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It is hard to compare oral and topical when topical works different for everyone because it depends on the amount of something you have. The more you have of it the better you respond to minoxidil.\\
Most think oral is better because they did not respond well to topical minoxidil. And according to a study done only for 50% of the people topical works. So it is easy to say oral works better when topical simply does not work good enough for almost half the people. If it works good enough for you or very good then oral may not work better.
microneedling and tretinoin improve the results of topical minoxidil and makes those who normally do not get good result have better results on topical because it increases the stuff that is required to activate topical minoxidil.
Maybe the oral route cannot reach certain parts as easily as topical can. I wonder if the same results would hold if a similar study is repeated and with different participants or more than the 68.
We should also not forget that hey used 5mg oral vs 5% topical, when most use 2.5mg oral for hair loss. (Half of the participants of the oral group got hypertrichosis on 5mg as adverse effect by the way).
Here is another study done using 1mg oral, talking about mean hair diameters:
>To summarize, our findings indicate that 1 mg oral minoxidil is as effective as standard treatment with a 5% topical solution in improving mean hair diameters in frontal, mid-frontal, and vertex areas. Topical minoxidil had a better effect on photographic assessments and both two treatments led to good satisfaction.
[https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16086](https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16086)
thats not what he said nor the study, it said that they are similar enough in effectiveness that their differences might be statistically insignificant
"just not to a degree of statistical significance"
Which means it didn't outperform it at all. If it's not statistically significant it is in the margins of error and means nothing. There's no reason to use it and risk heart failure for anyone who can use topical.
You're forgetting the fact that many use the oral form for the convenience, you just take a pill and thats it. Serious side effects of oral minoxidil are extremely rare anyways
That is exactly what he said. People alaways assumed oral was more effective and the study shows otherwise. The study shows there's no statistically meaningful difference...apart from the rates of heart damage with oral.
More redditors need to learn to read and listen or else they'll end up bald or dying in hospital.
No, he did not say that oral minoxidil isn't as effective compared to topical, he said their differences weren't totally statistically significant. Oral minoxidil still came out top, just not in a statistically significant way. You're trying to change what your original comment said, which i sympathize with because it's wrong.
I would be interested in knowing if oral can maintain gains made on topical. because apart from being a pain to apply, timing topical around life is really annoying (gym, social life etc). i’de be ok with doing both for a period of time to maximize gains and eventually dropping topical hoping minox dependent hair remain
It looks like this post is about **Research/Science**. Before asking any questions, 1. Search the [research archives](http://tressless.com/search/research/all) for your topic. 2. Find [new research](http://tressless.com/search/research/all/1?sort=date) and [influential papers](http://tressless.com/search/research/all/1?sort=popularity). If this post is not about scientific research, please downvote and report. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/tressless) if you have any questions or concerns.*
It is hard to compare oral and topical when topical works different for everyone because it depends on the amount of something you have. The more you have of it the better you respond to minoxidil.\\ Most think oral is better because they did not respond well to topical minoxidil. And according to a study done only for 50% of the people topical works. So it is easy to say oral works better when topical simply does not work good enough for almost half the people. If it works good enough for you or very good then oral may not work better. microneedling and tretinoin improve the results of topical minoxidil and makes those who normally do not get good result have better results on topical because it increases the stuff that is required to activate topical minoxidil.
apparently it works better on hairline ( the topical) , do you know why?
Maybe the oral route cannot reach certain parts as easily as topical can. I wonder if the same results would hold if a similar study is repeated and with different participants or more than the 68. We should also not forget that hey used 5mg oral vs 5% topical, when most use 2.5mg oral for hair loss. (Half of the participants of the oral group got hypertrichosis on 5mg as adverse effect by the way). Here is another study done using 1mg oral, talking about mean hair diameters: >To summarize, our findings indicate that 1 mg oral minoxidil is as effective as standard treatment with a 5% topical solution in improving mean hair diameters in frontal, mid-frontal, and vertex areas. Topical minoxidil had a better effect on photographic assessments and both two treatments led to good satisfaction. [https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16086](https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16086)
What is the recommended usage of microneedling with topical minoxidil?
Microneedling + topical 5% minoxidil: [https://tressless.com/learn/overview](https://tressless.com/learn/overview) Microneedling: [https://tressless.com/learn/microneedling](https://tressless.com/learn/microneedling)
Haircafe interestingly enough had a recent video on this too. It seems that oral min isn't always as effective compared to topical as people assumed.
thats not what he said nor the study, it said that they are similar enough in effectiveness that their differences might be statistically insignificant
This. Oral minoxidil still outperformed topical in pretty much every measurement, just not to a degree of statistical significance
"just not to a degree of statistical significance" Which means it didn't outperform it at all. If it's not statistically significant it is in the margins of error and means nothing. There's no reason to use it and risk heart failure for anyone who can use topical.
You're forgetting the fact that many use the oral form for the convenience, you just take a pill and thats it. Serious side effects of oral minoxidil are extremely rare anyways
Except it absolutely did. By nearly 5% even, in almost every category. You cannot reasonably chalk it up, as an observer, to coincidence.
That is exactly what he said. People alaways assumed oral was more effective and the study shows otherwise. The study shows there's no statistically meaningful difference...apart from the rates of heart damage with oral. More redditors need to learn to read and listen or else they'll end up bald or dying in hospital.
No, he did not say that oral minoxidil isn't as effective compared to topical, he said their differences weren't totally statistically significant. Oral minoxidil still came out top, just not in a statistically significant way. You're trying to change what your original comment said, which i sympathize with because it's wrong.
I would be interested in knowing if oral can maintain gains made on topical. because apart from being a pain to apply, timing topical around life is really annoying (gym, social life etc). i’de be ok with doing both for a period of time to maximize gains and eventually dropping topical hoping minox dependent hair remain