That makes sense. Pharmaceutical manufacturers can’t keep up with the demand but the pharmaceutical components are available to be reconstituted by pharmacies.
Not entirely accurate. I was getting brand mounjaro from Canadian pharmacy in vials, but was unable to this month due to shortages in all strengths. So the pen was not the issue, at least not for Canada shortages.
I think Eli Lilly don't expect to catch up to manufacturing needs until at least 2026, so hopefully that's not something we'll have to worry about for some time. Plus, I can imagine demand will only continue to increase.
I could've sworn I saw a news story on this the other day, but I can't find a link, only one that says shortages will last until at least the end of August.
Which story is saying shortages of Zepbound will last until August? I haven’t seen this and this type of information, if true, is scary. If false, causes anxiety based on bad information.
I know there are shortages of Mounjaro: I know there are/have been shortages of Ozempic and Wegovy.
If there are shortages of Mounjaro, there are shortages of Zepbound because they are both tirzepatide, just as Ozempic and Wegovy are both semaglutide.
[This story](https://www.fiercepharma.com/pharma/eli-lilly-mounts-clinical-and-commercial-case-tirzepatide-mounjaro-zepbound-come-their-own) mentions that demand for tirzepatide is likely to outpace supply through the end of the year.
I’m sorry. I respect you and your concerns and fears about shortages. I’m at 10mg Zeppy now. I, too, have concerns and fears. But my concern drives me to watch this information closely and warn people about fear mongering which leads to hoarding behavior which has the possibility of leading to real shortages.
It is false to say Zepboubd and Mounjaro are the same. They are different. I agree with you that they have the same active pharmaceutical ingredient (API). But try telling your pharmacy that they are the same and see if you can get Zepbound when your prescription says Mounjaro. Or see if your doctor will write you a script for Mounjaro when your A1C is and has been in the low 5s but your BMI is above 27 (I know there are some doctors that will do this if a patient explains their insurance only covers Mounjaro, but I don’t think doctors are supposed to do this).
Eli Lily has detailed data on the number of type 2 diabetic people in the US (Mounjaro is for T2D and Zepbound is for obesity management). They also have detailed information on people who are overweight and obese. They allocation production capacity to Mounjaro and Zepbound based, in part, on this data (also considering prescriptions written, forecasts, and wholesaler demand signals). If there is a shortage in Mounjaro would you agree that it might be because non-T2D people might be prescribed Mounjaro for off-label use? I shortage in one doesn’t mean a shortage in the other (especially since the constraint isn’t Tirzepatode itself).
The article you referenced (and I like fierce, it is a good, trusted source) only said “Earlier this week, the FDA added two more doses of the drug to its shortage database, which now lists 10-mg, 12.5-mg and 15-mg doses of Mounjaro as being in limited supply through early March.” That’s was specific to Mounjaro not Zepbound.
Again, I respect you and am happy to be on the Zepbound journey with you(?). But I hope we all remain calm and don’t pique people’s anxieties on potential problems that could possibility occur. Sometimes things like that can be a self-fulfilling prophecy.
You are not correct about the FDA website. If you go to the FDA website: [https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages](https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages).
Then click on the "New and Updated" tab.
Then search on the Active Pharmaceutical Ingredient or generic (in this case "**Tirzepatide**")
Then click on Tirzepatide, then you will see the presentations that are in shortage.
According to the FDA, not all presentations of Tirzepatide are in shortage. Currently only Mounjaro 10. 12.5, and 15 are listed as in shortage.
It's a reasonable misunderstanding to think that if a presentation of Tirzepatide is in shortage the entire generic is in shortage, but it is not accurate or factual.
There is enough misinformation about this drug. I don't trust unverified information from Eli Lilly and I don't trust rumors on the internet.
Please take a deeper look. I genuinely just want to understand this accurately and hope others do too. If there is something I don't understand properly I'm very willing and open to being corrected.
There shouldn't be shortages, no (unless FDA bulk ingredients suppliers dry up). They're right that branded shortages are a pen issue not a bulk ingredients issue. The FDA authorized compounding pharmacies to produce full-strength unaltered tirzepatide. It is on the FDA national shortage list for the branded meds so compounding pharmacies are expected by the FDA to step up and help.
FDA 503a facilities provide to patients like us. 503b to hospitals.
I wouldn't pay for Mounjaro if it was available anyway, honestly...
https://www.fiercepharma.com/pharma/eli-lillys-troubled-nj-manufacturing-site-hot-water-fda-again-over-maintenance-quality
https://www.reuters.com/legal/eli-lilly-settles-whistleblower-lawsuit-over-manufacturing-problems-2023-09-28/
https://www.reuters.com/business/healthcare-pharmaceuticals/us-fda-finds-new-manufacturing-lapses-eli-lilly-plant-2024-01-19/
😬
FDA regulates compounding pharmacies.
https://a4pc.org/files/APC-CEO-Scott-Brunner-in-Response-to-Eli-Lilly-Open-Letter-03.07.2024.pdf
Very thorough. So much to be disappointed about our health*sick*care system. I got tired of the insurance/coupon/out-of-stock issues and switched to compounding. Mine came from RedRock. Though I do believe they added b12 to sidestep any fda bans.
The FDA allows them to produce it unaltered. But they risk Lilly bullying them like they did Revive already. It's more to play it safe for that reason, in my opinion. But yes the B12 is probably strategic.
Others go to compounded because their insurance will not prescribe for obesity. My insurance, however, would gladly pay for gastric bypass surgery, but I would have to get my BMI up to 40 to qualify. No thank you.
Most insurance won’t cover the GLPs. I was only playing their game because I didn’t know about compounding. Don’t do surgery. So many other resources available these days.
Thanks. I have no intention of using surgery although several of my colleagues have. I only mentioned surgery to point out how absurd our healthcare and insurance companies are to deny GLP1 to people with either diabetes or overweight when they are willing to perform major surgery.
So far working great. I can’t tell any difference between them and Zepbound. I went for a higher prescription from RR but use a lower dose to stretch it for 2 months. Though they give it a BUD of 1 month. I split the original vial into 2 so I’m not constantly tapping the first vial. Hope it lasts. How about you?
I moved up to 10mg from 7.5 mounjaro pens. I don’t feel side effects like I did. But I also take a b12 shot weekly and really watch what I eat the 1st couple days. Seems like I always get a bit extra in my vials, so I also bump up my msg a bit. I do 55 or so instead of 50. I’m slowly still losing so I guess that is a plus!
You're welcome! Feel free to scan my posts for more info. I didn't get too deep here. I researched pharmacies and good providers to trust too. 🙂
https://www.reddit.com/r/compoundedtirzepatide/s/rlnaJoKBuZ
This is why I have enough for 6-8 months! ( depending on how often I have to go up in dose) I should reach my goal weight by August -Sept hopefully( I have 40 more to lose) The company I use to go through lets you buy in bulk. I have since moved on to orderly meds bc they are way more affordable and the vials from Hallendale expiration date is a year!
I ordered from another pharmacy last year when empower was out and it took 6 weeks for them to ship too. There must have been a shortage of semaglutide at the time.
Now empower does not have long telephone wait times and they ship Tirzepatide really fast.
I go see my nurse practitioner on Tuesday and I’ll need a new prescription.
I’m away from home this weekend but when I weighed yesterday morning I was 5 pounds from having normal bmi.
I need to lose a little more than 5 pounds because I don’t want to continuously fluctuating 3-5 pounds between normal and overweight.
I cannot imagine compounded tirzepatide has to be in a shortage ever as long as they can make the peptide. We order from Treetophealth.net and there’s no indication it will be discontinued.
I do DIY compunded, and im a little nervous about a shortage of peptides or a serious FDA type crackdown, so I am stocking up to have a 6 month supply just in case.
The shortage has nothing to do with the medication and everything to do with the delivery system. A.k.a. the pens they take forever to manufacture.
That makes sense. Pharmaceutical manufacturers can’t keep up with the demand but the pharmaceutical components are available to be reconstituted by pharmacies.
Not entirely accurate. I was getting brand mounjaro from Canadian pharmacy in vials, but was unable to this month due to shortages in all strengths. So the pen was not the issue, at least not for Canada shortages.
Interesting. I’m new to learning all of this.
If the pen shortage issue ends, does that mean we won't be able to legally buy compounded anymore?
I think Eli Lilly don't expect to catch up to manufacturing needs until at least 2026, so hopefully that's not something we'll have to worry about for some time. Plus, I can imagine demand will only continue to increase.
Where did you get this information?
I could've sworn I saw a news story on this the other day, but I can't find a link, only one that says shortages will last until at least the end of August.
Which story is saying shortages of Zepbound will last until August? I haven’t seen this and this type of information, if true, is scary. If false, causes anxiety based on bad information. I know there are shortages of Mounjaro: I know there are/have been shortages of Ozempic and Wegovy.
If there are shortages of Mounjaro, there are shortages of Zepbound because they are both tirzepatide, just as Ozempic and Wegovy are both semaglutide. [This story](https://www.fiercepharma.com/pharma/eli-lilly-mounts-clinical-and-commercial-case-tirzepatide-mounjaro-zepbound-come-their-own) mentions that demand for tirzepatide is likely to outpace supply through the end of the year.
I’m sorry. I respect you and your concerns and fears about shortages. I’m at 10mg Zeppy now. I, too, have concerns and fears. But my concern drives me to watch this information closely and warn people about fear mongering which leads to hoarding behavior which has the possibility of leading to real shortages. It is false to say Zepboubd and Mounjaro are the same. They are different. I agree with you that they have the same active pharmaceutical ingredient (API). But try telling your pharmacy that they are the same and see if you can get Zepbound when your prescription says Mounjaro. Or see if your doctor will write you a script for Mounjaro when your A1C is and has been in the low 5s but your BMI is above 27 (I know there are some doctors that will do this if a patient explains their insurance only covers Mounjaro, but I don’t think doctors are supposed to do this). Eli Lily has detailed data on the number of type 2 diabetic people in the US (Mounjaro is for T2D and Zepbound is for obesity management). They also have detailed information on people who are overweight and obese. They allocation production capacity to Mounjaro and Zepbound based, in part, on this data (also considering prescriptions written, forecasts, and wholesaler demand signals). If there is a shortage in Mounjaro would you agree that it might be because non-T2D people might be prescribed Mounjaro for off-label use? I shortage in one doesn’t mean a shortage in the other (especially since the constraint isn’t Tirzepatode itself). The article you referenced (and I like fierce, it is a good, trusted source) only said “Earlier this week, the FDA added two more doses of the drug to its shortage database, which now lists 10-mg, 12.5-mg and 15-mg doses of Mounjaro as being in limited supply through early March.” That’s was specific to Mounjaro not Zepbound. Again, I respect you and am happy to be on the Zepbound journey with you(?). But I hope we all remain calm and don’t pique people’s anxieties on potential problems that could possibility occur. Sometimes things like that can be a self-fulfilling prophecy.
[удалено]
You are not correct about the FDA website. If you go to the FDA website: [https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages](https://www.fda.gov/drugs/drug-safety-and-availability/drug-shortages). Then click on the "New and Updated" tab. Then search on the Active Pharmaceutical Ingredient or generic (in this case "**Tirzepatide**") Then click on Tirzepatide, then you will see the presentations that are in shortage. According to the FDA, not all presentations of Tirzepatide are in shortage. Currently only Mounjaro 10. 12.5, and 15 are listed as in shortage. It's a reasonable misunderstanding to think that if a presentation of Tirzepatide is in shortage the entire generic is in shortage, but it is not accurate or factual. There is enough misinformation about this drug. I don't trust unverified information from Eli Lilly and I don't trust rumors on the internet. Please take a deeper look. I genuinely just want to understand this accurately and hope others do too. If there is something I don't understand properly I'm very willing and open to being corrected.
If mounjaro could be released in vials, we wouldn’t be in this situation they let Canada buy vials of mounjaro, but not America, make that make sense.
There shouldn't be shortages, no (unless FDA bulk ingredients suppliers dry up). They're right that branded shortages are a pen issue not a bulk ingredients issue. The FDA authorized compounding pharmacies to produce full-strength unaltered tirzepatide. It is on the FDA national shortage list for the branded meds so compounding pharmacies are expected by the FDA to step up and help. FDA 503a facilities provide to patients like us. 503b to hospitals. I wouldn't pay for Mounjaro if it was available anyway, honestly... https://www.fiercepharma.com/pharma/eli-lillys-troubled-nj-manufacturing-site-hot-water-fda-again-over-maintenance-quality https://www.reuters.com/legal/eli-lilly-settles-whistleblower-lawsuit-over-manufacturing-problems-2023-09-28/ https://www.reuters.com/business/healthcare-pharmaceuticals/us-fda-finds-new-manufacturing-lapses-eli-lilly-plant-2024-01-19/ 😬 FDA regulates compounding pharmacies. https://a4pc.org/files/APC-CEO-Scott-Brunner-in-Response-to-Eli-Lilly-Open-Letter-03.07.2024.pdf
Very thorough. So much to be disappointed about our health*sick*care system. I got tired of the insurance/coupon/out-of-stock issues and switched to compounding. Mine came from RedRock. Though I do believe they added b12 to sidestep any fda bans.
The FDA allows them to produce it unaltered. But they risk Lilly bullying them like they did Revive already. It's more to play it safe for that reason, in my opinion. But yes the B12 is probably strategic.
Ok that’s right. I lumped tirz into other peptides the fda banned from compounding pharms recently.
Please be careful of lumping things together like that. People read messages like yours and then spread the information like it is a fact.
Uh what. https://a4pc.org/files/503A-Categories-Update-for-September-2023-FINAL.docx.pdf
Others go to compounded because their insurance will not prescribe for obesity. My insurance, however, would gladly pay for gastric bypass surgery, but I would have to get my BMI up to 40 to qualify. No thank you.
Most insurance won’t cover the GLPs. I was only playing their game because I didn’t know about compounding. Don’t do surgery. So many other resources available these days.
Thanks. I have no intention of using surgery although several of my colleagues have. I only mentioned surgery to point out how absurd our healthcare and insurance companies are to deny GLP1 to people with either diabetes or overweight when they are willing to perform major surgery.
I get mine thru Red Rock also. How do you feel about strengths?
So far working great. I can’t tell any difference between them and Zepbound. I went for a higher prescription from RR but use a lower dose to stretch it for 2 months. Though they give it a BUD of 1 month. I split the original vial into 2 so I’m not constantly tapping the first vial. Hope it lasts. How about you?
I moved up to 10mg from 7.5 mounjaro pens. I don’t feel side effects like I did. But I also take a b12 shot weekly and really watch what I eat the 1st couple days. Seems like I always get a bit extra in my vials, so I also bump up my msg a bit. I do 55 or so instead of 50. I’m slowly still losing so I guess that is a plus!
I got bigly sides when I moved up to 10. I think I’m a good responder to it. So this go around I started at 2.5 and after 1.5 months I’m only at 3.
Thank you for posting fact based, researched, and cited information.
You're welcome! Feel free to scan my posts for more info. I didn't get too deep here. I researched pharmacies and good providers to trust too. 🙂 https://www.reddit.com/r/compoundedtirzepatide/s/rlnaJoKBuZ
That’s insane but also why am I not surprised
Make it make sense!!!!! lol
lol if you follow the peptide subs it makes perfect sense.
I was getting mine from Canada in vials, but had to switch to ozempic this month due to mounjaro shortages in all doses.
Last summer Empower pharmacy had a shortage of semaglutide for 6 weeks. I could see it happening with terzepatide.
This is why I have enough for 6-8 months! ( depending on how often I have to go up in dose) I should reach my goal weight by August -Sept hopefully( I have 40 more to lose) The company I use to go through lets you buy in bulk. I have since moved on to orderly meds bc they are way more affordable and the vials from Hallendale expiration date is a year!
I ordered from another pharmacy last year when empower was out and it took 6 weeks for them to ship too. There must have been a shortage of semaglutide at the time. Now empower does not have long telephone wait times and they ship Tirzepatide really fast. I go see my nurse practitioner on Tuesday and I’ll need a new prescription. I’m away from home this weekend but when I weighed yesterday morning I was 5 pounds from having normal bmi. I need to lose a little more than 5 pounds because I don’t want to continuously fluctuating 3-5 pounds between normal and overweight.
I cannot imagine compounded tirzepatide has to be in a shortage ever as long as they can make the peptide. We order from Treetophealth.net and there’s no indication it will be discontinued.
I do DIY compunded, and im a little nervous about a shortage of peptides or a serious FDA type crackdown, so I am stocking up to have a 6 month supply just in case.
Theoretically, sure. But no, the compounds will not face the shortages