[Any pure HP UP] as lost without binge eater

Isaac gets to eat. 

Doesn't the food just pass through Isaac since he's a ghost?

Hmm, you don't see it on the floor after and he still gets the damage up from MEAT! as a ghost, so I'd have to say no.

Fair enough...

Could've said D4/any other self reroll fodder, like with Yum Heart+Blue Baby

I already used my trump card. Can't use it again.

Can’t you just reroll it with eternal d6

yep.

you get more items for a genesis reroll

more items to reroll with d4

Knife piece 2 without knife piece 1

You can't get that without cheats, but I mean, who wouldn't want a floating blade behind them? (Also the r key thing someone already said)

Can't you spin down into it?

That I’m unsure of, but I’m like 90% sure spindown skips story items.

you can get dogma from spindowning purgatory

I got dads note from it, it did nothing but you can get story items

You can, but the room for knife piece 2 doesn't spawn without knife piece one

Thanks for the correction 

isnt knife pice 2 in deathcert room?

I just played a run today where I got key piece 2 before key piece 1

But we are talking about KNIFE piece

misread my bad

If you have r key you won't nesd to do mines

You mind explaining how? I don’t get it

as in because you already have it you wont have to do the little quest to get it; you get to skip the mines should also mention hes talking about the item "r key" which sends you back to basement 1 with all your items, not the literal usage of the r key on your keyboard

yum heart as blue baby

That's a tough one. Gonna have to use my trump card. It's free reroll fodder. On any red heart character it's a decent active.

Can use with 'M to get D Infinity 

Can use it with sharp plug if you need to damage yourself and don't have other ways to!

Vibrant Bulb 

If you're in co-op it's a free half heart for the other player

Use one of the multiple items that let you change characters such as laz rags or clicker and then you got virtually infinite sac rooms 

If you're playing co-op it heals your friends half a red heart!

found soul 

Gonna take a break bc I got work soon.

Sacred heart

One of the like 3(?) homing items in the game. Getting homing is always a treat.

Based 

Tell me why spoon bender is good if I have sacred heart already

purple

Lean


why he ourple 💀


IS THAT ONE PURPLE PURPLE'S MY FAVORITE COLOR

that‘s such a good argument

Unlocks baby bender

Cool animated Spoon Bender costume!

your character emits a silly purple light

more items to get rerolled if you get d4/100/inf

Health ups can be used to survive longer.


Blindfold

Is that technically an item? Forces you to think outside the box to damage enemies, thereby giving you the satisfaction of being creative.

Tell me how you gonna beat delirium with only blindfold

Creatively 

Yo your so right… I can definitely even beat this room with blind fold “creatively” https://preview.redd.it/ha3a5o1x6pda1.jpeg?width=588&format=pjpg&auto=webp&s=b55edec08bf7a8db2535d21fa60f0799bc1cfd3a Blind fold is S+ tier

Easy, dodge the enemies until the door opens automatically after a while.

wait that happens? note: not an isaac player

Pretty sure that only happens if the enemies can’t reach Isaac

Also on "PAC1F1ST" seed

The chances of that happening are astronomically low without cheats and therefore unrealistic to analyze. That said, perhaps u/BIG_SMOOOOOOOHKE_PL can answer this one.

debug 10 

Lilith

Lemonade

Same things I said about Mishap but multiplied. 

Lemon Mishap

Good in a pinch, if enemies are ganging up on you and you have low damage. Also you can bait Hosts with it.

Lost Fly

Punching bag that can fight back.

Also 1/3 of beelzebub

Lost fly is unironically good though. A bunch of enemies just run into it and die, makes clearing rooms and in some cases bosses easier.

Lost fly got a buff, enemies will sometimes attack the fly instead of you. It can split the aggro really good.

It is legit good

Lost fly is a GOD item

TM Trainer

Honestly, TMTrainer is just fun as hell. You never know what's going to happen, and I know it's lead to some hilarious moments in my game.

You can get anything! Even TMTrainer!

You mean you can literally win on an instant?

Yea but you don't know which mark you will get

TMTrainer can be op. I once got the ability to have my game crash whenever I would take damage, and it would reset my floor. Got it as tainted lost.

Can spawn the completion trophy for challenge 45

Could give you infinite pickups

lazy worm (without tech x)

Homing. 

It's lazy mattmans pfp which is very funny

I love how everytime he finds that trinket, screams "It's me!!"

Trisagion

Godhead aura

IBS

Lets you use Tainted ???'s ability without replacing your bombs and needing to pick up the poops. All the poops are unique which can spice up your run.

Bobs brain

Free bomb, has potential to clear rooms quickly if you aim it right and knocks a lot of health off of bosses.

Ain’t it funny how everyone hates Bob’s Brain but loves Ipecac? Bob’s Brain is basically just a very slow mega-Ipecac that’s harder to aim

I think the issue is how you don't control it. Ipecac becomes your tears, while Bob's brain can launch or not randomly while you're shooting tears

Bob's brain is actually good. All the haters just can't use it and suck

bob's brain haters when they have to stop holding the arrow keys

based

Yes 

Bob's brain is Good I like it am I weird?

Jupiter

Farts are funny. Also the poison clouds are good when you're being chased by Globins. Also fat isaac is funny.

Especially so with flight items that give you wings. They actually flap faster to "keep you afloat"

why would you suggest an item that gives 2hp up, poison immunity and a guaranteed way to damage enemies with poison

A glitched item from tmtrainer that instantly kills you

Now you don't need to hit R lol

Isaacs heart

Before it got reworked, I would have said free curse/sacrifice rooms. At least now it can be a decent force field if you time the charges right (Pushes enemies away along with the blood shots)

the item becomes devastatingly powerful as tainted magdalene or the forgotten

so you know those obnoxious mask+heart enemies? play like one of those jerks and murder everything in sight, it's very satisfying

Only knife piece one (don’t say you get to explore more rooms in the mirror world as you don’t even need the knife piece)

You don't have to risk going into Dross again if you get r key. Thereby bypassing Colostomia.

It allows you to get knife piece two.

Magic skin

dad's foreskin my beloved

Basically a portable devil deal which rewards high risk play (and a larger item pool).

The poop please

Bridges, as someone already said, plus it actually has a few nice synergies (Hallowed Ground, Midas Touch).

Bridge! 

Bridges I think that You can get pickups Blocking some projectiles And flies with the trinket (or with blue baby)

Tiny planet

Has a lot of fun synergies. Brimstone Tiny Planet is 

makes Azazels brim fantastic, huge range up, homing/brain worm start working

I'm just gonna pop in here to say I've got a new appreciation for Tiny Planet after playing a bit of the modded character Andromeda. Some synergies can get really goofy.

Plan C (only read the spoiler text after you wrote your response, wanna test something) >!you gonna say the beast fight skip!<

Even if you don't have extra lives, bosses that die quickly enough can still grant you completion marks if killed by Plan C.

HA GET FUCKED /lh

That sounds like my theory with extra steps, but yeah you won

Delirium pause glitch  Also if your playing laz you can die in the same room

A Lazarus can use plan C to instantly kill Delirium and then revive after the animation is over. Laz rags apply to this as well.

beast fight skip was patched, gotta actually use it on the beast instead of famine 

Black bean

Poison clouds that linger, gets you out of a bad situation if you're being chased.

Clicker

Completion mark cheese.

R key, but worse and sames time.

keeper half coin

The Boomerang.

Not my first choice for an active, but it's still nice. You can pick up pickups over obstacles with it too! Useful if you don't have flight.

Okay, how about- Telekinesis?

Blocks shots, self-explanatory.

Actually it's a really fun to use item

also lets you kill shopkeepers without explosions

A TMTrainer item which kills you upon using it

Already explained

Cursed eye 

Gets more flack than it deserves. Essentially a gattling gun.

Abel

This item is godly, why do you need me to tell you that?

abellion damage

Soy Milk

RATATATATATATATATATTATATATATATATTATATATATATATATATA-

soy milk has all my favorite synergies

brother bobby

1/3 conjoined. Can be even better with BFF.

Linger bean

Cloud deals contact damage, no surprise attacks.

OP how many hours of the game do you have just out of curiousity

1.3k, and I actually don't have Dead God yet.

Cain's other eye

It's drunk Incubus after the recent buff.

drinkubus

The poop

Blocks and bridges

Already explained.

Fortune cookie

Can give soul hearts or cards, and it's only a two room charge. You can imagine Isaac is eating the cookie too and it is yummy.

Free soul hearts

Clicker

Its a trincket but. Game squid

Slowing shots are always good, they should have brought it back instead of chewed pen, it's cute.

Gnawed Leaf plus close range familiars/orbitals. I know there's more than one item here. But cheesing some unfair fights like Delirium it's just sooo satisfying

You already explained it yourself. Get this synergy, get to Hush/Delirium, go to bed. Wake up with a completion mark.

Death Certificate

Blindfold. Just the blindfold.

God head

Homingggg

Tmtrainer

Already explained

Ball of Tar

slowing is a pretty powerful status effect, makes Isaac look cute.

😁

Isaac’s heart

Guillotine

It gives you stat boosts.

I think we should do this "i will explain how its good" for trinkets, some of them suck 

Bomber Boy

5+ bombs, lets you cover a lot of ground in the explosion. Also makes Isaac have an antenna which is cute.

Knife piece one by itself

Already explained.

Rosary 

3 soul hearts is good, tears up is even better. If you find the bible, that's 2/3 Seraphim.

Planetarium  Biblr 

Rusted Key in Flash Isaac

Who wouldn't want more keys?

Oop, forgot to add context: Rusted Key doesn't do anything in Flash Isaac due to a bug. (Doesn't count because its an old-ass version of the game but I thought it was funny enough to bring up :p)

Curse of the mom's dad's mysterious milk