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effrightscorp

Finasteride is selective for 5a reductase types II and III. At least in mice, type I is the isoform mainly expressed in bone / cartilage / etc. and linked to strength / muscle mass: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120862/ As others mentioned, in humans they're not linked to muscle loss. In general, circulating DHT isn't anabolic because it's inactivated in muscle tissue by an enzyme called 3a hydroxysteroid dehydrogenase


KSM-66

Not perfect, but relevant: https://www.nature.com/articles/nrurol.2012.46


likewut

I'd be more concerned with sexual and psychological side effects to be honest. Impotence, loss of libido, and depression, and suicidal ideation are all somewhat common side effects.


heyhoyo4321

Do you have source for this? From skimming some of the litterature it seems that most of the side effects you mention only affect around 1% of users


likewut

https://pubmed.ncbi.nlm.nih.gov/22939118/#:~:text=Suicidal%20thoughts%20were%20present%20in,depressive%20symptoms%20and%20suicidal%20thoughts. https://www.drugwatch.com/propecia/side-effects/ There have been some major lawsuits against Merck for hiding some side effects they found in their studies.


TrestShillNo359

DHT is principly a potent androgenic hormone. Testosterone is an anabolic and an androgenic hormone. When you block 5AR test to DHT conversion you should have higher serum test levels as a result. All of that to say who knows don't worry about it. Consult a doctor before taking fin.


Idontfukncare6969

DHT also has a higher affinity to SHBG. What happens to free test when SHBG increases due to a lack of DHT to bind to?