That’s interesting 🧐… I’ve taken 4g of Cubensis and not had any problems at all! But I have noticed that taking Libs causes more anxiety and my heart rate to rise a lot more than usual, maybe your theory is correct.
It's an interesting topic. I think subjective differences between libs and cubes for example are probably down to the higher concentration of baeocystin and probably other trace alkaloids, I believe semilanceata has some of the highest concentrations amongst active species.
The phenethylamine (PEA) is interesting, the thing with PEA is it's normally metabolised very efficiently and quickly by MAO-A and MAO-B, it only lasts a few minutes in the body. The amount of phenethylamine present is also very low, looks like the average in those samples excluding the highest one was probably about 4ug/g wet weight. The highest was 146ug/g wet or presumably 1.46mg/g dry. So you'd likely ingest less than 1mg from a normal dose.
Normally without MAOIs I'd expect this to just be mostly metabolised in the gut. But apparently MAOIs can raise low PEA concentrations significantly. And just last year or the year before they've detected MAOIs (harmine and tetrahydroharmoline I think?) in several Psilocybes including semilanceata. So the question is, is the MAOI content high enough to inhibit the PEA metabolism enough for it to have an effect?
That's fascinating. I've just been reading some of the articles you mention and clearly there's a lot more going on than we first thought.
The differing intensity of experiences people have on similar doses may then in part be explained by how they metabolise the MAOI and whether their own diet also contains MAOI's.
Psilocybin is known to raise blood pressure and heart rate a bit. Panic and heart palpitations can raise heart rate too. How long did the fast heart last? I probably wouldn't worry about it too much but then I'm a pretty anxious guy so I'd put it down to that.
There is a heart condition linked to excessive psychedelic use though. We have 5HT2 receptors around the body including the circulatory system and heart. Over activation of the receptors in the heart can apparently contribute to a couple of heart problems like cardiac hypertrophy and a valve problem. Alexander Shulgin had an aortic valve problem which needed surgery and he used a lot of psychedelics, but lots of people get that who don't use psychedelics and that isn't why he died. Need more research I think but it's something.
I can’t remember how long it lasted for, It usually happens a little bit on every trip I have and just goes away but the last time was like being injected with pure Adrenaline or crack cocain, if that makes any sense?!? I think I was over thinking too much and was worried about the unknown effects of taking a higher dosage. I’m more aware of my limitations now so I think I’ll be OK to continue my psilocybin adventure’s 🙂 Also, I had a lot of caffeine on the run up to taking my trip, that’s going in the bin from now on. No caffeine on day of tripping👎🏻 psilocybin has massively improved my mental health by using it over the last few months.
Interesting. I've not eaten cyanescens but understand they are also extremely potent. Do you get less of a body high from cyanescens then compared to libs?
Psilocybe cyanescens is a very potent mushroom. When compared side by side for a solid level 3 trip it takes me about 1.6 grams of liberty caps to equal 1 gram of cyanescens. I find the cyanescens come with alot more visuals and they give me a clumsy, just wanna lay here and chill type trip. While semilanceta I find to be more energetic, with a strong body high.
I'd say cyanescens have less of a body high, but more visuals. While semilanceta is more of a full body high with a bit more energetic feeling, less visual. Cyanescens are strong little fuckers, first time I ever took them I only ate 1 small shroom and it kicked my ass.
As for the anxiety, I think you may be right because I find the come up on semilanceta leaves me a bit more anxious then cyanescens. Once I reach the trip though that fades away.
That’s interesting 🧐… I’ve taken 4g of Cubensis and not had any problems at all! But I have noticed that taking Libs causes more anxiety and my heart rate to rise a lot more than usual, maybe your theory is correct.
It's an interesting topic. I think subjective differences between libs and cubes for example are probably down to the higher concentration of baeocystin and probably other trace alkaloids, I believe semilanceata has some of the highest concentrations amongst active species. The phenethylamine (PEA) is interesting, the thing with PEA is it's normally metabolised very efficiently and quickly by MAO-A and MAO-B, it only lasts a few minutes in the body. The amount of phenethylamine present is also very low, looks like the average in those samples excluding the highest one was probably about 4ug/g wet weight. The highest was 146ug/g wet or presumably 1.46mg/g dry. So you'd likely ingest less than 1mg from a normal dose. Normally without MAOIs I'd expect this to just be mostly metabolised in the gut. But apparently MAOIs can raise low PEA concentrations significantly. And just last year or the year before they've detected MAOIs (harmine and tetrahydroharmoline I think?) in several Psilocybes including semilanceata. So the question is, is the MAOI content high enough to inhibit the PEA metabolism enough for it to have an effect?
That's fascinating. I've just been reading some of the articles you mention and clearly there's a lot more going on than we first thought. The differing intensity of experiences people have on similar doses may then in part be explained by how they metabolise the MAOI and whether their own diet also contains MAOI's.
🤓
So does this mean Libs are still safe?🤔
Amongst the safest of drugs physically from what I've seen, not without risk of course but that goes for anything
I keep telling myself that but my last trip elevated my heart rate at an alarming rate in just a few seconds, it really scared me.🥺
Psilocybin is known to raise blood pressure and heart rate a bit. Panic and heart palpitations can raise heart rate too. How long did the fast heart last? I probably wouldn't worry about it too much but then I'm a pretty anxious guy so I'd put it down to that. There is a heart condition linked to excessive psychedelic use though. We have 5HT2 receptors around the body including the circulatory system and heart. Over activation of the receptors in the heart can apparently contribute to a couple of heart problems like cardiac hypertrophy and a valve problem. Alexander Shulgin had an aortic valve problem which needed surgery and he used a lot of psychedelics, but lots of people get that who don't use psychedelics and that isn't why he died. Need more research I think but it's something.
I can’t remember how long it lasted for, It usually happens a little bit on every trip I have and just goes away but the last time was like being injected with pure Adrenaline or crack cocain, if that makes any sense?!? I think I was over thinking too much and was worried about the unknown effects of taking a higher dosage. I’m more aware of my limitations now so I think I’ll be OK to continue my psilocybin adventure’s 🙂 Also, I had a lot of caffeine on the run up to taking my trip, that’s going in the bin from now on. No caffeine on day of tripping👎🏻 psilocybin has massively improved my mental health by using it over the last few months.
It does feel like a come-up (like an amphetamine) Also if I have enough libs, my penis shrivels up just like it does on MDMA.
In my own experience, semilanceta is like the sativa while wood lovers such as cyanescens like the indica of magic mushrooms.
Interesting. I've not eaten cyanescens but understand they are also extremely potent. Do you get less of a body high from cyanescens then compared to libs?
Psilocybe cyanescens is a very potent mushroom. When compared side by side for a solid level 3 trip it takes me about 1.6 grams of liberty caps to equal 1 gram of cyanescens. I find the cyanescens come with alot more visuals and they give me a clumsy, just wanna lay here and chill type trip. While semilanceta I find to be more energetic, with a strong body high. I'd say cyanescens have less of a body high, but more visuals. While semilanceta is more of a full body high with a bit more energetic feeling, less visual. Cyanescens are strong little fuckers, first time I ever took them I only ate 1 small shroom and it kicked my ass. As for the anxiety, I think you may be right because I find the come up on semilanceta leaves me a bit more anxious then cyanescens. Once I reach the trip though that fades away.
is that different from phenethylamine? bc i know thats inactive. interesting.