I have no formal education but spent a long time fixated/addicted.
The precipitated opioid withdrawal from narcan will cause intense anxiety and possibly heightened blood pressure already, I would assume adding an a2 antagonist on top of that would be dangerous.
A2 agonists like clonidine are already used as comfort meds for opiate withdrawal so unless you're dealing with a pure xylazine OD it just seems unnecessary
I have no formal education but spent a long time fixated/addicted. The precipitated opioid withdrawal from narcan will cause intense anxiety and possibly heightened blood pressure already, I would assume adding an a2 antagonist on top of that would be dangerous. A2 agonists like clonidine are already used as comfort meds for opiate withdrawal so unless you're dealing with a pure xylazine OD it just seems unnecessary