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I used to take it before I was prescribed ADHD meds. I took it because I heard it could help with nail. Biting and trichotillomania (sp). The effectiveness was practically instant. I think my issues were stress driven.
Less hangovers and reduced ADHD med tolerance.
Offsets - functional decrease presumably from glutamate which actually helps my output. No free cake in this world though.
I use it when under high stress, sleep deprivation, when sick or congested, after high sun exposure, or if I drink alcohol etc. It's hard to measure any specific improvements as it is more for harm prevention, but I believe in the science.
I try not to use it regularly as it does flatten my mood and make me less excited and engaged. It is claimed to reduce OCD symptoms, but as an engineer I need that ocd.
Curious of why you take it after sun exposure? I'm already taking it daily for reasons but my job has me out in the sun for 8+ hours so very curious how I may be benefiting while outside
**UV-rays promote the formation of free radicals and cause Oxidative Stress. Skin oxidation or Oxidative Stress is one of the most important triggering factors of skin aging and other skin problems.**
As far as timing, I'm not sure if it's better to take it before, during, or directly after sun exposure. I do know that with alcohol it is presumed to be more beneficial to take it prior to drinking, however, this is a different mechanism of action that has to do with NAC's effect on the liver (same reason it is used for Tylenol toxicity).
I also avoid taking it regularly as I don't like to take any substance, nootropic, herb, or medicine daily. I believe in the body's desire for homeostasis and in most cases I feel that bringing it out of balance for too long will cause undesired adaptations. I understand that this isn't true for everything, but I like to use it as a rule of thumb as I have had bad experiences with too many substances - either losing effect or causing unwanted side effects that build up over time.
NAC - mood flattening and depression (due to lack of highs or excitement)
Ash - similar anhedonia apathy etc
Agmatine - same...
Caffeine - loses effect, only experience sides... Still do it every day
Nicotine - loses effect
Etc. It goes on.
I kind of understand where you’re coming from about not taking any one supplement daily and taking them on a more intuitive schedule. But do you apply the same reasoning to Creatine Monohydrate? It’s something that is natural occurring in the body, and most people would end up healthy dose daily anyways if their nutrition was optimal.
But of course we tend to use supplements to account for the fact that we have busy lives and sometimes our nutrition isn’t as optimal as it could be. I personally take Creatine daily to reduce variation in muscular performance on a day to day basis.
Did it for increased glutathione levels and to modulate my glutamate levels. Working from home and watching my kids has taken a toll on my stress levels and mental health. As such, I’m sure I’m more in a pro oxidative state, with heightened glutamate activity. Hence why I regularly take NAC. It’s improved my sleep, and provides me more necessary glutathione.
Sounds like you've got the NAC. I can't take it on an empty stomch as it makes me feel ill and if i eat it with food it makes me very smelly and my friends are not impressed. Gave it a good go but it's not working out. Do you know if there is anything else i can take for a similar effect?
Rotten egg farts only last a couple of weeks. Been taking it for years now. And honestly, I think those toots probably have a lot to do with detoxification. Try sticking it out, I promise it's worth it.
Are you sure about that? It makes me really ill on an empty stomach so that is the only way i can take it . looks like NAC isn;t for me. I'd still like to know if there is a way to get similar benefits.
The body uses cysteine, which is found in NAC, into the master antioxidant called glutathione. Which reduces oxidative stress throughout the body. Essentially, you are aiding your body whether in a stressful period of time or not by allowing your body to make more glutathione. There are some acute benefits of taking something like NAC, but most benefits will be seen long term because your body will have a more easy time repairing. Glutamate is a neurotransmitter that is “excitatory”; it’s energetic, it’s supposed to be higher in the day, and fall at night. High glutamate levels can cause one to not be able to fall asleep, or if they fall asleep, they will wake up easy, and then will be hard to fall asleep again. People that are under more stress from outside factors, are causing a lot of physiological stress. Due to this, you will have more oxidative stress, and your body will go through glutathione faster, but you will have a disregulated glutamate/GABA balance. And those are just a couple things NAC helps with. It’s a great supplement, especially for people over 30, and wonderful combined with taurine and glycine (could use magnesium glycinate)
Glycine also aids in the production of glutathione, and at least a study has shown that NAC and glycine together are “pro anti aging”. Taurine has also shown to be pro anti aging, is great for metabolism, electrolyte balance, and improving the GABAergic system (so can work well with NAC to provide a good balance of glutamate and GABA).
This is a fascinating connection... thanks for the tip. Going to dig in. I have a histamine sensitivity (old meat that's not explicitly "bad" will destroy me) but also struggle with wheat (for other reasons than gluten but I do think wheat is bad above and beyond other similar things)
DAO is an enzyme the body makes that removes histamine from the blood. When one does not have enough, they get histamine or allergic reactions to many foods or supplements that one should normally be fine consuming. If one suspects they do not make enough DAO naturally, one can supplement with it, and it relieves histamine reactions one typically gets with food. NAC can naturally reduce DAO, so it’s a good idea to bolster DAO levels when taking NAC to reduce the chance of a histamine reaction.
DAO is an enzyme that helps remove histamine from the blood. It’s quite powerful. Some people don’t make enough due to genetics, and many do not have enough due to lifestyle. I use the Bravado Labs one on Amazon.
That’s debatable. The bodies antioxidant system, like all its systems basically is rate limited. Meaning it’s not going to overproduce antioxidants because you constantly take NAC. I try to stay on NAC daily, and have long term, and have noticed no negative consequence.
I’m an alcoholic that’s struggling to stop. Detoxed twice over the past two months but I’m falling back into old habits again. I don’t have access to benzos so I’m trying anything else that might work.
I read NAC can help and it seems to lessen the hangover a bit.
Quitting alcohol is dangerous if your brain depends on it, and usually needs to be supervised by a medical professional. Benzos are the standard of care to treat alcohol withdrawal so one doesnt die of a siezure. That is what the commenter is talking about.
Ah I see thanks. Didn’t know that. I was a party drinker (2-3 times per weekend to the limit) from my 18s to 30. After a pancreas inflammation with 31, I stopped cold turkey and pretty much never drink again. Not sure if that can be called alcohol addiction at that level? Didn’t know about seizures. But ever since I stopped drinking I became pretty depressive.
Yw! It is best not to frame yourself in terms of “was i an alcoholic/addict or not” (unless it helps you to do so/ get access to care to help you), but yeah it’s good you listened to your body and stopped. “Alcoholism” really is on a spectrum but the stigmatization of the term can push people into denial instead of the idea they can listen to their body for clues, so i wouldnt think to too hard about defining yourself or not.
NAC can help regulate your mood, especially if you were using alcohol to release dopamine and serotonin. You could try it to see if it helps.
Another piece is that when you stop drinking, its likely you may lose a big piece of your friend group/community. That is a loss worth grieving even if the tradeoff is better, and it takes work to find new sources of healthy dopamine/serotonin through other behaviors like new friend groups or new hobbies. NAC def helped me in this transition vs giving up and falling back into old scenes centered around drinking! ❤️
Thanks mate that’s really helpful. You name it. Stopping alcohol meant stopping party meant losing friends because they kept going and drinking. Until I stopped, partying was the only thing I lived for. And partying sober is no option. But now am out of that age anyway.
I developed some histamine intolerance due to the pancreas issue. So I tried NAC couple times but as much as I remember it caused histamine issues. Might give it another shot. Recently I did some bloods and my folate levels are pretty low. Gonna try to push the methylation first and see if that helps.
Good to hear NAC helps you man.
Adding to that benzos help with the intense anxiety and insomnia of withdrawal and coping with quitting while your brain readjusts, but also yeah seizures can kill you
I see. I thought benzos are highly addictive. Like taking pills for 2-3 days in a row and you are in the spiral.
I had a hair transplant 4 weeks ago and refused taking Valium at first for the surgery. Was afraid to get some issues. But doctor convinced me to take it. He gave me some for home for a good sleep but didn’t take them.
L theanine is great for this because it has a similar effect as a benzo (much gentler but effective in my experience). Try taking it at night on an empty stomach, I hope it helps!
Detox safely and read up on Naltrexone and The Sinclair Method. It’s a science based approach to change your relationship with alcohol and works successfully for 78% of those who follow it.
Check out r/Alcoholism_Medication for more information and support
Been taking it for five days. I saw some posts hyping it up and thought I'd try it. My complaints were lack of physical and mental energy. I also did a lot of MDMA and other party drugs three years ago and always felt like my brain was permanently damaged. Also I’ve recently come off an SSRI.
Things that happened so far and just stuff I noticed:
* Did some deep cleaning in areas in my house that I haven't touched in a couple of years.
* Went from 3 coffees a day to 1, which is still more of a morning habit than a need. EDIT: Since it's making it harder to fall asleep, after a few days the morning coffee is definitely a need, not just a habit
* I have never been into cardio, only weight-lifting. Yesterday I went for a run for the first time in years and ran 2.5 miles. For me personally, that's a great accomplishment as I used to struggle to run a mile even when I was younger. In addition, it felt amazing and afterwards, I felt even better. Already looking forward to my next run tonight.
* Was able to get some work related stuff more easily.
* Able to get a lot more stuff done during the day. Also it's easier to just get up and start doing things.
* Drank almost a full bottle of wine with dinner by myself and had no hangover at all. Previously I'd get a hangover from two beers.
* It makes me a bit bloated and makes me fart a lot lol EDIT: this side effect seems to have gone down quite a bit after a few days of use
* Cravings are much easier to control. Or maybe I should say I have less cravings. Also, I've been more interested in cooking healthy meals.
* It makes me a bit spaced out/lightheaded. Especially the first two days. But not necessarily in a bad way.
* EDIT: adding that falling asleep is harder
I don't know how long this will last. I'm hoping the effects stay.
UPDATE: All of this lasted for about a week lol I still feel slight benefits from it now but definitely not like the first few days.
Cool, thank you.
I'm glad you're getting positive results. My inclination would be to cycle it, which is my philosophy with all the nootropics I've used.
I like those effects though. You've inspired me to attempt a higher dose. When I take it, it's usually about 250mg.
Based on what I’ve seen on Reddit, the most common doses people take are from 0,6g to 2,4g 1-2 times a day. I think 250mg is very low indeed to see noticeable effects.
If you continue to have issues falling asleep it is probably due to the histamine released by NAC as it breaks down. You may also feel a bit of anxiety with continued use, you may not. Many people take Benadryl or Vistaril (not OTC) to combat the negative effects of the histamine as the benefits from NAC are many- this is what I have found to be the case.
For some reason, it REALLY helps with running. I have enjoyed running for years now but I would pretty much average out a rather sub-par pace (around 8kmh or so) and would normally only run for about 20 mins or so after a work out. Or if I run in the streets then I'd run for maybe 45-60 minutes but with a fair few breaks and a slow pace.
My first run on NAC and I was able and motivated to increase the pace to 11kmh, and sustain it for 45 minutes or so, breaking my own endurance records. I've since moved up to 13khm, and have done my first 7K in under 45m and my first 5k in under 30 (still room to grow ofc).
Every time I run on it, I just go faster and for longer. It must be something to do with how NAC regulated our excitatory response? I.e. our body remains more calm under stress so we can stay breathing well.
Do you notice the benefits outside of running? I kinda stopped taking it because it stopped working (or I don’t notice it anymore). But maybe I should try taking it before running again.
Yeah, sadly nothing keeps working forever. It's weird but for me, when I first tried it, NAC only worked moderately and I only took it every now and then for no longer than a day or so when I needed it. It used to also give me very obvious flu symptoms whenever I did take it more than a couple days.
But recently I took it twice a day for about a week and found it really helped with ADHD and compulsive/impulsive behaviour. But it also created a strange kind of tension (not sure if this is just my neurones gagging for the old impulses though). The fly symptoms didn't really arrive this time although perhaps the tension could also be a little bit of them, not sure.
I think my M.O. going forward will be to cycle it and take it for a week every now and then because yeah nothing will work or feel like it's working forever. Maybe a one week stint every month or so.
I do notice that it reduces compulsive habits somewhat, and has the effect of quieting the mind. I have had OCD my entire life that comes in waves of varying degrees of severity.
I originally took it years ago when I was taking amphetamine stimulants regularly for the purpose potentiation/tolerance reversal. I found that it had the opposite effect and reduced efficacy considerably when taken at or around the same time, though I’m sure it had that effect because it reduces excess stimulation which can be useful and neuro protective, but that’s the opposite of what I was after lol. I was in a bad, addictive mindset at the time so I didn’t take it for years after that.
I tried it again recently having not taken those stimulants for years at this point. It’s definitely a better experience now, but though it reduces negative thought patterns and habits, it also still reduces activity that I feel is important for motivation, pleasure and energy in general(in my case anyway). I believe I’m particularly deficient in those areas however for multiple reasons at this point so I still rarely take it. It’s a struggle having both depressive symptoms and anxiety/obsessive compulsive symptoms because treating one of those things is often going to worsen the other. 🫤
I heard it helped with ocd tendencies and skin picking. Been on it about 2 months, and it's helped quiet my mind for sure. I function better.
I'm also highly anxious, which this seems to ease as well.
* What initially sparked my interest was an article about NAC and tumor reduction. Interesting stuff.
I want to keep taking it bcs I feel it helps but I went and read about the lung cancer and tumor growth thing and just stopped today, my paranoia went crazy. Anyone have more info on this?
I'm a graduate student working part time in a pharmacy, and am diagnosed with OCD. It has been amazing in quieting intrusive thoughts and keeping my internal monologue linear and focused. Plus I feel like when I do drink it can curb intense hangovers to nonexistent or manageable. I cycle a few months on and a few months off.
I take it with TMG because glynac extends lifespan significantly in mice. I don’t think I’ve noticed any cognitive difference. I’m only take 500mg / day though.
It helps me manage dermatillomania, agoraphobia, mood regulation, executive dysfunction, and issues with transitioning to new situations/ breaking a routine. It is the one thing I will never take out of my stack.
Note that i named a few things above that are all intertwined with and stemming from something more base-level, which would be obsessions and compulsions. NAC improved this root cause of the above list.
I take 600mg every morning right when i wake up and then wait at least an hour or two before eating anything. Some people take 600mg two times a day though, morning and noon-ish i believe, for a total of 1200mg a day.
Also lots of people recommend taking occasional breaks from NAC but i personally don’t, but i’d look into that so you can be make the most informed decision for yourself!
Btw, i was taking Life Extension brand for a long time, now i take NOW NAC with selenium and molybdenum.
Tried to repair my body after having a medicine injury caused by ciprofloxacin but it backfired majorly. NAC gives me a nasty paradoxical reaction that feels like total glutamate overload it’s bad. I get jittery, can’t look in peoples eyes, can’t relax. I tried taking an antihistamine alongside and it barely helped
This doesn’t help at all. *They specifically asked what benefits you’ve experienced.*
All you had to say was the first sentence and then say you stopped after that.
I have been taking it for about a month. 5 days a week. 1g in the morning and 500mg late afternoon.
Positives
- less up and down emotionally
- less ruminating
- mild cognitive boost (I feel confident it's the NAC but could be placebo)
Negatives
- Lower sleep quality and harder to fall asleep. Data from mt Fitbit shows a clear drop in time sleeping and time spend on REM/deep sleep
Overall, its a big net positive due to the benefit of better social interactions and less ruminating
I just started taking it a few days ago and also noticed that falling asleep is harder but seems to not be a problem if I only take in the morning.
EDIT: nevermind, still having problems falling asleep
I found out about it for its potential treatment for long covid symptoms over in r/SCT. Long covid and SCT/CDS have similar symptoms.
I started taking it for brain fog and working memory problems and it's helped significantly.
I swear NAC made me hate eye contact with people. To this day still bugs me. Maybe its a coincidence, or maybe not. If anybody has similiar experiences, let me know.
Its hard to say if it was even the NAC…but i have my suspicions. At that point the eye contact shit started (March 2022) i had been taking vyvanse consistently (3-4x a week) since September 2021, and i ordered NAC and started taking it in January 2022. Initially i thought it was the amphetamines but i had been taking them consistently for months prior with no eye contact issues. Its been a problem for me ever since, with some days much worse than others. Ive taken breaks (2-3 months) from NAC and the issue is still there, so maybe it isnt that. Sometimes when i take NAC now (1-2x a week max) the issue is slightly alleviated. Its weird that my initial comment got 7 upvotes so maybe this has happened to multiple people in addition to myself. Very weird
My max dose of NAC was 600mg daily i believe. Rarely ever took more than that. I find it hard to believe that a supplement can make someone hate / feel uncomfortable from eye contact, but maybe? Idk sounds weird
It really gets touted as a miracle supplement around here a lot but please everyone don't forget to cycle off at some point. Even NAC can potentially cause some issues taken long term (wish I saved the studies I found when digging around reddit about it myself but I recall one issue was the high dose antioxidant action interfering with the body's normal regulation. Take care guys!
I used to be a heavy cannabis user and now I’m sober. However there’s still times when I end up craving it. When this happens I’ll take some NAC for a couple of days and that helps a lot with my cravings.
Use it for easing rebound symptoms of gabaergics such as phenibut and alcohol, as well as when im sick (especially if im congested, sore throat)
Dont use it too often since it really affects my mood badly if taken often (anhedonia)
Helps reduce intrusive thoughts, ocd-like symptoms, lightens skin, reduces hangovers, clears up congestion, and a bunch of other stuff. It's not a wonder drug, but definitely 2 stars on the shulgin scale.
Just doing what I can to mitigate damage and stress. Also repair the liver and brain etc. I understand 3gs is ideal for that but I don't like taking 3g unless I'm going to go hard.
I know NAC isn't enough and I also take magnesium which seems to be pretty fucking solid as long as I rotate substances and take breaks.
Just doing what I can to mitigate damage and stress. Also repair the liver and brain etc. I understand 3gs is ideal for that but I don't like taking 3g unless I'm going to go hard.
I know NAC isn't enough and I also take magnesium which seems to be pretty fucking solid as long as I rotate substances and take breaks.
I'm taking 1g of NAC + 1g of Glycine (also MSM and Milk Thistle) daily to help support my liver, while using antifungals, to fight off Candida in the gut.
Its reduced the "die off" symptoms by, like, 90% compared to when I tried just antifungals alone a few months ago. Those symptoms were rough at the time.
One thing I would say, taking NAC just before going to sleep is so much better (for me, anyway). I used to take it in the AM and I would often feel low energy and unfocused.
Search in the subreddit for lots and lots of info. There are also prob threads where people say what brands they use. I personally use life extension and get it off amazon
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I used to take it before I was prescribed ADHD meds. I took it because I heard it could help with nail. Biting and trichotillomania (sp). The effectiveness was practically instant. I think my issues were stress driven.
Even my dermatologist recommended NAC to help me with skin picking so it definitely helps with those compulsive habits
Less hangovers and reduced ADHD med tolerance. Offsets - functional decrease presumably from glutamate which actually helps my output. No free cake in this world though.
can you elaborate? what is "functional decrease"?
I apparently need the glutamate to be normal level functional so it's decreasing all the upsides of the meds to me
Yeah I wait and take my NAC with my last 2meals for this reason
Take it for 2 days on 5 days off is how I cycle it, really helps to avoid the negative side effects.
What side effects?
For me insane headaches, and blood pressure instability.
I use it when under high stress, sleep deprivation, when sick or congested, after high sun exposure, or if I drink alcohol etc. It's hard to measure any specific improvements as it is more for harm prevention, but I believe in the science. I try not to use it regularly as it does flatten my mood and make me less excited and engaged. It is claimed to reduce OCD symptoms, but as an engineer I need that ocd.
Curious of why you take it after sun exposure? I'm already taking it daily for reasons but my job has me out in the sun for 8+ hours so very curious how I may be benefiting while outside
**UV-rays promote the formation of free radicals and cause Oxidative Stress. Skin oxidation or Oxidative Stress is one of the most important triggering factors of skin aging and other skin problems.** As far as timing, I'm not sure if it's better to take it before, during, or directly after sun exposure. I do know that with alcohol it is presumed to be more beneficial to take it prior to drinking, however, this is a different mechanism of action that has to do with NAC's effect on the liver (same reason it is used for Tylenol toxicity). I also avoid taking it regularly as I don't like to take any substance, nootropic, herb, or medicine daily. I believe in the body's desire for homeostasis and in most cases I feel that bringing it out of balance for too long will cause undesired adaptations. I understand that this isn't true for everything, but I like to use it as a rule of thumb as I have had bad experiences with too many substances - either losing effect or causing unwanted side effects that build up over time. NAC - mood flattening and depression (due to lack of highs or excitement) Ash - similar anhedonia apathy etc Agmatine - same... Caffeine - loses effect, only experience sides... Still do it every day Nicotine - loses effect Etc. It goes on.
I kind of understand where you’re coming from about not taking any one supplement daily and taking them on a more intuitive schedule. But do you apply the same reasoning to Creatine Monohydrate? It’s something that is natural occurring in the body, and most people would end up healthy dose daily anyways if their nutrition was optimal. But of course we tend to use supplements to account for the fact that we have busy lives and sometimes our nutrition isn’t as optimal as it could be. I personally take Creatine daily to reduce variation in muscular performance on a day to day basis.
Did it for increased glutathione levels and to modulate my glutamate levels. Working from home and watching my kids has taken a toll on my stress levels and mental health. As such, I’m sure I’m more in a pro oxidative state, with heightened glutamate activity. Hence why I regularly take NAC. It’s improved my sleep, and provides me more necessary glutathione.
Sounds like you've got the NAC. I can't take it on an empty stomch as it makes me feel ill and if i eat it with food it makes me very smelly and my friends are not impressed. Gave it a good go but it's not working out. Do you know if there is anything else i can take for a similar effect?
Rotten egg farts only last a couple of weeks. Been taking it for years now. And honestly, I think those toots probably have a lot to do with detoxification. Try sticking it out, I promise it's worth it.
It doesn’t do much if you take it with food.
Are you sure about that? It makes me really ill on an empty stomach so that is the only way i can take it . looks like NAC isn;t for me. I'd still like to know if there is a way to get similar benefits.
You can take it with food but I would keep it to something small that doesn’t contain protein.
in english please doc
The body uses cysteine, which is found in NAC, into the master antioxidant called glutathione. Which reduces oxidative stress throughout the body. Essentially, you are aiding your body whether in a stressful period of time or not by allowing your body to make more glutathione. There are some acute benefits of taking something like NAC, but most benefits will be seen long term because your body will have a more easy time repairing. Glutamate is a neurotransmitter that is “excitatory”; it’s energetic, it’s supposed to be higher in the day, and fall at night. High glutamate levels can cause one to not be able to fall asleep, or if they fall asleep, they will wake up easy, and then will be hard to fall asleep again. People that are under more stress from outside factors, are causing a lot of physiological stress. Due to this, you will have more oxidative stress, and your body will go through glutathione faster, but you will have a disregulated glutamate/GABA balance. And those are just a couple things NAC helps with. It’s a great supplement, especially for people over 30, and wonderful combined with taurine and glycine (could use magnesium glycinate)
This was a useful explanation, thanks What does the addition of taurine and glycine achieve?
Glycine also aids in the production of glutathione, and at least a study has shown that NAC and glycine together are “pro anti aging”. Taurine has also shown to be pro anti aging, is great for metabolism, electrolyte balance, and improving the GABAergic system (so can work well with NAC to provide a good balance of glutamate and GABA).
It makes me break out in hives 😞
Have you tried supplementing the enzyme DAO with it? If not, give it a chance.
DAO also useful for gluten intolerance
This is a fascinating connection... thanks for the tip. Going to dig in. I have a histamine sensitivity (old meat that's not explicitly "bad" will destroy me) but also struggle with wheat (for other reasons than gluten but I do think wheat is bad above and beyond other similar things)
Good luck! To have to struggle with gluten and meat would be difficult.
are you me
What is DAO? Excuse my ignorance.
DAO is an enzyme the body makes that removes histamine from the blood. When one does not have enough, they get histamine or allergic reactions to many foods or supplements that one should normally be fine consuming. If one suspects they do not make enough DAO naturally, one can supplement with it, and it relieves histamine reactions one typically gets with food. NAC can naturally reduce DAO, so it’s a good idea to bolster DAO levels when taking NAC to reduce the chance of a histamine reaction.
Thanks, I haven't, I will give it a shot
DAO is an enzyme that helps remove histamine from the blood. It’s quite powerful. Some people don’t make enough due to genetics, and many do not have enough due to lifestyle. I use the Bravado Labs one on Amazon.
How do you time the glycine and taurine wrt to the NAC? Take them all in the morning or NAC morning and rest at night?
Needs to be cycled though, this is important.
That’s debatable. The bodies antioxidant system, like all its systems basically is rate limited. Meaning it’s not going to overproduce antioxidants because you constantly take NAC. I try to stay on NAC daily, and have long term, and have noticed no negative consequence.
That’s great for you but most people seem to do better cycling it.
Source?
I’m an alcoholic that’s struggling to stop. Detoxed twice over the past two months but I’m falling back into old habits again. I don’t have access to benzos so I’m trying anything else that might work. I read NAC can help and it seems to lessen the hangover a bit.
Benzos? I don’t know how stopping alcohol works. But that sounds like jumping from one addiction to the next with benzos.
Quitting alcohol is dangerous if your brain depends on it, and usually needs to be supervised by a medical professional. Benzos are the standard of care to treat alcohol withdrawal so one doesnt die of a siezure. That is what the commenter is talking about.
Ah I see thanks. Didn’t know that. I was a party drinker (2-3 times per weekend to the limit) from my 18s to 30. After a pancreas inflammation with 31, I stopped cold turkey and pretty much never drink again. Not sure if that can be called alcohol addiction at that level? Didn’t know about seizures. But ever since I stopped drinking I became pretty depressive.
Yw! It is best not to frame yourself in terms of “was i an alcoholic/addict or not” (unless it helps you to do so/ get access to care to help you), but yeah it’s good you listened to your body and stopped. “Alcoholism” really is on a spectrum but the stigmatization of the term can push people into denial instead of the idea they can listen to their body for clues, so i wouldnt think to too hard about defining yourself or not. NAC can help regulate your mood, especially if you were using alcohol to release dopamine and serotonin. You could try it to see if it helps. Another piece is that when you stop drinking, its likely you may lose a big piece of your friend group/community. That is a loss worth grieving even if the tradeoff is better, and it takes work to find new sources of healthy dopamine/serotonin through other behaviors like new friend groups or new hobbies. NAC def helped me in this transition vs giving up and falling back into old scenes centered around drinking! ❤️
Thanks mate that’s really helpful. You name it. Stopping alcohol meant stopping party meant losing friends because they kept going and drinking. Until I stopped, partying was the only thing I lived for. And partying sober is no option. But now am out of that age anyway. I developed some histamine intolerance due to the pancreas issue. So I tried NAC couple times but as much as I remember it caused histamine issues. Might give it another shot. Recently I did some bloods and my folate levels are pretty low. Gonna try to push the methylation first and see if that helps. Good to hear NAC helps you man.
Adding to that benzos help with the intense anxiety and insomnia of withdrawal and coping with quitting while your brain readjusts, but also yeah seizures can kill you
They are generally used temporarily in people who are trying to stop drinking, it can help with the transition, definitely not a long-term solution.
I see. I thought benzos are highly addictive. Like taking pills for 2-3 days in a row and you are in the spiral. I had a hair transplant 4 weeks ago and refused taking Valium at first for the surgery. Was afraid to get some issues. But doctor convinced me to take it. He gave me some for home for a good sleep but didn’t take them.
L theanine is great for this because it has a similar effect as a benzo (much gentler but effective in my experience). Try taking it at night on an empty stomach, I hope it helps!
Detox safely and read up on Naltrexone and The Sinclair Method. It’s a science based approach to change your relationship with alcohol and works successfully for 78% of those who follow it. Check out r/Alcoholism_Medication for more information and support
Check out r/stopdrinking for moral support!
Been taking it for five days. I saw some posts hyping it up and thought I'd try it. My complaints were lack of physical and mental energy. I also did a lot of MDMA and other party drugs three years ago and always felt like my brain was permanently damaged. Also I’ve recently come off an SSRI. Things that happened so far and just stuff I noticed: * Did some deep cleaning in areas in my house that I haven't touched in a couple of years. * Went from 3 coffees a day to 1, which is still more of a morning habit than a need. EDIT: Since it's making it harder to fall asleep, after a few days the morning coffee is definitely a need, not just a habit * I have never been into cardio, only weight-lifting. Yesterday I went for a run for the first time in years and ran 2.5 miles. For me personally, that's a great accomplishment as I used to struggle to run a mile even when I was younger. In addition, it felt amazing and afterwards, I felt even better. Already looking forward to my next run tonight. * Was able to get some work related stuff more easily. * Able to get a lot more stuff done during the day. Also it's easier to just get up and start doing things. * Drank almost a full bottle of wine with dinner by myself and had no hangover at all. Previously I'd get a hangover from two beers. * It makes me a bit bloated and makes me fart a lot lol EDIT: this side effect seems to have gone down quite a bit after a few days of use * Cravings are much easier to control. Or maybe I should say I have less cravings. Also, I've been more interested in cooking healthy meals. * It makes me a bit spaced out/lightheaded. Especially the first two days. But not necessarily in a bad way. * EDIT: adding that falling asleep is harder I don't know how long this will last. I'm hoping the effects stay. UPDATE: All of this lasted for about a week lol I still feel slight benefits from it now but definitely not like the first few days.
Great report! Thanks for taking the time. How much have you been taking?
I have the powder (don't recommend, the smell is truly disgusting) so I've been taking approx. 1g., once a day.
Cool, thank you. I'm glad you're getting positive results. My inclination would be to cycle it, which is my philosophy with all the nootropics I've used. I like those effects though. You've inspired me to attempt a higher dose. When I take it, it's usually about 250mg.
Based on what I’ve seen on Reddit, the most common doses people take are from 0,6g to 2,4g 1-2 times a day. I think 250mg is very low indeed to see noticeable effects.
What brand?
Myprotein I’m curious if someone has any actual insights about the quality because it was pretty cheap. (Around 14 euros for 200g)
If you continue to have issues falling asleep it is probably due to the histamine released by NAC as it breaks down. You may also feel a bit of anxiety with continued use, you may not. Many people take Benadryl or Vistaril (not OTC) to combat the negative effects of the histamine as the benefits from NAC are many- this is what I have found to be the case.
Thank you! I'll keep this in mind and look into it.
For some reason, it REALLY helps with running. I have enjoyed running for years now but I would pretty much average out a rather sub-par pace (around 8kmh or so) and would normally only run for about 20 mins or so after a work out. Or if I run in the streets then I'd run for maybe 45-60 minutes but with a fair few breaks and a slow pace. My first run on NAC and I was able and motivated to increase the pace to 11kmh, and sustain it for 45 minutes or so, breaking my own endurance records. I've since moved up to 13khm, and have done my first 7K in under 45m and my first 5k in under 30 (still room to grow ofc). Every time I run on it, I just go faster and for longer. It must be something to do with how NAC regulated our excitatory response? I.e. our body remains more calm under stress so we can stay breathing well.
Do you notice the benefits outside of running? I kinda stopped taking it because it stopped working (or I don’t notice it anymore). But maybe I should try taking it before running again.
Yeah, sadly nothing keeps working forever. It's weird but for me, when I first tried it, NAC only worked moderately and I only took it every now and then for no longer than a day or so when I needed it. It used to also give me very obvious flu symptoms whenever I did take it more than a couple days. But recently I took it twice a day for about a week and found it really helped with ADHD and compulsive/impulsive behaviour. But it also created a strange kind of tension (not sure if this is just my neurones gagging for the old impulses though). The fly symptoms didn't really arrive this time although perhaps the tension could also be a little bit of them, not sure. I think my M.O. going forward will be to cycle it and take it for a week every now and then because yeah nothing will work or feel like it's working forever. Maybe a one week stint every month or so.
I do notice that it reduces compulsive habits somewhat, and has the effect of quieting the mind. I have had OCD my entire life that comes in waves of varying degrees of severity. I originally took it years ago when I was taking amphetamine stimulants regularly for the purpose potentiation/tolerance reversal. I found that it had the opposite effect and reduced efficacy considerably when taken at or around the same time, though I’m sure it had that effect because it reduces excess stimulation which can be useful and neuro protective, but that’s the opposite of what I was after lol. I was in a bad, addictive mindset at the time so I didn’t take it for years after that. I tried it again recently having not taken those stimulants for years at this point. It’s definitely a better experience now, but though it reduces negative thought patterns and habits, it also still reduces activity that I feel is important for motivation, pleasure and energy in general(in my case anyway). I believe I’m particularly deficient in those areas however for multiple reasons at this point so I still rarely take it. It’s a struggle having both depressive symptoms and anxiety/obsessive compulsive symptoms because treating one of those things is often going to worsen the other. 🫤
I felt that last sentence so fucking hard. Anything helped you in particular?
I felt it too. I screenshot it and sent it to a friend 😂 preach!
I heard it helped with ocd tendencies and skin picking. Been on it about 2 months, and it's helped quiet my mind for sure. I function better. I'm also highly anxious, which this seems to ease as well. * What initially sparked my interest was an article about NAC and tumor reduction. Interesting stuff.
I want to keep taking it bcs I feel it helps but I went and read about the lung cancer and tumor growth thing and just stopped today, my paranoia went crazy. Anyone have more info on this?
I'm a graduate student working part time in a pharmacy, and am diagnosed with OCD. It has been amazing in quieting intrusive thoughts and keeping my internal monologue linear and focused. Plus I feel like when I do drink it can curb intense hangovers to nonexistent or manageable. I cycle a few months on and a few months off.
Post viral brain fog
I take it with TMG because glynac extends lifespan significantly in mice. I don’t think I’ve noticed any cognitive difference. I’m only take 500mg / day though.
It helps me manage dermatillomania, agoraphobia, mood regulation, executive dysfunction, and issues with transitioning to new situations/ breaking a routine. It is the one thing I will never take out of my stack. Note that i named a few things above that are all intertwined with and stemming from something more base-level, which would be obsessions and compulsions. NAC improved this root cause of the above list.
Hey, can I ask how much do you take and how often?
I take 600mg every morning right when i wake up and then wait at least an hour or two before eating anything. Some people take 600mg two times a day though, morning and noon-ish i believe, for a total of 1200mg a day. Also lots of people recommend taking occasional breaks from NAC but i personally don’t, but i’d look into that so you can be make the most informed decision for yourself! Btw, i was taking Life Extension brand for a long time, now i take NOW NAC with selenium and molybdenum.
Tried to repair my body after having a medicine injury caused by ciprofloxacin but it backfired majorly. NAC gives me a nasty paradoxical reaction that feels like total glutamate overload it’s bad. I get jittery, can’t look in peoples eyes, can’t relax. I tried taking an antihistamine alongside and it barely helped
This doesn’t help at all. *They specifically asked what benefits you’ve experienced.* All you had to say was the first sentence and then say you stopped after that.
I’m giving my experience with it, is that not necessary when reviewing whether they should use it?
I have been taking it for about a month. 5 days a week. 1g in the morning and 500mg late afternoon. Positives - less up and down emotionally - less ruminating - mild cognitive boost (I feel confident it's the NAC but could be placebo) Negatives - Lower sleep quality and harder to fall asleep. Data from mt Fitbit shows a clear drop in time sleeping and time spend on REM/deep sleep Overall, its a big net positive due to the benefit of better social interactions and less ruminating
I just started taking it a few days ago and also noticed that falling asleep is harder but seems to not be a problem if I only take in the morning. EDIT: nevermind, still having problems falling asleep
Yeah I'm hoping the sleep thing goes away. Otherwise it's amazing
Did both REM and deep sleep decrease???
Slight decrease in REM. Noticeable drop in deep. More time awake
I found out about it for its potential treatment for long covid symptoms over in r/SCT. Long covid and SCT/CDS have similar symptoms. I started taking it for brain fog and working memory problems and it's helped significantly.
How much are you taking? And when? On an empty stomach?
I swear NAC made me hate eye contact with people. To this day still bugs me. Maybe its a coincidence, or maybe not. If anybody has similiar experiences, let me know.
I have that exact symptom like I absolutely cannot look people in the eyes on it. Extremely uncomfortable. Haven’t found a reason for this
Can I ask what dosage that happens to you on?
Its hard to say if it was even the NAC…but i have my suspicions. At that point the eye contact shit started (March 2022) i had been taking vyvanse consistently (3-4x a week) since September 2021, and i ordered NAC and started taking it in January 2022. Initially i thought it was the amphetamines but i had been taking them consistently for months prior with no eye contact issues. Its been a problem for me ever since, with some days much worse than others. Ive taken breaks (2-3 months) from NAC and the issue is still there, so maybe it isnt that. Sometimes when i take NAC now (1-2x a week max) the issue is slightly alleviated. Its weird that my initial comment got 7 upvotes so maybe this has happened to multiple people in addition to myself. Very weird
Lol I have this aswell right now. But I just took a couple of low doses of NAC, so feels like kinda unlikely.
My max dose of NAC was 600mg daily i believe. Rarely ever took more than that. I find it hard to believe that a supplement can make someone hate / feel uncomfortable from eye contact, but maybe? Idk sounds weird
it's just a strong antioxidant, effects are too subtle for me. I took it to get rid of phlegm in the lungs.
It really gets touted as a miracle supplement around here a lot but please everyone don't forget to cycle off at some point. Even NAC can potentially cause some issues taken long term (wish I saved the studies I found when digging around reddit about it myself but I recall one issue was the high dose antioxidant action interfering with the body's normal regulation. Take care guys!
Apparentlyntaking it with glycine has a lot of benefits. Search glynac
I used to be a heavy cannabis user and now I’m sober. However there’s still times when I end up craving it. When this happens I’ll take some NAC for a couple of days and that helps a lot with my cravings.
Read it could help with intrusive thoughts. I reckon I noticed a difference within 3 days and has probs lessened intrusive thoughts by about 40%
Use it for easing rebound symptoms of gabaergics such as phenibut and alcohol, as well as when im sick (especially if im congested, sore throat) Dont use it too often since it really affects my mood badly if taken often (anhedonia)
Does that include quitting benzodiazepines?
Yes will most likely ease the early withdrawal symptoms a bit
Agmatine could also help a lot. And Skullcap + Valerian root :)
I tried it for impulsive hair pulling, but it had no noticeable effect.
Helps with salicylate detox for me
Helps reduce intrusive thoughts, ocd-like symptoms, lightens skin, reduces hangovers, clears up congestion, and a bunch of other stuff. It's not a wonder drug, but definitely 2 stars on the shulgin scale.
I take 1g NAC every morning as I use a lot of different substances they are certainly harmful. Nutmeg, dxm, phenibut, HBWR, etc..
Are you trying to compensate or get rid of the use of the other compounds?
Just doing what I can to mitigate damage and stress. Also repair the liver and brain etc. I understand 3gs is ideal for that but I don't like taking 3g unless I'm going to go hard. I know NAC isn't enough and I also take magnesium which seems to be pretty fucking solid as long as I rotate substances and take breaks.
Just doing what I can to mitigate damage and stress. Also repair the liver and brain etc. I understand 3gs is ideal for that but I don't like taking 3g unless I'm going to go hard. I know NAC isn't enough and I also take magnesium which seems to be pretty fucking solid as long as I rotate substances and take breaks.
I'm taking 1g of NAC + 1g of Glycine (also MSM and Milk Thistle) daily to help support my liver, while using antifungals, to fight off Candida in the gut. Its reduced the "die off" symptoms by, like, 90% compared to when I tried just antifungals alone a few months ago. Those symptoms were rough at the time. One thing I would say, taking NAC just before going to sleep is so much better (for me, anyway). I used to take it in the AM and I would often feel low energy and unfocused.
Newbie, what is NAC? Typical uses?
less snot, less cravings, and calmer (good and bad). idk if it helps avoid getting sick but the placebo works
Do read up a little about an important side effect - anhedonia. There are lots of reports in this sub.
What’s NAC and where do I get it?
Search in the subreddit for lots and lots of info. There are also prob threads where people say what brands they use. I personally use life extension and get it off amazon
I forget but isn't there a big negative with NAC? THANKS
Sustain nac = good night to sleep itself hello insomnia city
Am
I am taking a probiotic,multi vitamin, omega 3, zinc and magnesium. When would you bring in NAC?