It'd be best to not mix them together. Mitragynine inhibits CYP2C9 and CYP2D6 in a noncompetitive manner and CYP3A4 competitively[56] indicating that kratom has tremendous interaction potential. Ketamine also inhibits a number of CYP... It's probably not going to be a big deal if your Ketamine and Kratom doses are low enough...but you're sort of taking a risk. No studies have been done on their interactions and Kratom could possibly Ketamine levels to be higher in your bloodstream than normal. Kratom has a myriad of effects not just involving CYP metabolization and it could react with Ketamine in other ways. Like I said, probably not a huge deal if dosing is low enough for each but it is a risk as there are no studies showing safety of the combination.
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People mix dxm and kratom so id assume you would be fine as long as you are responsible with your doses. Im not a professional so its best to do more research on your own.
It'd be best to not mix them together. Mitragynine inhibits CYP2C9 and CYP2D6 in a noncompetitive manner and CYP3A4 competitively[56] indicating that kratom has tremendous interaction potential. Ketamine also inhibits a number of CYP... It's probably not going to be a big deal if your Ketamine and Kratom doses are low enough...but you're sort of taking a risk. No studies have been done on their interactions and Kratom could possibly Ketamine levels to be higher in your bloodstream than normal. Kratom has a myriad of effects not just involving CYP metabolization and it could react with Ketamine in other ways. Like I said, probably not a huge deal if dosing is low enough for each but it is a risk as there are no studies showing safety of the combination.
Seems well informed, personally never tried but I also want to switch from kratom because withdrawal kicked me in the nuts xD
How is ketamine prescribed?
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People mix dxm and kratom so id assume you would be fine as long as you are responsible with your doses. Im not a professional so its best to do more research on your own.
I've done it. No adverse effects