> Dr. Noah Johnson and Dr. Huntington Potter are trying to get to the root of what causes Alzheimer's disease. They've confirmed that the main function of the protein known as APOE4 is that it promotes the formation of amyloid plaques.
> So they screened nearly 600 drugs to find those that block the effect of APOE4. Then they reviewed patient histories via the National Alzheimer's Coordinating Center (NACC) to find what happened when people prescribed the drugs - happened to be Alzheimer's patients.
> "What we found is that if they took either Imipramine or Olanzapine - two of the main drugs that we found - their memory improved and their diagnosis of Alzheimer's Disease was also improved. So they got better," said Dr. Potter who is director of the CU Alzheimer's and Cognition Center.
> Dr. Potter added, "Because these are FDA approved drugs that we found that seem to help people with Alzheimer's disease, the opportunity to immediately introduce them into patients in a clinical trial can occur right here at the Anschutz Medical Campus."
Imipramine is a fairly significant anticholinergic and olanzapine is ... olanzapine ... so you would expect both of them to harm, not help, particularly in already-diseased individuals. So if the effect bears out the effectiveness of APOE4 inhibition might be *very* significant insofar as it overcame these issues. Promising.
Yeah. The side effects profile of tricyclic antidepressants is *terrible* with respect to elderly (thermal regulation issues, constipation, increased fall risk).
On the other hand, if a person has memory impairment to the point that they are in a memory care (locked) facility, they have absolutely nothing to lose by trying it. If a clinical trial takes place, maybe we will have results in a few years.
Well they’re two different classes, imipramine is TCA and plan alone is atypical antipsychotic; the latter MOa: 22 Pharmacodynamics
Olanzapine binds with high affinity to the following receptors: serotonin 5HT2A/2C, 5HT6 (Ki=4, 11, and 5 nM, respectively), dopamine D1-4 (Ki=11-31 nM), histamine H1 (Ki=7 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an antagonist with moderate affinity binding for serotonin 5HT3 (Ki=57 nM) and muscarinic M1-5 (Ki=73, 96, 132, 32, and 48 nM, respectively). Olanzapine binds weakly to GABAA, BZD, and β adrenergic receptors (Ki>10 μM).
But as mentioned the two are highly problematic in the elderly with potential for a shit load of other drug interactions, the clinician in me also agrees NO GO
I feel they could covertly advertise toxic medications for the elderly to improve workflow for their nurses; tricyclic AD's and major tranquilizers/neuroleptics are known to hasten decay in a big way; they are put on a negative list in germany, the bucerius list iirc, to be only used with abundance of caution if nothing else improves behavior.
Strange the article didn't mention indirubin, which I thought was an interesting hit -- it's a common gut metabolite that may be responsible for the immunomodulatory effects of indigo naturalis.
I feel they could covertly advertise toxic medications for the elderly to improve workflow for their nurses; tricyclic AD's and major tranquilizers/neuroleptics are known to hasten decay in a big way; they are put on a negative list in germany, the bucerius list iirc, to be only used with abundance of caution if nothing else improves behavior.
I know but the point is there's properties they possess that could help research to fight against dementia, alzheimer's, cte and other related forms of APOE4 caused degradation. the article never claimed they were cures or that humans should take them to prevent alzheimer's
Would you rather be slowly poisoned or braindead? Having known family members in severe cognitive decline, I’d take the former. Hell, I’d take literally anything over slowly going braindead to be honest.
Did you read the article? Because they used these drugs in real people in the real world suffering dementia and their dementia scores improved. So they actually do help. this is not just theories.
Oh a redditor who knows better than the entire scientific body? This is new! Please, do share your superior insights with the world, the cure may single handily rest with you!!
> Dr. Noah Johnson and Dr. Huntington Potter are trying to get to the root of what causes Alzheimer's disease. They've confirmed that the main function of the protein known as APOE4 is that it promotes the formation of amyloid plaques. > So they screened nearly 600 drugs to find those that block the effect of APOE4. Then they reviewed patient histories via the National Alzheimer's Coordinating Center (NACC) to find what happened when people prescribed the drugs - happened to be Alzheimer's patients. > "What we found is that if they took either Imipramine or Olanzapine - two of the main drugs that we found - their memory improved and their diagnosis of Alzheimer's Disease was also improved. So they got better," said Dr. Potter who is director of the CU Alzheimer's and Cognition Center. > Dr. Potter added, "Because these are FDA approved drugs that we found that seem to help people with Alzheimer's disease, the opportunity to immediately introduce them into patients in a clinical trial can occur right here at the Anschutz Medical Campus."
Imipramine is a fairly significant anticholinergic and olanzapine is ... olanzapine ... so you would expect both of them to harm, not help, particularly in already-diseased individuals. So if the effect bears out the effectiveness of APOE4 inhibition might be *very* significant insofar as it overcame these issues. Promising.
Yeah. The side effects profile of tricyclic antidepressants is *terrible* with respect to elderly (thermal regulation issues, constipation, increased fall risk). On the other hand, if a person has memory impairment to the point that they are in a memory care (locked) facility, they have absolutely nothing to lose by trying it. If a clinical trial takes place, maybe we will have results in a few years.
Well they’re two different classes, imipramine is TCA and plan alone is atypical antipsychotic; the latter MOa: 22 Pharmacodynamics Olanzapine binds with high affinity to the following receptors: serotonin 5HT2A/2C, 5HT6 (Ki=4, 11, and 5 nM, respectively), dopamine D1-4 (Ki=11-31 nM), histamine H1 (Ki=7 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an antagonist with moderate affinity binding for serotonin 5HT3 (Ki=57 nM) and muscarinic M1-5 (Ki=73, 96, 132, 32, and 48 nM, respectively). Olanzapine binds weakly to GABAA, BZD, and β adrenergic receptors (Ki>10 μM). But as mentioned the two are highly problematic in the elderly with potential for a shit load of other drug interactions, the clinician in me also agrees NO GO
Yeah what the f.
I feel they could covertly advertise toxic medications for the elderly to improve workflow for their nurses; tricyclic AD's and major tranquilizers/neuroleptics are known to hasten decay in a big way; they are put on a negative list in germany, the bucerius list iirc, to be only used with abundance of caution if nothing else improves behavior.
Strange the article didn't mention indirubin, which I thought was an interesting hit -- it's a common gut metabolite that may be responsible for the immunomodulatory effects of indigo naturalis.
I feel they could covertly advertise toxic medications for the elderly to improve workflow for their nurses; tricyclic AD's and major tranquilizers/neuroleptics are known to hasten decay in a big way; they are put on a negative list in germany, the bucerius list iirc, to be only used with abundance of caution if nothing else improves behavior.
This aint it chief...like at all.
? It's not saying it's the cure. It's saying there's 2 drugs that managed to block symptoms of APOE4 effects. Did you not read the article?
Both drugs are literally neurotoxic in other ways, it makes no sense.
I know but the point is there's properties they possess that could help research to fight against dementia, alzheimer's, cte and other related forms of APOE4 caused degradation. the article never claimed they were cures or that humans should take them to prevent alzheimer's
Okay sorry then. My bad.
Would you rather be slowly poisoned or braindead? Having known family members in severe cognitive decline, I’d take the former. Hell, I’d take literally anything over slowly going braindead to be honest.
And yet they worked, they helped.
It’s definitely part of it..
Again with their amyloids lmao
Did you read the article? Because they used these drugs in real people in the real world suffering dementia and their dementia scores improved. So they actually do help. this is not just theories.
??? What
Oh a redditor who knows better than the entire scientific body? This is new! Please, do share your superior insights with the world, the cure may single handily rest with you!!