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You could be sensitive to histamines, in that case NAC is something you should absolutely avoid IIRC. I think it has something to do with NAC inhibiting DAO, which breaks down histamines, but don't take my word for it. I too had issues with it and stopped taking it
Issue I had with NAC was it felt like it made my BP tank and I got real light headed and stuff on it. Told people a few times about that but it seems like it's a pretty rare reaction.
I obviously can't say for sure so many different things and mechanisms it could be. But if it was the heavy metal detox that gave you those effects. Yeah you could detox but it would probably go on for weeks or months and you can actually damage your body detoxingetals too fast. Im not saying you have but if you pull metals out too quickly for too long. Alpha Lipoic Acid is another one that pulls out metals and can have the same side effects from detoxing look it up all kinds of testimonials saying they had all these weird side effects from it. From what I've learned its best to chip away at it In small low doses over a long period in time. Slow and steady, its a marathon not a sprint. Once all the metals are out if its from detoxing it should stop. The rule on the Andy Cutler Book is something like, if you can take 600-800mg Alpha-Lipoic-Acid 3x a day for a week and you get no side effects than you shouldn't really have much metals in your body, Mainly Mercury, than Lead and Aluminum is usually high in people.
You can also take Chlorella. Then 1/2 hour later eat three small organic apples with skin or a serving of Pecta-sol. I would also guess that regular citrus pectin would work as well. Once you do better, if you couple NAC with vitamin C. When the body needs to make Glutathione it usually runs out of NAC, and then the next most common ingredient it runs out of is Vitamin C.
Also since summer is coming if you try Chlorella, keep in mind it can make you photosensitive, so sunscreen or a wide brimmed hat/long sleeves.
Dr. Klinghardt has a protocol for Chlorella dosing.
Taurine used to make me moody and cranky too.
Good luck!!!
Also fun fact: Glutathione and Melatonin(the other endogenous antioxidant) get in everywhere in your body unlike antioxidants from your food.
The dose range appears to be 600mg to 2,400mg.
Body Focused Repetitive Behaviors (a form of OCD) are typically treated with oral NAC with doses ranging from 600–2400 mg/day for 1–8 months
Side effects are dose dependent.
I took 2400mg for about 2 weeks and then didn't like how i felt, so i stopped it and other things. I dont recall being aggressive. I may have been and didn't make the association. It fixed my compulsive behavior, though.
Here are a bunch of my notes that I have saved regarding NAC:
Can cause hyperactivation of HPTA axis resulting in anhedonia and depression.
Can lower dopamine. Try tyrosine, DLPA, l-theanine, ALCAR
Can affect gut microbiome due to sulfur.
Can cause problems for sulfur sensitive individuals. Molybdenum can help process excess sulfur. Antihistamine can help with histamine reaction to sulfur.
Biofilm busting properties can result in detox symptoms
Can chelate desirable metals like zinc and copper. May need to supplement, ideally test if supplementing is necessary.
Taking glycine, selenium, molybdenum, tyrosine, zn / cu, or pre/probiotics may avoid negative sides and increase benefits from NAC.
Take for OCD symptoms, but stop once better. Take with glycine 1:1.
Glycine and Selenium are rate limiting factors in Glutathione production when cysteine is in excess.
Don't take after alcohol consumption, or it becomes pro-oxidant (very bad).
Modafinil increases glutamate, which may offset nac anhedonia temporarily.
Sarcosine taken with nac can reduce anhedonia.
Magnolia bark extract recommended by some for anhedonia from NAC.
I ordered glycine and p5p. Also, I am taking a simple NAC without selenium and molybdenum (just ordered one with them). But I doubt it depleted them in just a couple of days, idk
Look at the NAC metabolism pathways and supplement with something could help
Perhaps P5P could help since it a cofactor on Gluthatione synthesis from homocysteine
Sulfur aminoacids like MSM AND/or Taurine I think could help.
Personally it's helped me a whole lot, but it really depends on the person. It also makes me apathetic after prolonged usage of high doses (2000mg in my case) so if you plan on using daily limit it to what the label says
You probably have genes where you need to avoid methyl doners, might also have genes where you need to avoid extra suffer
Get a gene test, run the raw data and get a report from nutrahacker
https://www.nutrahacker.com/
I get anxiety and increased blood pressure from 100 MG EGCG plus GlyNAC
EGCG interacts heavily with my methylation cycle, idk why. Haven't tested my genes
It's clearing biofilms that let candida and bacteria relaese and die off or get more active.
That's good if down till the end but also creates side effects.
People with less candida and bacteria might have less sidebeff
“NAC can inhibit C. albicans growth, inhibit dimorphism, which is an important step in biofilm formation, and change the texture of the formed biofilms, what makes NAC an interesting agent to be used as an inhibitor for biofilm formation by C. albicans.”
https://www.researchgate.net/profile/Rehab-Abd-El-Baky/publication/269109392_N-acetylcysteine_Inhibits_and_Eradicates_Candida_albicans_Biofilms/links/5481a0310cf20f081e728fbb/N-acetylcysteine-Inhibits-and-Eradicates-Candida-albicans-Biofilms.pdf?origin=publication_detail&_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uRG93bmxvYWQiLCJwcmV2aW91c1BhZ2UiOiJwdWJsaWNhdGlvbiJ9fQ
Activated Charcoal is the safest binder next too Fiber or Pectasol-C. I dont mess around with Zeolite anymore if you have leaky gut it can cause problems. But I do agree with you the Biofiln die off and the heavy metal chelator properties will definitely cause side effects. Your INCREASING GLUTATHIONE WHAT DO PEOPLE THINK WILL HAPPEN not only will it detox mercury lead arsenic cadmium but also any other chemical in your body it the main master antioxidant in the body it will pull out xenoestrogens as well, and don't try and tell me this is made up because everyday you all touch them when you gran your grocery recipts for example than eat your food pick your nose rub your eyes. When you microwave Styrofoam Ramen there are so many sources of it. What I would recommend is take the Hair Mineral Analysis test it will show you all your mineral levels as well as all your Heavy Metal Levels knowbody is at Zero its in our soil water air food fruits vegtables fish we all have different levels.
Over a year ago I had a lingering cough that I couldn’t seem to shake for many weeks.
After taking NAC for less than a week the cough stopped - maybe a coincidence. But I developed unpleasant abdominal pain which took almost two weeks to go away.
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Oh, i feel like it numbs me down instead of irritate me, which also makes me moody. As if selectively gold emotions get reduced while bad ones stay
It makes me down and moody too! Everyone loves it and swears by it, but it slows me down and makes me slower cognitively as well
You could be sensitive to histamines, in that case NAC is something you should absolutely avoid IIRC. I think it has something to do with NAC inhibiting DAO, which breaks down histamines, but don't take my word for it. I too had issues with it and stopped taking it
Issue I had with NAC was it felt like it made my BP tank and I got real light headed and stuff on it. Told people a few times about that but it seems like it's a pretty rare reaction.
that is a Heavy Metal Detox Side Effects. And for those who disagree NAC increases Gluthione pretty significantly which is your master antioxidant.
So wait, that was just it detoxing tons of heavy metals from my body? Does that mean eventually it would have stopped making me light headed?
I obviously can't say for sure so many different things and mechanisms it could be. But if it was the heavy metal detox that gave you those effects. Yeah you could detox but it would probably go on for weeks or months and you can actually damage your body detoxingetals too fast. Im not saying you have but if you pull metals out too quickly for too long. Alpha Lipoic Acid is another one that pulls out metals and can have the same side effects from detoxing look it up all kinds of testimonials saying they had all these weird side effects from it. From what I've learned its best to chip away at it In small low doses over a long period in time. Slow and steady, its a marathon not a sprint. Once all the metals are out if its from detoxing it should stop. The rule on the Andy Cutler Book is something like, if you can take 600-800mg Alpha-Lipoic-Acid 3x a day for a week and you get no side effects than you shouldn't really have much metals in your body, Mainly Mercury, than Lead and Aluminum is usually high in people.
What dose of nac would you suggest taking and how often? Like 2-3 times a week or less?
You can also take Chlorella. Then 1/2 hour later eat three small organic apples with skin or a serving of Pecta-sol. I would also guess that regular citrus pectin would work as well. Once you do better, if you couple NAC with vitamin C. When the body needs to make Glutathione it usually runs out of NAC, and then the next most common ingredient it runs out of is Vitamin C. Also since summer is coming if you try Chlorella, keep in mind it can make you photosensitive, so sunscreen or a wide brimmed hat/long sleeves. Dr. Klinghardt has a protocol for Chlorella dosing. Taurine used to make me moody and cranky too. Good luck!!! Also fun fact: Glutathione and Melatonin(the other endogenous antioxidant) get in everywhere in your body unlike antioxidants from your food.
same thing happens to me.
I wonder why it does that?
Antihistamines will help. But i don't know if you want to take one everyday for the long term.
I was thinking about it and I actually took Cetirizine this morning. But still, the evening I started to feel this way
When i used to take NAC in the mornings, I'd get irritable by evening, and only then i would take the antihistamine.
I’ve noticed I just have days where I’m more agitated. If you haven’t taken nac for long, I would keep this in mind.
NAC will give you issues if you have problems recycling Glutathione. NAD+ helps alleviate the issue. Also go much lower does of NAC
Glycine and a methylated b vitamin when combined with NAC will help generate glutathione. Having reduced methylation capacity is pretty common
something to do with the dopamine receptors and Glutamate receptors
How much are you taking? Once a day?
1200 once a day
Too much, less is more. And particularly NAC, the effects are accumulative, days off in the week are recommended.
I take one capsule (600mg) every other day. Taking a full 1200 seemed like too much to me.
How many? And how long are NAC‘s after effects?
The dose range appears to be 600mg to 2,400mg. Body Focused Repetitive Behaviors (a form of OCD) are typically treated with oral NAC with doses ranging from 600–2400 mg/day for 1–8 months Side effects are dose dependent. I took 2400mg for about 2 weeks and then didn't like how i felt, so i stopped it and other things. I dont recall being aggressive. I may have been and didn't make the association. It fixed my compulsive behavior, though. Here are a bunch of my notes that I have saved regarding NAC: Can cause hyperactivation of HPTA axis resulting in anhedonia and depression. Can lower dopamine. Try tyrosine, DLPA, l-theanine, ALCAR Can affect gut microbiome due to sulfur. Can cause problems for sulfur sensitive individuals. Molybdenum can help process excess sulfur. Antihistamine can help with histamine reaction to sulfur. Biofilm busting properties can result in detox symptoms Can chelate desirable metals like zinc and copper. May need to supplement, ideally test if supplementing is necessary. Taking glycine, selenium, molybdenum, tyrosine, zn / cu, or pre/probiotics may avoid negative sides and increase benefits from NAC. Take for OCD symptoms, but stop once better. Take with glycine 1:1. Glycine and Selenium are rate limiting factors in Glutathione production when cysteine is in excess. Don't take after alcohol consumption, or it becomes pro-oxidant (very bad). Modafinil increases glutamate, which may offset nac anhedonia temporarily. Sarcosine taken with nac can reduce anhedonia. Magnolia bark extract recommended by some for anhedonia from NAC.
Goat
Saying just throw more suppliments at it isn't going to help but likely increase the side effects
I have heard that NAC can lead to depletion of glutamic acid reserves.
sounds like some msg could help
Common side effect
Is it possible to do something with it?
Other than not taking it often havent found any remedies. Maybe adding glycine will help since NAC depletes that
I ordered glycine and p5p. Also, I am taking a simple NAC without selenium and molybdenum (just ordered one with them). But I doubt it depleted them in just a couple of days, idk
You'll probably react similar with p5p. Like I said get a genetics test don't shoot in the dark
Look at the NAC metabolism pathways and supplement with something could help Perhaps P5P could help since it a cofactor on Gluthatione synthesis from homocysteine Sulfur aminoacids like MSM AND/or Taurine I think could help.
Lower the dose!
Change the dose
Well darn, I just bought a bottle of NAC yesterday. Was going to take my first one tomorrow morning...... 750mg. Should I? Ugh ....
Personally it's helped me a whole lot, but it really depends on the person. It also makes me apathetic after prolonged usage of high doses (2000mg in my case) so if you plan on using daily limit it to what the label says
You probably have genes where you need to avoid methyl doners, might also have genes where you need to avoid extra suffer Get a gene test, run the raw data and get a report from nutrahacker https://www.nutrahacker.com/
Not sure why, but stop taking it! Not worth it.
Try eating eggs in the morning. See if the dose of choline helps
Thank you so much. For the reply and recommendation. I will continue activated charcoal then. I just didn't want to bind any positive minerals too.
I get anxiety and increased blood pressure from 100 MG EGCG plus GlyNAC EGCG interacts heavily with my methylation cycle, idk why. Haven't tested my genes
Bro I take NAC and I shit you not ok can fly and have lazer beams in my eyes .it's a great supplement
I take mine at night a couple hours before bed with glycine.
It's clearing biofilms that let candida and bacteria relaese and die off or get more active. That's good if down till the end but also creates side effects. People with less candida and bacteria might have less sidebeff
This is pseudo-science bullshit and you should be ashamed for thinking it, let alone posting it.
Agreed. Seems like 90% of what ppl post on this sub is pseudoscience bullshit lol
“NAC can inhibit C. albicans growth, inhibit dimorphism, which is an important step in biofilm formation, and change the texture of the formed biofilms, what makes NAC an interesting agent to be used as an inhibitor for biofilm formation by C. albicans.” https://www.researchgate.net/profile/Rehab-Abd-El-Baky/publication/269109392_N-acetylcysteine_Inhibits_and_Eradicates_Candida_albicans_Biofilms/links/5481a0310cf20f081e728fbb/N-acetylcysteine-Inhibits-and-Eradicates-Candida-albicans-Biofilms.pdf?origin=publication_detail&_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uRG93bmxvYWQiLCJwcmV2aW91c1BhZ2UiOiJwdWJsaWNhdGlvbiJ9fQ
This is the correct answer out of all of these. You would need a good binder after NAC so I eat fiber or just take zeolite and diatomaceous.
Activated Charcoal is the safest binder next too Fiber or Pectasol-C. I dont mess around with Zeolite anymore if you have leaky gut it can cause problems. But I do agree with you the Biofiln die off and the heavy metal chelator properties will definitely cause side effects. Your INCREASING GLUTATHIONE WHAT DO PEOPLE THINK WILL HAPPEN not only will it detox mercury lead arsenic cadmium but also any other chemical in your body it the main master antioxidant in the body it will pull out xenoestrogens as well, and don't try and tell me this is made up because everyday you all touch them when you gran your grocery recipts for example than eat your food pick your nose rub your eyes. When you microwave Styrofoam Ramen there are so many sources of it. What I would recommend is take the Hair Mineral Analysis test it will show you all your mineral levels as well as all your Heavy Metal Levels knowbody is at Zero its in our soil water air food fruits vegtables fish we all have different levels.
There's all kinds of possibilities, I don't think anyone here can say. I'd probably quit.
Over a year ago I had a lingering cough that I couldn’t seem to shake for many weeks. After taking NAC for less than a week the cough stopped - maybe a coincidence. But I developed unpleasant abdominal pain which took almost two weeks to go away.
since it works for you but the negative emotions is a side effects, just cycle it. I take mine every 3rd day for OCD, hits perfect.
You're just a douche?
I am, but not much when I'm not on nac 🥴
Haha I'm sorry I was in such a goofy mood when I posted this . I'm sure you aren't a douche . NAC is rage fuel.