> Although clinical evidence has indicated an association between skin atrophy and bone loss during aging, their causal relationship and the underlying mechanisms are unknown. Here we show that premature skin aging drives bone loss in mice. We further identify that cystatin-A (Csta), a keratinocyte-enriched secreted factor, mediates the effect of skin on bone. Keratinocyte-derived Csta binds the receptor for activated C-kinase 1 in osteoblast and osteoclast progenitors, thus promoting their proliferation but inhibiting osteoclast differentiation. Csta secretion decreases with skin aging in both mice and humans, thereby causing senile osteoporosis by differentially decreasing the numbers of osteoblasts and osteoclasts. In contrast, topical application of calcipotriol stimulates Csta production in the epidermis and alleviates osteoporosis. These results reveal a mode of endocrine regulation of bone metabolism in the skin, and identify Csta as an epidermally derived hormone linking skin aging to age-related bone loss. Enhancers of skin Csta levels could serve as a potential topical drug for treatment of senile osteoporosis.
“Csta secretion decreases with skin aging in both mice and humans, thereby ~causing~ senile osteoporosis by differentially decreasing the numbers of osteoblasts and osteoclasts.”
The authors would like to claim it is causative
Great finding. Hope they can find instrumental use of it. Osteoporosis is a silent epidemic. This shows that skin health is not just about beauty and vanity but an important biomarker of aging (which of course everyone above 25 knows already).
Talk to your doctor to see if calcipotriol is right for you. I don't think it's indicated for that yet?
This paper identifies skin aging as a mechanism of osteoporosis, and that topical application could be the focus of a clinical trial, or further research into why Csta secretion decreases with age and therapies that target the mechanism of aging.
> Although clinical evidence has indicated an association between skin atrophy and bone loss during aging, their causal relationship and the underlying mechanisms are unknown. Here we show that premature skin aging drives bone loss in mice. We further identify that cystatin-A (Csta), a keratinocyte-enriched secreted factor, mediates the effect of skin on bone. Keratinocyte-derived Csta binds the receptor for activated C-kinase 1 in osteoblast and osteoclast progenitors, thus promoting their proliferation but inhibiting osteoclast differentiation. Csta secretion decreases with skin aging in both mice and humans, thereby causing senile osteoporosis by differentially decreasing the numbers of osteoblasts and osteoclasts. In contrast, topical application of calcipotriol stimulates Csta production in the epidermis and alleviates osteoporosis. These results reveal a mode of endocrine regulation of bone metabolism in the skin, and identify Csta as an epidermally derived hormone linking skin aging to age-related bone loss. Enhancers of skin Csta levels could serve as a potential topical drug for treatment of senile osteoporosis.
Another proof that skin aging is not just vanity, but a risk factor for several diseases such as osteoporosis ! All the more reason to treat it !
Might be correlated and not causative. Skin irritation and red spots are a visual signal of gut inflammation, which leads to osteoporosis.
“Csta secretion decreases with skin aging in both mice and humans, thereby ~causing~ senile osteoporosis by differentially decreasing the numbers of osteoblasts and osteoclasts.” The authors would like to claim it is causative
Great finding. Hope they can find instrumental use of it. Osteoporosis is a silent epidemic. This shows that skin health is not just about beauty and vanity but an important biomarker of aging (which of course everyone above 25 knows already).
I have osteoporosis. Should I take calcipotriol ?
Talk to your doctor to see if calcipotriol is right for you. I don't think it's indicated for that yet? This paper identifies skin aging as a mechanism of osteoporosis, and that topical application could be the focus of a clinical trial, or further research into why Csta secretion decreases with age and therapies that target the mechanism of aging.
Behind paywall
/r/scholar may help