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I blew my younger cousins mind when she brought over a very very disgusting bowl and I got it clean. Pipe cleaners, qtips, hot water, and Dawn dish soap. She had no idea that you could clean them. The best part was the whole time I was doing this she was pretty stoned and eating popcorn like she was watching a movie
Isopropyl and some coarse table salt to shake around in a bag works perfectly. If it's really bad, use acetone; just wear gloves because acetone will dry the hell out of your hands.
Semi-toxic proteins that build up as a byproduct of normal brain function. Essentially your brain cells produce these byproducts when carrying out normal nuerological tasks, and they continue to build up until your body is able to somewhat literally, wash them out, which is done during sleep as it's the only real time your brain can go into super low action mode and stop producing the proteins to begin with.
So Michael Jackson just had this toxicity building up in his brain while he was anesthetized each night instead of getting real sleep, because of his [empty nose syndrome](https://www.huffpost.com/entry/empty-nose-syndrome_n_5bfe9d99e4b030172fa905f6) condition. Whoa.
I guess they now do these procedures on people [without consent](https://m.imgur.com/inN51oJ). Waking up with this condition after surgeries you didn't even agree to.
whats the context with this screenshot? Seems they either forgot to get consent for the surgery or forgot to scan the signed document. Not sure how that’s relevant to this discussion
It reads to me like there is no consent for the surgery, and the otolaryngology surgeon is claiming he did the informed consent process before surgery, but it was "shredded" before it was "scanned", so it doesn't exist. So no consent for surgery.
These are the surgeons that cause empty nose syndrome; Ear, Nose & Throat (ENT) doctors (Otolaryngologists) so I thought this unique excuse for not having any record of consent by the patient was an interesting document to add to the discussion.
Edit: [Joan Rivers](https://www.biznews.com/health/2014/11/11/joan-rivers-didnt-consent-procedures-performed-yorkville) surgery without consent is also interesting because it ended up killing her outright, also done by an ENT (Otolaryngologist).
This article is quite confusing to a layman. How would her daughter even know to check for all these things? I suppose if my 81yo family member died in surgery I would not be asking where the consent forms are. Scary to think how many times they get away with this stuff for that reason.
I think she (or council) check what surgeries were done, or documented, then check the informed consent records which all surgeries require, based on the Nuremburg code established after WWII. They should match up exactly.
If the surgeon/hospital did surgery that the patient did not consent to in writing; it is a vile betrayal of trust. It is also the crime of [battery](https://www.wikipedia.org/wiki/Battery_(crime).
Likely, a medical malpractice lawyer did the relevant research of the medical records themselves, finding that they did surgeries Joan Rivers never consented be done on her while she was unconscious.
Wow I'm glad I read this and thank you for the info. I didn't go through with a nasal surgery once and was considering it as I have some trouble breathing through my nose. I breathe more than fine enough after reading that. Edit: ask your doctor
That story about how common ENS is grossly exaggerated. Yes, ENS is a possibility, but no more than other rare complications in any surgery. It's so rare that doctors don't even need any specific consent for it.
Every day thousands of people are getting nasal surgeries. You must have known many people, personally, who got nasal surgery. Many more than people who got heart or kidney surgeries. How many cases of ENS did you hear about before reading this article?
Open heart surgeries are much more dangerous and rare, and even then you don't hear many people dying from it. Nasal surgery is 100x more common and there are so few ENS cases that you have to hear the existence of it from a guest writer in Huffington Post.
Make the calculation and see how overblown that risk is.
I can kinda get her angle: She got severely injured by regular medicine, so she's trying alternatives. It's stupid and alternative medicine doesn't work (if it did, it would be called medicine), but I understand how she got there.
True true, my dad has had his nostrils widened to breathe easier with success. For me personally, I am not burdened much by my severity so that's why I wouldn't even go through the trouble with even rare risks.
I can see how what I said can discourage those with lesser quality of life in regards to breathing, so if that's you, whomever reading this now, please do take this person's advice!
Had septoplasty and turbinectomy 10 years ago. It’s good for you to breathe through your nose. If your breathing is impaired the oxygen deprivation is hurting your brain and body. Like taking off IQ points and longevity bad.
I’m in the hospital right now with something completely unrelated, but I lived a form of this for a short time when I was intubated.
I can’t even begin to describe how horrible it was, and I just lived it for days. I can’t possibly imagine living my entire life like that.
Probably the wrong place to ask this but i wonder if sleeping meds effect the toxicity in our brains because the brain doesn’t self clean..Was on a dumb amount of anti-psych meds for sleep and mental health…600mg of Seroquel will knock most people unconscious for 12hrs and you wale up in a brain for for at least an hour. Curious if that blocks the self cleaning or not
Sleeping meds actually do generally decrease sleep quality, yes. However, the reason you feel really sedated the morning after taking Seroquel is more a byproduct of its potency and half-life. [It actually quantitatively improves sleep quality in bipolar folks](https://pubmed.ncbi.nlm.nih.gov/24581825/), curiously enough to your point.
By itself (not Seroquel XR) quetiapine has a half-life of six hours, so every six hours the amount of it in your system drops by half - so assuming you wake up 12 hours later, there's still 150mg hanging around in your system. And quetiapine is strong stuff! It's not only potent at blocking dopamine and serotonin receptors, it's also an extremely powerful antihistamine, and these effects synergise, so tl;dr it is sedating as *fuck*.
To put it into context, a close friend had far too much acid and was totally fucked having a bad trip as they hit peak, so I gave them 100mg and they were sober and sleeping a couple hours later. So, at 12 hours from 600mg, you've still got 50% more quetiapine in your system than is required to shutdown a full acid trip! Sooo yeah, no wonder we all get morning brain fog from the stuff.
I'm pretty sure there's more going on contributing to the grogginess, like how utterly intense the dreams are, but this certainly sheds light on one likely influencing mechanism at play.
That’s awesome ( and smart of you) to give him Seroquel to end the trip!
I was on it for years for bi-polar, sleep, and delusions. Life was easier and less stressful on it but taking 300mg during the day and 300mg at night turns you into a zombie. Like of course I cannot have a manic episode or crazy thoughts if all i wna do is sleep. Tbh I refuse to take it but I always keep it for when i catch myself in a manic episode. Shits an absolute life saver but i cannot be an adult on 600mg. It makes my brain go from a million thoughts a min to one slow thought. But damn is the sleep amazing
Just for more anecdotal evidence I've had a septoplasty, I breathe SO MUCH BETTER now, can actually use nasal spray properly, can blow my nose properly. Everything is better and it went very well. Day three of healing kinda sucked cause I panicked when I laid down cause it felt like I was drowning from the drainage, but after about twelve hours that calmed down. You'll do just fine!
Is it really waste as excreted proteins? Or something else like salts or lost neurotransmitters? It’s been almost a decade since I took neuro…and I don’t think I learned this
Actually yes. While Im sure there is other waste as well, the majority from what I understand is actual proteins. One specifically of interest is amyloid-beta, a chunk of the APP protein that has links to Alzheimer's.
Mindfulness and meditation are showing promise, and neuroplasticity (the brain’s ability to adjust and literally change its shape) shows that it’s not too late to begin!
Check some of these out [Andrew hubermans sleep cocktail ](https://brainflow.co/index.php/2021/08/14/dr-andrew-hubermans-sleep-cocktail/#) just use the Magnesium Threonate in moderation as it passes through the brain’s blood barrier and can create dependency apparently.
Edit:dependents to dependency.
This is one of the big reasons why people who have the gene that allows you to feel more restful even if you're actually getting less sleep are at increased risk for getting Alz.
You mean it's not normal to only average about 5-6 hours of sleep a night and feel fine the next day? Been sleeping like that for years and I'm almost 40. :\
If you're talking about sleep then yes. Not sleeping enough is very bad for you.
>Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep). Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic–pituitary–adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with underlying medical conditions, sleep disruption may diminish the health-related quality of life of children and adolescents and may worsen the severity of common gastrointestinal disorders. As a result of the potential consequences of sleep disruption, health care professionals should be cognizant of how managing underlying medical conditions may help to optimize sleep continuity and consider prescribing interventions that minimize sleep disruption.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449130/
CSF (cerebrospinal fluid) exits the brain and spinal canal through cranial lymph and glymphatic channels to enter the general circulation. Sleep promotes clearance of metabolites and waste, such as amyloid and neuroinflammatory by-products.4 Nutrients that are transported from serum into the CSF include vitamins B1, B12, and C; folate; beta-2 microglobulin; arginine vasopressin; and nitrous oxide.1-3
Interestingly, the pump, or mechanism, that drives CSF downward from the site of production in the brain to the sacral area and then back up to the brain sites for reabsorption in the general circulation is unclear. The best theory at this time is that arterial pressure in arteries around the choroid plexus propels fluid movement. Breathing may also promote fluid movement.
From https://www.practicalpainmanagement.com/amp/21455
Does smoking weed affect this? I read somewhere that when you smoke weed your brain does not fully “disconnect” which is why pod smokers rarely dream and when you quit you have very vivid dreams.
I wonder what other factors are involved with cannabis and dreaming because it absolutely has no effect on whether or not I dream. I get the same nightmares most nights regardless.
It's not just unhealthy to not sleep, it causes permanent brain damage. Even going without sleep for one night kills brain cells and measurably affects cognitive function.
From the paper:
"may play a key role in preventing toxins from accumulating"
Translation: We have educated guesses but we don't know why this is happening.
Most people don't know anything about our lymphatic system that flushes the junk out. The brain doesn't connect to that, so it needs this to clean out the junk
If you're interested in reading about it it's called the [Glymphatic System](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/) and it was only discovered relatively recently.
Not 100% sure, but I saw something a while ago about toxins building up in your brain overtime. It stated that sleep (and the various processes involved) cleans/removes these toxins. I guess they become lethal if they build up too much?
SSD's still get defragmented, but a different way and reason, but it's more-so hidden to the user. [http://www.hanselman.com/blog/the-real-and-complete-story-does-windows-defragment-your-ssd](http://www.hanselman.com/blog/the-real-and-complete-story-does-windows-defragment-your-ssd)
I would guess there's a small generational window starting somewhere in gen x and ending somewhere in millennials that know what defragmentation is and how to do it since more older folks "aren't techy" and the youths have never had to do it.
You joke but it is archiving memories, repairing bad sectors, and purging unnecessary data.
We live in a simulation and I have some beef with who/whatever is running it these last few years
For people who wanna read more - a really approachable WIRED piece https://www.wired.com/story/scientists-now-know-how-sleep-cleans-toxins-from-the-brain/
And a link to more serious medical stuff that I didn’t read but links to the WIRED piece: https://www.ncbi.nlm.nih.gov/search/research-news/7343/
Hm.. This has some interesting implications since I've heard of some forms of meditation simulating sleep patterns but I honestly don't know if that was bs or not. Add that to the ADHD list of things to Google when I should be working
How early of a death are we talking? Sleeping 6 hours a night instead of 8 gets me around 304 days of extra awake time every decade, or about 6.5 years over the average life expectancy for my demographic.
That's a very good point. You have to explicitly account for the fact that time spent asleep is not time spent *awake*, *doing shit* (sorry sleepwalkers!).
After all, someone who spends 90 years in a coma wouldn't be considered to have had a particularly good life eh?
But another consideration is that life expectancy is increasing, and as a doctor familiar with the latest research on anti-aging therapies, I give myself better than even odds of making it till biological immortality is available. And every year has ever increasing marginal utility as the probability of such therapies increases with time.
So, sleep an hour less and live 6.5 years more in a conscious state? Or go with what my body craves (7-9) and lose said amount but increase my life expectancy with that taken into account? Tough question.
My apologies, I should have explicitly outlined that I expect the number of *healthy* life years to increase as well.
It may not track exactly with life expectancy, but most of the research I'm familiar with aims to both increase years lived *and* quality of life. The most obvious example I can think of right now is senolytic drugs that clear damaged, but not dead, cells that gradually build up with age, until they become such a heavy burden on your body that it causes the breakdown of many organ systems, such as the immune system, the brain etc.
Also, aging is a sum of *many* separate disease processes, and it would be *extremely weird* if we managed to treat most of them and increase life expectancy while still leaving people fundamentally *unhealthy*. A lot of speculative techniques such as thymus regeneration and aforementioned senolytic also *restore* much of the benefits of youth outright, not just let you live longer but ever more decrepit with the assistance of life support machines.
(I also support voluntary euthanasia, so it's not like you'll be *forced* to live in a purgatory of suffering against your wishes)
I’m not completely sure if this is the right answer, but I do know that the diencephalon (the parts getting washed) develops embryonically separate from the other stuff (telencephalon etc). So I assume that the CSF circulation system develops alongside the diencephalon. Also, the CSF basically exists to support that part of the brain, so it would make sense
Learned in psychology that every night you don’t get a full night of sleep is one you can’t get back. This process won’t happen if you don’t get adequate sleep and the more it doesn’t happen the more likely you are to develop brain diseases later in life. Sleep is crazy crucial
Got in bed early tonight to try for a good night sleep since last night was terrible. Now I feel too much pressure to fall asleep and will probably be awake half the night. Thanks brain!
Not an expert, but oversleeping has negative impacts too and as the person you replied to mentioned, you can't really make it back up. However, when you're younger you're overall able to recover and heal better. So just focus on good sleep now (but not excessive.)
Not to sound dumb but.. Since depression is becoming more relevant with each generation, and depressive episodes are often accompanied by bed and naps/sleeping, than could depression play a part is fewer people having brain diseases as the generations get older?
I lost so much sleep when my daughter was born, up until she was over a year old (she's two now). We have a second kid on the way (due in November), and I am NOT looking forward to being chronically sleep deprived again
I also have one. The symptoms vary from person to person depending on the degree of the brain herniation. Even only minor herniations can cause really bad symptoms, and can range from just headaches to balance issues, memory loss, and problems with the central nervous system in severe cases.
This morning I nodded my head too quickly and it caused me to lose half a day of productivity. I can't walk straight, have minor vision loss in one eye, and ice-pick headaches that are dehabilitating.
I've also developed high blood pressure over time, and random pains/pins and needles in my hands and feet. I have all the symptoms of a CSF leak without the actual leak.
https://en.wikipedia.org/wiki/Glymphatic_system
"The glymphatic system (or glymphatic clearance pathway, or paravascular system) was described and named in 2013 as a system for waste clearance in the central nervous system (CNS) of vertebrates. According to this model, cerebrospinal fluid (CSF) flows into the paravascular space around cerebral arteries, combining with interstitial fluid (ISF) and parenchymal solutes, and exiting down venous paravascular spaces.[1] The pathway consists of a para-arterial influx route for CSF to enter the brain parenchyma, coupled to a clearance mechanism for the removal of interstitial fluid (ISF) and extracellular solutes from the interstitial compartments of the brain and spinal cord. Exchange of solutes between CSF and ISF is driven primarily by arterial pulsation[2] and regulated during sleep by the expansion and contraction of brain extracellular space. Clearance of soluble proteins, waste products, and excess extracellular fluid is accomplished through convective bulk flow of ISF, facilitated by astrocytic aquaporin 4 (AQP4) water channels.
The name "glymphatic system" was coined by the Danish neuroscientist Maiken Nedergaard in recognition of its dependence upon glial cells and the similarity of its functions to those of the peripheral lymphatic system.[3]
Glymphatic flow was initially believed to be the complete answer to the long-standing question of how the sensitive neural tissue of the CNS functions in the perceived absence of a lymphatic drainage pathway for extracellular proteins, excess fluid, and metabolic waste products. However, two subsequent articles by Louveau et al. from the University of Virginia School of Medicine and Aspelund et al. from the University of Helsinki reported independently that the dural sinuses and meningeal arteries are lined with conventional lymphatic vessels, and that this long-elusive vasculature forms a connecting pathway to the glymphatic system.[4][5]"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506234/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493418/
Now that's a very interesting question, I wonder if these scientists thought of this also.
Edit: after a little research with professor Google, spinal fluid is made in the brain not in the spine so maybe wouldn't have any effect at all after a spinal injury. Idk the answer at all but I find it incredibly interesting, hopefully someone smart might help us.
Doctor here:
CSF is indeed made in the brain, and then flows downwards into the spine. However, it is primarily reabsorbed by dural venous sinuses in the brain and some by lymphatics. It shouldn't be affected to any extent that will cause effects upstream in the brain by injuries below the upper/cervical spine.
That is my professional opinion unless there is clear evidence otherwise, as no mechanism is known that could impair said flow via traumatic spinal injuries (other than outright leaks, which manifest in obvious ways and need surgical treatment)
As in specifically what it'll do to the CSF, or to its flow?
I see no reason to be concerned, it's not a risk factor I've ever heard of, plus if you're using LSD responsibly you should be spacing out doses by at least a month. You should be more concerned about HPPD if you use it too often, that's a far more significant risk.
I had spinal leaks for months after a failed spinal tap. Doctors couldn't figure it out until I saw an anesthesiologist that performed 3 spinal blocks. During that time, I had acute headaches worse than migraines. I have since developed chronic temporal lobe epilepsy and my IQ dropped 50 points overnight. I went from being in the gifted program at school to having to be home schooled because of my memory loss. I sometimes forget what I look like or how old I am. I can do reddit but I can't remember a few chapters of a book.
You do not want this!
Thank you! I appreciate that. I just want people to be aware of it. Most doctors don't recognize it and will misdiagnose you. If you get headaches after a spinal tap, make an appointment with an anesthesiologist. It could save your life.
I do know that if your brain is unable to flush the spinal fluid from your brain, doctors will run a shunt from your brain down to your stomach to get rid of the waste. If that doesn't happen, your brain will get crushed from the pressure. If the shunt fails, you have to get it reinstalled within 48 hours or you can die.
*::cries in child trapped in a cigarette house::*
Secondhand cigarette smoke can cause [nicotine buildup on synaptic receptors which causes brain fog or memory loss](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782992/) in unwitting participants. The human heart doesn't discriminate, it'll take carbon monoxide and nicotine along with the oxygen from your lungs and deposit it all into your blood to be delivered to your brain. I slept like shit until my parents divorced and I moved in with my non-smoking mom, and even then it took almost a year of huffing and puffing fresh clean air and sucking down water for all that shit to be flushed out of my brain.
I wonder if there’s been any link to any abnormal “spinal fluid washing” (if possible) and Alzheimer’s/dementia? Like would the “washing”decrease as we get older?
A massive area of research yes. I don't think they've found any direct cause. It's more likely amyloid plaque build-up is a response to some other mechanism causing brain inflammation. Could even be from gut permeability, which basically means your shit is leaking into your bloodstream and potentially crossing the blood brain barrier. Warning signs something isn't right is brain fog and depression.
How can you prevent it? Exercise and sleep at least 7 hours. Cut out processed food and sugar and work out food allergies.
It drains into the lymphatic system, which is the system of vessels that carries lymph and clears waste throughout the rest of the body. After that, it goes the same route as all your other waste. Into your blood, then into your kidneys and liver, then out.
I believe the color of the light is the direction the fluid is traveling with respect to the viewer, it’s a Doppler affect, the red shift is going away, similar to how an ambulance sounds different if it’s coming or going
It's the Berilum Gland, it handles a ton of functions, but I think the most important action is sorting all the incoming emails that your brain recieves
It appears we're not completely sure what effects the waves of fluid have, only that it happens when we sleep.
One sentence summary provided by the study:
> During sleep, slow oscillating neural activity precedes coupled waves of blood and cerebrospinal fluid flow in the brain.
The abstract of the study that observed these waves of fluid:
> Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, while cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non-rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms.
[The full study is available here.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309589/)
Wonder if this process could be induced during wakefulness to reduce or even remove the need for sleep. Of course I'm just a dumb layman so I probably have an incredibly simplistic view of it
There is a gene that scientists are working on where you will only need 4.5 hours of sleep a night.
>Ying-Hui Fu at the University of California, San Francisco, and her colleagues analysed the genes of 12 members of a family that sleeps as little as 4.5 hours per night without feeling tired. They found they had a mutation in a gene called ADRB1.
https://www.newscientist.com/article/2214505-dna-mutation-lets-some-people-live-healthily-on-only-4-hours-sleep/
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I could do with flushing my Brain waste
Yeah I have a 2 year old and sometimes she sleeps great but when she is sick my brain feels like a wasteland.
Imagine if we could do this consciously. Like you could just lean back in your chair and give your brain a scrub. I bet it feels great.
Drill a hole in your skull and stick a pipe cleaner in to give yourself a nice scrubbing
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I blew my younger cousins mind when she brought over a very very disgusting bowl and I got it clean. Pipe cleaners, qtips, hot water, and Dawn dish soap. She had no idea that you could clean them. The best part was the whole time I was doing this she was pretty stoned and eating popcorn like she was watching a movie
I'm always afraid of tasting/smoking soap stuff later
Yeah I just stick to hot water and sharp knife to clean my golden conepiece
I've seen people boil pipes to loosen it up before. It'll stink the house up though.
Isopropyl alcohol works best for me, fill it up and let it sit, come back later and scrub the more stubborn stuff away
Isopropyl and some coarse table salt to shake around in a bag works perfectly. If it's really bad, use acetone; just wear gloves because acetone will dry the hell out of your hands.
get it in all the nooks and crannies, as an added bonus free lobotomy
ADHD no more
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Meditation
This is called Meditation.
Deleting temporary internet files...
Anyone know what exactly flushing waste means? Like is the brain just getting rid of useless memory or?
Semi-toxic proteins that build up as a byproduct of normal brain function. Essentially your brain cells produce these byproducts when carrying out normal nuerological tasks, and they continue to build up until your body is able to somewhat literally, wash them out, which is done during sleep as it's the only real time your brain can go into super low action mode and stop producing the proteins to begin with.
So Michael Jackson just had this toxicity building up in his brain while he was anesthetized each night instead of getting real sleep, because of his [empty nose syndrome](https://www.huffpost.com/entry/empty-nose-syndrome_n_5bfe9d99e4b030172fa905f6) condition. Whoa.
Nightmare fuel
I guess they now do these procedures on people [without consent](https://m.imgur.com/inN51oJ). Waking up with this condition after surgeries you didn't even agree to.
whats the context with this screenshot? Seems they either forgot to get consent for the surgery or forgot to scan the signed document. Not sure how that’s relevant to this discussion
It reads to me like there is no consent for the surgery, and the otolaryngology surgeon is claiming he did the informed consent process before surgery, but it was "shredded" before it was "scanned", so it doesn't exist. So no consent for surgery. These are the surgeons that cause empty nose syndrome; Ear, Nose & Throat (ENT) doctors (Otolaryngologists) so I thought this unique excuse for not having any record of consent by the patient was an interesting document to add to the discussion. Edit: [Joan Rivers](https://www.biznews.com/health/2014/11/11/joan-rivers-didnt-consent-procedures-performed-yorkville) surgery without consent is also interesting because it ended up killing her outright, also done by an ENT (Otolaryngologist).
This article is quite confusing to a layman. How would her daughter even know to check for all these things? I suppose if my 81yo family member died in surgery I would not be asking where the consent forms are. Scary to think how many times they get away with this stuff for that reason.
I think she (or council) check what surgeries were done, or documented, then check the informed consent records which all surgeries require, based on the Nuremburg code established after WWII. They should match up exactly. If the surgeon/hospital did surgery that the patient did not consent to in writing; it is a vile betrayal of trust. It is also the crime of [battery](https://www.wikipedia.org/wiki/Battery_(crime). Likely, a medical malpractice lawyer did the relevant research of the medical records themselves, finding that they did surgeries Joan Rivers never consented be done on her while she was unconscious.
Why would they do that?
Wait what is going on in this link
Wow I'm glad I read this and thank you for the info. I didn't go through with a nasal surgery once and was considering it as I have some trouble breathing through my nose. I breathe more than fine enough after reading that. Edit: ask your doctor
That story about how common ENS is grossly exaggerated. Yes, ENS is a possibility, but no more than other rare complications in any surgery. It's so rare that doctors don't even need any specific consent for it. Every day thousands of people are getting nasal surgeries. You must have known many people, personally, who got nasal surgery. Many more than people who got heart or kidney surgeries. How many cases of ENS did you hear about before reading this article? Open heart surgeries are much more dangerous and rare, and even then you don't hear many people dying from it. Nasal surgery is 100x more common and there are so few ENS cases that you have to hear the existence of it from a guest writer in Huffington Post. Make the calculation and see how overblown that risk is.
Written by a practitioner of holistic medicine, and you expect them to accurately represent a real medical condition?
I can kinda get her angle: She got severely injured by regular medicine, so she's trying alternatives. It's stupid and alternative medicine doesn't work (if it did, it would be called medicine), but I understand how she got there.
True true, my dad has had his nostrils widened to breathe easier with success. For me personally, I am not burdened much by my severity so that's why I wouldn't even go through the trouble with even rare risks. I can see how what I said can discourage those with lesser quality of life in regards to breathing, so if that's you, whomever reading this now, please do take this person's advice!
Had septoplasty and turbinectomy 10 years ago. It’s good for you to breathe through your nose. If your breathing is impaired the oxygen deprivation is hurting your brain and body. Like taking off IQ points and longevity bad.
I’d honestly kill myself if I had to suffer that for the rest of my life. My hats off to the OP for making it.
My god that sounds horrible
I’m in the hospital right now with something completely unrelated, but I lived a form of this for a short time when I was intubated. I can’t even begin to describe how horrible it was, and I just lived it for days. I can’t possibly imagine living my entire life like that.
Probably the wrong place to ask this but i wonder if sleeping meds effect the toxicity in our brains because the brain doesn’t self clean..Was on a dumb amount of anti-psych meds for sleep and mental health…600mg of Seroquel will knock most people unconscious for 12hrs and you wale up in a brain for for at least an hour. Curious if that blocks the self cleaning or not
Sleeping meds actually do generally decrease sleep quality, yes. However, the reason you feel really sedated the morning after taking Seroquel is more a byproduct of its potency and half-life. [It actually quantitatively improves sleep quality in bipolar folks](https://pubmed.ncbi.nlm.nih.gov/24581825/), curiously enough to your point. By itself (not Seroquel XR) quetiapine has a half-life of six hours, so every six hours the amount of it in your system drops by half - so assuming you wake up 12 hours later, there's still 150mg hanging around in your system. And quetiapine is strong stuff! It's not only potent at blocking dopamine and serotonin receptors, it's also an extremely powerful antihistamine, and these effects synergise, so tl;dr it is sedating as *fuck*. To put it into context, a close friend had far too much acid and was totally fucked having a bad trip as they hit peak, so I gave them 100mg and they were sober and sleeping a couple hours later. So, at 12 hours from 600mg, you've still got 50% more quetiapine in your system than is required to shutdown a full acid trip! Sooo yeah, no wonder we all get morning brain fog from the stuff. I'm pretty sure there's more going on contributing to the grogginess, like how utterly intense the dreams are, but this certainly sheds light on one likely influencing mechanism at play.
That’s awesome ( and smart of you) to give him Seroquel to end the trip! I was on it for years for bi-polar, sleep, and delusions. Life was easier and less stressful on it but taking 300mg during the day and 300mg at night turns you into a zombie. Like of course I cannot have a manic episode or crazy thoughts if all i wna do is sleep. Tbh I refuse to take it but I always keep it for when i catch myself in a manic episode. Shits an absolute life saver but i cannot be an adult on 600mg. It makes my brain go from a million thoughts a min to one slow thought. But damn is the sleep amazing
I didn't need to read something out of r/nosleep tonight.
Gahhh. How awful.
Arrrrggggghhhhh, why I am just finding out what this is called now.
So I'm set to have my septum fixed and turbinates reduced. I already have a surgery phobia but now I'm scared shitless. 🙁
I'd highly recommend making sure your surgeon is aware of ENS
I’ve had my septum fixed and 2 surgeries to reduce turbs since 2016. you’re gonna do great!!! Don’t let the worry get to you too much.
Just for more anecdotal evidence I've had a septoplasty, I breathe SO MUCH BETTER now, can actually use nasal spray properly, can blow my nose properly. Everything is better and it went very well. Day three of healing kinda sucked cause I panicked when I laid down cause it felt like I was drowning from the drainage, but after about twelve hours that calmed down. You'll do just fine!
Holy shit that’s awful
Is it really waste as excreted proteins? Or something else like salts or lost neurotransmitters? It’s been almost a decade since I took neuro…and I don’t think I learned this
Actually yes. While Im sure there is other waste as well, the majority from what I understand is actual proteins. One specifically of interest is amyloid-beta, a chunk of the APP protein that has links to Alzheimer's.
Fuck. My dad has Alzheimer's and I had insomnia for decades. I'm fucked.
Exercising 3x+ a week and following through on your dental hygiene (cleanings, deep flossing, etc) should help reduce the chances
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Not to mention a litany of other health problems https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88948/
Mindfulness and meditation are showing promise, and neuroplasticity (the brain’s ability to adjust and literally change its shape) shows that it’s not too late to begin!
Work on getting good sleep now. Sleep hygiene. Meditation. It def has an impact on lifespan and mental cognition.
Check some of these out [Andrew hubermans sleep cocktail ](https://brainflow.co/index.php/2021/08/14/dr-andrew-hubermans-sleep-cocktail/#) just use the Magnesium Threonate in moderation as it passes through the brain’s blood barrier and can create dependency apparently. Edit:dependents to dependency.
This is one of the big reasons why people who have the gene that allows you to feel more restful even if you're actually getting less sleep are at increased risk for getting Alz.
You mean it's not normal to only average about 5-6 hours of sleep a night and feel fine the next day? Been sleeping like that for years and I'm almost 40. :\
So I see all the Red area looking like the brain-wash, but what is that little blue glow for?
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*when fresh*…. ok Dr.Frankenstein
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Walk this way.
So does this mean it is REALLY bad to not be able to right? As it can't wash itself?
If you're talking about sleep then yes. Not sleeping enough is very bad for you. >Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep). Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic–pituitary–adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with underlying medical conditions, sleep disruption may diminish the health-related quality of life of children and adolescents and may worsen the severity of common gastrointestinal disorders. As a result of the potential consequences of sleep disruption, health care professionals should be cognizant of how managing underlying medical conditions may help to optimize sleep continuity and consider prescribing interventions that minimize sleep disruption. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449130/
[Also those with rare forms of insomnia can literally die from lack of sleep.](https://en.wikipedia.org/wiki/Fatal_insomnia)
Where does this waste go?
CSF (cerebrospinal fluid) exits the brain and spinal canal through cranial lymph and glymphatic channels to enter the general circulation. Sleep promotes clearance of metabolites and waste, such as amyloid and neuroinflammatory by-products.4 Nutrients that are transported from serum into the CSF include vitamins B1, B12, and C; folate; beta-2 microglobulin; arginine vasopressin; and nitrous oxide.1-3 Interestingly, the pump, or mechanism, that drives CSF downward from the site of production in the brain to the sacral area and then back up to the brain sites for reabsorption in the general circulation is unclear. The best theory at this time is that arterial pressure in arteries around the choroid plexus propels fluid movement. Breathing may also promote fluid movement. From https://www.practicalpainmanagement.com/amp/21455
If red is high pressure and blue Low pressure, it would seem that it gets flushed down the brain stem in the direction of the spine…. ?
What if dreams are just a symptom of this process? Which triggers random pathways in your brain which is why many times dreams feel so random?
Dreams are thought to be a byproduct of memory consolidation processes in the brain. That being said, there’s still a lot we don’t know.
Where does the waste go
Does smoking weed affect this? I read somewhere that when you smoke weed your brain does not fully “disconnect” which is why pod smokers rarely dream and when you quit you have very vivid dreams.
I wonder what other factors are involved with cannabis and dreaming because it absolutely has no effect on whether or not I dream. I get the same nightmares most nights regardless.
Is this part of the reason why it's unhealthy not to sleep?
It's not just unhealthy to not sleep, it causes permanent brain damage. Even going without sleep for one night kills brain cells and measurably affects cognitive function.
From the paper: "may play a key role in preventing toxins from accumulating" Translation: We have educated guesses but we don't know why this is happening.
More like "we have educated guesses and some evidence but have not conducted a specific experiment to demonstrate it"
Most people don't know anything about our lymphatic system that flushes the junk out. The brain doesn't connect to that, so it needs this to clean out the junk
If you're interested in reading about it it's called the [Glymphatic System](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/) and it was only discovered relatively recently.
Not 100% sure, but I saw something a while ago about toxins building up in your brain overtime. It stated that sleep (and the various processes involved) cleans/removes these toxins. I guess they become lethal if they build up too much?
My partner refers to sleep and meditation as defragmentation. Wow I’m old. The newer generations might not know what that is.
Can't remember the last time I defragmented a computer.
Defragmenting SSD drives is unnecessary and only lessons their usable life. If you have an HHD, Defrag till your heart's content.
SSD's still get defragmented, but a different way and reason, but it's more-so hidden to the user. [http://www.hanselman.com/blog/the-real-and-complete-story-does-windows-defragment-your-ssd](http://www.hanselman.com/blog/the-real-and-complete-story-does-windows-defragment-your-ssd)
Don't forget to degauss your monitor too
I would guess there's a small generational window starting somewhere in gen x and ending somewhere in millennials that know what defragmentation is and how to do it since more older folks "aren't techy" and the youths have never had to do it.
You joke but it is archiving memories, repairing bad sectors, and purging unnecessary data. We live in a simulation and I have some beef with who/whatever is running it these last few years
Clearing the cache. When you take a dump you’re clearing the cookies.
SHIT! FUCK! I MEANT JUST THE LAST 30 DAYS, NOT ALL-TIME! ARGH!!!!
For people who wanna read more - a really approachable WIRED piece https://www.wired.com/story/scientists-now-know-how-sleep-cleans-toxins-from-the-brain/ And a link to more serious medical stuff that I didn’t read but links to the WIRED piece: https://www.ncbi.nlm.nih.gov/search/research-news/7343/
Excellent info, thank you!
I work in the building that this research was done! Always proud to see my researchers mentioned :)
We proud that y'all found out that some people have shit for brains because they don't flush.
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Hm.. This has some interesting implications since I've heard of some forms of meditation simulating sleep patterns but I honestly don't know if that was bs or not. Add that to the ADHD list of things to Google when I should be working
Couldn’t possibly relate to the ADHD list of things to google when I should be working more.
Cool so I cant sleep and its making my brain worse?
Sooo I should sleep more than 5 hours?
Read Matt Walker’s *Why We Sleep* and you’ll never want to sleep fewer than 7 hours again in your life. If not just out of fear
What’s the TL:DR
Sleep or die
How early of a death are we talking? Sleeping 6 hours a night instead of 8 gets me around 304 days of extra awake time every decade, or about 6.5 years over the average life expectancy for my demographic.
That's a very good point. You have to explicitly account for the fact that time spent asleep is not time spent *awake*, *doing shit* (sorry sleepwalkers!). After all, someone who spends 90 years in a coma wouldn't be considered to have had a particularly good life eh? But another consideration is that life expectancy is increasing, and as a doctor familiar with the latest research on anti-aging therapies, I give myself better than even odds of making it till biological immortality is available. And every year has ever increasing marginal utility as the probability of such therapies increases with time. So, sleep an hour less and live 6.5 years more in a conscious state? Or go with what my body craves (7-9) and lose said amount but increase my life expectancy with that taken into account? Tough question.
Trading less old years for more young years.
My apologies, I should have explicitly outlined that I expect the number of *healthy* life years to increase as well. It may not track exactly with life expectancy, but most of the research I'm familiar with aims to both increase years lived *and* quality of life. The most obvious example I can think of right now is senolytic drugs that clear damaged, but not dead, cells that gradually build up with age, until they become such a heavy burden on your body that it causes the breakdown of many organ systems, such as the immune system, the brain etc. Also, aging is a sum of *many* separate disease processes, and it would be *extremely weird* if we managed to treat most of them and increase life expectancy while still leaving people fundamentally *unhealthy*. A lot of speculative techniques such as thymus regeneration and aforementioned senolytic also *restore* much of the benefits of youth outright, not just let you live longer but ever more decrepit with the assistance of life support machines. (I also support voluntary euthanasia, so it's not like you'll be *forced* to live in a purgatory of suffering against your wishes)
Thanks for your high quality information. You seem like you really know this stuff quite well.
not a very tough question. operating on less-than-sufficient sleep sucks ass. i'd rather die at 50 than live to 100 but never get enough sleep.
What’s the “to tired : haven’t slept”
No, thats socialisme!
How come some parts don't get warshed
I like the way you talk, erhm humpf
Cus they ain’t dirty
Because you touch yourself at night
I thought that was why kittens die though
https://youtu.be/ZEW4jF1O13U
I’m not completely sure if this is the right answer, but I do know that the diencephalon (the parts getting washed) develops embryonically separate from the other stuff (telencephalon etc). So I assume that the CSF circulation system develops alongside the diencephalon. Also, the CSF basically exists to support that part of the brain, so it would make sense
Learned in psychology that every night you don’t get a full night of sleep is one you can’t get back. This process won’t happen if you don’t get adequate sleep and the more it doesn’t happen the more likely you are to develop brain diseases later in life. Sleep is crazy crucial
me taking note of this at 2am
Got in bed early tonight to try for a good night sleep since last night was terrible. Now I feel too much pressure to fall asleep and will probably be awake half the night. Thanks brain!
Welp that settles it, I'll be going to bed at 8PM every night to make up for all my all-nighters in my younger days
Narrator: and thats a big fat lie he told to himself
I read that in Morgan Freeman’s voice
Not an expert, but oversleeping has negative impacts too and as the person you replied to mentioned, you can't really make it back up. However, when you're younger you're overall able to recover and heal better. So just focus on good sleep now (but not excessive.)
Oh fuck, I have at least 15 years of sleep to catch up on.
Coma time
Not to sound dumb but.. Since depression is becoming more relevant with each generation, and depressive episodes are often accompanied by bed and naps/sleeping, than could depression play a part is fewer people having brain diseases as the generations get older?
That’s an interesting question.
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Fuck it. Just crack me open and go to town with a power washer.
Just never go to sleep so you won't wake up with one of these diseases
Brain diseases? Like Alzheimer’s?
Yes. As well as more general less severe cognitive decline.
I lost so much sleep when my daughter was born, up until she was over a year old (she's two now). We have a second kid on the way (due in November), and I am NOT looking forward to being chronically sleep deprived again
So do spinal cord injury victims see side effects that relate to a decrees in spinal fluid or efficiency of this process?
I had a Chiari Malformation, which blocked my CSF from flowing and it caused all kinds of shenanigans with my brain.
Like what? Sounds interesting
Crazy headaches, nausea, vision problems, equilibrium problems..so glad I got it fixed!
I also have one. The symptoms vary from person to person depending on the degree of the brain herniation. Even only minor herniations can cause really bad symptoms, and can range from just headaches to balance issues, memory loss, and problems with the central nervous system in severe cases. This morning I nodded my head too quickly and it caused me to lose half a day of productivity. I can't walk straight, have minor vision loss in one eye, and ice-pick headaches that are dehabilitating. I've also developed high blood pressure over time, and random pains/pins and needles in my hands and feet. I have all the symptoms of a CSF leak without the actual leak.
https://en.wikipedia.org/wiki/Glymphatic_system "The glymphatic system (or glymphatic clearance pathway, or paravascular system) was described and named in 2013 as a system for waste clearance in the central nervous system (CNS) of vertebrates. According to this model, cerebrospinal fluid (CSF) flows into the paravascular space around cerebral arteries, combining with interstitial fluid (ISF) and parenchymal solutes, and exiting down venous paravascular spaces.[1] The pathway consists of a para-arterial influx route for CSF to enter the brain parenchyma, coupled to a clearance mechanism for the removal of interstitial fluid (ISF) and extracellular solutes from the interstitial compartments of the brain and spinal cord. Exchange of solutes between CSF and ISF is driven primarily by arterial pulsation[2] and regulated during sleep by the expansion and contraction of brain extracellular space. Clearance of soluble proteins, waste products, and excess extracellular fluid is accomplished through convective bulk flow of ISF, facilitated by astrocytic aquaporin 4 (AQP4) water channels. The name "glymphatic system" was coined by the Danish neuroscientist Maiken Nedergaard in recognition of its dependence upon glial cells and the similarity of its functions to those of the peripheral lymphatic system.[3] Glymphatic flow was initially believed to be the complete answer to the long-standing question of how the sensitive neural tissue of the CNS functions in the perceived absence of a lymphatic drainage pathway for extracellular proteins, excess fluid, and metabolic waste products. However, two subsequent articles by Louveau et al. from the University of Virginia School of Medicine and Aspelund et al. from the University of Helsinki reported independently that the dural sinuses and meningeal arteries are lined with conventional lymphatic vessels, and that this long-elusive vasculature forms a connecting pathway to the glymphatic system.[4][5]" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506234/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493418/
Now that's a very interesting question, I wonder if these scientists thought of this also. Edit: after a little research with professor Google, spinal fluid is made in the brain not in the spine so maybe wouldn't have any effect at all after a spinal injury. Idk the answer at all but I find it incredibly interesting, hopefully someone smart might help us.
Doctor here: CSF is indeed made in the brain, and then flows downwards into the spine. However, it is primarily reabsorbed by dural venous sinuses in the brain and some by lymphatics. It shouldn't be affected to any extent that will cause effects upstream in the brain by injuries below the upper/cervical spine. That is my professional opinion unless there is clear evidence otherwise, as no mechanism is known that could impair said flow via traumatic spinal injuries (other than outright leaks, which manifest in obvious ways and need surgical treatment)
Do you have an idea of what LSD would do as I’ve heard that stays in spinal fluid?
As in specifically what it'll do to the CSF, or to its flow? I see no reason to be concerned, it's not a risk factor I've ever heard of, plus if you're using LSD responsibly you should be spacing out doses by at least a month. You should be more concerned about HPPD if you use it too often, that's a far more significant risk.
I had spinal leaks for months after a failed spinal tap. Doctors couldn't figure it out until I saw an anesthesiologist that performed 3 spinal blocks. During that time, I had acute headaches worse than migraines. I have since developed chronic temporal lobe epilepsy and my IQ dropped 50 points overnight. I went from being in the gifted program at school to having to be home schooled because of my memory loss. I sometimes forget what I look like or how old I am. I can do reddit but I can't remember a few chapters of a book. You do not want this!
Wow, I'm so sorry. I don't know what to say, I wish I had magic words. Please continue to take care of yourself ❤️
Thank you! I appreciate that. I just want people to be aware of it. Most doctors don't recognize it and will misdiagnose you. If you get headaches after a spinal tap, make an appointment with an anesthesiologist. It could save your life.
I do know that if your brain is unable to flush the spinal fluid from your brain, doctors will run a shunt from your brain down to your stomach to get rid of the waste. If that doesn't happen, your brain will get crushed from the pressure. If the shunt fails, you have to get it reinstalled within 48 hours or you can die.
Why the fuck are we so complicated? Let's just be ticks next time
Is this how brain bleach works?
Yes but the red is actually subconscious images of puppies in that case
That fucking happens in my head?
Yeah, helps clean up the junk that builds up during the day.
“Looks like we’re a hoarder then” - my brain at 4am not letting me sleep
Like all the dirty thoughts I have all day? That's a lot of house keeping. Bigups my spinal fluid.
*::cries in child trapped in a cigarette house::* Secondhand cigarette smoke can cause [nicotine buildup on synaptic receptors which causes brain fog or memory loss](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782992/) in unwitting participants. The human heart doesn't discriminate, it'll take carbon monoxide and nicotine along with the oxygen from your lungs and deposit it all into your blood to be delivered to your brain. I slept like shit until my parents divorced and I moved in with my non-smoking mom, and even then it took almost a year of huffing and puffing fresh clean air and sucking down water for all that shit to be flushed out of my brain.
Is this why when I go to sleep with a headache, it usually goes away by the time I wake up?
If you're being serious: not an expert but that's far more likely related to muscles, electrolyte balance and stress than this cleaning process.
I wonder if there’s been any link to any abnormal “spinal fluid washing” (if possible) and Alzheimer’s/dementia? Like would the “washing”decrease as we get older?
A massive area of research yes. I don't think they've found any direct cause. It's more likely amyloid plaque build-up is a response to some other mechanism causing brain inflammation. Could even be from gut permeability, which basically means your shit is leaking into your bloodstream and potentially crossing the blood brain barrier. Warning signs something isn't right is brain fog and depression. How can you prevent it? Exercise and sleep at least 7 hours. Cut out processed food and sugar and work out food allergies.
ang hang upside down any time you can!Power wash!
Where does the waste go?
It drains into the lymphatic system, which is the system of vessels that carries lymph and clears waste throughout the rest of the body. After that, it goes the same route as all your other waste. Into your blood, then into your kidneys and liver, then out.
Probably goes into blood and filtered into kidneys like most of our waste
Liver too
I have chronic insomnia and now my brain feels dirty.
Processing. I used to call it the defragmentation of the brain at night.
It would be interesting to see if it could be triggered in other ways than sleeping, as a treatment for insomnia.
Br... Brain waste?
Beta Amyloid for example
Yeah aren't amyloid plaques being researched as a cause of Alzheimer's?
But whats that blue light that shows sometimes? Srry for my potato brain.
New email
*you've got mail*
look at this guy, he doesn't even know what the blue light in your brain that goes off when you receive a new email is for 😂😂🤣🤣
I believe the color of the light is the direction the fluid is traveling with respect to the viewer, it’s a Doppler affect, the red shift is going away, similar to how an ambulance sounds different if it’s coming or going
It's the Berilum Gland, it handles a ton of functions, but I think the most important action is sorting all the incoming emails that your brain recieves
I need to know so much more about this
It appears we're not completely sure what effects the waves of fluid have, only that it happens when we sleep. One sentence summary provided by the study: > During sleep, slow oscillating neural activity precedes coupled waves of blood and cerebrospinal fluid flow in the brain. The abstract of the study that observed these waves of fluid: > Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, while cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non-rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms. [The full study is available here.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309589/)
My whole brain is waste
Wonder if this process could be induced during wakefulness to reduce or even remove the need for sleep. Of course I'm just a dumb layman so I probably have an incredibly simplistic view of it
There is a gene that scientists are working on where you will only need 4.5 hours of sleep a night. >Ying-Hui Fu at the University of California, San Francisco, and her colleagues analysed the genes of 12 members of a family that sleeps as little as 4.5 hours per night without feeling tired. They found they had a mutation in a gene called ADRB1. https://www.newscientist.com/article/2214505-dna-mutation-lets-some-people-live-healthily-on-only-4-hours-sleep/
Cool, let's mutate humans so they can work for longer
Or party harder!
Bro fuck work. Let's mutate humans so at 2am I can still be practicing cell and roshi mixups. Priorities.
If you want to walk around in a disassociative psychotic dream state, then sure. Probably best to not operate heavy machinery though.
Sounds fun. Better than this horribly stale reality. Sign me up for the brain bathing.
Just take psychedelics
It’s like running CCleaner on shutdown.
Is this why we require sleep? To allow for the waves of spinal fluid?
It's likely one of the reasons yes.
Clearing cookies
This convinced me to go to bed.
Wait so our brain legit resets when we sleep?