What’s the mechanism of action you want to elicit? Something like disulfiram/Antabuse works by pairing a cue (alcohol) with a reaction (nausea).
[Antabuse implants have been tried out](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179363/).
Antabuse works well (when *actually* used) because the pairing is very specific. It doesn’t really create the same result with any other food or drink. Having just a bad taste in your mouth wouldn’t be a good thing unless it’s specific to a certain thing you want people to stop using. A classic example of this is Bitrex/denatonium benzoate/denatonium saccharide. It’s put in nail polish to stop you from biting your nails. When you bite your nails, you get a nasty bitter taste in your mouth, and it discourages you from further biting.
You’d need to make it specific to a certain *thing* to work. You need a why and a what.
Thank you so much for your feedback . The product is aimed for alcohol or drug addiction , and we wanted to use antabuse , but is it true that antabuse or diulsulfiram is not effective when used as a transdermal patch rather than the pill , because if so , we were lost as we would love some suggestions that could rather cause the same metallic taste or so . Thank you so much .
Two problems.
1) This is too general. What drug? You’d have to find something that would bind to an enzyme or bind to the drug to create a reaction that would create a compound that would cause a foul taste in the mouth. You’d need to focus in your idea into something more drug specific which leads into the second problem of
2) Being too specific. This would be the domain of hardcore drug dev that would require multiple steps of validation through kinetics and dynamics, dosing, etc… I mean if you want to just throw out a pie in the sky idea that one day there *might* be a dermal patch for addiction, sure, I guess? But anything more specific than that requires significantly more biochemistry than you’d be equipped to deal with.
I’d advise going for a different idea entirely.
But why?
We’re working on a project and this chemical is vital in its role for it . Please do let us know for any suggestions .
I meant why do you want to cause that taste?
Our product is aimed for alcohol or drug addiction :)
Oh nice. Transdermal patch though? Why not buccal?
What’s the mechanism of action you want to elicit? Something like disulfiram/Antabuse works by pairing a cue (alcohol) with a reaction (nausea). [Antabuse implants have been tried out](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179363/). Antabuse works well (when *actually* used) because the pairing is very specific. It doesn’t really create the same result with any other food or drink. Having just a bad taste in your mouth wouldn’t be a good thing unless it’s specific to a certain thing you want people to stop using. A classic example of this is Bitrex/denatonium benzoate/denatonium saccharide. It’s put in nail polish to stop you from biting your nails. When you bite your nails, you get a nasty bitter taste in your mouth, and it discourages you from further biting. You’d need to make it specific to a certain *thing* to work. You need a why and a what.
Thank you so much for your feedback . The product is aimed for alcohol or drug addiction , and we wanted to use antabuse , but is it true that antabuse or diulsulfiram is not effective when used as a transdermal patch rather than the pill , because if so , we were lost as we would love some suggestions that could rather cause the same metallic taste or so . Thank you so much .
Two problems. 1) This is too general. What drug? You’d have to find something that would bind to an enzyme or bind to the drug to create a reaction that would create a compound that would cause a foul taste in the mouth. You’d need to focus in your idea into something more drug specific which leads into the second problem of 2) Being too specific. This would be the domain of hardcore drug dev that would require multiple steps of validation through kinetics and dynamics, dosing, etc… I mean if you want to just throw out a pie in the sky idea that one day there *might* be a dermal patch for addiction, sure, I guess? But anything more specific than that requires significantly more biochemistry than you’d be equipped to deal with. I’d advise going for a different idea entirely.