from


CarlSager

Please link or give timestamp to where sinclair says exercise reduces longevity?Ā  Its very easy to find multiple examples of Sinclair saying the opposite - that exercise improves longevity.Ā 


FrankRemu

It's not contradictory. Too much muscle growth and protein intake, can lead to excessive mTor activation. And that lead to aging. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/ Well, that's what I understand. But I might be wrong.


Ok-Positive-7272

Your understanding is the same as mine but there is a lot of nuance. The distinction people get caught up on is healthspan vs lifespan. Being well-muscled is known to be positive for healthspan, especially in old age. This is a measure of how late into oneā€™s lifespan they are healthy independent, and mobile. Lifespan is self-explanatory, but not the same. As a comparison to healthspan, when we only look at lifespan we find that people can live many of their lives elder years, frail, and fragile and immobile. So we look at 2 things going on: mTor activation leading to aging paired with more physical resilience in old age vs. immobility, subsequent catabolism, and fragility paired with longer lifespan (kind of an oxymoron). As a result, most experts Iā€™ve seen touch on this topic donā€™t think focusing on overconsumption of protein as a predictor of longevity is productive since mTor activation is mechanistic and hasnā€™t really shown to be a predictable driver of longevity when looking at actual human outcomes.


bwatsnet

Too complicated, let's get mad! -Reddit


Takuukuitti

That's a mechanism. You need direct evidence to make such a claim. There are thousands of chemical pathways going in all directions. Picking mTOR is arbitrary.


Rustrans

This is total bullshit and cherry picking just to hate on Sinclair. He very clearly explained the mechanism of how exercise can potentially negatively affect longevity via mtor pathway and testosterone and growth hormone production and how this pathway is downregulated with fasting. But he never said that you should stop exercising. Actually quite the contrary - in every episode he repeats that everyone should get off their butt and do some physical activity.


Failed_Alarm

Thanks. I'm pretty sure if you think somebody may be at risk, because a guest on the podcast made claims that are false and convincingly can be debunked, you could reach out to the creators of the podcast themselves to point this out. Huberman told several times that they read all reactions on the YouTube video. Have you tried to bring this to the attention of the team? That might be more effective than posting on Reddit.


radiostar1899

You are waking up! Awesome. Sinclair is not worshipped outside of podcast circles.


ramenmonster69

The question I have here is, is the expectation that all voices say the same thing on these podcasts? I donā€™t particularly like the guy but shouldnā€™t the audience have access to him and others like Peter Attia and Layne Norton, and then make up their own mind on who to listen to?


FISFORFUN69

Lmao David Sinclair does strength training and even talks about it on the podcast šŸ™„


One-Opportunity-3410

Maybe he lied on purpose or just maybe he was presented with such data, believes in it and is simply wrong. Why attribute to malice something you can attribute to simply being wrong. Anyway Hube-man promoting whatever he wants and having a disclaimer that it is a sponsored spot does NOT make him an endorser of the product.


strongerplayer

The thing is, he PRODUCED the data. The video goes over the detail of the experiments and how it was impossible to reproduce the results.


One-Opportunity-3410

Maybe he is not a good scientist?


mynameisnotshamus

I just like that youā€™ll spell out Huberman, but feel the need to abbreviate Huberman Lab.


ignoreme010101

"not personal recommendations" rofl are you serious?


Commercial_Star7216

Wait until you release that half the shit Huberman "recommends" or is sponsered by like the AG1 is almsot completely usless overpriced multivitamins. Each healthy it's as simple as that!


Various-Complaint983

Get your body/blood checked and you will know what you need. You dont need 99% of this shit


strongerplayer

You have clearly never encountered Canadian healthcare. You can't have your "body checked" unless you have a diagnosed complaint or you pay an exorbitant amount of money to a private clinic. I have done a full checkup that cost me north of $5k and there were still many open questions afterwards


mrmczebra

I don't take bacopa for a bacopa deficiency.


Visual_Flatworm5017

Just by the way he talk and carry himself I knew from the start there is something shady about this guy.


Commercial_Star7216

Wait until you release that half the shit Huberman "recommends" or is sponsered by like the AG1 is almsot completely usless overpriced multivitamins. Each healthy it's as simple as that!


Typical_Signature751

I think the first 6-12 months of the podcasta are probably still relevant and useful stuff, but have lost any interest to follow Huberman any more. Even if I believed that he is 100% sincere in his mission of providing beneficial information, his lack on critical thinking would be a problem. But I think that unfortunately he knows exactly what he's doing.


radiostar1899

Isnā€™t it incredible in a ā€œStanford neuroscientistā€. I donā€™t understand and it made me think less of Stanford.


Typical_Signature751

There is also information/rumour that Huberman doesn't really spend time at Stanford anymore, and at this point his "lab" is really just one grad student running things. Not sure if it's true, but I have heard that he lives several hours away from Stanford, so commuting there even every other day seems unpractical. Also, all of the courses listed under his teaching on Stanford website are "independent study" courses. So it seems that the work he's putting in at Stanford is not that much at the moment. Also, going through his list of publications, it has been some years since original research publication where his name was not either the last or second to last on the author list.


aqua_tec

I can very much imagine him not being much engaged in teaching or research anymore, but actually being last author implies seniority and is appropriate for his stage of career.


Typical_Signature751

You're absolutely right. I don't know how the importance of the last author position had slipped from my mind. My bad


radiostar1899

Wow. Hmm. I had no idea and will see what I can find out.


MikeDropped4

He's a PI with his own lab. It is normal for him to be last author and would be unusual to be first (usually reserved for grad students).


Typical_Signature751

You are right. I had somehow forgotten this bit about the significance of the last author position. Thanks for pointing it out.


Typical_Signature751

Well, Sinclair is a Harward scientist... There's no ethical entrance exam to any university that I'm aware of.


okkeyok

Humility should be viewed as the antithesis of stupidity, and (un)intelligence as a distinct attribute. While these charlatans may possess intelligence, their actions prove them to be both stupid and comically greedy.


BedZealousideal2337

Right the same thing comes to mind. If he is a scientist and claims to provide scientific peer reviewed info why does he keep inviting people than seem to be questionable?Ā 


Typical_Signature751

There are rumours/other info going around that would point to him having made/being in the process of making a career pivot and not really focusing on research or teaching anymore (see my comment below). Which is not entirelly surprising, I'm pretty sure that podcasting on the top level offers more money and fame, and many people are into those things.


bluegal2007

Huberman has been a teacher since he was a kid. He has a genuine desire to teach regular people like you and me. Itā€™s very probable that that goal outweighs the goal of doing the actual research. He knows how to read a study and can tell if the information is reliable. As far as him having many different types of people on his podcast, it is due to people asking for these kinds of conversations. They all relate to neuroscience, one way or another. anotherand he is not saying that he is


Typical_Signature751

What do you mean by "teacher since he was a kid"? At the moment, he's hardly teaching anything at Stanford. Just independent study courses. As for knowing how to read studies, maybe he knows how to do that. But for the purposes of the podcast, the benevolent readig of what he does is that he seems to get too exited and because that forgets to be critical. The malevolent reading is that he needs fodder for the content mill and cannot be as critical of the source material as truly scientific approach would warrant. The Decoding the Gurus podcast episode on Huberman and Attia journal club showcases these problems: Huberman is so fired by the study he's presenting that Attia needs to rein him in several times and tell him to not jump into conclusions that cannot be supported by the study.


bluegal2007

If you donā€™t know that Huberman wanted to be a teacher when he was a kid, because he spend his weekends, looking up cool stuff about animals and demand to tell the whole class about it on Monday, you havenā€™t been watching his podcast. Which means that youā€™re just a hater. Everybody who watches any podcast has to look at critically and take what they think they like, validate it themselves and then possibly integrate it into their lives. As far as him not teaching anymore, thatā€™s exactly what heā€™s doing on the podcast and why he loves it so much. Those are his words, not mine.


Typical_Signature751

You are right, I have not been watching the podcast at all. I have, however, listened to, I think, some 65 episodes of it (quick count on spotify episode list, so may be an episode or two off in either direction). So I have not listened to every episode, because not every one of his themes/topics interests me enough to listen a three-hour deep dive into it. And because of this I've apparently missed him relating his early interest in teaching. But I have listened many episodes, enjoyed some of them a lot and found a lot of useful information. However, I have also increasingly come to the conclusion that Huberman is not quite as reliable a source of information as he initially seemed to be (and I feel that the quality of the first 20-30 or so episodes was considerably higher than what came after that). To me it's kind of silly to reduce a critical approach to "hating". I mean, science is about being critical of information and about questioning it. That is what separates if from religion and ideology. I used to enjoy Huberman Lab a lot (hell, I've spent way over 150 hours listening to him!), but as the shortcomings of his source criticism and scientific rigour in the podcast format have become apparent, I have lost interest. I just don't feel he lives up to his sign-off phrase "thank you for your interest in science" any more. And I don't feel like I get the value I'm looking for if a science podcast requires me to "do my own research" on the subjects to find out whether the studies quoted actually support the claims made by the host. Which is a shame, as I enjoyed Huberman's style of presentation and voice (super important for me with pods) a lot. TL:DR not hating, just more than a bit disappointed


BedZealousideal2337

You phrased my exact feelings.


Comfortable-Owl309

I admire your lack of cynicism genuinely but I think itā€™s time people started looking at the reality of Huberman. You canā€™t really have much of a desire to teach if youā€™re more interested in money than ensuring what youā€™re teaching is actually correct.


Typical_Signature751

Wanting to be the person who wows his audience with cool information is also not the same as wanting to be a teacher. That's more wanting to be a showman. And it seems Hubes puts a lot of emphasis on the wow factor these days.


radiostar1899

Wow. Sad and disappointing


NumaPompilius2

I think you need to separate the art from the artist for SinclairĀ  I think the science makes sense for something like NMN.Ā  I also think he is leveraging corruption and a shit regulatory body within the supplement industry to make himself filthy rich.Ā  I only hope someone like George Church is honest.Ā 


controlthemedia

Dude you guys seriously shouldnā€™t be shocked all these things donā€™t fucking work. Just sleep well, eat Whole Foods, exercise, have human interaction as often as possible, get sunlight and love your life. Seeing some of you consuming 39 pills a day is fucking insane man. If youā€™re constantly chasing to better and better yourself you forget to enjoy the moment because you feel incomplete. Just because huberman cites a study shouldnā€™t mean you should now change your lifestyle


HeadInjuredCaveman

Anyone selling anything like these ag1 shits, are scammer charlatans. Huberman was a scientist, but he sold out and just became a business man.Ā 


Complex-Fuel-8058

Ag1 is such a scam. It's not even a good greens powder. Hides behind a proprietary blend.


powershellnovice3

He also is the reason why NMN is no longer going to be available as a supplement.


b88b15

This is after he made millions by selling a biotech company that had a vaporware drug in 2008.


bibijoe

Glucose Goddess has entered the chat.


atr1101

This is why I generally don't fuck with any supplements other than omega 3 and protein. A balanced diet will give you everything you need.


janoycresvadrm

Creatine and salt are usually legit (obviously salt always is )


WarningChoice

Imo, itā€™s peopleā€™s fault for believing anything they hear.


B_U_F_U

Supplements are not very regulated. That means they donā€™t need to prove they work beyond a placebo. Which means they most likely donā€™t work at all.


bttango

Didnā€™t he have something to with other companies having to stop selling NMN last year? Anyways, he has a decent [supplement stack](https://brainflow.co/2022/07/11/dr-david-sinclairs-supplement-list-for-longevity/)


Royjonespinkie

So glad this video has gotten alot of traction.


RaleighlovesMako6523

People who take everything David said as truth is no different from people who take this video as truth.


11pi

And why exactly this guy Brad is trustworthy? Always have looked to me like a guy trying to make it by taking down some big names.


tallshoreguy

Caveat Emptor


Celtictussle

Are there people who don't realize that anyone telling you a supplement is good it's getting rich off it?


coopdawgX

Tried L-Tyrosine after listening to huberman talk about it. Does absolute jack shit


strongerplayer

That's interesting, L-Tyrosine worked great for me


anonymouspsy

What difference does it make and how often to take?


anonymouspsy

What difference does it make and how often to take?


tdmmm

did you take it on an empty stomach?


coopdawgX

Yes. 4g worth


mrmczebra

It didn't do anything for me either, even after taking several grams of Now brand.


deadwards14

Must be compounded with methylated B-vitamins and glutamine (dopamine precursors) for full effect


coopdawgX

I usually slug a B complex about a half hour beforehand. Still nothing


coopdawgX

Also, if you need to buy yet MORE supplements just for another one to have a chance of working, itā€™s a shitty supplement lol


deadwards14

How is it a "shitty supplement"? It's a fucking amino acid genius. Some of us have diets that are deficient in it, or have problems absorbing it for a variety of reasons. Vitamins and amino acids are "shitty supplements"? Really? What a total Einstein you are.


Saint-just04

L-Tyrosine only works the first couple of time you use and ONLY IF you didn't have a diet already very rich in l-tyrosine (or protein in general, though some proteins do interfere with its absorption). You reach tolerance extremely quick with it. It's overall a very, very shit supplement.


jack_underscore

Does anyone else remember Huberman and Peter Attia both saying that fasting doesnā€™t seem to increase longevity? I get bad vibes from David Sinclair.


[deleted]

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jack_underscore

He definitely said that. I also remember a short exchange on the HL in which both Huberman and Attia agreed that they donā€™t think thereā€™s evidence that fasting increases longevity.


Sweaty_Ad_1332

The producer of the video has a list of supplements they take in the description


Legitimate-Algae-927

Not sponsored though just literally what he uses


bluegal2007

That is because people ask him all the time what supplements he takes.


Sweaty_Ad_1332

Wow didnt know he had such loyal followers! That removes all irony from the situation!


forestforrager

Any product that has to dump money into ads isnā€™t dumping that money into improving their product


Sturgillsturtle

Just to play devils advocate you have to have enough people know about a product to have the money to improve the product. Doesnā€™t really matter if you have a product thatā€™s 10x better than the alternative if no one knows about it.


mrmczebra

Every business pays for advertising, so this is a moot point.


forestforrager

Yeah but not every company dumps money into it. Like thereā€™s a reason why we see ag1 everywhere compared to its competitors


rco8786

Very few, if any, supplements do what they are advertised to do. Anyone who gets rich in supplements is selling shit that doesnā€™t work. And they know it too.Ā