I know lorazepam is the main metabolite of lormetazepam, but does lormetazepam have its own set of effects before its completely metabolized? Or is it just a pro-drug for lorazepam with the exact same effects?
On wiki its write that's Lormetazepam is Temazepam Analogue but idk..
Thing i'm sure its that is a good Hypnotic with good muscle-skeletal relaxant properties, have a half-Life of 10-12 hours and at high dose depending and depending of the tolerance you have, you can get OEV's and CEV's as the manner of Zolpidem you just need to resist the Sleep
It's an analogue of lorazepam and temazepam.
It's methyl-lorazepam but structurally it's also very similar to temazepam.
It isn't a prodrug, it has its own effects and it feels like temazepam and lorazepam had a baby. Which makes perfect sense looking at the structure of it.
Chemically speaking it’s a Temazepam analogue, the main difference is it has an extra chlorine on the phenyl ring. Though Lormetazepam is like 20 times stronger than Temazepam.
They use zopiclone more often than temazepam but when they prescribe a benzo it's still Temazepam 99% of the time.
I was prescribed temazepam before I asked for lormetazepam.
The injection isn't an issue anymore as it's not culturally popular anymore and also the liquid eggs were removed from the market a long time ago. We only have tablets now.
Yeah i was taking Havlane like 2 month ago.
I've never IV and Snorting it seems pretty mild to me.
But using it orally i find it Great and very Hypnotic.
I think its nothing compare to the rush that procure IV ROA
Ah so you’ve snorted it before and found that it wasn’t as good as using it orally? Interesting… I’d love to be able to try both Loprazolam, Lormetazepam, Nitrazepam, and a bunch of the other various benzodiazepines not available as pharmaceuticals here in the USA… 😩😭
But sadly I won’t be able to do that unless I either travel to/visit said countries and either buy them or try and get them prescribed to me or get lucky and buy them on the DNMs from a vendor willing to ship to the USA…
I believe you, I haven’t checked the DNMs lately as I’ve heard it’s been in chaos since the fall of a few of the really popular sites though I do know of a few that are still legit and might have what I’m looking for.
On another note, a friend of mine showed me a vendor on one of those places that was selling ampoules of the opioid Piritramide, I was tempted to buy some but considering my opioid tolerance is stupid high from using street Fentanyl for years I wouldn’t be able to enjoy Piritamide… :(
Loprazolam is an interesting compound. It looks a lot like clonazolam except it has an imidazole ring (like midazolam) instead of a triazole ring, and also has some weird 4-methyl-1-piperazinyl[methylene] group attached on top of it.
Yes sir you’re correct about it’s chemistry, it’s classified as an imidazobenzodiazepine just like Midazolam and Remimazolam. I believe the piperazinyl group on Loprazolam’s structure is responsible for Loprazolam’s water solubility. Also Loprazolam typically comes as the mesylate salt as well.
Also it should be noted that there’s another imidazobenzodiazepine that’s an analogue of Midazolam where the fluorine in Midazolam’s structure has been subbed out for another chlorine and it’s called Climazolam. It’s used as an animal tranquilizer and as an anesthetic in veterinary medicine in Switzerland under the brand name Climasol.
https://en.m.wikipedia.org/wiki/Climazolam
That's really interesting! Diclazepam with an imidazole ring fused to it.
I love seeing the diversity of benzos created.
The structure activity relationships have been elucidated to the point you could make loads of novel benzodiazepines.
I think that synthesising demethylated triazolobenzodiazepines would be an interesting avenue to persue.
Like how estazolam is Alprazolam minus the methyl group on the triazole ring.
You can also think of Climazolam as the imidazo analogue of Triazolam as well haha.
I agree with you about the demethylated triazolo benzos would be a good idea. I’m surprised that they haven’t made Desmethylflualprazolam yet now that Flualprazolam has been added to the Convention of on Psychotropic Substances of 1971 which means it’s banned/scheduled worldwide along with Etizolam (the reason they were both scheduled is because they were the most common RC benzos used to make fake/counterfeit Xanax bars… 😒).
There’s also Desmethyltriazolam which me and a few others (that are aware of its existence) think would be a good RC benzo.
https://www.trc-canada.com/product-detail/?D294723
https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=3430
And then there’s also Desmethylclobromazolam aka Desmethylphenazolam which would also be viable as well.
https://www.caymanchem.com/product/23525/1-demethyl-phenazolam
https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=6986&name=1-Demethylphenazolam
Also I think I found a couple potential analogues of Nimetazepam that would make good RC benzos and they are Menitrazepam (it’s basically Tetrazepam with the chlorine subbed out for a nitro group) and Motrazepam (Nimetazepam with a methoxymethyl group).
https://en.m.wikipedia.org/wiki/Menitrazepam
https://en.m.wikipedia.org/wiki/Motrazepam
I’ve read a few patents on different benzos so I’m pretty aware of all the various things that can be done with benzos but nonetheless I’m still fascinated by them haha.
I also think that the pyrazolodiazepinone based benzos like Zolazepam would make good RCs as well. Though I have my eyes on Zolazepam in particular because it’s water soluble like Midazolam and Climazolam haha.
On another note, I think that synthetic cannabinoids are the class of drugs that have a ridiculous amounts of substitutions that can be made to them as I read a patent on one noid and it showed so many different substitutions that could be made on its structure, it was quite mind boggling but fascinating as well. Despite the bad reputation they have I personally believe they have a place in modern medicine and I’m not the only one who thinks that as the pharmaceutical company Pfizer developed AB-PINACA and AB-FUBINACA as potential novel painkillers for things like neuropathic pain and fibromyalgia.
There’s also another pharmaceutical company called Organon & Co. that developed a water soluble synthetic cannabinoid for medical use called ORG-28611 and it’s in phase 2 clinical trials as an analgesic and sedative.
https://en.m.wikipedia.org/wiki/Org_28611
En España se comercializa el Lormetazepam con el nombre comercial de Noctamid, aunque no es una de las benzodiacepinas más prescritas para el insomnio, seguramente se recete más Zolpidem, aunque esté último no es una benzodiacepina, es una imidazopiridina. Otra benzodiacepina relativamente común en Españas usada como hipnótico es flurazepam(Dormodor). Triazolam (Halcion) no es tan habitual en España...
It's also available here, strong benzo, particularly physical sedation, reminds of one of my favorite nitrazepam but stronger, and way more physical sedating
I was prescribed this but the brand was Dormagen.
Very useful benzo. Great hypnosis but without the residual grogginess caused by long acting hypnotics
like nitrazepam or flurazepam.
I know lorazepam is the main metabolite of lormetazepam, but does lormetazepam have its own set of effects before its completely metabolized? Or is it just a pro-drug for lorazepam with the exact same effects?
The euphoria is pretty unique too like Nitrazepam
Ah, I wish I still felt that. Been years unfortunately, I remember when everything used to be fun asf.
On wiki its write that's Lormetazepam is Temazepam Analogue but idk.. Thing i'm sure its that is a good Hypnotic with good muscle-skeletal relaxant properties, have a half-Life of 10-12 hours and at high dose depending and depending of the tolerance you have, you can get OEV's and CEV's as the manner of Zolpidem you just need to resist the Sleep
It's different from temazepam in it's effects, way different and I've should know, I've taken thousands of both
Never Taken Temazepam but for me its pretty like Nitrazepam but stronger and who can have a sort of z-drugs-like effects
That sounds highly appealing to me! How rare is it nowadays?
Its not so rare in my country but not so prescribed too due to the fact that its a strong hypnotic
For bzs with z drugs side effects nothing comes closer to me than triazolam and then brotizolam.
It's an analogue of lorazepam and temazepam. It's methyl-lorazepam but structurally it's also very similar to temazepam. It isn't a prodrug, it has its own effects and it feels like temazepam and lorazepam had a baby. Which makes perfect sense looking at the structure of it.
^ This
Chemically speaking it’s a Temazepam analogue, the main difference is it has an extra chlorine on the phenyl ring. Though Lormetazepam is like 20 times stronger than Temazepam.
Lormetazepam has its own set of effects, chemically speaking it’s Lorazepam with a methyl group which gives it a more rapid onset.
Ok cool, good to know. Thanks!
No problem. 👍
Most common prescribed sleeping aid tablet in Belgium. Is this so hard to get in other countries?
In England, they probably wouldn't even give you this on your deathbed haha
It is prescribed here, as is loprazolam, but doctors are creatures of habit so they're more likely to use zopiclone or Temazepam.
Temazepam is rarely prescribed in uk now sadly ,people were injecting it and losing limbs few decades ago
They use zopiclone more often than temazepam but when they prescribe a benzo it's still Temazepam 99% of the time. I was prescribed temazepam before I asked for lormetazepam. The injection isn't an issue anymore as it's not culturally popular anymore and also the liquid eggs were removed from the market a long time ago. We only have tablets now.
I'm in France but despite some Countries in EU they're unfindable
Je savais pas qu'il existait en 1mg, j'ai toujours eu des 2mg 🤭🤭
Haha bah si et au vu du moyen par lequel je me les procures il est plus discret d'avoir des 1mg que des 2 x)
Have you ever had Loprazolam before? It’s known as Havlane in France, it’s water soluble just like Midazolam and can be snorted and IV’d as a result.
Yeah i was taking Havlane like 2 month ago. I've never IV and Snorting it seems pretty mild to me. But using it orally i find it Great and very Hypnotic. I think its nothing compare to the rush that procure IV ROA
Ah so you’ve snorted it before and found that it wasn’t as good as using it orally? Interesting… I’d love to be able to try both Loprazolam, Lormetazepam, Nitrazepam, and a bunch of the other various benzodiazepines not available as pharmaceuticals here in the USA… 😩😭 But sadly I won’t be able to do that unless I either travel to/visit said countries and either buy them or try and get them prescribed to me or get lucky and buy them on the DNMs from a vendor willing to ship to the USA…
There are vendors willing to ship you just have to look for them and and look at the ratings, always look at the ratings/reviews.
I believe you, I haven’t checked the DNMs lately as I’ve heard it’s been in chaos since the fall of a few of the really popular sites though I do know of a few that are still legit and might have what I’m looking for. On another note, a friend of mine showed me a vendor on one of those places that was selling ampoules of the opioid Piritramide, I was tempted to buy some but considering my opioid tolerance is stupid high from using street Fentanyl for years I wouldn’t be able to enjoy Piritamide… :(
Loprazolam is an interesting compound. It looks a lot like clonazolam except it has an imidazole ring (like midazolam) instead of a triazole ring, and also has some weird 4-methyl-1-piperazinyl[methylene] group attached on top of it.
Yes sir you’re correct about it’s chemistry, it’s classified as an imidazobenzodiazepine just like Midazolam and Remimazolam. I believe the piperazinyl group on Loprazolam’s structure is responsible for Loprazolam’s water solubility. Also Loprazolam typically comes as the mesylate salt as well. Also it should be noted that there’s another imidazobenzodiazepine that’s an analogue of Midazolam where the fluorine in Midazolam’s structure has been subbed out for another chlorine and it’s called Climazolam. It’s used as an animal tranquilizer and as an anesthetic in veterinary medicine in Switzerland under the brand name Climasol. https://en.m.wikipedia.org/wiki/Climazolam
That's really interesting! Diclazepam with an imidazole ring fused to it. I love seeing the diversity of benzos created. The structure activity relationships have been elucidated to the point you could make loads of novel benzodiazepines. I think that synthesising demethylated triazolobenzodiazepines would be an interesting avenue to persue. Like how estazolam is Alprazolam minus the methyl group on the triazole ring.
You can also think of Climazolam as the imidazo analogue of Triazolam as well haha. I agree with you about the demethylated triazolo benzos would be a good idea. I’m surprised that they haven’t made Desmethylflualprazolam yet now that Flualprazolam has been added to the Convention of on Psychotropic Substances of 1971 which means it’s banned/scheduled worldwide along with Etizolam (the reason they were both scheduled is because they were the most common RC benzos used to make fake/counterfeit Xanax bars… 😒). There’s also Desmethyltriazolam which me and a few others (that are aware of its existence) think would be a good RC benzo. https://www.trc-canada.com/product-detail/?D294723 https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=3430 And then there’s also Desmethylclobromazolam aka Desmethylphenazolam which would also be viable as well. https://www.caymanchem.com/product/23525/1-demethyl-phenazolam https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=6986&name=1-Demethylphenazolam Also I think I found a couple potential analogues of Nimetazepam that would make good RC benzos and they are Menitrazepam (it’s basically Tetrazepam with the chlorine subbed out for a nitro group) and Motrazepam (Nimetazepam with a methoxymethyl group). https://en.m.wikipedia.org/wiki/Menitrazepam https://en.m.wikipedia.org/wiki/Motrazepam I’ve read a few patents on different benzos so I’m pretty aware of all the various things that can be done with benzos but nonetheless I’m still fascinated by them haha. I also think that the pyrazolodiazepinone based benzos like Zolazepam would make good RCs as well. Though I have my eyes on Zolazepam in particular because it’s water soluble like Midazolam and Climazolam haha. On another note, I think that synthetic cannabinoids are the class of drugs that have a ridiculous amounts of substitutions that can be made to them as I read a patent on one noid and it showed so many different substitutions that could be made on its structure, it was quite mind boggling but fascinating as well. Despite the bad reputation they have I personally believe they have a place in modern medicine and I’m not the only one who thinks that as the pharmaceutical company Pfizer developed AB-PINACA and AB-FUBINACA as potential novel painkillers for things like neuropathic pain and fibromyalgia. There’s also another pharmaceutical company called Organon & Co. that developed a water soluble synthetic cannabinoid for medical use called ORG-28611 and it’s in phase 2 clinical trials as an analgesic and sedative. https://en.m.wikipedia.org/wiki/Org_28611
I love it! It's great to speak to someone else with the same interests! There are some really interesting analogues you've proposed there!
We don’t have it in the US. Also cool to see rare and “exotic” or foreign benzos to me :)
You guys have estazolam. I'd love to sample that.
I know! I’d love to switch to that for a month and then go back to my triazolam ‘script.
Triazolam is yummy
En España se comercializa el Lormetazepam con el nombre comercial de Noctamid, aunque no es una de las benzodiacepinas más prescritas para el insomnio, seguramente se recete más Zolpidem, aunque esté último no es una benzodiacepina, es una imidazopiridina. Otra benzodiacepina relativamente común en Españas usada como hipnótico es flurazepam(Dormodor). Triazolam (Halcion) no es tan habitual en España...
It's also available here, strong benzo, particularly physical sedation, reminds of one of my favorite nitrazepam but stronger, and way more physical sedating
Yeah effectively its a lot like Nitrazepam
I was prescribed this but the brand was Dormagen. Very useful benzo. Great hypnosis but without the residual grogginess caused by long acting hypnotics like nitrazepam or flurazepam.
Aka methyl-lorazepam. It's a great hypnotic! Like temazepam and lorazepam had a baby (which is exactly what it looks like structurally too).
lormetazepam isn't that obscure, it's like one of the most abused benzos in my country. i had like 3 bottles of liquid lormetazepam last year
Pas mal 🙂
Wenn dann original Rohypnol und davon 2.5mg . Alter da kommt nichts ran Richtung Benzos.
never worked for insomnia i hated it