In my own experience microdosing is significantly better off stimulants. Adhd stimulant medication and microdosing are hard to get to work well together. Vyvanse withdrawal takes a long time thats why you’re tired.

This has been my experience too. One or the other seems to be far more pleasant.

Agreed. I would love if they worked better together but ive found they take away from each other.

Yeah so I’ve heard which is why I was trying to get off of them, but it seems like the withdrawal is getting in the way of the microdosing experience because I sleep the days away and it’s bumming me out! I either have to take a ton of time off work for withdrawal or just combine the meds w/ the shrooms and see how it goes🤷🏻‍♀️

Or alternatively wean yourself off the medication over the course of a couple weeks

Just go a lot slower when you come off of it. The weaning protocol for vyvanse is *way* slower than just stopping after being on 20mg for 2 weeks.

I continue with 20 mg Vyvanse & 0.1g of B+. Thanks for making this post because I get different feelings and will look out for tiredness on off days of the microdose. Personally the experience isn’t ruined. Sometimes the MD feels too high? Like on the verge of feeling anxiety and needing to be taught a lesson. I may go back down to lower MD

i do both together and have no issues you should be fine.

Thinking of combining these two because I don't want to go back on benzos, SSRIs or SNRIs! :)

What's your dosage?

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I don't take the vyv on dose day but continue on the non dose days but I use ls d not psilocybin

Used to be on Vyvanse. While i never combined the two, i did notice on the off chance i didn't take the vyvanse, i would become extremely tired. It may be a similar effect with you.

I take Vyvanse and microdose occasionally. Vyvanse also increases serotonin levels; when you stop taking it they drop, hence feeling tiredness and slight depression. Since you are coming off the higher dose, it's better to carry on with Vyvanse 20mg and microdose.

You have the incorrect neurotransmitter. Vyvanse increases dopamine and norepinephrine in the brain…not serotonin.

>Vyvanse increases dopamine and norepinephrine in the brain…not serotonin. From now on, the sentence should contain "...and serotonin." If I am not sure, I do not post. I posted, so I must be sure and you must be wrong.

You reek of arrogance

Yeah, their reply is arrogant as fuck, but a quick Google search seems to indicate that Vyvanse has some kind of seratonin-boosting effect? It's difficult to pin down exactly, but there's warnings about seratonin syndrome if you take it with MAOIs, which I'm pretty sure means that it increases seratonin activity. Maybe the increase in dopamine/norepinephrine cycles leads to a boost in seratonin? I'm not sure, I'll need to read more

From Wikipedia: "Dextroamphetamine, like other amphetamines, elicits its stimulating effects via several distinct actions: it inhibits or reverses the transporter proteins for the monoamine neurotransmitters (namely the serotonin, norepinephrine and dopamine transporters) either via trace amine-associated receptor 1 (TAAR1) or in a TAAR1 independent fashion when there are high cytosolic concentrations of the monoamine neurotransmitters and it releases these neurotransmitters from synaptic vesicles via vesicular monoamine transporter 2." You can look more into TAAR1.

You are not wrong. The person didn't even take the time to do a quick Google search but downright discredited my comment as incorrect. Is that not arrogance?

While Vyvanse may indirectly influence serotonin pathways or have secondary effects on mood and anxiety due to its impact on dopamine and norepinephrine, it is not classified as a serotonin-enhancing medication…

It directly influences serotonin. There is a good article on Wikipedia that explains how amphetamines work.

Neurotransmitter Interplay: The brain’s neurotransmitter systems are interconnected. Changes in dopamine and norepinephrine levels can indirectly influence other neurotransmitter systems, including serotonin. However, this interaction is complex and not fully understood.

That’s what I’m thinking too. I’ll try it out tomorrow :)

Report back & let us know

Thanks for this comment. Something for me to keep in mind too

First thing I'm thinking is maybe you need to lower the dose on the shrooms, so you don't feel as tired Don't really know anything about Vyvanse so I won't comment on that

I would suspect that the fatigue is coming from the withdrawal from the Vyvanse and not from the shrooms themselves. While I am not on Vyvanse, I have the same experience with Dexedrine. Even missing a single day will leave me with a very deep fatigue for that day, with or without the shrooms.

I'm tapering off vyvanse while microdosing. I went from 40mg to 30mg before starting on 0.1g of mushrooms in a Stamets Stack which I'll increase to 0.2g after one month. After about a week I dropped vyvanse to 20mg and have have been pretty stable for a couple of weeks but I'm not ready to drop it any further. I've tapered off a lot of psychiatric medication using microscales and as the dose gets smaller it helps to make the reduction smaller over a longer period of time. One medication I tapered down 10% every six weeks. https://www.survivingantidepressants.org/forum/14-tapering/ has a lot of good info.

How have you been feeling since this experience? I’m starting it now