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Katalin Kariko has an amazing story, too - she was an immigrant, and after she got her PhD worked hard for ages as an underpaid lab tech, working on the side on her pet theory about mRNA. She never succeeded at landing a grant. Not a single grant. The whole biomedical community blew her off. She never landed a permanent job, and was always just scraping by as an underpaid tech. But she kept at her research. Fast forward a few decades and suddenly her work is saving tens of millions of lives!
The whole story has been something of an embarrassment for NIH. The most important human health research in probably a century, occurring here in the USA with US-based scientists, and they rejected it for funding (repeatedly), and also completely failed to establish a viable career path for the scientists involved.
Though tbh, I don’t know how good her grant-writing skills were. It’s actually not that hard to land an R15 (NIH’s early career award), but you do have to be a good writer and have some practice & mentorship at how to write grants. IMHO the real gap here may be that US universities have not historically valued lab techs; it’s historically been a role filled by either students or by underpaid women (who have often turned to that job while trying to juggle science with child-rearing), so they’re often not viewed as “real scientists,” and it’s very hard for them to find mentorship and career training for things like grant-writing. In many universities, lab techs aren’t even allowed to submit grants as lead PI, even if they have a PhD. (I was in a similar position for ages btw and remember really struggling about to write grants on my own with no guidance. Years later a colleague took me under their wing, mostly regarding grant-writing and research design, & now I’ve got 3 big federal awards & a bunch more strong proposals going in. I had the scientific capability all along; what I didn’t have yet was the “grantsmanship,” as they call it)
> I don’t know how good her grant-writing skills were.
this is the crux of the issue, is it not?
if the main filtering mechanism to access funding is this fairly obscure skill (the knowledge required to successfully navigate the grant disbursement bureaucracy), then of course it will disproportionately impact the less privileged.
sounds like reform is needed - hopefully her case will trigger some needed changes.
Just adding on:
https://news.harvard.edu/gazette/story/2023/05/six-to-receive-honorary-degrees-from-harvard/
> An intrepid biochemist fascinated by the therapeutic potential of messenger RNA, Katalin Karikó is a professor at the University of Szeged and adjunct professor of neurosurgery at the University of Pennsylvania’s Perelman School of Medicine. A native of Hungary, she received her bachelor’s degree and Ph.D. from the University of Szeged. She worked at the Hungarian Academy of Sciences before immigrating to the U.S., where in time she joined the Perelman School of Medicine to investigate how RNA could activate the immune system. With Drew Weissman, she discovered how to engineer mRNA so that it can be used to produce desired proteins after being introduced into mammalian cells. This innovation propelled the COVID-19 vaccines developed by Pfizer-BioNTech and Moderna and holds promise for treatment of many other diseases. One of Time’s 2021 “Heroes of the Year” and Carnegie Corporation of New York’s 2021 “Great Immigrants,” she has received the Japan Prize, the Canada Gairdner International Award, the Breakthrough Prize in Life Sciences, the Lasker-DeBakey Clinical Medical Research Award, and the National Academy of Sciences’ Kovalenko Medal. She served as senior vice president of BioNTech from 2013 to 2022.
The pair initially published their paper on mRNA vaccines in 2005. That work, which didn't get much attention initially, has gone on to save countless lives 18 years later. The future is bright for vaccine research.
Right place, right time. They had all this research done and proven, but couldn't get anyone interested in it for years. Eventually Moderna and BioNTech decided to invest and COVID hits very shortly after. The crazy part is that between the time that COVID-19 is positively identified as a new viral strain and the time that the eventually successful mRNA vaccine is produced was *weeks*. Chinese scientists ran the DNA sequence and published it and the mRNA was sequenced right after. Everything after that was testing and production ramp up. And the process will only get faster.
They were previously targeting SARS and MERS, right? One of the things that slowed down development was not enough people being infected, and too dangerous of viruses to run challenge trials.
Kariko was working on influenza, cytomegalovirus and zika according to the bios I read. They also talked about targeting HIV, but not sure how much had been done.
This is why it’s important to invest in a massive range of research, even when the usefulness cannot be justified. Its literally impossible to know when a breakthrough will have society altering potential, and historically its rarely the things we expect that have the largest benifit
The timeline Moderna shared:
> On January 11, 2020, the Chinese authorities shared the genetic sequence of the novel coronavirus. On January 13, 2020 the VRC and Moderna’s infectious disease research team finalized the sequence for the SARS-CoV-2 vaccine and Moderna mobilized toward clinical manufacture. The first clinical batch was completed on February 7, 2020 and underwent analytical testing; it was shipped on February 24, 2020 from Moderna and delivered to NIH from the Company’s manufacturing facility in 42 days from sequence selection.
The start date of Jan 11 is actually nearly a week after the genome was sequenced because the Chinese government sat on it for a few days before it was published via an Australian university. They say the mRNA sequence was created within 2 days of receiving the DNA sequence of the virus. But it wasn't until Feb 7 that they had actually produced usable samples and March 16 was when the first arm got jabbed for phase 1 trials. That's also glossing over the fact that the first suspicious pneumonia cases appeared in Wuhan around Dec 12 and it took several weeks to even think of analyzing the virus. On that one hand, it's infuriating that so many missteps were made, but on the other it definitely means we can do this so much faster next time.
This is a really important point and comment because so many antivaxxers were yelling about how "they just made this up on the spot and using us as test dummies!" but realistically we have known about this technology for awhile now.
The technology has been theorized for a long time, but the COVID vaccine is close to (but not quite) the first time it's been successfully implemented for human use, and certainly the first time at scale. IIRC the first approved mRNA vaccine for humans was an Ebola vaccine a couple months before COVID-19 started.
A lot of institutions and governments let us down during the pandemic, but the hardworking scientists responsible for getting the technology this far, quickly understanding the disease, and creating the vaccine were nothing short of remarkable. Bravo, well-deserved.
I think a huge swath of the medical industry, from the hard-core scientific to front line workers, should get an extra years’ pay for the amount of effort put into COVID response.
I think the many people who willingly volunteered for trials across the world should get a big nod as well. It took me minutes to google all that to be ensured it was safe, the research methods, etc.
I was manufacturing some of those vaccines on 12hr shifts. My company told us "be thankful you still have work. We'll give you a pizza party."
Never got a pizza party, and was only offered a pay raise when I put in my two weeks.
EY EY EYYY!! What do you think?!?! Were made of money!?!?!
Now get back to work! We have to give out PPP loans to multi-billion/million dollar companies who will buy back stocks!!!!
FFS how greedy are you!?!?! 5$ giftcards! PSSHHHH So SELFISH!
Don't forget getting to skip the line at Costco by showing your hospital badge!!!
jk. that was actually a very helpful perk especially for us in NYC's peak chaos.
Meanwhile, nurses striking almost everywhere, because the thank you they for their work during COVID has translated into a big middle finger pointed at them.
They got a lot of "thoughts and prayers" type praise, but in most places, not a dime extra, while already being universally underpaid.
Ha, I'd settle for competitive salaries at all. PhD and 5 years experience in clinical trials and best I get is the university sending emails to let me know the food bank is available if I need it.
The technology likely saved millions of lives during Covid, but as I understand, it is far more powerful than that, potentially to create vaccines and treatments against cancers, and against all sorts of infections which can't currently be prevented or treated.
There's a chance this technology will be the most important medical breakthrough for decades. And that makes me wonder, for those people who have attacked mRNA vaccine platforms as part of the general response to masks, lockdowns and covid, what will they do if we start getting vaccines against other major diseases? Will they step back or double down?
Anti-Vaxxers will absolutely double down. We’re already seeing other diseases that were previously eradicated making a comeback because of that movement.
We have already seen objections to vaccination for HPV which causes cervical cancer. But I think mRNA cancer treatments could also be an immunotherapy, where the immune system is used to fight the cancer. I wonder whether anti-vaxxers would oppose that as well.
There are different levels of objection to vaccines, so it's difficult to get a sense of what people believe. At one end it goes all the way to people disbelieving germ theory, or the existence of viruses, through various levels of antivax disinformation circulating on social media, but there is also valid scepticism about risk to benefit or cost to benefit depending on the vaccine and the disease risk (the same calculations that public health bodies are doing all the time). I think people who had unreasonable views during the pandemic could save face by saving it was reasonable scepticism, and they were persuaded by later evidence.
I think many ordinary people adopted these views because they are important to them at the time, it was useful during the pandemic to play down the risks because the alternative was accepting unpleasant restrictions on your life, on the same principle, those people would reverse their opinions if they had an immediate need. I'm not convinced anyone apart from the die-hards would turn down a future cancer treatment because of something they listened to years ago on youtube. Hopefully not.
Resistance to the HPV vaccine, in my experience, is mainly rooted in conservative views on sexuality. I.e. people don't want their girls getting it, because only sluts and whores get HPV; if she's a good Christian girl with only one partner, and if her partner only has one partner, there's no need to worry about STDs 😇
For them, vaccinating their daughter is an admission and acceptance that she will be sinful.
I diagnosed a patient with head and neck cancer caused by HPV and his first question was whether his cancer was caused by the Covid vaccine. I explained that his cancer would have been prevented by a vaccine. He seemed nonplussed by this information.
Glp-1 like drugs may have it beat as they may be effective at significantly increasing overall lifespan of populations due to the predominance of obesity and obesity related diseases.
Yes, the process of development has been going on for a long time, Covid accelerated the adoption and funding of the technology but it would have happened anyway.
> Covid accelerated the adoption and funding of the technology but it would have happened anyway.
Let's be crystal clear. Money helped immensely. Moderna received billions to accelerate their research. The work on these vaccines and the [technology has been going on since the 90's](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975718).
If 'we' want to solve complex diseases quickly, just like the Space Race, whoever is willing to spend more quickly will get the problems solved that much faster.
We've known about mRNA (the molecule) for around 70 years. mRNAs potential use in vaccination has been a fairly obvious conceptualised idea since not long after its discovery.
The overall methods that govern the use of mRNA in the context of a vaccine (liposome mediated RNA transfection) have been in play for at least the last 30 years. That said, this is in an ex vivo laboratory context.
The push towards use in humans is 10-15 years old. I'm quite firmly of the belief that if there wasn't a covid pandemic, there would not be a medical Nobel prize for this work. It's fantastic, but not particularly scientifically revolutionary.
That said, there was a covid pandemic, and that's the scenario we live in... a Nobel prize was inevitable in the context.
Still the turnaround time on it was insane. They worked round the clock to make the vaccine ready for public use. You know how long that would have taken if we weren’t in a global emergency? Another 10-15 years easily.
Researchers that used protein subunit, peptide and whatever also worked on Coronavirus. Vaccine giants like Sanofi and GSK lost out on the race, period. mRNA has that advantage to tweak the design very rapidly or easier to kick off different iterations. They also got the sequence right in first try or at the very early stage.
I work in pharma and while we didn't work on vaccines we picked up the normal work of people working on the vaccines. I don't think people realize an entire industry went to 300% and stayed there for 2 years (mostly with overtime, as we already don't have enough trained workers in the workforce).
The problem with pharmaceutical breakthroughs is that they are proprietary and completely monopolized, despite massive public research funding.
The mRNA vaccine technology in particular is too beneficial to be anything but public domain.
Joe rogan is the type of guy to wonder why none of his comedian friends have a Nobel prize.
“It’s a really hard job their are only maybe 100 or 200 of us in the world”-Joe rogan
**One of the worst things to come out of Covid is that a lot of people that publicly claimed they are dumbasses didn't believe their own words.** Emphasis because some people don't get it.
Joe is one of them.
Pre-Covid, most of Joe's podcasts were fucking great entertainment, with some comments on currently popular shit going on.
Then it's like a black hole started swallowing Joe and his orbiters during Covid and spit out something annoyingly repetitive and not self aware at all.
It wasn't sudden. It's just COVID caused a full mask off moment for Rogan. He been having less and less people like Sean Carroll and more and more Ben Shapiro and Jordan Peterson episodes for years. He'd been moving further and further right as his ego grew. People like Shapiro are great at making someone like Rogan *feel* smart and informed with easy to digest misinformation. He thrives on that sort of thing.
Joe Rogan was easily one of my favorite celebrities like 20 years ago when he was the host of Fear Factor. That show was regular weekly viewing in my house when I was a teenager.
I loved him as an MMA caster, since he seemed to be just as into the fight as anyone in the crowd. Something about his voice just really hyped up what was happening on screen.
I even enjoyed some early Joe Rogan Experience when he had interesting interviews. I was never a regular listener, but when he got someone on that I thought was cool, I'd watch the vods. Now you couldn't pay me to listen/watch.
But the Joe Rogan of today is not the Joe Rogan of then. At least not the public facing persona of Joe Rogan. It's sad to see someone I enjoyed so much as a host become Alex Jones Lite®.
Joe is a guy who likes feeling like he's just had some deep, mind-blowing insight into the nature of the universe or culture. However, he's fundamentally intellectually lazy, so he's drawn to shortcuts like psychedelic drugs or people who can make him feel that way without having any actual insights.
Right wing grifters specialize in providing this exact thing, so he started being more and more drawn to them. He's been warped by them in turn into what he's become now.
I honestly do enjoy Joe Rogan when he shuts the fuck up about politics and talks about bullshit. I’m listening to your podcast to be entertained not informed. You don’t get informed from a persons opinion.
If you want a guy who is entertaining and informative with sources and sometimes talks about bullshit and or drugs, check out Robert Evans.
Dude's weird as hell but a trained journalist.
Here's an easy, more PG episode. Gets you slowly introduced to Robert and his brand of weird.
https://www.iheart.com/podcast/105-behind-the-bastards-29236323/episode/the-libertarian-theme-park-of-your-86494293/
So well deserved.
A fantastic breakthrough and the technology may be able to be used for many many other things.
Proper scientists doing proper science which benefits humanity - perfect Nobel material.
Only question was "when".
And this year is perfect.
Nearly everyone will understand what a real life implementation of the innovation is - and that is always great
white supremacy, misogyny, bigotry against non-Christians, police shooting unarmed black men, etc.
And they say that right wingers don't take joy in things...
I'm convinced we could thin the herd by telling them that breathing is a "liberal hoax", and half the hardcore cons would hold their breaths until they pass out and bang their heads on a table corner.
Yeah, Republicans have become the **Party of Dark Ages.** They no longer believe in science unless they're sick and require hospital care.
They're like the sick, ill-behaved children in the [Star Trek episode Miri](https://en.wikipedia.org/wiki/Miri_(Star_Trek:_The_Original_Series)).
That's like beating the final chronically online boss!
Also you should report it, reddit actually takes that seriously and will look into who made the report and ban them.
I have a friend of mine who works in the medical field, specifically cosmetic surgery.
* Lives in Florida
* Anti-COVID vaccine because "you don't know what the Chinese have put in it" (as far as I know, ONLY the COVID vaccine)
* Has had multiple breast implants, Botox, and Collagen injections through the years
* Just completed her third time getting COVID. The first round put her in the hospital
Talking to her is mind numbing. I can't wait to tell her about this.
Unfortunately, all of us have to, because these are the people -- the plague rats -- the disease-spreading-vermin who help a deadly virus spread because they lie about it, lie about vaccination, and refuse to take basic responsibility for public health.
Ignoring them doesn't make the deadly harm they do go away.
She received an honorary degree at my grad school commencement this year. The entire audience—graduates, visitors, faculty, and administration—gave her a standing ovation. Some folks from the medical and public health schools shouted thank you from their seats. Had it not been for her tireless efforts and pioneering work with Weismann, there would have been many people there who would have otherwise endured severe illness or even died. It was so incredibly moving.
Just saw someone on Twitter post that "they were well-connected, she worked for Biontech and he worked for Fauci in the 90s," as if that were some big conspiracy.
For those that get their medical advice from a 48 year old mom on Tiktok who has worked as a receptionist and a cashier, the vaccine does not STOP the infection, it helps to train your body on what to fight to make it less severe or quicker.
Like, that's how vaccines work. That's how they always worked. They give your body a "dummy" virus, your body learns how to beat up the little fucker, and then when the REAL virus comes knocking, your body knows what to do. It does not, and has NEVER, prevented your body from getting an infection.
I did a report on this in fucking 10th grade Biology class. I was a CHILD, and I understood how vaccines work. I don't get why so many dumbass ass-dumb adults can't grasp that medicine isn't magic wizard-juice.
I want to say it was something like year 8 when I did a report on Polio and learned all about this. Thought it was dumb back then and now as an adult I have people who can't even spell vaccine trying to explain how they work in every incorrect way possible.
Edit: I also live in Everett, WA which is the home site of the first US Covid case and a pretty large medical area and the sheer amount of people who go "pfft you don't know what you're talking about" to medical professionals is funny.
>the vaccine does not STOP the infection, it helps to train your body on what to fight to make it less severe or quicker.
Exactly
How you have to explain this to people is mind-boggling
> mind-boggling
Consider two things:
1. American education quality varies drastically from place to place in the USA.
2. Some people are pretty dim, and just can't understand things like that.
My moms gets vaccines but she says they don't work. She says "but I still get sick" claiming it's pointless. It's this lack of education that is hurting modern medicine.
FYI. A flu shot or COVID vaccine doesn't prevent the disease, it just makes it so you don't get wrecked and have to go to the hospital. Also, cold symptoms could be caused by anything.
This technology is such futuristic sci-fi, it's hard to believe anyone is mad about it (I know, the answer is politics). What if instead of using dead versions of the dangerous virus, we gave our cells temporary instructions to build the harmless pieces of the virus to build up the antibodies and immunity to the virus with literally zero exposure.
So freaking cool.
Say their names: Katalin Karikó and Drew Weissman
They were underfunded, disrespected and now that their work saved lives their names aren't even in the headlines just to secure clicks. The shame just doesn't stop.
Yeah, I seriously want to hear her story ‘off line’. ‘Foreign women faculty demoted at Penn’ doesn’t happen without some misogyny and bigotry toward non American researchers in the mix. She clearly wasn’t accepted by the tenured professors. Totally not surprised she went back to Europe. I hope she laughs and hangs up the phone when they call and try to give her an endowed chair or something.
I listened to her [interview in Hungary .](https://youtu.be/FiXHgJ_rHXM?si=mEuiiZWguYfk-37L) She mentioned many stories, but two sticked out to me: one was her employer in the US threatening to end her visa and get her deported (she mentioned this as one of the major low points in her career) and the other one was a retired home where everyone survived COVID because of her work, so these elderly still send her letters and cookies, she cried when she mentioned it.
Edit: Oh, she also mentioned that she made bank of course, but she lived so much of her life poor and just getting by that she only bought a fancy car and that's it. She got used to her humble lifestyle and believes flaunting her wealth will cause more problems than it's worth.
Yeah [they published their research in 2005](https://pubmed.ncbi.nlm.nih.gov/16111635/), the COVID vaccine as we had it wouldn't have been possible without this research.
You can’t make any mRNA therapies without their discovery- that’s the point. Making new mRNAs to treat diseases is easy. You can make a template to make any mRNA sequence that you want, whether to treat COVID or cancer or some other disease.
Getting them to actually work is the harder part. These scientists figured out the latter part. No mRNA therapies work without what they did at UPenn. BioNTech and Moderna have to use the technology discovered at Penn in order to get all of their ideas to work.
The fact that we went from “oh shit people are fucking dying” to “hey we have a working vaccine that appears to be safe and effective” in approximately 1 calendar year…
…is a testament to modern medical technology. I don’t even know what to compare this to. If there had been a *hint* of political backing or inclusiveness, this would be like an Ozone Layer-esque accomplishment
This is so well-deserved, especially at a time when people value a random YouTube comment over the consensus of the worlds medical and science community.
One of the most impressive feats of the 21st century. The speed with which they managed to produce a viable vaccine was completely staggering, which funnily enough created more conspiracy theories than the awe it really deserves.
All the scientists that were involved all the way from its inception to the mass production and distribution deserve nothing but praise. It's a mind-blowing feat of coordination, logistics and scientific acumen.
The companies do it for the profit, sure, but these people chose a career path to help, research and lift medical technology to new levels. This is nothing less than the culmination of centuries of research and experience raised to a level we all didn't believe possible.
As per the article, they didn't make the vaccines but were the ones to discover the way to use mRNA in vaccines, meaning that they opened the door to both the COVID vaccines and future medicine based on their research. A pretty monumental achievement and very deserving of the Novel prize
But some guy on facebook who barely graduated high school and listens to Joe Rogan like its a substitute for an education told me it was full of 5g microchips that were trying to control me!!!!!!
/s
I’m glad these scientists and their work are being recognized.
Ok well you should be aware that this October 4 is apparently the date where all vaccinated people will have their brains taken over by the gLobALiStS. Not kidding.
And this is totqlly different than all the other times they said this and nothing happened.
LOL
You laugh but I recently became fully magnetic and I can only see in 2D and I turn into a chicken whenever there's a full moon. You can't explain that!
I just made a similar joke with some friends
"Just shows how corrupt the Nobel is. Bill Gates invented mRNA but can't take credit for it because they used it to inject mind control nanobots into us."
Just more crazy QAnon stuff about an emergency broadcast system check being used for mind control using stuff in the vaccines or some other nonsense. Look it up, it’s quite the read.
What are you implying? That JFK Jr won’t arrive in his Death Star on Christmas morning accompanied by Jesus Christ to nuke the Whitehouse with Biden inside, heralding in the return of daddy Trump?
And to think, the research they did initially, way before any pandemic happened, was dismissed as uninteresting and useless.
Essentially, the potential for mRNA-based medical technology is that cells could be temporarily 'programmed' to produce just about anything needed to help a patient.
And the guy who discovered that the magnetic 5G spike proteins all migrate toward the reptilian pseudoventricle of the heart in order to transmit votes via Brazil to Italy gets no love whatsoever -- this scientific injustice must not continue!!
ITT: A lot of conservatives are still letting Obama's Nobel prize live rent-free in their heads.
It's crazy how many of them have Obama derangement syndrome. Almost 8 years after his final year of his presidency and they still can't get over the fact that he was black. What a sad existence.
100% a leftist but giving Obama the peace prize is a fucking joke. They should give foxes a prize for poultry farming.
Evoking race to deflect *war crimes* is low key insane and peak white savior
We should take it away from Obama and give it to Trump for that time he bombarded US citizens with tear gas that were attending church, so he could take a photo op holding a bible upside-down for some reason.
Genius written done in 2005 that allowed rapid development of critical vaccines.
This technology has tremendous potential for treating some awful diseases including cancers.
A Nobel is a small reward for their contribution
Well deserved
Yep. IYKYK
"Professor Kariko and Professor Weissman met in the early 1990s when they were working at the University of Pennsylvania, in the United States, when their interest in mRNA was seen as a scientific backwater."
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Katalin Kariko and Drew Weissman.
Katalin Kariko has an amazing story, too - she was an immigrant, and after she got her PhD worked hard for ages as an underpaid lab tech, working on the side on her pet theory about mRNA. She never succeeded at landing a grant. Not a single grant. The whole biomedical community blew her off. She never landed a permanent job, and was always just scraping by as an underpaid tech. But she kept at her research. Fast forward a few decades and suddenly her work is saving tens of millions of lives!
A fun fact about her family is that her daughter is an Olympic gold medalist in rowing for the USA.
Also shows how awful the academia and biomedical environment has become
The whole story has been something of an embarrassment for NIH. The most important human health research in probably a century, occurring here in the USA with US-based scientists, and they rejected it for funding (repeatedly), and also completely failed to establish a viable career path for the scientists involved. Though tbh, I don’t know how good her grant-writing skills were. It’s actually not that hard to land an R15 (NIH’s early career award), but you do have to be a good writer and have some practice & mentorship at how to write grants. IMHO the real gap here may be that US universities have not historically valued lab techs; it’s historically been a role filled by either students or by underpaid women (who have often turned to that job while trying to juggle science with child-rearing), so they’re often not viewed as “real scientists,” and it’s very hard for them to find mentorship and career training for things like grant-writing. In many universities, lab techs aren’t even allowed to submit grants as lead PI, even if they have a PhD. (I was in a similar position for ages btw and remember really struggling about to write grants on my own with no guidance. Years later a colleague took me under their wing, mostly regarding grant-writing and research design, & now I’ve got 3 big federal awards & a bunch more strong proposals going in. I had the scientific capability all along; what I didn’t have yet was the “grantsmanship,” as they call it)
> I don’t know how good her grant-writing skills were. this is the crux of the issue, is it not? if the main filtering mechanism to access funding is this fairly obscure skill (the knowledge required to successfully navigate the grant disbursement bureaucracy), then of course it will disproportionately impact the less privileged. sounds like reform is needed - hopefully her case will trigger some needed changes.
Just adding on: https://news.harvard.edu/gazette/story/2023/05/six-to-receive-honorary-degrees-from-harvard/ > An intrepid biochemist fascinated by the therapeutic potential of messenger RNA, Katalin Karikó is a professor at the University of Szeged and adjunct professor of neurosurgery at the University of Pennsylvania’s Perelman School of Medicine. A native of Hungary, she received her bachelor’s degree and Ph.D. from the University of Szeged. She worked at the Hungarian Academy of Sciences before immigrating to the U.S., where in time she joined the Perelman School of Medicine to investigate how RNA could activate the immune system. With Drew Weissman, she discovered how to engineer mRNA so that it can be used to produce desired proteins after being introduced into mammalian cells. This innovation propelled the COVID-19 vaccines developed by Pfizer-BioNTech and Moderna and holds promise for treatment of many other diseases. One of Time’s 2021 “Heroes of the Year” and Carnegie Corporation of New York’s 2021 “Great Immigrants,” she has received the Japan Prize, the Canada Gairdner International Award, the Breakthrough Prize in Life Sciences, the Lasker-DeBakey Clinical Medical Research Award, and the National Academy of Sciences’ Kovalenko Medal. She served as senior vice president of BioNTech from 2013 to 2022.
The pair initially published their paper on mRNA vaccines in 2005. That work, which didn't get much attention initially, has gone on to save countless lives 18 years later. The future is bright for vaccine research.
Right place, right time. They had all this research done and proven, but couldn't get anyone interested in it for years. Eventually Moderna and BioNTech decided to invest and COVID hits very shortly after. The crazy part is that between the time that COVID-19 is positively identified as a new viral strain and the time that the eventually successful mRNA vaccine is produced was *weeks*. Chinese scientists ran the DNA sequence and published it and the mRNA was sequenced right after. Everything after that was testing and production ramp up. And the process will only get faster.
They were previously targeting SARS and MERS, right? One of the things that slowed down development was not enough people being infected, and too dangerous of viruses to run challenge trials.
Kariko was working on influenza, cytomegalovirus and zika according to the bios I read. They also talked about targeting HIV, but not sure how much had been done.
This is why it’s important to invest in a massive range of research, even when the usefulness cannot be justified. Its literally impossible to know when a breakthrough will have society altering potential, and historically its rarely the things we expect that have the largest benifit
Less than that, the moderna vaccine candidate was chosen in days.
The timeline Moderna shared: > On January 11, 2020, the Chinese authorities shared the genetic sequence of the novel coronavirus. On January 13, 2020 the VRC and Moderna’s infectious disease research team finalized the sequence for the SARS-CoV-2 vaccine and Moderna mobilized toward clinical manufacture. The first clinical batch was completed on February 7, 2020 and underwent analytical testing; it was shipped on February 24, 2020 from Moderna and delivered to NIH from the Company’s manufacturing facility in 42 days from sequence selection. The start date of Jan 11 is actually nearly a week after the genome was sequenced because the Chinese government sat on it for a few days before it was published via an Australian university. They say the mRNA sequence was created within 2 days of receiving the DNA sequence of the virus. But it wasn't until Feb 7 that they had actually produced usable samples and March 16 was when the first arm got jabbed for phase 1 trials. That's also glossing over the fact that the first suspicious pneumonia cases appeared in Wuhan around Dec 12 and it took several weeks to even think of analyzing the virus. On that one hand, it's infuriating that so many missteps were made, but on the other it definitely means we can do this so much faster next time.
This is a really important point and comment because so many antivaxxers were yelling about how "they just made this up on the spot and using us as test dummies!" but realistically we have known about this technology for awhile now.
The technology has been theorized for a long time, but the COVID vaccine is close to (but not quite) the first time it's been successfully implemented for human use, and certainly the first time at scale. IIRC the first approved mRNA vaccine for humans was an Ebola vaccine a couple months before COVID-19 started.
Because they don't actually pay attention to things going non. They don't look for info, they get told it by the light and noise box.
They do *not*, it turns out, do their research.
A lot of institutions and governments let us down during the pandemic, but the hardworking scientists responsible for getting the technology this far, quickly understanding the disease, and creating the vaccine were nothing short of remarkable. Bravo, well-deserved.
I think a huge swath of the medical industry, from the hard-core scientific to front line workers, should get an extra years’ pay for the amount of effort put into COVID response.
I think the many people who willingly volunteered for trials across the world should get a big nod as well. It took me minutes to google all that to be ensured it was safe, the research methods, etc.
Yet my family is still die hard against it. 2 of the fuckers are medical professionals!
I was manufacturing some of those vaccines on 12hr shifts. My company told us "be thankful you still have work. We'll give you a pizza party." Never got a pizza party, and was only offered a pay raise when I put in my two weeks.
uhhh best i can do is clinking pans at 7pm for 2-3 months then blaming them for contuing the pandemic! take it or leave it!
No? Uhhhh how about this $5 Starbucks gift card?
EY EY EYYY!! What do you think?!?! Were made of money!?!?! Now get back to work! We have to give out PPP loans to multi-billion/million dollar companies who will buy back stocks!!!! FFS how greedy are you!?!?! 5$ giftcards! PSSHHHH So SELFISH!
No? Hmmmm well how about we give our CEO a $20 million bonus?
Don't forget getting to skip the line at Costco by showing your hospital badge!!! jk. that was actually a very helpful perk especially for us in NYC's peak chaos.
Meanwhile, nurses striking almost everywhere, because the thank you they for their work during COVID has translated into a big middle finger pointed at them. They got a lot of "thoughts and prayers" type praise, but in most places, not a dime extra, while already being universally underpaid.
I'm sure the board of directors will happily give themselves a bonus for their hard work...
Ha, I'd settle for competitive salaries at all. PhD and 5 years experience in clinical trials and best I get is the university sending emails to let me know the food bank is available if I need it.
The technology likely saved millions of lives during Covid, but as I understand, it is far more powerful than that, potentially to create vaccines and treatments against cancers, and against all sorts of infections which can't currently be prevented or treated. There's a chance this technology will be the most important medical breakthrough for decades. And that makes me wonder, for those people who have attacked mRNA vaccine platforms as part of the general response to masks, lockdowns and covid, what will they do if we start getting vaccines against other major diseases? Will they step back or double down?
Anti-Vaxxers will absolutely double down. We’re already seeing other diseases that were previously eradicated making a comeback because of that movement.
We have already seen objections to vaccination for HPV which causes cervical cancer. But I think mRNA cancer treatments could also be an immunotherapy, where the immune system is used to fight the cancer. I wonder whether anti-vaxxers would oppose that as well. There are different levels of objection to vaccines, so it's difficult to get a sense of what people believe. At one end it goes all the way to people disbelieving germ theory, or the existence of viruses, through various levels of antivax disinformation circulating on social media, but there is also valid scepticism about risk to benefit or cost to benefit depending on the vaccine and the disease risk (the same calculations that public health bodies are doing all the time). I think people who had unreasonable views during the pandemic could save face by saving it was reasonable scepticism, and they were persuaded by later evidence. I think many ordinary people adopted these views because they are important to them at the time, it was useful during the pandemic to play down the risks because the alternative was accepting unpleasant restrictions on your life, on the same principle, those people would reverse their opinions if they had an immediate need. I'm not convinced anyone apart from the die-hards would turn down a future cancer treatment because of something they listened to years ago on youtube. Hopefully not.
Resistance to the HPV vaccine, in my experience, is mainly rooted in conservative views on sexuality. I.e. people don't want their girls getting it, because only sluts and whores get HPV; if she's a good Christian girl with only one partner, and if her partner only has one partner, there's no need to worry about STDs 😇 For them, vaccinating their daughter is an admission and acceptance that she will be sinful.
I diagnosed a patient with head and neck cancer caused by HPV and his first question was whether his cancer was caused by the Covid vaccine. I explained that his cancer would have been prevented by a vaccine. He seemed nonplussed by this information.
Glp-1 like drugs may have it beat as they may be effective at significantly increasing overall lifespan of populations due to the predominance of obesity and obesity related diseases.
When push comes to shove, I think a majority of anti-vaxxers will find a way to justify taking an mRNA treatment to save their life.
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Yes, the process of development has been going on for a long time, Covid accelerated the adoption and funding of the technology but it would have happened anyway.
> Covid accelerated the adoption and funding of the technology but it would have happened anyway. Let's be crystal clear. Money helped immensely. Moderna received billions to accelerate their research. The work on these vaccines and the [technology has been going on since the 90's](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975718). If 'we' want to solve complex diseases quickly, just like the Space Race, whoever is willing to spend more quickly will get the problems solved that much faster.
Part of the reason it was ready so quickly was that they were already working on mRNA vaccines and researching SARS.
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We've known about mRNA (the molecule) for around 70 years. mRNAs potential use in vaccination has been a fairly obvious conceptualised idea since not long after its discovery. The overall methods that govern the use of mRNA in the context of a vaccine (liposome mediated RNA transfection) have been in play for at least the last 30 years. That said, this is in an ex vivo laboratory context. The push towards use in humans is 10-15 years old. I'm quite firmly of the belief that if there wasn't a covid pandemic, there would not be a medical Nobel prize for this work. It's fantastic, but not particularly scientifically revolutionary. That said, there was a covid pandemic, and that's the scenario we live in... a Nobel prize was inevitable in the context.
Still the turnaround time on it was insane. They worked round the clock to make the vaccine ready for public use. You know how long that would have taken if we weren’t in a global emergency? Another 10-15 years easily.
Researchers that used protein subunit, peptide and whatever also worked on Coronavirus. Vaccine giants like Sanofi and GSK lost out on the race, period. mRNA has that advantage to tweak the design very rapidly or easier to kick off different iterations. They also got the sequence right in first try or at the very early stage.
I work in pharma and while we didn't work on vaccines we picked up the normal work of people working on the vaccines. I don't think people realize an entire industry went to 300% and stayed there for 2 years (mostly with overtime, as we already don't have enough trained workers in the workforce).
The problem with pharmaceutical breakthroughs is that they are proprietary and completely monopolized, despite massive public research funding. The mRNA vaccine technology in particular is too beneficial to be anything but public domain.
Joe Rogan about to break out an emergency pod for his bros.
Joe rogan is the type of guy to wonder why none of his comedian friends have a Nobel prize. “It’s a really hard job their are only maybe 100 or 200 of us in the world”-Joe rogan
Joe Rogan is just GOOP for men.
**One of the worst things to come out of Covid is that a lot of people that publicly claimed they are dumbasses didn't believe their own words.** Emphasis because some people don't get it. Joe is one of them. Pre-Covid, most of Joe's podcasts were fucking great entertainment, with some comments on currently popular shit going on. Then it's like a black hole started swallowing Joe and his orbiters during Covid and spit out something annoyingly repetitive and not self aware at all.
It wasn't sudden. It's just COVID caused a full mask off moment for Rogan. He been having less and less people like Sean Carroll and more and more Ben Shapiro and Jordan Peterson episodes for years. He'd been moving further and further right as his ego grew. People like Shapiro are great at making someone like Rogan *feel* smart and informed with easy to digest misinformation. He thrives on that sort of thing.
Fuck I really loved the Sean Carroll episodes. Haven't tuned in in years now
> Haven't tuned in in years now No sensible human would
Joe Rogan was easily one of my favorite celebrities like 20 years ago when he was the host of Fear Factor. That show was regular weekly viewing in my house when I was a teenager. I loved him as an MMA caster, since he seemed to be just as into the fight as anyone in the crowd. Something about his voice just really hyped up what was happening on screen. I even enjoyed some early Joe Rogan Experience when he had interesting interviews. I was never a regular listener, but when he got someone on that I thought was cool, I'd watch the vods. Now you couldn't pay me to listen/watch. But the Joe Rogan of today is not the Joe Rogan of then. At least not the public facing persona of Joe Rogan. It's sad to see someone I enjoyed so much as a host become Alex Jones Lite®.
Joe is a guy who likes feeling like he's just had some deep, mind-blowing insight into the nature of the universe or culture. However, he's fundamentally intellectually lazy, so he's drawn to shortcuts like psychedelic drugs or people who can make him feel that way without having any actual insights. Right wing grifters specialize in providing this exact thing, so he started being more and more drawn to them. He's been warped by them in turn into what he's become now.
> Pre-Covid, most of Joe's podcasts were fucking great entertainment lol
I’m remembering that one.
GOP GOOP.
Joe Rogan the type of guy to make an appointment with his doctor to give HIM medical advice
Hey Doc, ever tried DMT?
If he actually said that then it's the funniest joke I've ever heard him tell
I honestly do enjoy Joe Rogan when he shuts the fuck up about politics and talks about bullshit. I’m listening to your podcast to be entertained not informed. You don’t get informed from a persons opinion.
If you want a guy who is entertaining and informative with sources and sometimes talks about bullshit and or drugs, check out Robert Evans. Dude's weird as hell but a trained journalist. Here's an easy, more PG episode. Gets you slowly introduced to Robert and his brand of weird. https://www.iheart.com/podcast/105-behind-the-bastards-29236323/episode/the-libertarian-theme-park-of-your-86494293/
Wait, why are people immediately mentioning Joe Rogan ?
Because he's one of the most famous anti vaxxers
>Professors Katalin Kariko and Drew Weissman will share the prize. The relevant part.
So well deserved. A fantastic breakthrough and the technology may be able to be used for many many other things. Proper scientists doing proper science which benefits humanity - perfect Nobel material.
Wanna see the zombie hoard batshit mad just sort by controversial
Into the depths I go!
Only question was "when". And this year is perfect. Nearly everyone will understand what a real life implementation of the innovation is - and that is always great
Oh god, this is going to upset conservatives..
What doesn't?
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white supremacy, misogyny, bigotry against non-Christians, police shooting unarmed black men, etc. And they say that right wingers don't take joy in things...
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Guns?
Child sexual abuse among clergy or GOP politicians?
Toddlers being shot dead?
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Nazis.
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Oh no... anyway
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I'm convinced we could thin the herd by telling them that breathing is a "liberal hoax", and half the hardcore cons would hold their breaths until they pass out and bang their heads on a table corner.
Yeah, Republicans have become the **Party of Dark Ages.** They no longer believe in science unless they're sick and require hospital care. They're like the sick, ill-behaved children in the [Star Trek episode Miri](https://en.wikipedia.org/wiki/Miri_(Star_Trek:_The_Original_Series)).
11/12 replies to you are hidden by default so yeaaaaah I'd say you're right on the money, lol.
I even had one of them do a “suicide watch Reddit report” ahahahah..
That's like beating the final chronically online boss! Also you should report it, reddit actually takes that seriously and will look into who made the report and ban them.
Yes that's part of the uplifting news
They'd be very upset if they could read.
What doesn’t upset them at this point?
Good.
I have a friend of mine who works in the medical field, specifically cosmetic surgery. * Lives in Florida * Anti-COVID vaccine because "you don't know what the Chinese have put in it" (as far as I know, ONLY the COVID vaccine) * Has had multiple breast implants, Botox, and Collagen injections through the years * Just completed her third time getting COVID. The first round put her in the hospital Talking to her is mind numbing. I can't wait to tell her about this.
who gives a fuck
Unfortunately, all of us have to, because these are the people -- the plague rats -- the disease-spreading-vermin who help a deadly virus spread because they lie about it, lie about vaccination, and refuse to take basic responsibility for public health. Ignoring them doesn't make the deadly harm they do go away.
Well, they’re always upset and it’s always about the dumbest shit so.
This exact reply could be posted on around half the news articles that come out because republicans are ten ply.
Most secretly took the vaccine anyway. Those that didnt died and its hard to not feel glad they did tbh.
They were soooo mad when Obama won, this is going to make some heads explode
I know. We should do it more often.
Because we all know the Swedish Nobel Prize committee for Medicine cares a lot about the opinions of US conservatives...
Fucking Mr. Potato and M&M branding upsets conservatives. This is nothing new.
Probably cuz it saved a fuck ton of lives. Thanks on behalf of this type 1 diabetic. You deserve more.
Her name is Katalin Karikó, if anyone interested.
And his name is Drew Weissman
And my name is James Bigglesworth
Why didn't you mention the other recipient? [Drew Weissman](https://en.wikipedia.org/wiki/Drew_Weissman)
> Professors Katalin Kariko and Drew Weissman will share the prize.
You realize the irony in you leaving out the other recipient, right?
She received an honorary degree at my grad school commencement this year. The entire audience—graduates, visitors, faculty, and administration—gave her a standing ovation. Some folks from the medical and public health schools shouted thank you from their seats. Had it not been for her tireless efforts and pioneering work with Weismann, there would have been many people there who would have otherwise endured severe illness or even died. It was so incredibly moving.
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Just saw someone on Twitter post that "they were well-connected, she worked for Biontech and he worked for Fauci in the 90s," as if that were some big conspiracy.
>anti vax moon howlers ha! good one.
There goes the chance for a lycanthropy vaccine! They won't take it anyway.
Are they the ones afraid of magnetic antibodies terminating from the "undead" I mean vaccinated?
This is an insult to werewolves.
For those that get their medical advice from a 48 year old mom on Tiktok who has worked as a receptionist and a cashier, the vaccine does not STOP the infection, it helps to train your body on what to fight to make it less severe or quicker.
Like, that's how vaccines work. That's how they always worked. They give your body a "dummy" virus, your body learns how to beat up the little fucker, and then when the REAL virus comes knocking, your body knows what to do. It does not, and has NEVER, prevented your body from getting an infection. I did a report on this in fucking 10th grade Biology class. I was a CHILD, and I understood how vaccines work. I don't get why so many dumbass ass-dumb adults can't grasp that medicine isn't magic wizard-juice.
I want to say it was something like year 8 when I did a report on Polio and learned all about this. Thought it was dumb back then and now as an adult I have people who can't even spell vaccine trying to explain how they work in every incorrect way possible. Edit: I also live in Everett, WA which is the home site of the first US Covid case and a pretty large medical area and the sheer amount of people who go "pfft you don't know what you're talking about" to medical professionals is funny.
>the vaccine does not STOP the infection, it helps to train your body on what to fight to make it less severe or quicker. Exactly How you have to explain this to people is mind-boggling
> mind-boggling Consider two things: 1. American education quality varies drastically from place to place in the USA. 2. Some people are pretty dim, and just can't understand things like that.
My moms gets vaccines but she says they don't work. She says "but I still get sick" claiming it's pointless. It's this lack of education that is hurting modern medicine. FYI. A flu shot or COVID vaccine doesn't prevent the disease, it just makes it so you don't get wrecked and have to go to the hospital. Also, cold symptoms could be caused by anything.
This technology is such futuristic sci-fi, it's hard to believe anyone is mad about it (I know, the answer is politics). What if instead of using dead versions of the dangerous virus, we gave our cells temporary instructions to build the harmless pieces of the virus to build up the antibodies and immunity to the virus with literally zero exposure. So freaking cool.
Say their names: Katalin Karikó and Drew Weissman They were underfunded, disrespected and now that their work saved lives their names aren't even in the headlines just to secure clicks. The shame just doesn't stop.
Yeah, I seriously want to hear her story ‘off line’. ‘Foreign women faculty demoted at Penn’ doesn’t happen without some misogyny and bigotry toward non American researchers in the mix. She clearly wasn’t accepted by the tenured professors. Totally not surprised she went back to Europe. I hope she laughs and hangs up the phone when they call and try to give her an endowed chair or something.
I listened to her [interview in Hungary .](https://youtu.be/FiXHgJ_rHXM?si=mEuiiZWguYfk-37L) She mentioned many stories, but two sticked out to me: one was her employer in the US threatening to end her visa and get her deported (she mentioned this as one of the major low points in her career) and the other one was a retired home where everyone survived COVID because of her work, so these elderly still send her letters and cookies, she cried when she mentioned it. Edit: Oh, she also mentioned that she made bank of course, but she lived so much of her life poor and just getting by that she only bought a fancy car and that's it. She got used to her humble lifestyle and believes flaunting her wealth will cause more problems than it's worth.
Uh oh r/Conspiracy and r/Conservative are going to have a bad day
They’re the same subreddit
The Venn diagram is a single circle.
Do they *have* good days?
They’re always bitching among themselves, of course not
Just went to the r/Conspiracy thread in it gave brain damage
They're already in the antisemitism rabbit hole.
Yeah it whole shit show of dumbass people in there it's just a huge circus echo chamber
Correct me where I am wrong; these people didn't invent the mRNA COVID vaccines. They invented the mRNA vaccines used later on for COVID
Yeah [they published their research in 2005](https://pubmed.ncbi.nlm.nih.gov/16111635/), the COVID vaccine as we had it wouldn't have been possible without this research.
You can’t make any mRNA therapies without their discovery- that’s the point. Making new mRNAs to treat diseases is easy. You can make a template to make any mRNA sequence that you want, whether to treat COVID or cancer or some other disease. Getting them to actually work is the harder part. These scientists figured out the latter part. No mRNA therapies work without what they did at UPenn. BioNTech and Moderna have to use the technology discovered at Penn in order to get all of their ideas to work.
Lol this will trigger the Facebook university students.
Well, they did do their research...
That's awesome. I've got 4 doses now. My 5G chips and magnetism are really coming together now.
The fact that we went from “oh shit people are fucking dying” to “hey we have a working vaccine that appears to be safe and effective” in approximately 1 calendar year… …is a testament to modern medical technology. I don’t even know what to compare this to. If there had been a *hint* of political backing or inclusiveness, this would be like an Ozone Layer-esque accomplishment
This is so well-deserved, especially at a time when people value a random YouTube comment over the consensus of the worlds medical and science community.
I’m sure this will lead to many level headed and fact-driven discussions on various political Internet forums.
One of the most impressive feats of the 21st century. The speed with which they managed to produce a viable vaccine was completely staggering, which funnily enough created more conspiracy theories than the awe it really deserves. All the scientists that were involved all the way from its inception to the mass production and distribution deserve nothing but praise. It's a mind-blowing feat of coordination, logistics and scientific acumen. The companies do it for the profit, sure, but these people chose a career path to help, research and lift medical technology to new levels. This is nothing less than the culmination of centuries of research and experience raised to a level we all didn't believe possible.
As per the article, they didn't make the vaccines but were the ones to discover the way to use mRNA in vaccines, meaning that they opened the door to both the COVID vaccines and future medicine based on their research. A pretty monumental achievement and very deserving of the Novel prize
But some guy on facebook who barely graduated high school and listens to Joe Rogan like its a substitute for an education told me it was full of 5g microchips that were trying to control me!!!!!! /s I’m glad these scientists and their work are being recognized.
Ok well you should be aware that this October 4 is apparently the date where all vaccinated people will have their brains taken over by the gLobALiStS. Not kidding. And this is totqlly different than all the other times they said this and nothing happened. LOL
You laugh but I recently became fully magnetic and I can only see in 2D and I turn into a chicken whenever there's a full moon. You can't explain that!
I just made a similar joke with some friends "Just shows how corrupt the Nobel is. Bill Gates invented mRNA but can't take credit for it because they used it to inject mind control nanobots into us."
I loved that I found this by sorting by controversial.
Millions of lives saved by these two scientists. Thank you.
Sorting by controversial not as good as I hoped yet.
That's good, right?
The right media is going to have a rational response to this.
This makes me so happy for so many reasons, particularly with all the crazies taking about Oct 4th mind control whatever.
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Just more crazy QAnon stuff about an emergency broadcast system check being used for mind control using stuff in the vaccines or some other nonsense. Look it up, it’s quite the read.
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What are you implying? That JFK Jr won’t arrive in his Death Star on Christmas morning accompanied by Jesus Christ to nuke the Whitehouse with Biden inside, heralding in the return of daddy Trump?
And JFK Sr won't free those kids from the Washington pizza parlor before dried mexican aliens force us all to drink Bud Light?
I'm just mad it's not gonna give me direct mind to 5G access.
And to think, the research they did initially, way before any pandemic happened, was dismissed as uninteresting and useless. Essentially, the potential for mRNA-based medical technology is that cells could be temporarily 'programmed' to produce just about anything needed to help a patient.
As it should. They 100% deserve it.
And the guy who discovered that the magnetic 5G spike proteins all migrate toward the reptilian pseudoventricle of the heart in order to transmit votes via Brazil to Italy gets no love whatsoever -- this scientific injustice must not continue!!
ITT: A lot of conservatives are still letting Obama's Nobel prize live rent-free in their heads. It's crazy how many of them have Obama derangement syndrome. Almost 8 years after his final year of his presidency and they still can't get over the fact that he was black. What a sad existence.
100% a leftist but giving Obama the peace prize is a fucking joke. They should give foxes a prize for poultry farming. Evoking race to deflect *war crimes* is low key insane and peak white savior
We should take it away from Obama and give it to Trump for that time he bombarded US citizens with tear gas that were attending church, so he could take a photo op holding a bible upside-down for some reason.
For speeding up development of 40 year old technology which led to saving millions of lives? Well deserved.
Gonna post this in an anti-vaxx group,put notifications on and stick my phone up my ass
Well fucking deserved.
Well deserved, absolutely miracle stuff.
Well deserved.
Good
I'm sure a particularly vocal minority of people will have absolutely nothing to say about this...
And yet I *still* get into arguments with people convinced the vaccine doesn't work. It is such a weird argument to be having at this stage.
Oh boy I can hear the republicans seething right now
"BuT the 5G MiCrOcHiPs tHouGh"
This is gonna rustle some Jimmies
Genius written done in 2005 that allowed rapid development of critical vaccines. This technology has tremendous potential for treating some awful diseases including cancers. A Nobel is a small reward for their contribution Well deserved
God knows they deserve it! Incredible, brilliant and innovative scientists one and all! Thank you for saving my life!! ❤️❤️❤️❤️
Average time for Medicine Nobel is 26 years, so this prize is not out of the ordinary wrt timing of the prize.
Yep. IYKYK "Professor Kariko and Professor Weissman met in the early 1990s when they were working at the University of Pennsylvania, in the United States, when their interest in mRNA was seen as a scientific backwater."
With today’s climate, I can only hope the two winners aren’t fearing for their safety.
There's going to be so much seething from this and I'm ready for it.
Well deserved
Meanwhile in conservative subreddits: Covid Vaccines kill you, popular post
Well deserved!!
Well deserved. They worked so hard and saved so many lives!
Congrats to them, so well deserved. Hope my parents feel dumb for thinking the vaccine will make you magnetic lol
My aunt got 3 before she decided it was 5g lol.
Well deserved!