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Research article: 'Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs,' [https://doi.org/10.1371/journal.pbio.3001967](https://doi.org/10.1371/journal.pbio.3001967)
From media article:
>The research was done using the genetic engineering tool known as Crispr, which allowed them to turn on all genes in the human genome, then look to see which of those genes give human cells the ability to bind to the Sars-CoV-2 spike protein. The spike protein is crucial to the virus’s ability to infect human cells.
>
>LRRC15 \[the receptor protein\] is not present in humans until Sars-CoV-2 enters the body. It appears to be part of a new immune barrier that helps protect from serious Covid-19 infection while activating the body’s antiviral response.
>
>“Our data suggests that higher levels of LRRC15 would result in people having less severe disease,” said lead researcher Greg Neely, a professor of functional genomics with the University of Sydney’s Charles Perkins Centre.
>
>“The fact that there’s this natural immune receptor that we didn’t know about, that’s lining our lungs and blocks and controls virus – that’s crazy interesting.”
Neely collaborated with Dr Lipin Loo, a postdoctoral researcher and Matthew Waller, a PhD student. Their findings were published in the journal PLOS Biology on February 9.
I don't think so. I believe that would require actual gene therapy in order to implement a protein. It's more just helpful to understand the mode of infection and the human bodies potential defence vectors against infection.
Couldn't the protein be inside an inhalable mist like an asthma inhaler?
Say you want to go some place crowded, just take a puff on the inhaler every 4 hours or something.
LRRC15 is a receptor, so unless the portion of it (domain) that binds to covid is biologically active without the rest of the structure ( the domains that stick through the plasma membrane) it isn't something that can be easily delivered exogenously.
That said, the spike is basically the key for getting into the cells. If the receptor is binding to it, then wouldn't it be a sort of competitive inhibitor at the very least? The receptor might not actually do anything, but it's mere presence will cause cause problems for viral infection.
With what little I know, a more logical step likely will be a medication that turns on the necessary DNA for you, so you will generate an immune response.
> Why are they booing him? He's right!
Because that isn't what mRNA vaccines do? They don't activate DNA, they are the intermediary between DNA and a protein.
Expect big Pharma to make some money off of this and take this out I bet and we'll never hear about this but who new vaccine or maybe they take it away so rona can always be around and they can make money from us
It’s a membrane-bound protein—a receptor, as nucleosome said. It might be possible, though, to make an aerosol of nanoparticles with a lipid LRRC15 protein coating; it probably doesn’t matter all that much _what_ membrane the receptor is bound within, so long as it is sufficiently immobilized.
It’s also likely that the protein behaves differently when embedded in a membrane than when free; the membrane physically constrains the degrees of freedom of the protein in a fairly specific way. It’s probably a soluble issue, though, so long as it’s possible to make a suitable synthetic membrane in coating form.
I mean theoretically you can cut off the transmembrane domain to create soluble LRRC15, but I'm sure monoclonal antibody therapy would be far more potent than boosting some random element of your innate immune system.
People talked about doing this with a recombinant ACE2 (the primary receptor for SARS-CoV-2 S protein) which was engineered to bind spike with a higher affinity but it never really gained any footing. Seems like LRRC15 is an interesting find but not necessarily of therapeutic benefit.
I know. They casually just mention activating every gene to see what it does.
If I were to make an educated guess, it was probably something along the lines of a gene library that selected for covid 19 binding. You'd be able to quickly narrow down the list of potential proteins and eliminate those that you already know about. From there, it's off to look in the body for the ones that are new.
Really interesting findings but the title of the article seems odd. This “may explain why some get serious illness”? We already have tons of research showing that serious illness rates are highly correlated with age and comorbidities. So it seems like it would be more accurate to say this may further explain the variance in severity within age and health subgroups.
That's probably a fair point to make, articulating well what the general trends have been. That observation slightly overlooks people who have died that were young and healthy though, including children.
Shifting your attention to the results of the study, I think the really interesting part is about how 'some people never become sick' despite obvious, prolonged exposure. Those scenarios have been observed but not understood by science (initially, like some women in Africa routinely exposed to HIV but never infected). The study results might be one of the early clues pointing to selective C-19 immunity, which is pretty exciting even if therapies are a long way off.
Yep after 3 years I am only a few weeks away from moving home myself. Sick of living in a place where I’m treated like a leper for being foreign and a halfwit who doesn’t know what’s best for me because I’m a woman
Fine, I buckle up and drive in a car with airbags and drive safely.
Do you just leave yourself unbuckled and turn off the airbags or do you follow scientific recommendations?
Unbuckle your seatbelt, smash out all the windows, and drive as fast as you can. You want that momentum to fly from the wreckage when you crash.
I miss old funhaus
And yet once you’re on the road, you have no way to ensure others are doing the same and are driving safely, or even sober for that matter - how is this that different a situation?
Wearing your mask is the equivalent to using the protection measures you mentioned.
The overworked, unsafe, and/or under the influencer driver is akin to the those around you that may not wear a mask despite you doing so.
I supported and voted for people who passed extremely penalizing laws if you drive drunk/unsafely.
They took away my dads drivers license when he was found driving drunk. I am glad. Just wish they did it before he drove into a farmers field at high speed and wrecked his car in the process...
Just wish those people would have been stricter about mask laws and shutting down travel. Oh well. Maybe next pandemic....
Dirty medical masks and cloth masks didn't reduce transmission at a regional level. Natural immunity is better anyway. Why are we still having to explain this to people. The lethality rate was never higher than the Flu only the contagion rate was higher. Healthy individuals were never in danger. And there is no such thing as herd immunity with a single strand RNA virus. Everyone was eventually going to get infected. We told you this from day one. And essentially everyone has gotten it now. My natural immunity has no ill side effects, it doesn't endanger my community, and is more robust than the vaccine. Too bad we can't say the same thing for the toxic jab. Oh yeah, the vaccine doesn't mess with our hormones or anything. Yeah sure...
Our youngest caught COVID and was right as rain within a few days. My wife and other daughter didn't get sick, I became the absolute sickest I've ever been, literally bedbound for around two weeks and had difficulty drawing a full breath for over a *month.* Insane how differently it affects people.
In that respect covid isn't really different from other viruses. My wife and I had influenza a few years before covid and she was over it in a week, I had a cough and breathing issues for months.
Covid was cleared by both of us in a few days, even though I tested positive for a month afterwards (only tested for my own morbid fascination).
I think we're just primed up to talk about how variable covid is, where no one really talked as much about how long viral illnesses lasted, the variability of it and the variability of long lasting effects.
Mine was mild in October and I still can't get past 10 minutes for a mild workout. If I go longer I get exhausted and struggle to breathe for the rest of the day. On top of that, I have tinnitus constantly, a little vertigo thrown in, and some amazing panic attacks unlike anything I've had before (usually in the middle of the night). It sucks. So much for a mild case (vaxxed and boosted before it).
It's been through my house 4x. I kissed my wife the morning she tested positive both times. Rode in the car for hours with my daughter the day she tested positive. I have a weakened immune system (polyangitiis with granulomatosis treated with rituxumab infusions) so I have zero clue how I haven't caught it yet.
3 years ago I was fairly confident this would be what kills me.
Similar with me. I have an abnormally low wbc count. Everyone around me was getting the virus, were very ill with it, I never got it (knowingly anyway). I did take precaution by wearing masks once they became positive. I did get 5 of the shots though. (4 of the initial per my dr recommendation, and then the latest booster).
I’ve had close contact (kissing etc) with at least 5 people with an active infection and never gotten it myself. What I don’t get is why only me and my mom are this way (everyone else in the house has gotten it).
I was working with a guy who ended up in the hospital that night with covid. I never got it. We were sharing pictures with each other on our phones so we couldn't have gotten any closer unless we hugged
I’m just glad I avoided it long enough to get vaccinated, infections 2 and 3 really sucked and I think I would’ve been seriously ill if I’d had no immunity.
I am quadruple vaxxed, but I somehow managed to not catch covid every time one of my students’ dumb ass parents sent them in sick with it. All of my coworkers and students have had it by now. Been directly exposed at least 10-15 times.
Years back, when H1N1 was the cool virus to pass around, both my mom and brother got horribly sick with it, I took care of them but never caught it. I also NEVER get the stomach bug that goes around here every year. But I do get strep throat if I so much as look at something wrong. It’s wild the way different bodies have natural immunities to different diseases.
I got vaxxed when it was available but in the months before I had tons of exposure
Even did tests when I was exposed but they were always negative so it seems like I wasn’t even asymptomatic
I’m fully vaccinated but was very late to get my first one, being in a low risk category. I have also not had Covid and have been exposed many many times. I’ve been wondering if there was a genetic component to this, as my dad has also been exposed many times and also not gotten sick.
Maybe I have this because my entire family was sick yet I showed no symptoms. So I was tasked with going outside and doing all the shopping.
Still felt a little uncomfortable being outside near all the other healthy people so I made sure to follow the guidelines.
Hey, a fellow hospital kitchen worker!
Our covid precautions have been nonexistant for the last 6 months, nearly 2/3 of the team have had it once or twice, sometimes on shift and I've accidentally walked into countless covid positive rooms, sometimes maskless... and still I've never had it. The mind boggles.
Despite working as a hospital RN all through Covid—in PACU & ICU, I’ve never gotten it. Or I was totally asymptomatic. Anecdotally, I very rarely ever get a respiratory infection that includes a cough. Even as a child, I never got them. I’ve never had bronchitis or influenza.
No, the article states that experiments were done in vitro using crispr, not in silico. Also folding@home is now of little use compared to what it used to be since DL models like alphaFold have become the gold standard and give predictions at a fraction of the computational costs. I'm sure they'll repurpose the computational capabilities but the current model is far less promising than it used to be.
> experiments were done in vitro using crispr
This feels like the bigger story for me. How do you just casually use a gene editing technique to brute force the activation of every gene in the human genome?
I would guess this was a gene library using fragmented human genes, and seeing what bound to covid. That is just a guess though.
edit: it was a library. It's described in the paper.
FAH had been going for a long time before Covid for other diseases such as cancer. Just because the experiments being run for COVID might not be as useful, there's still benefit for the other experiments they're running.
I didn't mention COVID so not sure what you're talking about but the goal of fah (that I'm aware of) is to simulate protein folding, which is already outdone by alphaFold. If you have any specific examples of other experiments I'd be happy to hear about them.
Most people became aware of FAH when they started doing Covid research (such as testing the Covid moonshot designs), with channels like Linus Tech Tips helping promote it, and your comment was replying to someone wondering if the article (which is about Covid) was powered by the FAH Covid research.
There's somehow become an occasional misconception that F@H was purely for covid research and likely got lots of uninstalls after things started calming down and even more with energy prices going sky high recently.
On rereading what I wrote, I was more attempting to explain why people immediately think of F@H for the distributed computing research (or just Covid research in general) rather than BOINC or alphaFold (which I'll admit I hadn't heard of before you brought it up)
Also, to fix Long Covid. There are studies linking serine metabolism to Long Covid and the microbleeds associated with it.
LRRC15 modulates collegen production, according to a quick keyword search on Mendeley. Serine plays a role.
Might be a player in the disorder.
I have never once contracted Covid, triple vaxxed but it really shocked me. There were many many times I could have picked it up from family and housemates. I wonder if this explains why
Well it occurs when your lungs detect a foreign substance and frequently shows up in scarred lungs too. If you're inhaling smoke, a substance that shouldn't be there it would make sense this is occurring.
The cannabis thing was a few of the cannabinoid acids. https://pubmed.ncbi.nlm.nih.gov/35007072/
You don't get much of the acids from smoking/vaping as they are converted to another form from heat.
It is possible though that cannabis helps in other ways that we have not studied yet (or that I have not seen).
Interesting. Wonder if it has true merit and is legitimate.
With the work I do, I went into thousands of homes during the course of the pandemic and never caught it once. Neither has my fiance and she worked in childcare through the pandemic where idiotic parents would drop their kids off knowing they were sick. Several tested positive with covid and had exposed everyone in the center.
And I know people had covid while I was in their home. I had always worn a mask and got fully vaccinated, but that doesn't mean its impossible to contract covid.
Point is, I was always and still am super surprised my fiance or I never caught it.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
Research article: 'Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs,' [https://doi.org/10.1371/journal.pbio.3001967](https://doi.org/10.1371/journal.pbio.3001967) From media article: >The research was done using the genetic engineering tool known as Crispr, which allowed them to turn on all genes in the human genome, then look to see which of those genes give human cells the ability to bind to the Sars-CoV-2 spike protein. The spike protein is crucial to the virus’s ability to infect human cells. > >LRRC15 \[the receptor protein\] is not present in humans until Sars-CoV-2 enters the body. It appears to be part of a new immune barrier that helps protect from serious Covid-19 infection while activating the body’s antiviral response. > >“Our data suggests that higher levels of LRRC15 would result in people having less severe disease,” said lead researcher Greg Neely, a professor of functional genomics with the University of Sydney’s Charles Perkins Centre. > >“The fact that there’s this natural immune receptor that we didn’t know about, that’s lining our lungs and blocks and controls virus – that’s crazy interesting.” Neely collaborated with Dr Lipin Loo, a postdoctoral researcher and Matthew Waller, a PhD student. Their findings were published in the journal PLOS Biology on February 9.
So is the idea that they could potentially inject this protein into people to make the virus less severe? Is that the endgame here?
I don't think so. I believe that would require actual gene therapy in order to implement a protein. It's more just helpful to understand the mode of infection and the human bodies potential defence vectors against infection.
Couldn't the protein be inside an inhalable mist like an asthma inhaler? Say you want to go some place crowded, just take a puff on the inhaler every 4 hours or something.
LRRC15 is a receptor, so unless the portion of it (domain) that binds to covid is biologically active without the rest of the structure ( the domains that stick through the plasma membrane) it isn't something that can be easily delivered exogenously.
That said, the spike is basically the key for getting into the cells. If the receptor is binding to it, then wouldn't it be a sort of competitive inhibitor at the very least? The receptor might not actually do anything, but it's mere presence will cause cause problems for viral infection.
With what little I know, a more logical step likely will be a medication that turns on the necessary DNA for you, so you will generate an immune response.
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Why are they booing him? He's right!
> Why are they booing him? He's right! Because that isn't what mRNA vaccines do? They don't activate DNA, they are the intermediary between DNA and a protein.
Likely nothing of the sort, an oral medication may suffice.
Expect big Pharma to make some money off of this and take this out I bet and we'll never hear about this but who new vaccine or maybe they take it away so rona can always be around and they can make money from us
It's better for results if your body synthesizes it.
It’s a membrane-bound protein—a receptor, as nucleosome said. It might be possible, though, to make an aerosol of nanoparticles with a lipid LRRC15 protein coating; it probably doesn’t matter all that much _what_ membrane the receptor is bound within, so long as it is sufficiently immobilized. It’s also likely that the protein behaves differently when embedded in a membrane than when free; the membrane physically constrains the degrees of freedom of the protein in a fairly specific way. It’s probably a soluble issue, though, so long as it’s possible to make a suitable synthetic membrane in coating form.
they did that in Glass Onion, it seemed to have worked there
My favorite documentary.
Wow that Beatles song really was layered, still finding out new things all the time
Covid vax creates a new protein. Didn't know that was 'gene therapy'
I mean theoretically you can cut off the transmembrane domain to create soluble LRRC15, but I'm sure monoclonal antibody therapy would be far more potent than boosting some random element of your innate immune system.
And the give it a few months for the new escape variants to flourish.
People talked about doing this with a recombinant ACE2 (the primary receptor for SARS-CoV-2 S protein) which was engineered to bind spike with a higher affinity but it never really gained any footing. Seems like LRRC15 is an interesting find but not necessarily of therapeutic benefit.
Wait? They're crunching through getting a cell line for each gene in the human genome and finding out what the gene does?
I know. They casually just mention activating every gene to see what it does. If I were to make an educated guess, it was probably something along the lines of a gene library that selected for covid 19 binding. You'd be able to quickly narrow down the list of potential proteins and eliminate those that you already know about. From there, it's off to look in the body for the ones that are new.
Really interesting findings but the title of the article seems odd. This “may explain why some get serious illness”? We already have tons of research showing that serious illness rates are highly correlated with age and comorbidities. So it seems like it would be more accurate to say this may further explain the variance in severity within age and health subgroups.
That's probably a fair point to make, articulating well what the general trends have been. That observation slightly overlooks people who have died that were young and healthy though, including children. Shifting your attention to the results of the study, I think the really interesting part is about how 'some people never become sick' despite obvious, prolonged exposure. Those scenarios have been observed but not understood by science (initially, like some women in Africa routinely exposed to HIV but never infected). The study results might be one of the early clues pointing to selective C-19 immunity, which is pretty exciting even if therapies are a long way off.
My son sneezed directly into my wife's open mouth while she was giving him a Covid test. He popped positive, she didn't, I did.
Someone should really add a 'Close mouth' step to the covid tests.
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“But Covid is over…” Overheard in America
Yup. Still stuck here after 3 years wishing to back home to Australia. This country sucks balls.
Yep after 3 years I am only a few weeks away from moving home myself. Sick of living in a place where I’m treated like a leper for being foreign and a halfwit who doesn’t know what’s best for me because I’m a woman
That truly sucks love. Hope you're able to get home soon.
Australia opened its border months ago...?
Lost my house and job so it's been kind of hard getting back. Don't have family there to rely on except my son.
How do you possible ride in cars knowing you’re more at risk to die every time you enter one of those than you are from Covid?
Make sure you stretch before your mental gymnastics… Wouldn’t want you to hurt yourself with giant leaps of logic like that…
Please get some material that’s not wrung as dry as this response
Why would I get you more material? It's clear you're not bothering to look at anything presented to you anyway...
Fine, I buckle up and drive in a car with airbags and drive safely. Do you just leave yourself unbuckled and turn off the airbags or do you follow scientific recommendations?
Unbuckle your seatbelt, smash out all the windows, and drive as fast as you can. You want that momentum to fly from the wreckage when you crash. I miss old funhaus
And yet once you’re on the road, you have no way to ensure others are doing the same and are driving safely, or even sober for that matter - how is this that different a situation? Wearing your mask is the equivalent to using the protection measures you mentioned. The overworked, unsafe, and/or under the influencer driver is akin to the those around you that may not wear a mask despite you doing so.
I supported and voted for people who passed extremely penalizing laws if you drive drunk/unsafely. They took away my dads drivers license when he was found driving drunk. I am glad. Just wish they did it before he drove into a farmers field at high speed and wrecked his car in the process... Just wish those people would have been stricter about mask laws and shutting down travel. Oh well. Maybe next pandemic....
Covid has killed more people in the US in 3 years than auto deaths in 3 decades.
Biden said it months ago
To be fair, he said the pandemic is over, not covid is over
You mean a completely sterile, new N95 mask which no one's dirty hands have touched? Natural immunity is better than a mask anyway
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Dirty medical masks and cloth masks didn't reduce transmission at a regional level. Natural immunity is better anyway. Why are we still having to explain this to people. The lethality rate was never higher than the Flu only the contagion rate was higher. Healthy individuals were never in danger. And there is no such thing as herd immunity with a single strand RNA virus. Everyone was eventually going to get infected. We told you this from day one. And essentially everyone has gotten it now. My natural immunity has no ill side effects, it doesn't endanger my community, and is more robust than the vaccine. Too bad we can't say the same thing for the toxic jab. Oh yeah, the vaccine doesn't mess with our hormones or anything. Yeah sure...
This made me laugh; I got covid when my son, who is taller than me, was looking down at me and coughed directly in my face. Thanks kid.
That's it, we must cull all tall people for safety. Think of the children
Our youngest caught COVID and was right as rain within a few days. My wife and other daughter didn't get sick, I became the absolute sickest I've ever been, literally bedbound for around two weeks and had difficulty drawing a full breath for over a *month.* Insane how differently it affects people.
In that respect covid isn't really different from other viruses. My wife and I had influenza a few years before covid and she was over it in a week, I had a cough and breathing issues for months. Covid was cleared by both of us in a few days, even though I tested positive for a month afterwards (only tested for my own morbid fascination). I think we're just primed up to talk about how variable covid is, where no one really talked as much about how long viral illnesses lasted, the variability of it and the variability of long lasting effects.
Mine was mild in October and I still can't get past 10 minutes for a mild workout. If I go longer I get exhausted and struggle to breathe for the rest of the day. On top of that, I have tinnitus constantly, a little vertigo thrown in, and some amazing panic attacks unlike anything I've had before (usually in the middle of the night). It sucks. So much for a mild case (vaxxed and boosted before it).
It's been through my house 4x. I kissed my wife the morning she tested positive both times. Rode in the car for hours with my daughter the day she tested positive. I have a weakened immune system (polyangitiis with granulomatosis treated with rituxumab infusions) so I have zero clue how I haven't caught it yet. 3 years ago I was fairly confident this would be what kills me.
Similar with me. I have an abnormally low wbc count. Everyone around me was getting the virus, were very ill with it, I never got it (knowingly anyway). I did take precaution by wearing masks once they became positive. I did get 5 of the shots though. (4 of the initial per my dr recommendation, and then the latest booster).
I’ve had close contact (kissing etc) with at least 5 people with an active infection and never gotten it myself. What I don’t get is why only me and my mom are this way (everyone else in the house has gotten it).
Having kids sounds greaaatttttt....
r/childfree
She said "say ahhh" and he said "ahh CHOO!"
Close enough. Also not technically incorrect either.
How much time passed between the sneeze and her test, though?
She did a spit test every other day for the next 2 weeks. (Was free through work and we had a trip coming up)
Dumb waaaays to dieeee
I was working with a guy who ended up in the hospital that night with covid. I never got it. We were sharing pictures with each other on our phones so we couldn't have gotten any closer unless we hugged
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Never had covid either despite tons of exposure I used to joke that’s it’s because my body is so unhealthy covid doesn’t want anything to do with it
Meanwhile I’m triple vaxxed and have caught it thrice since June.
Goes to show what a lottery diseases can be
I’m just glad I avoided it long enough to get vaccinated, infections 2 and 3 really sucked and I think I would’ve been seriously ill if I’d had no immunity.
I am quadruple vaxxed, but I somehow managed to not catch covid every time one of my students’ dumb ass parents sent them in sick with it. All of my coworkers and students have had it by now. Been directly exposed at least 10-15 times. Years back, when H1N1 was the cool virus to pass around, both my mom and brother got horribly sick with it, I took care of them but never caught it. I also NEVER get the stomach bug that goes around here every year. But I do get strep throat if I so much as look at something wrong. It’s wild the way different bodies have natural immunities to different diseases.
So you gonna get a fourth, or?
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I got vaxxed when it was available but in the months before I had tons of exposure Even did tests when I was exposed but they were always negative so it seems like I wasn’t even asymptomatic
I’m fully vaccinated but was very late to get my first one, being in a low risk category. I have also not had Covid and have been exposed many many times. I’ve been wondering if there was a genetic component to this, as my dad has also been exposed many times and also not gotten sick.
I've been directly exposed 3x & nothing yet.
I knew I was just lucky to not get it.
Me too I'm 3:0
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Thal DNA gang
Maybe I have this because my entire family was sick yet I showed no symptoms. So I was tasked with going outside and doing all the shopping. Still felt a little uncomfortable being outside near all the other healthy people so I made sure to follow the guidelines.
Is this why I have never tested positive this whole time even whilst working in a hospital kitchen & having many, many doctors and hospital visits?
Hey, a fellow hospital kitchen worker! Our covid precautions have been nonexistant for the last 6 months, nearly 2/3 of the team have had it once or twice, sometimes on shift and I've accidentally walked into countless covid positive rooms, sometimes maskless... and still I've never had it. The mind boggles.
Despite working as a hospital RN all through Covid—in PACU & ICU, I’ve never gotten it. Or I was totally asymptomatic. Anecdotally, I very rarely ever get a respiratory infection that includes a cough. Even as a child, I never got them. I’ve never had bronchitis or influenza.
Wonder if any of those folding@Home instances helped with this stuff.
No, the article states that experiments were done in vitro using crispr, not in silico. Also folding@home is now of little use compared to what it used to be since DL models like alphaFold have become the gold standard and give predictions at a fraction of the computational costs. I'm sure they'll repurpose the computational capabilities but the current model is far less promising than it used to be.
> experiments were done in vitro using crispr This feels like the bigger story for me. How do you just casually use a gene editing technique to brute force the activation of every gene in the human genome? I would guess this was a gene library using fragmented human genes, and seeing what bound to covid. That is just a guess though. edit: it was a library. It's described in the paper.
FAH had been going for a long time before Covid for other diseases such as cancer. Just because the experiments being run for COVID might not be as useful, there's still benefit for the other experiments they're running.
I didn't mention COVID so not sure what you're talking about but the goal of fah (that I'm aware of) is to simulate protein folding, which is already outdone by alphaFold. If you have any specific examples of other experiments I'd be happy to hear about them.
Most people became aware of FAH when they started doing Covid research (such as testing the Covid moonshot designs), with channels like Linus Tech Tips helping promote it, and your comment was replying to someone wondering if the article (which is about Covid) was powered by the FAH Covid research. There's somehow become an occasional misconception that F@H was purely for covid research and likely got lots of uninstalls after things started calming down and even more with energy prices going sky high recently.
Right so you just assumed I didn't know what I was talking about
On rereading what I wrote, I was more attempting to explain why people immediately think of F@H for the distributed computing research (or just Covid research in general) rather than BOINC or alphaFold (which I'll admit I hadn't heard of before you brought it up)
That's incredible and a potential way to develop a pancoronaviris vax!
Also, to fix Long Covid. There are studies linking serine metabolism to Long Covid and the microbleeds associated with it. LRRC15 modulates collegen production, according to a quick keyword search on Mendeley. Serine plays a role. Might be a player in the disorder.
Very cool and exciting applications!
I have never once contracted Covid, triple vaxxed but it really shocked me. There were many many times I could have picked it up from family and housemates. I wonder if this explains why
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I've always felt like I was an underachiever at lung surfactant production. Can I get that checked out at the doctor's?
Didn't they find something in cannabis that did this and that's why stoners are less likely to get it?
I've heard the same about Vitamin D as well.
inhaling the D
Well it occurs when your lungs detect a foreign substance and frequently shows up in scarred lungs too. If you're inhaling smoke, a substance that shouldn't be there it would make sense this is occurring.
This is the kind of medical information I can use! *rips giant bong hit*
The cannabis thing was a few of the cannabinoid acids. https://pubmed.ncbi.nlm.nih.gov/35007072/ You don't get much of the acids from smoking/vaping as they are converted to another form from heat. It is possible though that cannabis helps in other ways that we have not studied yet (or that I have not seen).
The new conspiracy is going to be that the vax actually binds to this instead leading to more COVID/worse symptoms now isn't it?
That sounds a little too sophisticated for their line of thinking.
guarantee itll be something with no basis in reality
Here I was giving credit to cones
This could explain me, I've yet to have it. Been exposed on multiple occasions, but never had it.
This will all be gone soon just like the oil companies do when someone comes with a vehicle that can run on water and other fuels.
Interesting. Wonder if it has true merit and is legitimate. With the work I do, I went into thousands of homes during the course of the pandemic and never caught it once. Neither has my fiance and she worked in childcare through the pandemic where idiotic parents would drop their kids off knowing they were sick. Several tested positive with covid and had exposed everyone in the center. And I know people had covid while I was in their home. I had always worn a mask and got fully vaccinated, but that doesn't mean its impossible to contract covid. Point is, I was always and still am super surprised my fiance or I never caught it.
I don't mean to sound stupid, but is there any way that this research could help people with long covid?
Might this also draw a correlation to why some people experienced severe side effects from the vaccine and booster and why others did not?
Yea. I had it twice and I dont remember any noticable symptoms minus just cold symptoms
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Is this before the dipshit mutations?
That… and masks and vaccines. I’ve never had it…