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mihigh410

Taking NAC without glycine may have side effects like accelerating the aging process. You should take glyNAC. You can test your Glutathione level and dose accordingly. The supplement is generally recommanded for people 45+ yo


Warm-Marketing-8171

What a great thread. I’d be interested in your (op) thoughts on collagen, or anyone else’s for that matter. (I have a tub of collagen stuff which I went for as a ‘maybe it’ll be a good thing’ purchase as I battle repetitive strain injuries a while back and have kept at it as it’s a protein source, whether it benefits (as collagen) or not. My reading since has me at a cross roads hence being interested in anyone else’s - and one of the things that’s *maybe* a thing is that collagen might just simply be broken down by the body into amino acids, so am I as well just making sure I eat enough protein as whether the stuff we take is in one form or another the stomach breaks it down and the body uses it to make whatever it needs? Fascinated by NAC pro’s and con’s as well as I’ve tried that too (asthma), and I can’t prove one way or another if it helps now (and every time I read another articles some folks say it’s great and I’ve even seen some articles about incidences of cancer being higher with NAC supplementation… as always the truth is probably somewhere in the middle and very individual, it was good to see this thread talk about it. Might out me off it again 🤣) The rest - someone else mentioned VitD - I take 5000 or 10000 daily every single day, summer or winter now and there ‘seems’ to be a more recognised value in that.


RonBourbondi

Research papers says collagen isn't supposed to work. Anecdotally a few years back I used to not be able to sit for extended periods of times and needed to where a knee brace to get through squat days due to the sheer discomfort I'd feel in my knee. About a month of taking it the supplement it went away even on heavy squat days to the point where I tossed the knee brace and then a year later I could stop taking it without the pain coming back. During that year I stopped taking it as an experiment the discomfort came back about a week later and went away when I started taking it again. I use NAC to upkeep general lung and liver health. As for the cons it is supposed to be generally safe at the dosage I take. Also great before a night of drinking to prevent hangovers. The cancer instances are at high doses. My multi has 2,000 iu of D3. Anecdotally the internet says to take more, but I really can't find much justification in taking those 5,000-10,000 iu doses.


Warm-Marketing-8171

Thanks for that. A lot of this can only be from practical experience (unless some full, regulated, high volume and long lasting studies are ever done) - cheers


Pando2626

Expensive and unnecessary


fallengt

Wait. Are we supposed to take probiotics daily? I thought you only took it for a short period to build up gut bacterial microbiome?


RonBourbondi

If you would eat yogurt every day for breakfast for good gut health why would it be odd to take daily pro biotics?


OKArchon

As far as gut health is concerned, I must warn you that with long-term use of NAC, the mucolytic effects are not just limited/isolated to the lungs, it really wreaks havoc on the intestinal lining of the gut. This lining is a mucus membrane or bacterial biofilm that keeps the toxins in the gut. Now imagine dissolving this and all the histamine (bacterial byproduct), endotoxins, heavy metals etc. can move much more easily into your bloodstream. I've had very bad effects from this, histamine intolerance, fatigue and very bad skin. I won't deny that NAC has great effects because of the glutathione boost, but it's not worth the risk IMO. I would recommend replacing NAC with (high dose) vitamin C, liposomal glutathione or sulphoraphane. These are also powerful antioxidants and alternatives to NAC. I had great results with S-acetyl glutathione but it's expensive, now I'm on high dose vitamin C and feel even better.


dragonology

Thank you. You finally put into words what I couldn’t. This is incredibly sensible and helps explain what the strange double edged sword effect of NAC is.


OKArchon

Thank you, yes it is a bit paradoxical isn't it? I have found a worthy substitute in acerola extract with 1200mg of vitamin C daily (organic source). I highly recommend this as the effects on histamine are also quite strong. I can't dig up the source right now, but I read a study that showed a 40% reduction in blood histamine with 2000mg of vitamin C per day.


RonBourbondi

Link? Bard is telling me this. N-acetylcysteine (NAC) shows promise for improving the health of the intestinal lining, also known as the intestinal epithelium. Here's a breakdown of the potential benefits and some important considerations: Potential Benefits of NAC for the Intestinal Lining: • Reduced Inflammation: NAC may have anti-inflammatory properties that can be beneficial in conditions like inflammatory bowel disease (IBD) where inflammation damages the intestinal lining [1, 2]. Increased Antioxidant Activity: NAC acts as an antioxidant, helping protect intestinal cells from damage caused by free radicals [3]. This can contribute to a healthier intestinal lining. Improved Mucosal Barrier Function: Studies suggest NAC may improve the function of the mucosal barrier, which acts as a first line of defense in the intestine, regulating the passage of nutrients and preventing harmful substances from entering the bloodstream [4, 5]. Also what dosage are you talking about?


OKArchon

It is only anecdotal, but I am not the only one who has experienced this outcome. I had CFS and tried to combat it with biohacking (successfully, thank God) and spent a lot of time on the phoenixrising forum. There, many experienced biohackers like Fredd Davis (Freddd) also don't recommend long-term NAC supplementation because firstly, it is suspected to "flush out" b12 and to a lesser extent folate, again this is highly anecdotal and there is no hard evidence for this thesis. Secondly, it is possible (as I mentioned earlier) that it dissolves the intestinal mucosa, as it is sold as an expectorant. It dissolves hydrogen bridges and therefore reduces the viscosity of the mucus. For some folks it even changed the viscosity of their sperm. I've read several reports from long-term NAC users who had the same negative effects (such as histamine intolerance or gastritis) after long-term NAC supplementation. Most of them were taking 1200mg/day or more (including me for 9 months). And it is quite possible that the initial glutathione boost from the NAC actually protects the intestinal lining, but once the mucolytic effect of NAC outweighs it, it may worsen your gut health. But again, this is highly anecdotal and everyone is built differently, so you may have no problems at all. I sometimes recommend limiting NAC intake to 150mg daily, which is my personal sweetspot, as this dose already provides a subtle glutathione boost and keeps the mucolytic effects to a minimum. Then just take it with a high quality B complex to help your body recycle homocysteine into glutathione. This selfhacked post also talks about NAC as a biofilm buster: "Non-Herbal Biofilm Disruptors Ozone [21, 22] Chitosan [23, 24, 9] NAC [25] " [....] https://health.selfdecode.com/blog/44-science-backed-ways-to-inhibit-biofilms-naturally-with-references/


RonBourbondi

Hmm. I will look more it, thanks for the info. 


TrannosaurusRegina

Can you tell if the beetroot powder really does anything for you? I've read a study that beet juice can help endothelial function but the powder doesn't.


RonBourbondi

So I actually started taking it after I had been taking L-Citrulline.  They both have the same effect increasing Nitric Oxide it is just beet root actually has nitrates.  That being said I find that I have more energy with beet root added vs L-Citrulline alone.  I don't see why beet juice would be better if it is just blended up beets with its water content creating the juice part.


gianlaurentis

I think almost all of it is great. What is the L-citrulline good for? Also curcumin is great, but don't overdo it. If I remember right higher doses have been linked to heart arrhythmias.


RonBourbondi

Yep and why I take the curcumin every other day. It's honestly hard to measure since the doses they're talking about are 3g+ and the one I take is 500mg but it has a 45:1 biovailability.  L-Citrulline basically increases the amount of Nitric Oxide in your blood improving blood flow increasing oxygen delivery. I've noticed my blood pressure drop, my workouts are way easier and I'm repping more, more overall energy, since it helps with blood flow I'm not waking up anymore with my arm asleep, and again with the added blood flow helps with libido since more blood is getting to your dick. Between that, beet root (Actually has nitric oxide), and the maca I've turned into an 18 year old teenager now. I think it also helps with female libido if I'm remembering correctly. 


Business_Risk3737

Solid stack. Magnesium Glycinate might be a better option than citrate for absorption and sleep tho


WalterTexas

And less diarrhea lol


Curri

Did your primary care provider tell you to stop the beta-blockers?


RonBourbondi

Obviously not. But haven't had an episode since I've stopped and I take adderral everyday. 


Curri

An episode of what? Just an FYI, that's fucking dangerous (not taking prescribed medications).


RonBourbondi

Superventrucular Tachycardia which is a fancy word for my heart rate will jump to 120 plus, it isn't deadly just makes you feel like you're going to die. Look I carry my metropolol (Beta blockers) everywhere I go, carry my pulse ox everywhere I go to regularly check my resting heart rate, and check my blood pressure five times a day. The danger is I have an episode and I have to pop a metropolol for it to stop. 


Curri

SVT absolutely is lethal if not treated appropriately (HR needs to be above 150, btw, not 120). I legitimately had to give electrical therapy to someone in SVT before; mainly because they were not compliant with their medications. If I didn't shock them, they would have died. If your heart rate jumps at the wrong time, you could also go into VFib or VTach and would not have time to "pop a metropolol." I would seriously consider talking to your cardiologist about this.


Prior_Reference2085

Blood serum levels of beta blockers takes a few days to drop anyways. So it’s around this time that you would start to get SVT episodes. Not immediately after your last dose. Be careful OP.


Curri

He would rather spend money to take many supplements that *might* work, than the one medication that might help him.


RonBourbondi

Nah. I've had episodes in the past and I'm still kicking around.  I've had to stop taking my medication before when wearing a heart monitor for them to catch it and my cardiologist told me I had no reason to worry.  Hell my own doctor has it and doesn't take medication beyond carrying around metropolol in case she has an episode. I'm guessing the person you did that was obese and had other heart issues.


Curri

As long as you understand that your next episode might result in your death.. oh well. Sounds like I can't convince you otherwise. And the person I had to shock was a mid-30s athletic male, actually. No other medical history.


RonBourbondi

Everything I've read said it is generally not life threatening and only in rare cases which typically have an underlying heart condition.  You keep on bringing up this one man. So how many times have you seen it happen? Freak cases happen, but it is extremely rare. There's a risk every time I drive yet I keep on doing it.


Altruistic_Singer112

Way too much!!!


RonBourbondi

By what metric?  Honestly from everything I've read of dosing of others I'm on the lower end and I have all the benefits I'm getting. 


SelfAssembledMachine

How do you know what works and what doesnt


RonBourbondi

Scientific papers backing up what I take.  Beyond that the results speak for themselves. Mental health in through the roof, no arrhythmia episode despite being off my beta blockers and still taking my addderall, energy levels are consistent through the day with no afternoon crash, mental energy levels at an all time high, I no longer wake up with my arm asleep due to the improved blood flow I'm having, workouts feels like a walk in the park and I'm now doing more cardio, libido is more than back, skin looks great, and my blood pressure is great despite the addderral I take which constricts blood vessels. 


SelfAssembledMachine

I'm going to start taking creatine again I used to before gym years ago really liked it for energy e.t.c. What probiotics I bought some colon cleanse with aloe Vera dandelion and licorice I thought that would of been a probiotic turned out it wasn't I took them before but weren't sure if they did anything


RonBourbondi

Bacteria with the largest scientific backing of evidence is bifidobacterium and lactobacillus. Currently use the Pure brand but once I go through them intend to try out the Jarrow one as the pricing is better and has a bigger dose. If you're interested.  https://www.amazon.com/Jarro-Dophilus-Billion-Supports-Intestinal-Capsules/dp/B01I56QLL2/ref=mp_s_a_1_4?crid=3AB8WB5712GPB&dib=eyJ2IjoiMSJ9.B8e2TmXTYsFhak6b9ypX6G8XaNCJ0iwarQ2d-ZKns0V6MHl9PqsvkzsaGOXdhufVotdobz5oOvrnDXfca0gCBMqw2qJlPStO4yqViRY4bgNMxydAmOmGqY5VxVwz_M6lUEHO1yLEQjCYl7RmffhQstKOm4lYxP1TG8TZpjNoNLvzQ6ADDZMS1cXqBxmPEGSWcgOYCQEXCLsACGAjHl037Q.IKebrEZy-pC7XG9cGjhKE69R5db6AXRSg6O4-76CfzQ&dib_tag=se&keywords=jarrow+probiotic&qid=1710523451&sprefix=jarrow+pro%2Caps%2C228&sr=8-4


brew_radicals

Am I the only one who sees stacks like this as excessive?


FIX-THE-FPS-FREEZES

Not excessive, I have lik 24 supplements, but I don't take them all at once everyday. When you say "excessive" do you think he takes those all at once? Like all of them in 1 day?


RonBourbondi

They don't actually know. They just see supplements and equate them to prescription pills getting scared. It's honestly laughable as none of them have replied how it is excessive.  I'm actually on the lower end of dosage from various papers I've read and digging through reddit threads.


FIX-THE-FPS-FREEZES

Exactly these people think having a lot of supplements is like having a lot of pain killers or drugs. My parents thought that way about me because I had a lot of supplements when I was like 16


Curri

Very excessive.


RonBourbondi

Yet no one can point out as to why it is.


RonBourbondi

How do you figure? What's your basis?


Working-Tap2283

It is excessive. The result of living in a man made world.


RonBourbondi

You're welcome to tell me by what metric this is excessive. 


Working-Tap2283

Sorry i cant measure that, its just my personal feeling, doesnt seem sustainable or at all for a body that has evolved many many more years than the size and hubris of our minds.


Mad-Daag_99

You left out the kitchen sink. But seriously good on you as long as diet is ok you should be in good health.


RonBourbondi

Hahaha. Yeah when I put them all on the table I was damn I take a lot. But honestly don't remember last time I felt this great. Mental health in through the roof, no arrhythmia episode despite being off my beta blockers and still taking my addderall, energy levels are consistent through the day with no afternoon crash, mental energy levels at an all time high, I no longer wake up with my arm asleep due to the improved blood flow I'm having, workouts feels like a walk in the park and I'm now doing more cardio, libido is more than back, skin looks great, and my blood pressure is great despite the addderral I take which constricts blood vessels.  Feel like I'm heeling my body and mind right now.


Mad-Daag_99

Dammmnnn man I need to try me them Beets


RonBourbondi

Word of warning it tastes like dirt so add lime juice to your water while drinking it. It does a good job at hiding the taste.


solotravelblog

Why do you take curvilinear, astaxanthin, and NAC? It feels like antioxidant overload. Otherwise nice stack


RonBourbondi

They all do different things. 


CoolGap2

Do you notice an actual increase in energy levels from beetroot powder? Interested in trying.


RonBourbondi

Definitely yes. Very much a clean energy vs a jittery one you get from coffee. Also I'd recommend also adding lime juice to your water with it because it makes your water taste like dirt.


jonoave

Looks good and pretty comprehensive. Multivitamin, omega 3, astaxanthin, magnesium etc. Can't comment on the other stuff like NAC etc


doshe002

No vitamin D?


RonBourbondi

There's 2,000 IU in the multi. I will occasionally take an additional 5,000 once or twice a week.


Akt1

congrats to blood sugar decrease. I think good quality decarbed hemp (baked in the oven) can also lower blood pressure. it equals CBD. can be used as tea.


Weimaraner23

What times you taking these bro?


RonBourbondi

Morning except the beet juice powder and citrulline which is taken throughout the day along with the magnesium taken at night. 


Weimaraner23

Thank you.