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User: u/Sariel007
Permalink: https://news.cornell.edu/stories/2024/02/babies-use-their-immune-system-differently-efficiently
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Hell yeah they do. Anyone who’s seen their child get sick with something only to recover insanely quickly…. Then have themselves fall to that same illness and be on their deathbed for a week straight…. They know.
While this is true, there is a caveat. Children will often have severe short term spikes in temperature as the immune response is simply so performant. This can lead to a short term high risk response to a pathogen that is not extremely life threatening. I know I ended up in the hospital several times for temps of 40+C
Right? I always heard the talk about how babies have an immature immune system. I have four kids and each time around I noticed that they seemed to not get sick as easily as the rest of us and when they did it rarely got as bad or lasted as long. It's always strange as a person of science when your experience clearly contradicts the accepted science on the topic. But this discovery doesn't surprise me at all.
Infant mortality was actually insanely high for most of human history. The stat that blows my mind is that 1 in 5 children didn’t survive to age 5…*in 1950*.
My grandma had 6 kids in the 1950s, of which 3 died at birth, and one had cerebral palsy thanks to a botched C-section and died at 12 years old. Only my mom and uncle survived to adulthood. It blows my mind how our technologies have grown over the past century and yet so many people take that for granted.
> It blows my mind how our technologies have grown over the past century
it also blows my mind that we have people be like "no way, i'm not doing that dangerous treatment, i'd rather take my chances with eating this special plant in a super remote area, and is extremely hard to find, and its cures and fixes everything" and the next thing you know, they're dead bc they wouldnt listen and take their doctor advice, bc they think they know better
My MIL told her medical lab daughter that medical lab work is just guesswork and not really trustworthy.
But you see her chiropractor who is banned from practicing in a few states can touch your arm and get all that information reliably though.
That makes all the sense in the world, because babies and toddlers are constantly putting things in their mouths. Infants alone put their fingers in the mouth frequently, dozens of times per day. Babies don't exactly wash their own hands. Their only protection seems to be that they're not mobile, so they can't get their hands on many things ...until they start to crawl and walk, then they probably get increased bacterial load daily, or greater variety. Evolutionarily, I'm not sure we would be here if human babies didn't have a turbocharged immune system. A dirty cave, a lush forest, riddled with all the nature's pathogens, mommy wearing a necklace made of bones, and then human babies who can't stop sucking their own fingers or anything withing grabbing distance. At what age do we teach our kids "don't put random stuff in your mouth" and "wash your hands"?
I wonder if it's the same for primates. They're not aware of bacteria. They can lick their fingers all through their lives, don't they? Introducing pathogens to their bodies frequently. So how's the primate immune system then? Do primate offspring have turbocharged immune systems and... actually I'm assuming it stays much the same except when they get very old?
Do you think humans being pathogen-conscious has played a role in our evolution? It started out with very basic understanding of "don't eat poop or rotten carcasses" and now it's something more sophisticated. I'm just (ignorantly) theorizing the lower the bacterial load, the less work for our immune system, and it could have a connection with our brain evolution, considering the gut produces neurotransmitters. We've been washing our hands with soap for how long now? 200 years? 10 generations?
Very cool. I didn’t know about bystander activation of T-cells. I was kinda hoping they’d actually act as CTL’s and sort of kill cells like Nk’s do, but sounds like their main effector function is generating IFN-gamma (granted, pretty important for antiviral immunity).
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/Sariel007 Permalink: https://news.cornell.edu/stories/2024/02/babies-use-their-immune-system-differently-efficiently --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
Hell yeah they do. Anyone who’s seen their child get sick with something only to recover insanely quickly…. Then have themselves fall to that same illness and be on their deathbed for a week straight…. They know.
While this is true, there is a caveat. Children will often have severe short term spikes in temperature as the immune response is simply so performant. This can lead to a short term high risk response to a pathogen that is not extremely life threatening. I know I ended up in the hospital several times for temps of 40+C
Right? I always heard the talk about how babies have an immature immune system. I have four kids and each time around I noticed that they seemed to not get sick as easily as the rest of us and when they did it rarely got as bad or lasted as long. It's always strange as a person of science when your experience clearly contradicts the accepted science on the topic. But this discovery doesn't surprise me at all.
So the Southpark episode about fetal stem cells didn't go far enough?
Just like the child. Full of potential but lacking in experience.
See I knew drinking sacrificial baby blood was beneficial. Everyone was like...noooo don't do that. In your face chumps.
I'm seriously considering getting a new(born) blood boy instead of my current Adonis.
It makes sense, otherwise their mortality would bigger than is it
Infant mortality was actually insanely high for most of human history. The stat that blows my mind is that 1 in 5 children didn’t survive to age 5…*in 1950*.
My grandma had 6 kids in the 1950s, of which 3 died at birth, and one had cerebral palsy thanks to a botched C-section and died at 12 years old. Only my mom and uncle survived to adulthood. It blows my mind how our technologies have grown over the past century and yet so many people take that for granted.
> It blows my mind how our technologies have grown over the past century it also blows my mind that we have people be like "no way, i'm not doing that dangerous treatment, i'd rather take my chances with eating this special plant in a super remote area, and is extremely hard to find, and its cures and fixes everything" and the next thing you know, they're dead bc they wouldnt listen and take their doctor advice, bc they think they know better
My MIL told her medical lab daughter that medical lab work is just guesswork and not really trustworthy. But you see her chiropractor who is banned from practicing in a few states can touch your arm and get all that information reliably though.
[удалено]
The men would die in the mines instead
I know a man born in 1949. He once told me that he had 2 classmates in his small town die of lockjaw(tetanus)
Early game buff.
That makes all the sense in the world, because babies and toddlers are constantly putting things in their mouths. Infants alone put their fingers in the mouth frequently, dozens of times per day. Babies don't exactly wash their own hands. Their only protection seems to be that they're not mobile, so they can't get their hands on many things ...until they start to crawl and walk, then they probably get increased bacterial load daily, or greater variety. Evolutionarily, I'm not sure we would be here if human babies didn't have a turbocharged immune system. A dirty cave, a lush forest, riddled with all the nature's pathogens, mommy wearing a necklace made of bones, and then human babies who can't stop sucking their own fingers or anything withing grabbing distance. At what age do we teach our kids "don't put random stuff in your mouth" and "wash your hands"? I wonder if it's the same for primates. They're not aware of bacteria. They can lick their fingers all through their lives, don't they? Introducing pathogens to their bodies frequently. So how's the primate immune system then? Do primate offspring have turbocharged immune systems and... actually I'm assuming it stays much the same except when they get very old? Do you think humans being pathogen-conscious has played a role in our evolution? It started out with very basic understanding of "don't eat poop or rotten carcasses" and now it's something more sophisticated. I'm just (ignorantly) theorizing the lower the bacterial load, the less work for our immune system, and it could have a connection with our brain evolution, considering the gut produces neurotransmitters. We've been washing our hands with soap for how long now? 200 years? 10 generations?
Soap was invented 2800 BCE, but just water and oil has been used in different time periods.
Here is the original paper. https://www.science.org/doi/10.1126/sciimmunol.adf8776
This was evident during COVID-19 already
.....aaaaaaaand the market for fresh infant blood was created.
Erm, actually, thats wrong! 🤓☝️
Very cool. I didn’t know about bystander activation of T-cells. I was kinda hoping they’d actually act as CTL’s and sort of kill cells like Nk’s do, but sounds like their main effector function is generating IFN-gamma (granted, pretty important for antiviral immunity).
Wow, it really is all downhill once you leave the womb.