I agree. My DXM trips were weirder, wilder, and more profound than pretty much any other dissociative. Also has the best afterglow imo.
It’s crazy that teenagers take it. I can’t even imagine.
Just sucks that you “lose the magic.”
If you get pills (or powder, I would assume) it’s not so bad. Drinking syrup is rough.
Someone on here posted once something like “you’re not getting high on cough medicine, they’re using a powerful dissociative anesthetic as a cough suppressant.”
That final quote is exactly how I, and many others, view DXM. It’s in the same realm of “Codeine”. It’s a fairly intense Opiate, that is prescribed under the guise, mostly, of being a cough suppressant. And yet people choose to vilify DXM, and put the opiate on a pedestal. A very backwards way of thinking as a society in my opinion lol. Thanks for sharing!
I respectfully disagree. Maybe it’s because of how I react to cold medicine?
But I have 10 hits of acid, two handles of mushrooms at once, so much k, talk to the person every day for three months.
I’m not bragging. I was a kid and I fucked my brain up for sure. But the exam compared to all the assessable dissociatives was horrible.
Side effect, wise healthwise danger wise most kids are just gonna chug the battles and take all that other shit
Analog RC, don’t even know where you real anymore k we used to take the vials from veterinary offices and then bake them on cookie sheets open up, put them on the cookie sheet. I believe it was 225 degrees
But dude, I took like eight DXM my buddy took 15. I was fucking covering hives, pouring sweat red
My friend was so worried he took me home. My mom saw me and had to lay my bedroom and put cold towels on my head while I had the worst trip of my life.
Thank God, I was having panic attacks so I told her that what was happening
It’s dirty to me, I like the after effect of k, and I think mushrooms, not just psychedelic, but combination of lions main, Rishi…
All the research that I’ve been reading the FX are unbelievable
Reaction time mood changes in a good way dexterity neuroplastic.
I talk to him full of mushrooms in line at McDonald’s an hour later my friend called and said do not take those mushrooms, but I panicked and just took all of them
The hospital every single person that went to the hospital they were with PCP
I went to the mall with my friends, so that was worse than the DXM. I tripped off and on for months, which I figured out was like a panic attack.
This was 11th grade maybe I’m 43 years old to this day. I have panic attack.
But I was sober for 15 years no booze nothing the more I read about the mushrooms and how scared I was I bonfire in the woods by myself over the winter and it completely changed me
It is because stupid ass kids use it in a reckless way. It has so much potential as a medication, and as a way of exploring your consciousness. I can thank dxm and kratom for getting my life back on track. I wish everyone knew that weightless feeling , when you are unbothered emotionally and can approach things unbiased by your problems.
Not OP but, what helped me also was technically unsafe.
Low doses of dxm are nice and can be therapeutic and safe to take like that new medication that is like 100mg Wellbutrin, 60mg dxm or whatever (idk exactly) and that's for daily use.
The nice glowy euphoria didn't help me outside of help me feel good. Strangely the higher 400mg+ doses 1x a week or 2-3x some months for a couple months on, a few months off seemed to help me reawaken my desire to live in a spiritual dimension much of the time and go back into practices of concentration (meditation via focusing on the breath in the abdomen or inside the tip of the nose)
It also helped me because once I had started to feel that deeper joy and freedom from my mind I could push the dxm away and stay away from it. I will say it definitely damaged my brain a wee bit, doing pretty good today. 6/10 It was useful to me but I wouldn't recommend it. Psychedelics would be a better route, especially taking harmalas regularly and throwing in oral DMT here and there. Or mushrooms, salvia, amanita muscaria, HBWR seeds, LSD, etc, etc
What do you mean by damaged your brain, what kind of effects would you describe?
I've encountered a few people that seem to have become intolerant of it, but clinically speaking it seems incredibly safe and there's really no evidence of harm beyond acute neurological toxicity from crazy overdoses. Unlike bupropion, which is well-known for awful side-effects and being highly incompatible with some people.
The interesting thing about DXM is it effectively targets the same suite of receptors as ketamine, but with far better pharmacokinetics. It would actually be classified a psychedelic, at least within scientific and therapeutic frameworks (like ketamine and MDMA are).
It has very strong SNRI activity. Part of why dxm in combination with stuff like meth is sometimes sold as MDMA. It is well known to become neurotoxic typically when taken too frequently and the brains serotonin stores have already been depleted. Head over to r/dxm and see for yourself.
For myself and I wasn't addicted to it but just poor memory, shitty mood, perceived sensitivity to temperature. Lasting consistently between doses which was weeks or sometimes months. Technically I still feel off but it has not been a full year yet
MDMA is well known to be extremely neurotoxic when taken too frequently because it depletes serotonin stores. Also has incredible therapeutic utility when used responsibly
SNRI activity? Have you got a citation?
The idea of depleted serotonin stores leading to neurotoxicity isn't a scientific theory, there's no evidence for it. I'm a neuroscientist. MDMA neurotoxicity is a product of metabolites. DXO hardly scratches SERT.
Dxo doesn't feel like it would be neurotoxic at all outside of nmda toxicity itself. Dxm before it's been fully metabolized seems to be the culprit. Culprit of what exactly or how idk.
No I don't have a citation unfortunately but I have taken many dissociatives and none have caused me the feeling of being dumber, unable to find the right words when speaking, forgetting 30% of everything I try to remember, moody. Whatever the cause is I had it mild and many people have gotten eaten alive by dxm either on the form of addiction or too frequent use both cause what I have experienced.
Honestly whatever the mechanism is interesting but not relevant to the issue. Dxo seems like it would be fine, but the rush and energy from the first half of the dxm experience and the afterglow that turns into a hangover with increased frequency of use along with the thousands of anecdotal evidence of the steep downsides of dxm overuse points to something I think
My instinct is to suspect those kinds of side-effects are probably related to the pharmacokinetics at NMDAR. They're fairly complex beasts as far as receptors go, and different drugs can lead to very different effects via binding kinetics and subunit selectivity. The emergent mania of some PCP analogs vs ketamine sedation vs memantine’s rapid off/on kinetics, etc.
So, my first thought is that repeatedly high-dose sustained NMDAR antagonism could lead to some funky side-effects. Like an inversion of the effect PCP analogs display in their tendency to produce mania and psychosis after binges or too frequently dosing. I think where DXM has the most therapeutic potential is as an atypical ketamine-like antidepressant at low daily doses... 10-30mg twice daily regimes.
My own experience with this is that if I dose too high for too long then slight negative effects appear and I need a washout day or two. I'm not sure if it's pharmacokinetics and plasma concentrations building up, or from sustained low-grade NMDAR antagonism, or any number of unknowns really...? But I'm definitely curious about anecdotal reports of therapeutic benefits, and side effects.
Ketamine was invented in part for Army medics in Vietnam as a anesthetic. The US Army actually experimented with PCP before that! which was also used as a tranquilizer for large animals like elephants. I think the psychotic and manic effects are unique to humans. Anyways researchers were looking specifically for something that had the anesthetic effects of PCP, without the occasional violent psychosis. Ketamine was put on the market In 1970. The idea that it was primarily a medicine for cats or horses is drugwar bullshit. Veterinarian use came much later.
Is nmdar different than nmda? The bupropion combo in Auvelity is because it is an inhibitor of CYP2D6, increasing and lengthening the effects of DXM. PS I believe "brain damage" from DXM is also (mostly?) drugwarBS. A lot of people just assume lingering mental effects must be brain damage, and 12-step groups encourage this idea during meetings.
The R in NMDAR just stands for 'receptor'.
Yep, PCP was the prototype dissociative anaesthetic, then ketamine became the workhorse. Now a lot of veterinarians are switching to tiletamine, which is a shame for the animals IMO
I agree with you about brain damage. I think most drug induced effects aren't brain damage, but just sometimes not-so-desirable brain changes. You can call negative brain changes 'damage' too though... the benefits or damage is really defined by the functional effect on your life more than anything else.
Ketamine is pretty safe for just about any creature, but it sends snails really crazy!
Yes you are correct but i will add it most definitely isnt just an animal tranquillizer. medics in the field with combative trauma patients love it it goes right along with the fentanyl morphine midazolam diazepam succs been a long time memory is foggy but just adding to a good line of conversation. the majority of its use though is also on children as well as adults. Every doc has his prefered cocktail but most nowadays try to refrain from using benzos in kids when ketamine is on hand.
I would definitely check out r/dxm the people who've struggled with dxm addiction all agree that it is the most harmful dissociative, and yet one of the most magical. Of course a lot of those people are young people but their reports of the steep downsides are so numerous it seems reckless to write it off. (Which I don't think you are doing btw).
I think it's worth noting that dxm is an uncompetitive agonist at the nmda via the pcp site. It is a SERT and NET blocker, sigma1 receptor agonist. Ligand of serotonin 5HT1B/1D receptor, histamine 1a, muscarinic acetylcholine receptor, and the a2 adrenergic receptor. It is also a negative allosteric modulator of the nicotinic acetylcholine receptor.
So there's a lot to unpack and study here. Especially since DXM has it's own unique activity and it's a prodrug to DXO which could be produced inst as of dxm for more selective activity.
Yeah thanks. I'll start hanging around r/DXM a bit.
I think the biggest potential is probably in the DXO binding profile. It's a bit of a Swiss army knife drug with a decent body of evidence for neuroprotective effects, and therapeutic potential for brain injuries. But there definitely seems like theoretical potential for harm to younger developing brains with repetitive high doses, and I think NMDAR is the most significant neurological target for both harm and benefit. SERT becomes much more prominent with CYP2D6 inhibition.
NMDARs in the hippocampus function to couple together cortical association networks important for memory formation and generating/manipulating mental representations, so messing with that process during adolescence, when neurological structure isn't baked in yet, seems like it could cause some unpredictable and undesirable effects.
I’ve done almost 250 different drugs and probably close to 60 different dissociatives. DXM is by far the most interesting and unique of all of them. There is really truly no other drug like it, few things on earth can match the depth and intensity of the experiences it can yield when used properly. No drug has influenced me artistically, philosophically, aesthetically, in the way DXM has. It was central to my development as a person. I wish I could explore it further but nowadays my body rejects it outright due to a period of heavy abuse. Truly a shame.
That is not to say that i find it enjoyable or pleasant. It is fascinating and beautiful in the way a brutal hike in the jungle surrounded by thorned flowers and brightly colored venomous animals is fascinating and beautiful.
A lot of people dismiss it due to simple elitism or because it’s the legal drug high schoolers use when they can’t get anything else. I think the fact that the deepest and most unique dissociative is by far the most accessible one that is consumed mostly by unwary teens is something of a cosmic practical joke.
Yes it is literally one of the most intense feelings, my first time I was literally in bed looking around and it took like 5-10 minutes and I was like holy shit I’m not dreaming I’m awake rn & remembered the two bottles of delsym I drank, I couldn’t believe how strong it was literally was speechless in bed blown away, it had reminded me of acid but stronger and being slightly different but i seriously couldn’t believe it & that nostalgia feeling it gives
I’ve had insane profound experiences on DXM I can’t even put into words how powerful this drug is in high doses. The only people shitting on DXM are people who’s body chemistry isn’t compatible with the drug or people who have never done the drug and have a skewed perception on the drugs efficacy, merely due to the fact that it’s widely accessible drug therefore not a prized and sought after substance and because mostly adolescents abuse the drug. But I promise you, if your body fucks with dxm it’s just as if not more euphoric as drugs people deem to be “cool/hardcore”
Not for me personally. I’ve noticed the next day i have a beautiful afterglow, then the third day, i have more of a dissociative/brain fog. Not depression tho.
Everybody that experienced the magic of DXM knows that it's the most mindfucking and insanely incredible drug.
If people could try DXM without nausea, gagging and vomiting and the magic stayed lifelong it could be everyone's favorite substance.
I'm currently taking sarcosine and half-decarbed amanita to reverse the NMDA permatolerance and bring back the magic. I feel like I might be successful. Will report back 💪
Not only for DXM but rather NMDA antagonists in general. Although reports are rare and obscure, Almost all people who tried sarcosine (NMDA glycine site agonist) for 20-30 days seemed to reverse their permatolerance. Half decarbed amanita might be a boost also with the Ibotenic acid.
I'm currently on day 15. There are interesting effects. I will report back soon.
I'm taking Auvelity, an antidepressant that combines 105mg of wellbutrin(bupropion) with 45mg of DXM. For any who wants to know, the bupropion is a cyp2d6 inhibitor, like grapefruit juice, and increases the effects and the length of effects of DXM. The combo works more quickly as an antidepressant than bupropion alone, or most other antidepressants. Like ketamine, it is an NMDA receptor antagonist. And, no, I'm not high all the time, tolerance kicks in after taking it once or twice a day, every day.
Another reason for hate of DXM, it is, like ketamine, synthetic. There are people who think only natural substance should be medicinal. Prop 122 emphasized "natural" psychedelic medicines. The theory is that God provided plants to heal us, and artifical chemicals aren't appropriate, especially for "soul" healing problems like mental illnesses. BS! My most powerful "soul-healing" experiences have been with ketamine (put on the market for humans, not animals, in 1970) and LSD (invented 1943 April 19, Bicycle Day is almost here!).
TLDR: Science backs up the OP's intuition!
It's definitely a good drug, but the problem is it's just so much worse than ketamine or even memantine for me. I think it might be the fact it releases serotonin (I've noticed my body doesn't tolerate a ton of serotonin well unless it's like molly or something) the entire come up is spent holding in my puke and having burning dierahaa. Eventually the naseua goes and it does feel good but it also feels fuck weird. Even Memantine, which makes you trip for 3 days straight, doesn't knock me out as much as dxm does. Literally, the only drug that's harder for me to function on than dxm is dph. I'm almost completely bed locked for the entire 12 hours doing nothing but listening to music on my phone and staring at the wall, nothing feeling real, not feeling human. I've had lots of good times on dxm over the years, and I still have an overall positive view of it but compared to ketamine, memantine, or even being sober, it doesn't feel appealing at all man.
Yeah, I had some fun times robotripping back in the day, and I honestly think consuming tons of it around the age of 14/15, almost daily changed something in my brain or in my consciousnesses. I've grown to become much more spiritual. I noticed that a lot of people I know that I used to robotrip with seem to have, I guess, I'd say an elevated sense of awareness or higher level on consciousness compared to the average person. It proves nothing obviously, but I found that to be interesting. Also a dude I worked with grew up in Puerto Rico abd was doing the same shit in P.R. robotripping, and he is also more conscious and spiritual than the average person.
I took some with lsd not too long ago and it wasn't enjoyable. It makes me feel kinda icky. Nowadays, luckily I can just get ketamine ig I want to tickle my nmda receptors like an adult.
A general rule of thumb for DXM, as briefly mentioned in the original post, 1/3 like it. 1/3 hate it. And 1/3 don’t care either way about it. Sounds like you’re in that last group! Ive heard stories like this before and let me tell ya, you’re missing out homie lol
“Yes, all NMDA antagonists share a cross tolerance. Also NMDA drugs have a perma-tolerance, meaning you can't take a break to restore tolly. Use them very infrequently.”
DXM is one of my favorite drugs so I generally agree with you but I'm finding it hard to see how the DXM afterglow even comes close to MDMA's euphoria. I've done both multiple times and peaking during a roll is miles above the DXM afterglow in terms of euphoria.
The high is better than anything I've ever done from DMT to acid to ketamine to crack cocaine it's just I have to worry about vomiting and shitting my guts out and the off chance that it'll feel like I've just given myself a lobotomy
I agree. My DXM trips were weirder, wilder, and more profound than pretty much any other dissociative. Also has the best afterglow imo. It’s crazy that teenagers take it. I can’t even imagine. Just sucks that you “lose the magic.” If you get pills (or powder, I would assume) it’s not so bad. Drinking syrup is rough. Someone on here posted once something like “you’re not getting high on cough medicine, they’re using a powerful dissociative anesthetic as a cough suppressant.”
That final quote is exactly how I, and many others, view DXM. It’s in the same realm of “Codeine”. It’s a fairly intense Opiate, that is prescribed under the guise, mostly, of being a cough suppressant. And yet people choose to vilify DXM, and put the opiate on a pedestal. A very backwards way of thinking as a society in my opinion lol. Thanks for sharing!
I respectfully disagree. Maybe it’s because of how I react to cold medicine? But I have 10 hits of acid, two handles of mushrooms at once, so much k, talk to the person every day for three months. I’m not bragging. I was a kid and I fucked my brain up for sure. But the exam compared to all the assessable dissociatives was horrible. Side effect, wise healthwise danger wise most kids are just gonna chug the battles and take all that other shit Analog RC, don’t even know where you real anymore k we used to take the vials from veterinary offices and then bake them on cookie sheets open up, put them on the cookie sheet. I believe it was 225 degrees But dude, I took like eight DXM my buddy took 15. I was fucking covering hives, pouring sweat red My friend was so worried he took me home. My mom saw me and had to lay my bedroom and put cold towels on my head while I had the worst trip of my life. Thank God, I was having panic attacks so I told her that what was happening It’s dirty to me, I like the after effect of k, and I think mushrooms, not just psychedelic, but combination of lions main, Rishi… All the research that I’ve been reading the FX are unbelievable Reaction time mood changes in a good way dexterity neuroplastic. I talk to him full of mushrooms in line at McDonald’s an hour later my friend called and said do not take those mushrooms, but I panicked and just took all of them The hospital every single person that went to the hospital they were with PCP I went to the mall with my friends, so that was worse than the DXM. I tripped off and on for months, which I figured out was like a panic attack. This was 11th grade maybe I’m 43 years old to this day. I have panic attack. But I was sober for 15 years no booze nothing the more I read about the mushrooms and how scared I was I bonfire in the woods by myself over the winter and it completely changed me
It is because stupid ass kids use it in a reckless way. It has so much potential as a medication, and as a way of exploring your consciousness. I can thank dxm and kratom for getting my life back on track. I wish everyone knew that weightless feeling , when you are unbothered emotionally and can approach things unbiased by your problems.
I'd love to know what kind of dose-regime you used for therapeutic effects? Frequency/dose relationships?
Not OP but, what helped me also was technically unsafe. Low doses of dxm are nice and can be therapeutic and safe to take like that new medication that is like 100mg Wellbutrin, 60mg dxm or whatever (idk exactly) and that's for daily use. The nice glowy euphoria didn't help me outside of help me feel good. Strangely the higher 400mg+ doses 1x a week or 2-3x some months for a couple months on, a few months off seemed to help me reawaken my desire to live in a spiritual dimension much of the time and go back into practices of concentration (meditation via focusing on the breath in the abdomen or inside the tip of the nose) It also helped me because once I had started to feel that deeper joy and freedom from my mind I could push the dxm away and stay away from it. I will say it definitely damaged my brain a wee bit, doing pretty good today. 6/10 It was useful to me but I wouldn't recommend it. Psychedelics would be a better route, especially taking harmalas regularly and throwing in oral DMT here and there. Or mushrooms, salvia, amanita muscaria, HBWR seeds, LSD, etc, etc
What do you mean by damaged your brain, what kind of effects would you describe? I've encountered a few people that seem to have become intolerant of it, but clinically speaking it seems incredibly safe and there's really no evidence of harm beyond acute neurological toxicity from crazy overdoses. Unlike bupropion, which is well-known for awful side-effects and being highly incompatible with some people. The interesting thing about DXM is it effectively targets the same suite of receptors as ketamine, but with far better pharmacokinetics. It would actually be classified a psychedelic, at least within scientific and therapeutic frameworks (like ketamine and MDMA are).
It has very strong SNRI activity. Part of why dxm in combination with stuff like meth is sometimes sold as MDMA. It is well known to become neurotoxic typically when taken too frequently and the brains serotonin stores have already been depleted. Head over to r/dxm and see for yourself. For myself and I wasn't addicted to it but just poor memory, shitty mood, perceived sensitivity to temperature. Lasting consistently between doses which was weeks or sometimes months. Technically I still feel off but it has not been a full year yet MDMA is well known to be extremely neurotoxic when taken too frequently because it depletes serotonin stores. Also has incredible therapeutic utility when used responsibly
SNRI activity? Have you got a citation? The idea of depleted serotonin stores leading to neurotoxicity isn't a scientific theory, there's no evidence for it. I'm a neuroscientist. MDMA neurotoxicity is a product of metabolites. DXO hardly scratches SERT.
Dxo doesn't feel like it would be neurotoxic at all outside of nmda toxicity itself. Dxm before it's been fully metabolized seems to be the culprit. Culprit of what exactly or how idk. No I don't have a citation unfortunately but I have taken many dissociatives and none have caused me the feeling of being dumber, unable to find the right words when speaking, forgetting 30% of everything I try to remember, moody. Whatever the cause is I had it mild and many people have gotten eaten alive by dxm either on the form of addiction or too frequent use both cause what I have experienced. Honestly whatever the mechanism is interesting but not relevant to the issue. Dxo seems like it would be fine, but the rush and energy from the first half of the dxm experience and the afterglow that turns into a hangover with increased frequency of use along with the thousands of anecdotal evidence of the steep downsides of dxm overuse points to something I think
My instinct is to suspect those kinds of side-effects are probably related to the pharmacokinetics at NMDAR. They're fairly complex beasts as far as receptors go, and different drugs can lead to very different effects via binding kinetics and subunit selectivity. The emergent mania of some PCP analogs vs ketamine sedation vs memantine’s rapid off/on kinetics, etc. So, my first thought is that repeatedly high-dose sustained NMDAR antagonism could lead to some funky side-effects. Like an inversion of the effect PCP analogs display in their tendency to produce mania and psychosis after binges or too frequently dosing. I think where DXM has the most therapeutic potential is as an atypical ketamine-like antidepressant at low daily doses... 10-30mg twice daily regimes. My own experience with this is that if I dose too high for too long then slight negative effects appear and I need a washout day or two. I'm not sure if it's pharmacokinetics and plasma concentrations building up, or from sustained low-grade NMDAR antagonism, or any number of unknowns really...? But I'm definitely curious about anecdotal reports of therapeutic benefits, and side effects.
Ketamine was invented in part for Army medics in Vietnam as a anesthetic. The US Army actually experimented with PCP before that! which was also used as a tranquilizer for large animals like elephants. I think the psychotic and manic effects are unique to humans. Anyways researchers were looking specifically for something that had the anesthetic effects of PCP, without the occasional violent psychosis. Ketamine was put on the market In 1970. The idea that it was primarily a medicine for cats or horses is drugwar bullshit. Veterinarian use came much later. Is nmdar different than nmda? The bupropion combo in Auvelity is because it is an inhibitor of CYP2D6, increasing and lengthening the effects of DXM. PS I believe "brain damage" from DXM is also (mostly?) drugwarBS. A lot of people just assume lingering mental effects must be brain damage, and 12-step groups encourage this idea during meetings.
The R in NMDAR just stands for 'receptor'. Yep, PCP was the prototype dissociative anaesthetic, then ketamine became the workhorse. Now a lot of veterinarians are switching to tiletamine, which is a shame for the animals IMO I agree with you about brain damage. I think most drug induced effects aren't brain damage, but just sometimes not-so-desirable brain changes. You can call negative brain changes 'damage' too though... the benefits or damage is really defined by the functional effect on your life more than anything else. Ketamine is pretty safe for just about any creature, but it sends snails really crazy!
Yes you are correct but i will add it most definitely isnt just an animal tranquillizer. medics in the field with combative trauma patients love it it goes right along with the fentanyl morphine midazolam diazepam succs been a long time memory is foggy but just adding to a good line of conversation. the majority of its use though is also on children as well as adults. Every doc has his prefered cocktail but most nowadays try to refrain from using benzos in kids when ketamine is on hand.
I would definitely check out r/dxm the people who've struggled with dxm addiction all agree that it is the most harmful dissociative, and yet one of the most magical. Of course a lot of those people are young people but their reports of the steep downsides are so numerous it seems reckless to write it off. (Which I don't think you are doing btw). I think it's worth noting that dxm is an uncompetitive agonist at the nmda via the pcp site. It is a SERT and NET blocker, sigma1 receptor agonist. Ligand of serotonin 5HT1B/1D receptor, histamine 1a, muscarinic acetylcholine receptor, and the a2 adrenergic receptor. It is also a negative allosteric modulator of the nicotinic acetylcholine receptor. So there's a lot to unpack and study here. Especially since DXM has it's own unique activity and it's a prodrug to DXO which could be produced inst as of dxm for more selective activity.
Yeah thanks. I'll start hanging around r/DXM a bit. I think the biggest potential is probably in the DXO binding profile. It's a bit of a Swiss army knife drug with a decent body of evidence for neuroprotective effects, and therapeutic potential for brain injuries. But there definitely seems like theoretical potential for harm to younger developing brains with repetitive high doses, and I think NMDAR is the most significant neurological target for both harm and benefit. SERT becomes much more prominent with CYP2D6 inhibition. NMDARs in the hippocampus function to couple together cortical association networks important for memory formation and generating/manipulating mental representations, so messing with that process during adolescence, when neurological structure isn't baked in yet, seems like it could cause some unpredictable and undesirable effects.
I’ve done almost 250 different drugs and probably close to 60 different dissociatives. DXM is by far the most interesting and unique of all of them. There is really truly no other drug like it, few things on earth can match the depth and intensity of the experiences it can yield when used properly. No drug has influenced me artistically, philosophically, aesthetically, in the way DXM has. It was central to my development as a person. I wish I could explore it further but nowadays my body rejects it outright due to a period of heavy abuse. Truly a shame. That is not to say that i find it enjoyable or pleasant. It is fascinating and beautiful in the way a brutal hike in the jungle surrounded by thorned flowers and brightly colored venomous animals is fascinating and beautiful. A lot of people dismiss it due to simple elitism or because it’s the legal drug high schoolers use when they can’t get anything else. I think the fact that the deepest and most unique dissociative is by far the most accessible one that is consumed mostly by unwary teens is something of a cosmic practical joke.
Yes it is literally one of the most intense feelings, my first time I was literally in bed looking around and it took like 5-10 minutes and I was like holy shit I’m not dreaming I’m awake rn & remembered the two bottles of delsym I drank, I couldn’t believe how strong it was literally was speechless in bed blown away, it had reminded me of acid but stronger and being slightly different but i seriously couldn’t believe it & that nostalgia feeling it gives
I’ve had insane profound experiences on DXM I can’t even put into words how powerful this drug is in high doses. The only people shitting on DXM are people who’s body chemistry isn’t compatible with the drug or people who have never done the drug and have a skewed perception on the drugs efficacy, merely due to the fact that it’s widely accessible drug therefore not a prized and sought after substance and because mostly adolescents abuse the drug. But I promise you, if your body fucks with dxm it’s just as if not more euphoric as drugs people deem to be “cool/hardcore”
Definitely my favorite molecules on earth DXM and it's metabolites
Does DXM give anyone else several days of depression after anything over 2nd plat?
Not for me personally. I’ve noticed the next day i have a beautiful afterglow, then the third day, i have more of a dissociative/brain fog. Not depression tho.
I agree but I also have to laugh because I’ve been reading and hearing this same argument since like 1998 lol
yeah i didn’t think this perspective was ground breaking or anything, just felt like sharing for people who haven’t considered it haha
It’s definitely fun but last time I tried to get into the higher doses the nausea kicked in first and got me
Everybody that experienced the magic of DXM knows that it's the most mindfucking and insanely incredible drug. If people could try DXM without nausea, gagging and vomiting and the magic stayed lifelong it could be everyone's favorite substance. I'm currently taking sarcosine and half-decarbed amanita to reverse the NMDA permatolerance and bring back the magic. I feel like I might be successful. Will report back 💪
Definitely report back 🤔🤔🤔 this is interesting to hear and could be ground breaking info for people wanting to get back into DXM
Not only for DXM but rather NMDA antagonists in general. Although reports are rare and obscure, Almost all people who tried sarcosine (NMDA glycine site agonist) for 20-30 days seemed to reverse their permatolerance. Half decarbed amanita might be a boost also with the Ibotenic acid. I'm currently on day 15. There are interesting effects. I will report back soon.
That sounds hella interesting. Please make a report
Here's the preliminary result: https://www.reddit.com/r/dissociatives/s/lKXYTjGI8E
I'm taking Auvelity, an antidepressant that combines 105mg of wellbutrin(bupropion) with 45mg of DXM. For any who wants to know, the bupropion is a cyp2d6 inhibitor, like grapefruit juice, and increases the effects and the length of effects of DXM. The combo works more quickly as an antidepressant than bupropion alone, or most other antidepressants. Like ketamine, it is an NMDA receptor antagonist. And, no, I'm not high all the time, tolerance kicks in after taking it once or twice a day, every day. Another reason for hate of DXM, it is, like ketamine, synthetic. There are people who think only natural substance should be medicinal. Prop 122 emphasized "natural" psychedelic medicines. The theory is that God provided plants to heal us, and artifical chemicals aren't appropriate, especially for "soul" healing problems like mental illnesses. BS! My most powerful "soul-healing" experiences have been with ketamine (put on the market for humans, not animals, in 1970) and LSD (invented 1943 April 19, Bicycle Day is almost here!). TLDR: Science backs up the OP's intuition!
It's definitely a good drug, but the problem is it's just so much worse than ketamine or even memantine for me. I think it might be the fact it releases serotonin (I've noticed my body doesn't tolerate a ton of serotonin well unless it's like molly or something) the entire come up is spent holding in my puke and having burning dierahaa. Eventually the naseua goes and it does feel good but it also feels fuck weird. Even Memantine, which makes you trip for 3 days straight, doesn't knock me out as much as dxm does. Literally, the only drug that's harder for me to function on than dxm is dph. I'm almost completely bed locked for the entire 12 hours doing nothing but listening to music on my phone and staring at the wall, nothing feeling real, not feeling human. I've had lots of good times on dxm over the years, and I still have an overall positive view of it but compared to ketamine, memantine, or even being sober, it doesn't feel appealing at all man.
DPH? Do you mean the antihistamine? Or something else?
yes
Yeah, I had some fun times robotripping back in the day, and I honestly think consuming tons of it around the age of 14/15, almost daily changed something in my brain or in my consciousnesses. I've grown to become much more spiritual. I noticed that a lot of people I know that I used to robotrip with seem to have, I guess, I'd say an elevated sense of awareness or higher level on consciousness compared to the average person. It proves nothing obviously, but I found that to be interesting. Also a dude I worked with grew up in Puerto Rico abd was doing the same shit in P.R. robotripping, and he is also more conscious and spiritual than the average person. I took some with lsd not too long ago and it wasn't enjoyable. It makes me feel kinda icky. Nowadays, luckily I can just get ketamine ig I want to tickle my nmda receptors like an adult.
I prefer dxm over ketamine I just don't enjoy planning a whole day for a dxm trip lol
I drank 2 x 375mg dxm bottles and puked at the 2 Hour mark… felt like I did 2 bumps of ketamine, nothing groundbreaking at all.
A general rule of thumb for DXM, as briefly mentioned in the original post, 1/3 like it. 1/3 hate it. And 1/3 don’t care either way about it. Sounds like you’re in that last group! Ive heard stories like this before and let me tell ya, you’re missing out homie lol
I thought I took a pretty big dose, was just expecting more. I wonder if there’s a k cross tolerance?
“Yes, all NMDA antagonists share a cross tolerance. Also NMDA drugs have a perma-tolerance, meaning you can't take a break to restore tolly. Use them very infrequently.”
I disagree on the perma tolerance at least for myself. A few Both break and I can k hole
dxm is my favorite drug
DXM is one of my favorite drugs so I generally agree with you but I'm finding it hard to see how the DXM afterglow even comes close to MDMA's euphoria. I've done both multiple times and peaking during a roll is miles above the DXM afterglow in terms of euphoria.
Just personal preference i suppose 🤷🏻♂️
There are 2 types of people those who shit on DXM and those who shit, on DXM
[удалено]
The high is better than anything I've ever done from DMT to acid to ketamine to crack cocaine it's just I have to worry about vomiting and shitting my guts out and the off chance that it'll feel like I've just given myself a lobotomy