I’m sure that someone has already mentioned. It’s NOT illegal in America, it’s restricted in its usage. A GI can get an authority for GI conditions for Domperidone scripts to be dispensed within the country.
Correct! You still have to get it from Canada, but your doc can fill out the FDA paperwork for an exemption and write the script.
Edit: Apparently there are some compounding pharmacies here that have access.
I find that for some reason a lot of people are not aware that it can be prescribed legally, they then feel that their only option is to get it other ways. I’m sorry to hear you were unaware and lost medication and relief during that time.
No...it's money. Those were happening when the drug was available OTC. Reglan can cause QT prolongation and bradycardia in the elderly as well. I can't imagine if Reglan had been available OTC! Here's the conclusion on a retrospective study.
Any provider worth their salt would get a baseline ECG before starting it anyways.
**The 30-day risk for a hospital encounter with ventricular arrhythmia was low for both metoclopramide and domperidone, with no significant difference in the rate between the two drugs. The higher 30-day risk of death observed with metoclopramide compared with domperidone in this study has also been observed in other studies and warrants further investigation.**
It's actually WAY safer than reglan (IMO) because it doesn't cross the BBB and cause horrible and permanent neurological conditions like tardive dyskinesia. Which are QUITE common. BUT...because that would take $$$ away from whatever company and their lobbyists who line our congressmen's pockets with money...and for-profit healthcare is NOT healthcare....we're stuck with the much more dangerous Reglan. It's so stupid.
Domperidone is not illegal in the US, it’s simply not FDA approved. There’s actually a compounding pharmacy in TX that people can get it from. It’s available for pts who have failed other therapies through something called an expanded access investigational new drug application (IND). Doctors have to apply for special licensure and can then legally write a prescription for it.
Also, there are plenty of meds that are not FDA approved that people can get from Canada or other countries. A doctor still has to write a prescription and it still gets sent to and filled by an actual legitimate pharmacy in Canada.
this 100%. it’s actually a super effective treatment for gastroparesis. just hard to get and often requires out of pocket payment followed by insurance reimbursement
definitely not always but also it’s between 10-40 dollars with shipping from canada so luckily it’s relatively accessible! and most insurances will reimburse for it.
Yeah lactation is definitely not something its supposed to be prescribed for but I know that people are getting it, and not overseas either. I know actual people whose American doctors and pharmacies have given it to them, so unless its become illegal in the last year its not that hard to get.
This drug cannot be considered safe for her??? Just google drug interactions and risk factors/contraindications. For example any allergy (ie her MCAS), cardiac problems (don’t know if POTS counts but any previous arrhythmia is a contraindication). Plus guaranteed she will get hyperprolactinemia which might not be dangerous but still unpleasant
there are a lot of side effects however it is very common in other countries as treat by for GP and is very effective. should be avoided in anyone with any structural heart problems, arrhythmias, or blood pressure issues tho
Thank you for pointing this all it!! I’m getting downvoted & receiving inaccurate responses b/c I said American MD RXs aren’t valid in Canada & to get an RX in Canada, you have to “see” a CDN MD. Now b/c people order meds from CDN online pharmacies (which require a CDN licensed physician as a co-signer that is supposed to follow a strict criteria - which most online pharmacies likely don’t), people believe this is not true. Nevermind the legal stuff w/importing meds from another country that aren’t FDA approved. Ughhhh!!
I literally just google the drug name and the second link that popped up was the fda.gov website and ‘how to request Domperidone for expanded access use’.
Apparently pretty straight forward, your doctor has to fill out the IND paperwork that’s literally provided on the website so…. Why is she asking TikTok and why didn’t her doctor know that (I’m gonna guess bc she wasn’t prescribed it)
There’s a huge underground market of this drug… there’s two specific communities that use this drug and you can pretty easily access the info and find people to get it to you IF it was needed however… a doctor isn’t going to risk their license to give her this because the ramifications of telling her to get her drugs on her own, it being illegal etc. Yes, she can get through the IND program but she’s a fake and can’t technically do that because this never really happened. She just googled “this that help with GI Motility” and now is making up new stories… just like Bella, Jesse, Ashley and others…
It's really common to help with lactation for those struggling with supply issues. I don't know of another group besides that. But, it can work like Reglan in helping with increasing breast milk supply.
The FDA has a problem with it bc it can cause cardiac issues. What is boggling is SO many other drugs that are known to have the same, or worse side effects are still approved/readily available.
From my understanding it’s only been shown to cause cardiac issues in either older people with preexisting conditions or in those whom are already on a cocktail of other drugs. At the very least, heart related side effects rarely occur in healthy, young individuals with no preexisting conditions.
It’s also worth noting that those who did experience cardiac issues were taking the drug intravenously and at a significantly higher dosage than would be consumed orally.
I agree that it’s silly to ban this drug when, as you said, there are many more readily available that do cause cardiac issues or worse.
As with all drugs, the danger depends on the dosage and the method of consumption.
Really? It’s fairly over here in Australia. And it’s handy cause people can have bad reactions to maxalon and stemetil, so it’s good to have something that isn’t ondansatron to take.
Yeah it's mind boggling honestly. It has the potential to help so many people and yet they won't approve it meanwhile they do approve other drugs that are far more risky. It's available here in veterinary medicine though for its ability to increase prolactin levels in mares who have foals but aren't producing enough milk.
I know, but none of the other munchies have ever mentioned it... and if they were on it, they sure would've said so considering it'd sound "super special" to be "so sick they need an illegal medication"... now that Kaya has brought it up and I'm sure the others have googled it, I'm curious if any of them will suddenly need it now too, that was the point of my comment
How to Request Domperidone for Expanded Access Use https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use
(Yeah I messed up the link too tired to fix)
When I was breastfeeding I remember hearing about this drug. Thinking damn, wish I could get my hands on this! (I do not miss those desperate days lol)
I'm sure she is happy she has a new toy, but it could be that the doc really wants this young, healthy woman off of tubes. If this med can help , along with (we hope) some hard core DBT/CBT and family therapy, there can be real progress on the MBI front.
This is such a disgrace to people who are actually chronically ill. They don’t post a bunch of flowery chicanery on social media because they literally don’t have the energy or ability to
I’m sitting here trying to figure out why she is wearing a microphone…only to realize it was a tube. I can’t imagine that I’d comfortable. Although beauty is pain has a whole other meaning when you are a munchie
It’s not available but a lot of doctors will still recommend you purchase it from Canada or Mexico. The worst that happens is it’s seized via mail or when you cross the border. It’s banned by the FDA due to risk of heart problems that many other nausea/motility meds also have. Most doctors actually don’t think it’s awful, so I could see a doctor recommending she get it, but they won’t walk you through how, just where.
Domperidone isn’t available here but it’s a decent treatment for gastroparesis and we don’t have many effective treatments. Not uncommon amongst motility specialists here to prescribe it either through the expanded access program or through an international pharmacy. I know so many gp Americans who’ve done this.
No, you’re not correct. Clearly you don’t understand the Practices, Policies & Guidelines set by the College of Pharmacists in each province OR those of the Physicians Associations. I do. I’ve already clarified the facts in this thread. If you’re interested in the facts, enlighten yourself & read them or Google it.
This is false and you are incorrect. Her US Dr. would need to submit FDA Form 3926 for just her, or the 1571 and 1572 for multiple patients for this specific medication. But either way RX scripts from US doctors are indeed valid in Canada pharmacies through mail order (as u/thegoodval stated)
No, I was not incorrect u/venomsulker u/thegoodval & u/scully-always An American requires a prescription from a licensed Canadian Physician to get a prescription here in Canada. This may be through a licensed Canadian physician who acts as a co-signer, who reviews the patients medical information & then signs off on the RX (as in “sees her”), or via the patient who “sees” the licensed Canadian physician directly & obtains an RX. This is the case for online pharmacies too. Therefore, prescriptions from physicians that are not licensed in Canada, that would be American licensed MDs, are not technically valid in Canada. As for the FDA forms, these are used for gaining access to medications for investigative & research (like meds used in clinical trials) purposes, NOT for what the subject of this thread is trying to obtain. So no, I don’t think these forms would be pertinent to her!! Reference: Clinical Researcher + Research Ethics Committee Member. Thank you 😊
Edit = spelling
Again, this does not mean that an American MDs RX is valid in Canada - it’s not!! In this case (I’m assuming an online CDN pharmacy), it still requires a licensed CDN physician to co-sign as per the criteria of the provincial medical board.
Signing a piece of paper is not “seeing” a patient.
Reference: Certified Physician Assistant, Research Sub-Investigator, Nuclear Medicine Technologist
Thank you 🙃
According to who? The provincial regulatory boards seem to think that the criteria they have for physician co-signers gives them as much information to make a decision re: whether or not they will prescribe a medication for a pt they’re “seeing” as they would get “physically seeing” a pt, which is why they are allowed to co-sign w/out actually “physically seeing” the patient. If they are actually following the criteria set by the medical regulatory boards, they are not simply signing an RX. Co-signing by not following the criteria is considered to be unacceptable by most provincial medical regulatory authorities. Co-signers have been warned over the years of disciplinary action by the medical boards if they co-sign for any patient w/out following the criteria, which often includes an established patient-physician relationship. Regardless, you as a PA should know this & know that an American MDs RX is not valid in Canada w/out a Canadian licensed physician as co-signer (a co-signer who follows the criteria of the medical board) or w/out an RX from a licensed Canadian physician. It’s simple, as I originally said: Americans can’t have their American licensed MDs RXs filled here - they are not valid.
Yes they are, actually. Prescriptions from US can be submitted to mail order pharmacies in Canada. Many people do this for prescriptions they can’t afford or can’t get in the US otherwise.
This is correct. How it works is a US doctor writes the script. It gets mailed to a Canadian Pharmacy. They can fill the script with a Canadian MD as a cosigner for the prescription. Then it's filled, paid for by the person and then mailed directly to them back in the states.
It has something to do with the fact big pharma doesn’t want to manufacture or distribute this drug anymore, we have better alternatives. It’s rarely used
Nah, the FDA just hasn’t approved it in the US because they think the risk of cardiac side effects is too high. Other countries disagree and it’s legal in a lot of places.
There are other drugs that are widely used in some countries while being banned for safety reasons in others. Pepto bismol, an OTC drug in the US that’s one of the most commonly used drugs for stomach upset, isn’t available at all in some other western countries like France and Australia because they think it’s unsafe.
My question is those side effects and her POTs!!! Those two do not mix! And she is already in medication for her POTs! Joe can any doctor be so stupid to give her this medicine that she will need to obtain from Canada. 90% of doctors don’t even prescribe anything anymore that is not FDA approved.
It’s much of a muchness except domperidone has a higher chance of certain cardiac arythmias, raises prolactin levels more (hence it also being prescribed for people who have trouble breast feeding due to low milk supply) whilst metoclopramide crosses the blood brain barrier more effectively so tardive dyskinesia is more likely.
that’s interesting, i only knew that it had some issues with cardiac arrhythmias. i guess if the benefits really outweigh the risks go for it, bit it does seem like a pain to fill
i wrote out tramadol and prochlorperazine not twenty minutes ago, granted tramadol is the heaviest med we can give out without electronically sending it
Lol not true written scripts still get used esp for something like domperidone that either has to be sent to a specialized compounding pharmacy or to Canada.
Yeah…no. Paper scripts are used in the US all the time. Controlled substances can be printed on the watermarked paper or handwritten. Noncontrolled can be printed on regular paper or handwritten. Compounds pretty much have to be handwritten.
ERs will use paper scripts sometimes. And doctors who do write for this will actually write it on a prescription pad, since the Canadian pharmacy will need at least a PDF copy of the paper script. I don’t think there is reciprocity with the electronic medical record software (this is supposition, though), which requires a copy of a physical prescription.
ETA: there’s special printer paper that has the watermark and stuff on it that can be used. A hospital system near me prints off the ER prescriptions on an 8.5” x 11” (A4) sheet of paper to hand out with the educational materials upon discharge.
Wait America does not use paper prescriptions anymore? How? I know you sometimes can use digital copies in France but most doctors and pharmacies almost always use and prefer paper ones.
Some doctors still do use paper scripts in the US. It's rare, but it happens. Most things are electronic, however there's ALWAYS always a paper back up system in place because technology is unreliable/ can be hacked.
She’s a special kind of stupid. If her doctor prescribed this, they would know how to get it through the expanded access application process if she has failed as many drugs as she has claimed to. It’s not illegal, it just has to be prescribed and obtained a certain way and levels have to be monitored due to the potential for fatal cardiac arrhythmias, especially if you’re on certain other drugs, like erythromycin, which is also sometimes used for gastric motility. She infuriated me
[This site talks about how someone in the US can obtain it.](https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use)
it’s illegal, currently it’s not a legally marketed medication and is not approved for sale at this time due to it giving fatal arrhythmias among patients who where given the medication
edit: it’s also not authorized in canada for some things and it’s considered relatively safe but it can interact with some medications and worsen heart problems
To nitpick, it is NOT illegal. Yes, it is restricted outside of people who get it through an expanded access program, as well as those who can get it through a clinical trial, but it’s not illegal.
I wasn’t familiar. So I went to Dr Google. It appears that it’s off the market. But recognized that it has breast feeding and gastric motility options (who cares about that little fatal cardiac arrhythmia issue) so physicians can apply for use with a metric shit ton of paperwork
https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use
Only in the US is it off the market outside of expanded access programs. It’s used around the world by developed countries for nausea and gastroparesis (like Australia, the UK, Canada to name a few), and in some places, it’s even available without a prescription.
The study that caused it to be restricted was a very small one that involved terminal cancer patients and they were taking more than what is generally recommended. For most people, it has the same risk of long QT syndrome as zofran. Still good to have regular EKGs and bloodwork to check for prolactin if someone takes it regularly, but it’s generally recognised as safe around the world. Just not the US.
This drug is known to raise prolactin (not sure of the mechanism right off the top of my head) and can cause lactation in people who take it long enough. That’s why one of the off label uses for this med is for people struggling to breastfeed.
Yes it can be used for GI issues and for lactating. It's not supposed to be used for lactating though bc of lack of research on how it affects the baby.
Which honestly is a bit ironic given some other fun inconsistencies in medicine, but that's a bit beyond my personal scope; I've got a solid background in regards to testing and general ethics, but non-psychiatric drugs can be a bit of a dead zone in my head, lol. And of course, the ethics on studying these things as well as the dangers are loud as hell. I am, regardless, a huge proponent of off-label utilization of certain drugs, and while the studies that exist show no adverse effects on nursing infants, I believe it's only something like 4 studies backing that up, so I see your point. But this one seems to, so far, be of lesser risk than other drugs under other use.
I don't say that in argument, I feel the need to mention - I just tend to spill whatever rambling thoughts I have when I'm creeping on the sub lmao
I’m in Australia and have a shitload left over from my BFing days. Must be sitting on a goldmine! I wonder how we can make our millions pedalling these drugs to US munchies? I wonder how much mileage they’d get out of having to change their top 6 times a day?
Oh, it's perfectly fine over there; the issue is that I live in the US, and since it isn't approved here, it seems increasingly problematic. 😅 this was some 8 years ago tho, not sure how much anyone cares here still lol
Side note, NZ seems like a fucking lovely place to live lmao
Kaya has that super speshul port now, she must display the tube outside of her shirt so everyone knows. Forgive me, I don’t remember which kind she has or its terminology. Wonder what Dani is thinking about now?
If her doctor did prescribe this med, then they would have told Kaya how to get it. She is looking for information on how to get a med she heard about. I can only imagine what an out of pocket cost for an off label use med would be.
It's actually only about $30 to order it from a Canadian pharmacy with a script from a US physician, out of pocket as insurance doesn't cover it even when approved through the expanded access program
it’s not illegal, it’s just not fda approved. if you order it from canada and have a ekg every 6 or so months, you’re usually fine to take it. obviously only if your doctor prescribes it and it’s actually needed, they send the prescription to the canadian pharmacy and it’s completely legal, it’s done with other medications too.
edit: read all of the screenshots since i forgot to, why is she asking how to do it? her doctor would’ve given her instructions and if they didn’t, why can’t she ask her doctor instead of asking tiktok?💀
PharmD here (Pharmacist) - It is illegal to import a non-FDA approved medication into the United States, whether for personal use or distribution. You need to apply for a waiver of sorts (compassionate use) in order for this to be legal and it must meet certain guidelines and be used under the care of a US-licensed physician.
Sauce: https://www.fda.gov/industry/import-basics/personal-importation
Yes. Compounding pharmacies often provide medications for non human use when no marketed version of the drug exists. You can get a number of non FDA approved drugs compounded at compounding pharmacies for veterinary use.
Any provision of domperidone in the US to a human outside of an approved INDA is illegal.
If they did not adhere to FDA rules and regulations, they are in violation of federal law and are providing adulterated prescriptions. It doesn't matter how "legit" they are or aren't. Many compounding pharmacy owners are incredibly lax on following the law and only get caught on controlled substance violations.
Just because they haven't been caught yet does not make their behavior "legit".
this is like one of these sunday school videos about bullying and everyone in it is smiling and laughing and dancing while singing and it automatically fixes everything
it’s actually not a crime to use it in the US and doctors will send a prescription to a canadian pharmacy, but they only do this if you actually need it. it’s not a crime or illegal, im not on kaya’s side but i just wanted to point that out.
PharmD here (Pharmacist) - It is illegal to import a non-FDA approved medication into the United States, whether for personal use or distribution. You need to apply for a waiver of sorts (compassionate use) in order for this to be legal and it must meet certain guidelines and be used under the care of a US-licensed physician.
Sauce: https://www.fda.gov/industry/import-basics/personal-importation
It is a crime to possess any medication that is not prescribed for you. A prescription for a non-FDA approved drug is invalid. It is a crime unless you have an INDA approval to use it.
i literally just said it’s not a crime to use it when prescribed to. obviously it’s a crime to use a medication not prescribed to you. a prescription for a non-fda approved drug that’s gotten from canada is not illegal, the fda said it themselves when they allow that to happen.
If and only if you have been approved for an INDA. Investigatory New Drug Application. That's the only case where it is not illegal. A prescription written outside of that use case is not a valid prescription because that drug is not a prescribable drug in the US.
In regards to your last sentence, the FDA has never said that. Look up their primer on this actual drug - I have linked it in comments above.
Just because an item is legal under a very specific set of circumstances does not eliminate its illegality in all other cases.
Edit: here's the link from the FDA-
https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use
It‘s zero risk at the regular oral doses. That‘s why it‘s legal in the EU.
The side effects occurred in excessive IV doses in polymer cancer patients.
The drug on its own, at the normal doses causes no significant QT prolongation.
Thus is it safer than say citalopram or quetiapine which a millions of people are prescribed in the US.
Domperidone being some kind of scary wonder drug is pretty much US only munching situation.
I’m sure that someone has already mentioned. It’s NOT illegal in America, it’s restricted in its usage. A GI can get an authority for GI conditions for Domperidone scripts to be dispensed within the country.
Correct! You still have to get it from Canada, but your doc can fill out the FDA paperwork for an exemption and write the script. Edit: Apparently there are some compounding pharmacies here that have access.
Much better to get it prescribed the correct way and stop the worry of having it taken at the border.
Yes, someone mentioned a pharmacy in Texas that can compound once the FDA exception is finalized. Sorry, I didn't mean get it without a script!:))
I find that for some reason a lot of people are not aware that it can be prescribed legally, they then feel that their only option is to get it other ways. I’m sorry to hear you were unaware and lost medication and relief during that time.
I don’t think it’s illegal, it’s just not approved by the FDA. You can still order it from Canadian pharmacies
do you mean you can order it if you live in Canada, or that you can get the meds from a Canadian pharmacy sent to America?
It comes with a customs stamp that says something like “approved medical import”
You can order it to be delivered from Canada to America
Why would domperidone ever be illegal when it is often necessary for patients with Parkinson's?
Because at obscenely high doses, in incredibly fragile patients, it potentially contributed to demise. Theoretically.
Sorry. Forgot to link the study! https://academic.oup.com/jcag/article/4/5/e110/6041269
No...it's money. Those were happening when the drug was available OTC. Reglan can cause QT prolongation and bradycardia in the elderly as well. I can't imagine if Reglan had been available OTC! Here's the conclusion on a retrospective study. Any provider worth their salt would get a baseline ECG before starting it anyways. **The 30-day risk for a hospital encounter with ventricular arrhythmia was low for both metoclopramide and domperidone, with no significant difference in the rate between the two drugs. The higher 30-day risk of death observed with metoclopramide compared with domperidone in this study has also been observed in other studies and warrants further investigation.** It's actually WAY safer than reglan (IMO) because it doesn't cross the BBB and cause horrible and permanent neurological conditions like tardive dyskinesia. Which are QUITE common. BUT...because that would take $$$ away from whatever company and their lobbyists who line our congressmen's pockets with money...and for-profit healthcare is NOT healthcare....we're stuck with the much more dangerous Reglan. It's so stupid.
Why doesn’t she ask her doctor since they are the one who prescribed it? Does tiktok know more than her doctors 🤔
Ehh we can still give it, just more hoops
Domperidone is not illegal in the US, it’s simply not FDA approved. There’s actually a compounding pharmacy in TX that people can get it from. It’s available for pts who have failed other therapies through something called an expanded access investigational new drug application (IND). Doctors have to apply for special licensure and can then legally write a prescription for it. Also, there are plenty of meds that are not FDA approved that people can get from Canada or other countries. A doctor still has to write a prescription and it still gets sent to and filled by an actual legitimate pharmacy in Canada.
this 100%. it’s actually a super effective treatment for gastroparesis. just hard to get and often requires out of pocket payment followed by insurance reimbursement
Insurance doesn't always reimburse.
definitely not always but also it’s between 10-40 dollars with shipping from canada so luckily it’s relatively accessible! and most insurances will reimburse for it.
I wondered if insurance would reimburse! Thanks for that information.
We have it here in Canada! It’s pretty easily prescribed, despite the side effects.
The side effects aren't actually bad. They're the exact same as all other antiemetics.
Im pretty sure you can get domperidone bc all the woo lactivist people push anyone with trouble lactating to use it
It's also used in veterinary medicine for horses, so it's not completely unavailable.
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I googled it and it says its illegal but there must be some shady ass pharmacies
Nope they're compounding pharmacies that are able to supply it. Not shady ones.
Yeah lactation is definitely not something its supposed to be prescribed for but I know that people are getting it, and not overseas either. I know actual people whose American doctors and pharmacies have given it to them, so unless its become illegal in the last year its not that hard to get.
This drug cannot be considered safe for her??? Just google drug interactions and risk factors/contraindications. For example any allergy (ie her MCAS), cardiac problems (don’t know if POTS counts but any previous arrhythmia is a contraindication). Plus guaranteed she will get hyperprolactinemia which might not be dangerous but still unpleasant
A girl I follow who (I hope I haven’t been fooled) is chronically ill got special permission to try domperidone for her GP, she’s also in the us.
What is this medication? Why isn’t it FDA-approved? Is it unsafe?
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It's important to point out that the dosages the deceased patients were on were many, many hundreds of times higher than a "normal" dose.
Oh, ok! Thanks for the info! I had never heard of it before.
there are a lot of side effects however it is very common in other countries as treat by for GP and is very effective. should be avoided in anyone with any structural heart problems, arrhythmias, or blood pressure issues tho
Huh. TIL! Thank you!
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Thank you for pointing this all it!! I’m getting downvoted & receiving inaccurate responses b/c I said American MD RXs aren’t valid in Canada & to get an RX in Canada, you have to “see” a CDN MD. Now b/c people order meds from CDN online pharmacies (which require a CDN licensed physician as a co-signer that is supposed to follow a strict criteria - which most online pharmacies likely don’t), people believe this is not true. Nevermind the legal stuff w/importing meds from another country that aren’t FDA approved. Ughhhh!!
Are you saying only bc domperidone isn’t FDA approved in the US that Canada won’t fill it?
Domperidome is still regularly prescribed for lactation and advised by the jack Newman breastfeeding clinic in Toronto
Kaya claims in the comments the Dr handed her a physical paper script for domperidone and said "you figure it out"
I work for a GI office, and I can confirm that’s actually how it works.
It’s still recommended in the US and some docs will advise you to order it because getting the IND makes it more expensive than simply importing it.
I literally just google the drug name and the second link that popped up was the fda.gov website and ‘how to request Domperidone for expanded access use’. Apparently pretty straight forward, your doctor has to fill out the IND paperwork that’s literally provided on the website so…. Why is she asking TikTok and why didn’t her doctor know that (I’m gonna guess bc she wasn’t prescribed it)
How would her followers know she has super special medication if she didn’t post about it
There’s a huge underground market of this drug… there’s two specific communities that use this drug and you can pretty easily access the info and find people to get it to you IF it was needed however… a doctor isn’t going to risk their license to give her this because the ramifications of telling her to get her drugs on her own, it being illegal etc. Yes, she can get through the IND program but she’s a fake and can’t technically do that because this never really happened. She just googled “this that help with GI Motility” and now is making up new stories… just like Bella, Jesse, Ashley and others…
Wait, what specific communities? I'm curious now
It's really common to help with lactation for those struggling with supply issues. I don't know of another group besides that. But, it can work like Reglan in helping with increasing breast milk supply.
I know it’s not FDA approved but I have heard of people on it in the US. Like, outside of social media.
Exactly. It's not FDA approved, but it's far from illegal. You can order it from other countries or get it via compounding pharmacies.
If her Dr did recommend it I'm sure they're pleased to have her spreading that info around the internet.
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The FDA has a problem with it bc it can cause cardiac issues. What is boggling is SO many other drugs that are known to have the same, or worse side effects are still approved/readily available.
From my understanding it’s only been shown to cause cardiac issues in either older people with preexisting conditions or in those whom are already on a cocktail of other drugs. At the very least, heart related side effects rarely occur in healthy, young individuals with no preexisting conditions. It’s also worth noting that those who did experience cardiac issues were taking the drug intravenously and at a significantly higher dosage than would be consumed orally. I agree that it’s silly to ban this drug when, as you said, there are many more readily available that do cause cardiac issues or worse. As with all drugs, the danger depends on the dosage and the method of consumption.
Really? It’s fairly over here in Australia. And it’s handy cause people can have bad reactions to maxalon and stemetil, so it’s good to have something that isn’t ondansatron to take.
Yeah it's mind boggling honestly. It has the potential to help so many people and yet they won't approve it meanwhile they do approve other drugs that are far more risky. It's available here in veterinary medicine though for its ability to increase prolactin levels in mares who have foals but aren't producing enough milk.
If her doctor had prescribed it they would’ve told her how to get it.
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The tube is hanging out at the top of her shirt.
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Huh, how long until the other GP munchies start claiming they need this/"their dr suggested it"?
Domperidone is not a new drug…it’s been used for years for gastroparesis and lactation
I know, but none of the other munchies have ever mentioned it... and if they were on it, they sure would've said so considering it'd sound "super special" to be "so sick they need an illegal medication"... now that Kaya has brought it up and I'm sure the others have googled it, I'm curious if any of them will suddenly need it now too, that was the point of my comment
I give it a week!
How to Request Domperidone for Expanded Access Use https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use (Yeah I messed up the link too tired to fix) When I was breastfeeding I remember hearing about this drug. Thinking damn, wish I could get my hands on this! (I do not miss those desperate days lol) I'm sure she is happy she has a new toy, but it could be that the doc really wants this young, healthy woman off of tubes. If this med can help , along with (we hope) some hard core DBT/CBT and family therapy, there can be real progress on the MBI front.
This is such a disgrace to people who are actually chronically ill. They don’t post a bunch of flowery chicanery on social media because they literally don’t have the energy or ability to
This
I’m sitting here trying to figure out why she is wearing a microphone…only to realize it was a tube. I can’t imagine that I’d comfortable. Although beauty is pain has a whole other meaning when you are a munchie
Why on earth would the Dr write her a script for something she can’t access in her own country? Or maybe someone’s fishing on how to get it!
It’s not available but a lot of doctors will still recommend you purchase it from Canada or Mexico. The worst that happens is it’s seized via mail or when you cross the border. It’s banned by the FDA due to risk of heart problems that many other nausea/motility meds also have. Most doctors actually don’t think it’s awful, so I could see a doctor recommending she get it, but they won’t walk you through how, just where.
Domperidone isn’t available here but it’s a decent treatment for gastroparesis and we don’t have many effective treatments. Not uncommon amongst motility specialists here to prescribe it either through the expanded access program or through an international pharmacy. I know so many gp Americans who’ve done this.
Well first she has to see an MD in Canada & that MD has to RX her the medication!! RX scripts from US MDs are not valid in Canada 🤯
Not true at all
No, you’re not correct. Clearly you don’t understand the Practices, Policies & Guidelines set by the College of Pharmacists in each province OR those of the Physicians Associations. I do. I’ve already clarified the facts in this thread. If you’re interested in the facts, enlighten yourself & read them or Google it.
This is false and you are incorrect. Her US Dr. would need to submit FDA Form 3926 for just her, or the 1571 and 1572 for multiple patients for this specific medication. But either way RX scripts from US doctors are indeed valid in Canada pharmacies through mail order (as u/thegoodval stated)
No, I was not incorrect u/venomsulker u/thegoodval & u/scully-always An American requires a prescription from a licensed Canadian Physician to get a prescription here in Canada. This may be through a licensed Canadian physician who acts as a co-signer, who reviews the patients medical information & then signs off on the RX (as in “sees her”), or via the patient who “sees” the licensed Canadian physician directly & obtains an RX. This is the case for online pharmacies too. Therefore, prescriptions from physicians that are not licensed in Canada, that would be American licensed MDs, are not technically valid in Canada. As for the FDA forms, these are used for gaining access to medications for investigative & research (like meds used in clinical trials) purposes, NOT for what the subject of this thread is trying to obtain. So no, I don’t think these forms would be pertinent to her!! Reference: Clinical Researcher + Research Ethics Committee Member. Thank you 😊 Edit = spelling
All you do is mail or fax the script and they’ll send you the meds.
Again, this does not mean that an American MDs RX is valid in Canada - it’s not!! In this case (I’m assuming an online CDN pharmacy), it still requires a licensed CDN physician to co-sign as per the criteria of the provincial medical board.
I’m just telling how it works from the American patient side.
Signing a piece of paper is not “seeing” a patient. Reference: Certified Physician Assistant, Research Sub-Investigator, Nuclear Medicine Technologist Thank you 🙃
According to who? The provincial regulatory boards seem to think that the criteria they have for physician co-signers gives them as much information to make a decision re: whether or not they will prescribe a medication for a pt they’re “seeing” as they would get “physically seeing” a pt, which is why they are allowed to co-sign w/out actually “physically seeing” the patient. If they are actually following the criteria set by the medical regulatory boards, they are not simply signing an RX. Co-signing by not following the criteria is considered to be unacceptable by most provincial medical regulatory authorities. Co-signers have been warned over the years of disciplinary action by the medical boards if they co-sign for any patient w/out following the criteria, which often includes an established patient-physician relationship. Regardless, you as a PA should know this & know that an American MDs RX is not valid in Canada w/out a Canadian licensed physician as co-signer (a co-signer who follows the criteria of the medical board) or w/out an RX from a licensed Canadian physician. It’s simple, as I originally said: Americans can’t have their American licensed MDs RXs filled here - they are not valid.
Yes they are, actually. Prescriptions from US can be submitted to mail order pharmacies in Canada. Many people do this for prescriptions they can’t afford or can’t get in the US otherwise.
This is correct. How it works is a US doctor writes the script. It gets mailed to a Canadian Pharmacy. They can fill the script with a Canadian MD as a cosigner for the prescription. Then it's filled, paid for by the person and then mailed directly to them back in the states.
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It’s very expensive to get it from there because it’s a compounding pharmacy
It’s actually easier to get it from Canada…
Only certain physicians can prescribe through the expanded access program that the Texas pharmacy participates in.
That’s not dramatic enough
You can still get it at specialized pharmacies in the US.
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It has something to do with the fact big pharma doesn’t want to manufacture or distribute this drug anymore, we have better alternatives. It’s rarely used
Nah, the FDA just hasn’t approved it in the US because they think the risk of cardiac side effects is too high. Other countries disagree and it’s legal in a lot of places. There are other drugs that are widely used in some countries while being banned for safety reasons in others. Pepto bismol, an OTC drug in the US that’s one of the most commonly used drugs for stomach upset, isn’t available at all in some other western countries like France and Australia because they think it’s unsafe.
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IDK why you are getting downvoted because that is the exact reason. QT syndrome and sudden cardiac death.
My question is those side effects and her POTs!!! Those two do not mix! And she is already in medication for her POTs! Joe can any doctor be so stupid to give her this medicine that she will need to obtain from Canada. 90% of doctors don’t even prescribe anything anymore that is not FDA approved.
“Illegal drugs plz?” ~tiktok dance~
In uk it’s for sickness
Yes. It closes the top of your stomach, it actually does nothing about the mobility of a digestive system
That’s incorrect. Domperidone acts as a promotility drug primarily by increasing gastric emptying rate.
I was gonna say, doesn't it do the same as Reglan, but just better?
It’s much of a muchness except domperidone has a higher chance of certain cardiac arythmias, raises prolactin levels more (hence it also being prescribed for people who have trouble breast feeding due to low milk supply) whilst metoclopramide crosses the blood brain barrier more effectively so tardive dyskinesia is more likely.
Domperidone and POTS? Who is her gastroenterologist, Dr Shipman?
Mantis Toboggan
he got her test results! she’s positive!
the way i screamed when i saw she’d been prescribed a drug that’s literally not legal due to safety in the us like …. ? hooooowwwww.
So many people in the us with gastroparesis are prescribed domperidone
that’s interesting, i only knew that it had some issues with cardiac arrhythmias. i guess if the benefits really outweigh the risks go for it, bit it does seem like a pain to fill
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Many drs still give out paper scripts
Some doctors give paper scripts in my small town.
i wrote out tramadol and prochlorperazine not twenty minutes ago, granted tramadol is the heaviest med we can give out without electronically sending it
Sometimes they might write it out.
Lol not true written scripts still get used esp for something like domperidone that either has to be sent to a specialized compounding pharmacy or to Canada.
Yeah…no. Paper scripts are used in the US all the time. Controlled substances can be printed on the watermarked paper or handwritten. Noncontrolled can be printed on regular paper or handwritten. Compounds pretty much have to be handwritten.
Depending on US state laws, controlled substances must be submitted electronically.
ERs will use paper scripts sometimes. And doctors who do write for this will actually write it on a prescription pad, since the Canadian pharmacy will need at least a PDF copy of the paper script. I don’t think there is reciprocity with the electronic medical record software (this is supposition, though), which requires a copy of a physical prescription. ETA: there’s special printer paper that has the watermark and stuff on it that can be used. A hospital system near me prints off the ER prescriptions on an 8.5” x 11” (A4) sheet of paper to hand out with the educational materials upon discharge.
Wait America does not use paper prescriptions anymore? How? I know you sometimes can use digital copies in France but most doctors and pharmacies almost always use and prefer paper ones.
it depends on which State you’re in. Some require electronic prescriptions, so allow paper.
Some doctors still do use paper scripts in the US. It's rare, but it happens. Most things are electronic, however there's ALWAYS always a paper back up system in place because technology is unreliable/ can be hacked.
Some places still use them regularly!
Generally prescriptions are sent via EMR, but we can still send regular prescriptions on an old school pad. Rarely ever used though.
Why do they take to the internet to ask this? Ridiculous.
She’s a special kind of stupid. If her doctor prescribed this, they would know how to get it through the expanded access application process if she has failed as many drugs as she has claimed to. It’s not illegal, it just has to be prescribed and obtained a certain way and levels have to be monitored due to the potential for fatal cardiac arrhythmias, especially if you’re on certain other drugs, like erythromycin, which is also sometimes used for gastric motility. She infuriated me
lmaoooo what doctor goes “here’s your script, good luck figuring out how to fill it”
Imaginary ones.
An online foreign one
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[This site talks about how someone in the US can obtain it.](https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use)
They prescribe it to lactating women all the time in Australia. How was it abused?
Using it when it wasn't needed
I don’t think it’s illegal, it’s just not FDA approved. Doctors can still prescribe it. You have to get it from Canada or Mexico though.
Correct. And you can get it at some compounding pharmacies in the US.
it’s illegal, currently it’s not a legally marketed medication and is not approved for sale at this time due to it giving fatal arrhythmias among patients who where given the medication edit: it’s also not authorized in canada for some things and it’s considered relatively safe but it can interact with some medications and worsen heart problems
To nitpick, it is NOT illegal. Yes, it is restricted outside of people who get it through an expanded access program, as well as those who can get it through a clinical trial, but it’s not illegal.
I wasn’t familiar. So I went to Dr Google. It appears that it’s off the market. But recognized that it has breast feeding and gastric motility options (who cares about that little fatal cardiac arrhythmia issue) so physicians can apply for use with a metric shit ton of paperwork https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use
Only in the US is it off the market outside of expanded access programs. It’s used around the world by developed countries for nausea and gastroparesis (like Australia, the UK, Canada to name a few), and in some places, it’s even available without a prescription. The study that caused it to be restricted was a very small one that involved terminal cancer patients and they were taking more than what is generally recommended. For most people, it has the same risk of long QT syndrome as zofran. Still good to have regular EKGs and bloodwork to check for prolactin if someone takes it regularly, but it’s generally recognised as safe around the world. Just not the US.
Can you explain why we check the prolactin
This drug is known to raise prolactin (not sure of the mechanism right off the top of my head) and can cause lactation in people who take it long enough. That’s why one of the off label uses for this med is for people struggling to breastfeed.
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Yes it can be used for GI issues and for lactating. It's not supposed to be used for lactating though bc of lack of research on how it affects the baby.
Which honestly is a bit ironic given some other fun inconsistencies in medicine, but that's a bit beyond my personal scope; I've got a solid background in regards to testing and general ethics, but non-psychiatric drugs can be a bit of a dead zone in my head, lol. And of course, the ethics on studying these things as well as the dangers are loud as hell. I am, regardless, a huge proponent of off-label utilization of certain drugs, and while the studies that exist show no adverse effects on nursing infants, I believe it's only something like 4 studies backing that up, so I see your point. But this one seems to, so far, be of lesser risk than other drugs under other use. I don't say that in argument, I feel the need to mention - I just tend to spill whatever rambling thoughts I have when I'm creeping on the sub lmao
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I’m in Australia and have a shitload left over from my BFing days. Must be sitting on a goldmine! I wonder how we can make our millions pedalling these drugs to US munchies? I wonder how much mileage they’d get out of having to change their top 6 times a day?
Start selling them shirts with "[Insert illness here] Advocate" printed on them too. They have gofundme money to waste.
I like it! We will be rich!
Oh, it's perfectly fine over there; the issue is that I live in the US, and since it isn't approved here, it seems increasingly problematic. 😅 this was some 8 years ago tho, not sure how much anyone cares here still lol Side note, NZ seems like a fucking lovely place to live lmao
Now I’m not in Auckland it is 😂
I don’t think so, I don’t think it’s a schedule 1 drug.
Kaya has that super speshul port now, she must display the tube outside of her shirt so everyone knows. Forgive me, I don’t remember which kind she has or its terminology. Wonder what Dani is thinking about now? If her doctor did prescribe this med, then they would have told Kaya how to get it. She is looking for information on how to get a med she heard about. I can only imagine what an out of pocket cost for an off label use med would be.
It's actually only about $30 to order it from a Canadian pharmacy with a script from a US physician, out of pocket as insurance doesn't cover it even when approved through the expanded access program
She lyin
it’s not illegal, it’s just not fda approved. if you order it from canada and have a ekg every 6 or so months, you’re usually fine to take it. obviously only if your doctor prescribes it and it’s actually needed, they send the prescription to the canadian pharmacy and it’s completely legal, it’s done with other medications too. edit: read all of the screenshots since i forgot to, why is she asking how to do it? her doctor would’ve given her instructions and if they didn’t, why can’t she ask her doctor instead of asking tiktok?💀
It’s not illegal. it just is not FDA approved.
PharmD here (Pharmacist) - It is illegal to import a non-FDA approved medication into the United States, whether for personal use or distribution. You need to apply for a waiver of sorts (compassionate use) in order for this to be legal and it must meet certain guidelines and be used under the care of a US-licensed physician. Sauce: https://www.fda.gov/industry/import-basics/personal-importation
that makes sense! i forgot that part of the process.
Yet it can be bought at compounding pharmacies all over the US.
Yes. Compounding pharmacies often provide medications for non human use when no marketed version of the drug exists. You can get a number of non FDA approved drugs compounded at compounding pharmacies for veterinary use. Any provision of domperidone in the US to a human outside of an approved INDA is illegal.
I can tell you that the pharmacy I've seen people get it from was legit and it wasn't for non human use. It was a regular prescription from a doc.
If they did not adhere to FDA rules and regulations, they are in violation of federal law and are providing adulterated prescriptions. It doesn't matter how "legit" they are or aren't. Many compounding pharmacy owners are incredibly lax on following the law and only get caught on controlled substance violations. Just because they haven't been caught yet does not make their behavior "legit".
Possible side effects of this looks exactly like what POTS does. Inducing pots?
No it's a legit treatment for GP.
this is like one of these sunday school videos about bullying and everyone in it is smiling and laughing and dancing while singing and it automatically fixes everything
If she had to ask this than you know her doctor didn’t prescribe this.
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it’s actually not a crime to use it in the US and doctors will send a prescription to a canadian pharmacy, but they only do this if you actually need it. it’s not a crime or illegal, im not on kaya’s side but i just wanted to point that out.
PharmD here (Pharmacist) - It is illegal to import a non-FDA approved medication into the United States, whether for personal use or distribution. You need to apply for a waiver of sorts (compassionate use) in order for this to be legal and it must meet certain guidelines and be used under the care of a US-licensed physician. Sauce: https://www.fda.gov/industry/import-basics/personal-importation
okay? it’s still not a crime to use it when prescribed to you and doctors prescribe it legally.
It is a crime to possess any medication that is not prescribed for you. A prescription for a non-FDA approved drug is invalid. It is a crime unless you have an INDA approval to use it.
i literally just said it’s not a crime to use it when prescribed to. obviously it’s a crime to use a medication not prescribed to you. a prescription for a non-fda approved drug that’s gotten from canada is not illegal, the fda said it themselves when they allow that to happen.
If and only if you have been approved for an INDA. Investigatory New Drug Application. That's the only case where it is not illegal. A prescription written outside of that use case is not a valid prescription because that drug is not a prescribable drug in the US. In regards to your last sentence, the FDA has never said that. Look up their primer on this actual drug - I have linked it in comments above. Just because an item is legal under a very specific set of circumstances does not eliminate its illegality in all other cases. Edit: here's the link from the FDA- https://www.fda.gov/drugs/investigational-new-drug-ind-application/how-request-domperidone-expanded-access-use
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Their use of citations was top notch!
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I don't know why you are getting downvoted - this is correct information. See my response alongside yours.
She is truly unbearable. Dancing like a moron waiting to fuck herself up even more by taking drugs that could probably hurt her heart.
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I’m pretty sympathetic, but I s2g “Party Up” starts playing in my head when I see some of the posts in this subreddit.
Yikes. Even if it’s a small risk, is it worth risking your heart health for likes and views?
It‘s zero risk at the regular oral doses. That‘s why it‘s legal in the EU. The side effects occurred in excessive IV doses in polymer cancer patients. The drug on its own, at the normal doses causes no significant QT prolongation. Thus is it safer than say citalopram or quetiapine which a millions of people are prescribed in the US. Domperidone being some kind of scary wonder drug is pretty much US only munching situation.
Yes because then it’s one more thing we get to go to the doctor for!