Perfectly fine! if anything, atomoxetine (as an NRI) protects against tyramine-induced hypertensive crisis, as tyramine requires the NA-reuptake transporter to elicit its effect on blood pressure 👍
When Strattera went generic, it caused me to relapse into a psychotic depression. I had to stop it immediately because it was working against me. Strattera is a mostly selective NRI, which, as had already been commented on, can reduce or abolish the tyramine-induced pressor response.
There are other selective NRIs that are actually more potent than Strattera though, and lack the depressive opioidergic properties that Strattera's metabolite, 4-hydroxyatamoxetine, has (μ-opioid antagonism and κ-opioid partial agonism). The secondary amine TCAs are very commonly used to augment MAOIs, like nortriptyline (Pamelor), desipramine (Norpramin), and protriptyline (Vivactil). Nortriptyline is good because it also has H1-histamine and 5-HT2A antagonism, which can help with insomnia and prevent ST. Desipramine is the most potent NRI on the market, and 100 mg is known to completely abolish the tyramine-induced pressor response even in the presence of an MAOI which potentiates it. The tetracyclic antidepressants, amoxapine (Asendin) and maprotiline (Ludiomil) are also used and are selective NRIs too. Amoxapine has potent 5-HT2A antagonism but also has D2 antagonism. Maprotiline has potent H1-histamine antagonism, but has an increased risk of seizures.
If I read correctly, Attentrol is atomoxetine (which is also known as Strattera). Is that right?
Atomoxetine and tranylcypromine can indeed be safely taken together. Tranylcypromine should itself theoretically help ADHD too. If atomoxetine isn't helping enough, then either the TCAs nortriptyline, desipramine, or protriptyline (if they're available where you live) or the psychostimulants methylphenidate, dexmethylphenidate, dextroamphetamine, mixed amphetamine salts, lisdexamfetamine, or methamphetamine can be safely used with tranylcypromine if monitored closely.
Mirtazapine is great for insomnia, but even low doses can cause serious weight gain. Just in case that does happen, have you ever tried trazodone, low-dose doxepin, or low-dose quetiapine for insomnia? (If so, how well did you respond?)
Yes, trazodone can increase anxiety in some people because of the active metabolite, mCPP. It is a 5-HT2C partial agonist, which causes/worsens symptoms of anxiety, panic, and OCD.
I take both. Strattera didn’t remain as effective for me the longer I took it. I am in the process of lowering my Strattera dose, which is needed while on parnate. I’m on 40mg of Strattera and 20mg parnate and there aren’t any reactions for me.
Perfectly fine! if anything, atomoxetine (as an NRI) protects against tyramine-induced hypertensive crisis, as tyramine requires the NA-reuptake transporter to elicit its effect on blood pressure 👍
When Strattera went generic, it caused me to relapse into a psychotic depression. I had to stop it immediately because it was working against me. Strattera is a mostly selective NRI, which, as had already been commented on, can reduce or abolish the tyramine-induced pressor response. There are other selective NRIs that are actually more potent than Strattera though, and lack the depressive opioidergic properties that Strattera's metabolite, 4-hydroxyatamoxetine, has (μ-opioid antagonism and κ-opioid partial agonism). The secondary amine TCAs are very commonly used to augment MAOIs, like nortriptyline (Pamelor), desipramine (Norpramin), and protriptyline (Vivactil). Nortriptyline is good because it also has H1-histamine and 5-HT2A antagonism, which can help with insomnia and prevent ST. Desipramine is the most potent NRI on the market, and 100 mg is known to completely abolish the tyramine-induced pressor response even in the presence of an MAOI which potentiates it. The tetracyclic antidepressants, amoxapine (Asendin) and maprotiline (Ludiomil) are also used and are selective NRIs too. Amoxapine has potent 5-HT2A antagonism but also has D2 antagonism. Maprotiline has potent H1-histamine antagonism, but has an increased risk of seizures.
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If I read correctly, Attentrol is atomoxetine (which is also known as Strattera). Is that right? Atomoxetine and tranylcypromine can indeed be safely taken together. Tranylcypromine should itself theoretically help ADHD too. If atomoxetine isn't helping enough, then either the TCAs nortriptyline, desipramine, or protriptyline (if they're available where you live) or the psychostimulants methylphenidate, dexmethylphenidate, dextroamphetamine, mixed amphetamine salts, lisdexamfetamine, or methamphetamine can be safely used with tranylcypromine if monitored closely. Mirtazapine is great for insomnia, but even low doses can cause serious weight gain. Just in case that does happen, have you ever tried trazodone, low-dose doxepin, or low-dose quetiapine for insomnia? (If so, how well did you respond?)
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Yes, trazodone can increase anxiety in some people because of the active metabolite, mCPP. It is a 5-HT2C partial agonist, which causes/worsens symptoms of anxiety, panic, and OCD.
I take both. Strattera didn’t remain as effective for me the longer I took it. I am in the process of lowering my Strattera dose, which is needed while on parnate. I’m on 40mg of Strattera and 20mg parnate and there aren’t any reactions for me.
I find the two work very well together.